The Mean Platelet Volume in the Prognosis of Coronary Artery Disease Severity and Risk Stratification of Acute Coronary Syndromes.
Acute Coronary Syndrome
/ blood
Aged
Aged, 80 and over
C-Reactive Protein
/ metabolism
Coronary Angiography
Coronary Artery Disease
/ blood
Creatinine
/ blood
Female
Heart Diseases
/ mortality
Heart Failure
/ epidemiology
Humans
Male
Mean Platelet Volume
Middle Aged
Myocardial Infarction
/ blood
Prognosis
Recurrence
Severity of Illness Index
Troponin T
/ blood
Mean platelet volume
Syntax score
acute coronary syndrome
prognosis
Journal
Medical archives (Sarajevo, Bosnia and Herzegovina)
ISSN: 1986-5961
Titre abrégé: Med Arch
Pays: Bosnia and Herzegovina
ID NLM: 101635337
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
entrez:
9
8
2019
pubmed:
9
8
2019
medline:
1
2
2020
Statut:
ppublish
Résumé
Platelets play a crucial role in thrombotic episodes. Mean Platelet Volume (MPV) is the primary indicator of platelet's activation; its measurement is easy and time-effective. We tested the hypothesis that MPV is correlated with SYNTAX score in patients that suffered from an Acute Coronary Syndrome (ACS). One hundred and four (104) patients (79 male-25 female, mean age 64.2±11.1 years), who were hospitalized for an ACS and underwent coronary angiography, were included in the study. Syntax score, as an indicator of the severity of coronary artery disease (CAD), was calculated. We tried to investigate the correlation between the first measured MPV, CRP, Creatinine and high sensitivity Troponin with the Syntax score of the patient and the association of MPV and a possible Major Advanced Cardiac Event (MACE) during hospitalization. The patients were divided into four groups according to the SYNTAX score: Group A (SYNTAX score: 0, n=12), group B: Mild CAD (SYNTAX score: 1-22, n=68), group C: Moderate CAD (SYNTAX score: 23-32, n=12), and group D: Severe CAD (SYNTAX score: ≥ 33, n=12). Four patients (3.8%) developed a MACE during their hospitalization. MPV was significantly correlated to Syntax score (r=0.658, p<0.001) and was found to be an independent predictor factor of MACE with HR=6.8 (95% Confidence Interval 1.46-33.36). The cut-off value of MPV was 7.5 with a sensitivity of 98% and a specificity of 30.8%. We determined a positive correlation between MPV and Syntax score, transforming this simple test in a possible factor of risk stratification in ACS.
Identifiants
pubmed: 31391691
doi: 10.5455/medarh.2019.73.76-80
pmc: PMC6643353
doi:
Substances chimiques
Troponin T
0
C-Reactive Protein
9007-41-4
Creatinine
AYI8EX34EU
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
76-80Références
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