Peri-operative monocyte count is a marker of poor prognosis in gastric cancer: increased monocytes are a characteristic of myeloid-derived suppressor cells.
Aged
Biomarkers, Tumor
Cell Count
/ methods
Cells, Cultured
Female
Flow Cytometry
Gastrectomy
Humans
Male
Monocytes
/ pathology
Myeloid-Derived Suppressor Cells
/ pathology
Neoplasm Recurrence, Local
Neoplasm Staging
Perioperative Period
Prognosis
Retrospective Studies
Stomach Neoplasms
/ diagnosis
Survival Analysis
Biomarker
Immunosuppression
Post-operative monocyte count
Prognosis
Journal
Cancer immunology, immunotherapy : CII
ISSN: 1432-0851
Titre abrégé: Cancer Immunol Immunother
Pays: Germany
ID NLM: 8605732
Informations de publication
Date de publication:
Aug 2019
Aug 2019
Historique:
received:
21
10
2018
accepted:
05
07
2019
pubmed:
22
7
2019
medline:
14
8
2019
entrez:
21
7
2019
Statut:
ppublish
Résumé
Gastric cancer (GC) is the most common malignant tumor in digestive organs, and the prognosis of GC patients who have undergone surgery remains poor because of frequent recurrence. Therefore, the identification of new markers to predict the outcome of these patients is needed. Monocyte count is a negative prognostic factor associated with inflammation. We investigated the relationship between peripheral monocytes in the peri-operative period and prognosis in GC patients. A high pre-operative monocyte count was identified as a prognostic factor in a retrospective analysis of 278 stage II and III GC patients who underwent curative gastrectomy. In contrast, an increased post-operative monocyte count compared to the pre-operative monocyte count was a marker of poor prognosis, particularly for early relapse. In a prospective analysis of 75 GC patients, a subset of the increased post-operative monocytes was similar to CD14
Identifiants
pubmed: 31324947
doi: 10.1007/s00262-019-02366-0
pii: 10.1007/s00262-019-02366-0
doi:
Substances chimiques
Biomarkers, Tumor
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM