A review of inflammation and fibrosis: implications for the pathogenesis of Peyronie's disease.
Cytokines
Dupuytren’s contracture
Fibrosis
Inflammation
Ledderhose disease
Penile induration
Peyronie’s disease
Transforming growth factor beta
Journal
World journal of urology
ISSN: 1433-8726
Titre abrégé: World J Urol
Pays: Germany
ID NLM: 8307716
Informations de publication
Date de publication:
Feb 2020
Feb 2020
Historique:
received:
03
04
2019
accepted:
17
05
2019
pubmed:
14
6
2019
medline:
15
12
2020
entrez:
14
6
2019
Statut:
ppublish
Résumé
Peyronie's disease (PD) is a superficial fibrosing disorder that causes penile deformity and can interfere with sexual intercourse and reproduction, as well as diminish quality of life. While the exact mechanism of PD is still being investigated, there is likely a genetic component to the predisposition to penile plaque formation. Ultimately, however, perturbations in normal wound healing and aberrant deposition of extracellular matrix components lead to fibrotic tissue deposition. Fibrosis in PD is regulated by a complex pathway of inflammatory and fibrotic mediators. Currently there are no treatments for PD that address an underlying cause or disease progression. In this review, we provide an overview of the known inflammatory and fibrotic mediators of PD and explore the pathophysiology of other human superficial fibrosing disorders to develop further insights into PD.
Identifiants
pubmed: 31190155
doi: 10.1007/s00345-019-02815-6
pii: 10.1007/s00345-019-02815-6
pmc: PMC7333524
mid: NIHMS1603365
doi:
Types de publication
Journal Article
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
253-261Subventions
Organisme : NIDDK NIH HHS
ID : K08 DK115835
Pays : United States
Organisme : NIDDK NIH HHS
ID : K08DK115835-01
Pays : United States
Commentaires et corrections
Type : CommentIn
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