Growth hormone acts on liver to stimulate autophagy, support glucose production, and preserve blood glucose in chronically starved mice.
calorie restriction
ghrelin
hepatic growth hormone receptors
hypoglycemia
liver-specific knockout mice
Journal
Proceedings of the National Academy of Sciences of the United States of America
ISSN: 1091-6490
Titre abrégé: Proc Natl Acad Sci U S A
Pays: United States
ID NLM: 7505876
Informations de publication
Date de publication:
09 04 2019
09 04 2019
Historique:
pubmed:
27
3
2019
medline:
23
5
2019
entrez:
27
3
2019
Statut:
ppublish
Résumé
When mice are subjected to 60% calorie restriction for several days, they lose nearly all of their body fat. Although the animals lack energy stores, their livers produce enough glucose to maintain blood glucose at viable levels even after a 23-hour fast. This adaptation is mediated by a marked increase in plasma growth hormone (GH), which is elicited by an increase in plasma ghrelin, a GH secretagogue. In the absence of ghrelin, calorie-restricted mice develop hypoglycemia, owing to diminished glucose production. To determine the site of GH action, in the current study we used CRISPR/Cas9 and Cre recombinase technology to produce mice that lack GH receptors selectively in liver (
Identifiants
pubmed: 30910968
pii: 1901867116
doi: 10.1073/pnas.1901867116
pmc: PMC6462072
doi:
Substances chimiques
Blood Glucose
0
Growth Hormone
9002-72-6
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
7449-7454Subventions
Organisme : NHLBI NIH HHS
ID : P01 HL020948
Pays : United States
Déclaration de conflit d'intérêts
The authors declare no conflict of interest.
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