Human iPSC-based model of severe congenital neutropenia reveals elevated UPR and DNA damage in CD34
Antigens, CD34
/ metabolism
Biomarkers
Cell Transformation, Neoplastic
/ metabolism
Cells, Cultured
Cellular Reprogramming
Congenital Bone Marrow Failure Syndromes
DNA Damage
Endoplasmic Reticulum Stress
Hematopoietic Stem Cells
/ cytology
Humans
Immunophenotyping
Induced Pluripotent Stem Cells
/ cytology
Leukemia
/ etiology
Models, Biological
Neutropenia
/ congenital
Unfolded Protein Response
Journal
Experimental hematology
ISSN: 1873-2399
Titre abrégé: Exp Hematol
Pays: Netherlands
ID NLM: 0402313
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
10
10
2018
revised:
23
12
2018
accepted:
30
12
2018
pubmed:
8
1
2019
medline:
7
5
2019
entrez:
8
1
2019
Statut:
ppublish
Résumé
We describe the establishment of an embryoid-body-based protocol for hematopoietic/myeloid differentiation of human induced pluripotent stem cells that allows the generation of CD34
Identifiants
pubmed: 30615903
pii: S0301-472X(19)30004-9
doi: 10.1016/j.exphem.2018.12.006
pii:
doi:
Substances chimiques
Antigens, CD34
0
Biomarkers
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
51-60Commentaires et corrections
Type : ErratumIn
Informations de copyright
Copyright © 2019 ISEH -- Society for Hematology and Stem Cells. Published by Elsevier Inc. All rights reserved.