A Novel PET Probe "[
Animals
Fluorine Radioisotopes
Glutathione
/ metabolism
Head and Neck Neoplasms
/ diagnosis
Heterografts
Humans
Hypoxia
/ diagnosis
Male
Mice
Mice, Inbred BALB C
Mice, Nude
Nitroimidazoles
/ chemistry
Oxidation-Reduction
Oxidative Stress
/ physiology
Positron-Emission Tomography
/ methods
Tissue Distribution
Tumor Cells, Cultured
Tumor Hypoxia
/ drug effects
DiFA
Glutathione
Hypoxia
Imaging mass spectrometry
Molecular imaging
Journal
Molecular imaging and biology
ISSN: 1860-2002
Titre abrégé: Mol Imaging Biol
Pays: United States
ID NLM: 101125610
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
pubmed:
31
5
2018
medline:
30
7
2019
entrez:
31
5
2018
Statut:
ppublish
Résumé
Hypoxia in tumor has close relationship with angiogenesis and tumor progression. Previously, we developed 2,2-dihydroxymethyl-3-[ FaDu human head and neck cancer cells were treated with [ In the in vitro study, the radioactivity of FaDu cells was significantly higher under hypoxia than that under normoxia (0.53 ± 0.02 vs. 0.27 ± 0.02 %dose/mg protein, p < 0.05). The radioactivity of the low-molecular-weight fraction was 66.3 ± 0.6% in the hypoxic cell. In the in vivo study, [ Our results suggest that [
Identifiants
pubmed: 29845425
doi: 10.1007/s11307-018-1214-y
pii: 10.1007/s11307-018-1214-y
doi:
Substances chimiques
Fluorine Radioisotopes
0
Nitroimidazoles
0
Glutathione
GAN16C9B8O
Fluorine-18
GZ5I74KB8G
Types de publication
Evaluation Study
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
122-129Références
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