Wesley R Legant

Affiliations

Department of Pharmacology, UNC-Chapel Hill School of Medicine, Chapel Hill, North Carolina 27599, United States.

Publications (23)

A Photopolymerized Hydrogel System with Dual Stiffness Gradients Reveals Distinct Actomyosin-Based Mechano-Responses in Fibroblast Durotaxis.

ACS nano

Avec: Reem M Hakeem , Bhagawat C Subramanian , Max A Hockenberry , Zayna T King , Mitchell T Butler , Wesley R Legant , James E Bear

Augmin accumulation on long-lived microtubules drives amplification and kinetochore-directed growth.

The Journal of cell biology

Avec: Ana F David , Philippe Roudot , Wesley R Legant , Eric Betzig , Gaudenz Danuser , Daniel W Gerlich

Software for lattice light-sheet imaging of FRET biosensors, illustrated with a new Rap1 biosensor.

The Journal of cell biology

Avec: Ellen C O'Shaughnessy , Orrin J Stone , Paul K LaFosse , Mihai L Azoitei , Denis Tsygankov , John M Heddleston , Wesley R Legant , Erika S Wittchen , Keith Burridge , Timothy C Elston , Eric Betzig , Teng-Leong Chew , David Adalsteinsson , Klaus M Hahn

Cell dynamics revealed by microscopy advances.

Current opinion in cell biology

Avec: Max A Hockenberry , Timothy A Daugird , Wesley R Legant

u-track3D: Measuring, navigating, and validating dense particle trajectories in three dimensions.

Cell reports methods

Avec: Philippe Roudot , Wesley R Legant , Qiongjing Zou , Kevin M Dean , Tadamoto Isogai , Erik S Welf , Ana F David , Daniel W Gerlich , Reto Fiolka , Eric Betzig , Gaudenz Danuser

3D ATAC-PALM: super-resolution imaging of the accessible genome.

Nature methods

Avec: Liangqi Xie , Peng Dong , Xingqi Chen , Tsung-Han S Hsieh , Sambashiva Banala , Margherita De Marzio , Brian P English , Yifeng Qi , Seol Kyoung Jung , Kyong-Rim Kieffer-Kwon , Wesley R Legant , Anders S Hansen , Anton Schulmann , Rafael Casellas , Bin Zhang , Eric Betzig , Luke D Lavis , Howard Y Chang , Robert Tjian , Zhe Liu

High-resolution imaging reveals how the spindle midzone impacts chromosome movement.

The Journal of cell biology

Avec: Melissa C Pamula , Lina Carlini , Scott Forth , Priyanka Verma , Subbulakshmi Suresh , Wesley R Legant , Alexey Khodjakov , Eric Betzig , Tarun M Kapoor

Coro1B and Coro1C regulate lamellipodia dynamics and cell motility by tuning branched actin turnover.

The Journal of cell biology

Avec: Zayna T King , Mitchell T Butler , Max A Hockenberry , Bhagawat C Subramanian , Priscila F Siesser , David M Graham , Wesley R Legant , James E Bear

A quantitative analysis of various patterns applied in lattice light sheet microscopy.

Nature communications

Avec: Yu Shi , Timothy A Daugird , Wesley R Legant

A series of spontaneously blinking dyes for super-resolution microscopy.

bioRxiv : the preprint server for biology

Avec: Katie L Holland , Sarah E Plutkis , Timothy A Daugird , Abhishek Sau , Jonathan B Grimm , Brian P English , Qinsi Zheng , Sandeep Dave , Fariha Rahman , Liangqi Xie , Peng Dong , Ariana N Tkachuk , Timothy A Brown , Robert H Singer , Zhe Liu , Catherine G Galbraith , Siegfried M Musser , Wesley R Legant , Luke D Lavis

Correlative single molecule lattice light sheet imaging reveals the dynamic relationship between nucleosomes and the local chromatin environment.

bioRxiv : the preprint server for biology

Avec: Timothy A Daugird , Yu Shi , Katie L Holland , Hosein Rostamian , Zhe Liu , Luke D Lavis , Joseph Rodriguez , Brian D Strahl , Wesley R Legant

Smart Lattice Light Sheet Microscopy for imaging rare and complex cellular events.

bioRxiv : the preprint server for biology

Avec: Yu Shi , Jimmy S Tabet , Daniel E Milkie , Timothy A Daugird , Chelsea Q Yang , Andrea Giovannucci , Wesley R Legant

A posterior approach to correct for focal plane offsets in lattice light sheet structured illumination microscopy.

bioRxiv : the preprint server for biology

Avec: Yu Shi , Tim A Daugird , Wesley R Legant

Shared and redundant proteins coordinate signal cross-talk between MAPK pathways in yeast.

Molecular biology of the cell

Avec: Shu Zhang , Hao Wang , Emily L Sipko , Shuang Li , Timothy A Daugird , Wesley R Legant , Henrik G Dohlman

Posterior approach to correct for focal plane offsets in lattice light-sheet structured illumination microscopy.

Journal of biomedical optics

Avec: Yu Shi , Tim A Daugird , Wesley R Legant

Mapping the nuclear landscape with multiplexed super-resolution fluorescence microscopy.

bioRxiv : the preprint server for biology

Avec: Fariha Rahman , Victoria Augoustides , Emma Tyler , Timothy A Daugird , Christian Arthur , Wesley R Legant

A multi-functional microfluidic device compatible with widefield and light sheet microscopy.

Lab on a chip

Avec: Regan P Moore , Ellen C O'Shaughnessy , Yu Shi , Ana T Nogueira , Katelyn M Heath , Klaus M Hahn , Wesley R Legant

Deep learning enables fast and dense single-molecule localization with high accuracy.

Nature methods

Avec: Artur Speiser , Lucas-Raphael Müller , Philipp Hoess , Ulf Matti , Christopher J Obara , Wesley R Legant , Anna Kreshuk , Jakob H Macke , Jonas Ries , Srinivas C Turaga

Phase separation drives aberrant chromatin looping and cancer development.

Nature

Avec: Jeong Hyun Ahn , Eric S Davis , Timothy A Daugird , Shuai Zhao , Ivana Yoseli Quiroga , Hidetaka Uryu , Jie Li , Aaron J Storey , Yi-Hsuan Tsai , Daniel P Keeley , Samuel G Mackintosh , Ricky D Edmondson , Stephanie D Byrum , Ling Cai , Alan J Tackett , Deyou Zheng , Wesley R Legant , Douglas H Phanstiel , Gang Greg Wang

Superresolution microscopy reveals actomyosin dynamics in medioapical arrays.

Molecular biology of the cell

Avec: Regan P Moore , Stephanie M Fogerson , U Serdar Tulu , Jason W Yu , Amanda H Cox , Melissa A Sican , Dong Li , Wesley R Legant , Aubrey V Weigel , Janice M Crawford , Eric Betzig , Daniel P Kiehart

Smart lattice light-sheet microscopy for imaging rare and complex cellular events.

Nature methods

Avec: Yu Shi , Jimmy S Tabet , Daniel E Milkie , Timothy A Daugird , Chelsea Q Yang , Alex T Ritter , Andrea Giovannucci , Wesley R Legant

Patient-derived extracellular matrix demonstrates role of COL3A1 in blood vessel mechanics.

Acta biomaterialia

Avec: Elizabeth L Doherty , Wen Yih Aw , Emily C Warren , Max Hockenberry , Chloe P Whitworth , Grace Krohn , Stefanie Howell , Brian O Diekman , Wesley R Legant , Hadi Tavakoli Nia , Anthony J Hickey , William J Polacheck

Correlative single molecule lattice light sheet imaging reveals the dynamic relationship between nucleosomes and the local chromatin environment.

Nature communications

Avec: Timothy A Daugird , Yu Shi , Katie L Holland , Hosein Rostamian , Zhe Liu , Luke D Lavis , Joseph Rodriguez , Brian D Strahl , Wesley R Legant

Réseau de co-auteurs

Timothy A Daugird 10 collaborations

Yu Shi 8 collaborations

Eric Betzig 6 collaborations

Luke D Lavis 4 collaborations

Zhe Liu 4 collaborations

Max A Hockenberry 3 collaborations

Katie L Holland 3 collaborations

Bhagawat C Subramanian 2 collaborations

Zayna T King 2 collaborations

Mitchell T Butler 2 collaborations

James E Bear 2 collaborations

Ana F David 2 collaborations

Philippe Roudot 2 collaborations

Gaudenz Danuser 2 collaborations

Daniel W Gerlich 2 collaborations

Ellen C O'Shaughnessy 2 collaborations

Klaus M Hahn 2 collaborations

Liangqi Xie 2 collaborations

Peng Dong 2 collaborations

Brian P English 2 collaborations

Fariha Rahman 2 collaborations

Hosein Rostamian 2 collaborations

Joseph Rodriguez 2 collaborations

Brian D Strahl 2 collaborations

Jimmy S Tabet 2 collaborations

Daniel E Milkie 2 collaborations

Chelsea Q Yang 2 collaborations

Andrea Giovannucci 2 collaborations

Tim A Daugird 2 collaborations

Regan P Moore 2 collaborations

Reem M Hakeem 1 collaboration

Orrin J Stone 1 collaboration

Paul K LaFosse 1 collaboration

Mihai L Azoitei 1 collaboration

Denis Tsygankov 1 collaboration

John M Heddleston 1 collaboration

Erika S Wittchen 1 collaboration

Keith Burridge 1 collaboration

Timothy C Elston 1 collaboration

Teng-Leong Chew 1 collaboration

David Adalsteinsson 1 collaboration

Qiongjing Zou 1 collaboration

Kevin M Dean 1 collaboration

Tadamoto Isogai 1 collaboration

Erik S Welf 1 collaboration

Reto Fiolka 1 collaboration

Xingqi Chen 1 collaboration

Tsung-Han S Hsieh 1 collaboration

Sambashiva Banala 1 collaboration

Margherita De Marzio 1 collaboration

Yifeng Qi 1 collaboration

Seol Kyoung Jung 1 collaboration

Kyong-Rim Kieffer-Kwon 1 collaboration

Anders S Hansen 1 collaboration

Anton Schulmann 1 collaboration

Rafael Casellas 1 collaboration

Bin Zhang 1 collaboration

Howard Y Chang 1 collaboration

Robert Tjian 1 collaboration

Melissa C Pamula 1 collaboration

Lina Carlini 1 collaboration

Scott Forth 1 collaboration

Priyanka Verma 1 collaboration

Subbulakshmi Suresh 1 collaboration

Alexey Khodjakov 1 collaboration

Tarun M Kapoor 1 collaboration

Priscila F Siesser 1 collaboration

David M Graham 1 collaboration

Sarah E Plutkis 1 collaboration

Abhishek Sau 1 collaboration

Jonathan B Grimm 1 collaboration

Qinsi Zheng 1 collaboration

Sandeep Dave 1 collaboration

Ariana N Tkachuk 1 collaboration

Timothy A Brown 1 collaboration

Robert H Singer 1 collaboration

Catherine G Galbraith 1 collaboration

Siegfried M Musser 1 collaboration

Shu Zhang 1 collaboration

Hao Wang 1 collaboration

Emily L Sipko 1 collaboration

Shuang Li 1 collaboration

Henrik G Dohlman 1 collaboration

Victoria Augoustides 1 collaboration

Emma Tyler 1 collaboration

Christian Arthur 1 collaboration

Ana T Nogueira 1 collaboration

Katelyn M Heath 1 collaboration

Artur Speiser 1 collaboration

Lucas-Raphael Müller 1 collaboration

Philipp Hoess 1 collaboration

Ulf Matti 1 collaboration

Christopher J Obara 1 collaboration

Anna Kreshuk 1 collaboration

Jakob H Macke 1 collaboration

Jonas Ries 1 collaboration

Srinivas C Turaga 1 collaboration

Jeong Hyun Ahn 1 collaboration

Eric S Davis 1 collaboration

Shuai Zhao 1 collaboration

Ivana Yoseli Quiroga 1 collaboration

Hidetaka Uryu 1 collaboration

Jie Li 1 collaboration

Aaron J Storey 1 collaboration

Yi-Hsuan Tsai 1 collaboration

Daniel P Keeley 1 collaboration

Samuel G Mackintosh 1 collaboration

Ricky D Edmondson 1 collaboration

Stephanie D Byrum 1 collaboration

Ling Cai 1 collaboration

Alan J Tackett 1 collaboration

Deyou Zheng 1 collaboration

Douglas H Phanstiel 1 collaboration

Gang Greg Wang 1 collaboration

Stephanie M Fogerson 1 collaboration

U Serdar Tulu 1 collaboration

Jason W Yu 1 collaboration

Amanda H Cox 1 collaboration

Melissa A Sican 1 collaboration

Dong Li 1 collaboration

Aubrey V Weigel 1 collaboration

Janice M Crawford 1 collaboration

Daniel P Kiehart 1 collaboration

Alex T Ritter 1 collaboration

Elizabeth L Doherty 1 collaboration

Wen Yih Aw 1 collaboration

Emily C Warren 1 collaboration

Max Hockenberry 1 collaboration

Chloe P Whitworth 1 collaboration

Grace Krohn 1 collaboration

Stefanie Howell 1 collaboration

Brian O Diekman 1 collaboration

Hadi Tavakoli Nia 1 collaboration

Anthony J Hickey 1 collaboration

William J Polacheck 1 collaboration