Brian D Strahl

Affiliations

Curriculum in Genetics and Molecular Biology, University of North Carolina, Chapel Hill, NC 27599, USA. brian_strahl@med.unc.edu.
Department of Biochemistry and Biophysics, University of North Carolina, Chapel Hill, NC 27599, USA. brian_strahl@med.unc.edu.
Lineberger Comprehensive Cancer Center, University of North Carolina, Chapel Hill, NC 27599, USA. brian_strahl@med.unc.edu.

Publications (31)

H3K9 Promotes Under-Replication of Pericentromeric Heterochromatin in Drosophila Salivary Gland Polytene Chromosomes.

Genes

Avec: Robin L Armstrong , Taylor J R Penke , Samuel K Chao , Gabrielle M Gentile , A Gregory Matera , Daniel J McKay , Robert J Duronio

Unique and Shared Roles for Histone H3K36 Methylation States in Transcription Regulation Functions.

Cell reports

Avec: Julia V DiFiore , Travis S Ptacek , Yi Wang , Bing Li , Jeremy M Simon ,

Catalysis-dependent and redundant roles of Dma1 and Dma2 in maintenance of genome stability in Saccharomyces cerevisiae.

The Journal of biological chemistry

Avec: Andrew R Yoblinski , Seoyoung Chung , Sophie B Robinson , Kaitlyn E Forester , Raghuvar Dronamraju

BAHCC1 binds H3K27me3 via a conserved BAH module to mediate gene silencing and oncogenesis.

Nature genetics

Avec: Huitao Fan , Jiuwei Lu , Yiran Guo , Dongxu Li , Zhi-Min Zhang , Yi-Hsuan Tsai , Wen-Chieh Pi , Jeong Hyun Ahn , Weida Gong , Yu Xiang , David F Allison , Huimin Geng , Shenghui He , Yarui Diao , Wei-Yi Chen , Ling Cai , Jikui Song , Gang Greg Wang

HDAC inhibition results in widespread alteration of the histone acetylation landscape and BRD4 targeting to gene bodies.

Cell reports

Avec: Mariesa J Slaughter , Erin K Shanle , Abid Khan , Katrin F Chua , Tao Hong , Lisa D Boxer , C David Allis , Steven Z Josefowicz , Benjamin A Garcia , Scott B Rothbart , Ian J Davis

Binding specificity and function of the SWI/SNF subunit SMARCA4 bromodomain interaction with acetylated histone H3K14.

The Journal of biological chemistry

Avec: Paul Enríquez , Krzysztof Krajewski , Scott B Rothbart , Robert H Dowen , Robert B Rose

SETD2 safeguards the genome against isochromosome formation.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Frank M Mason , Emily S Kounlavong , Anteneh T Tebeje , Rashmi Dahiya , Tiffany Guess , Abid Khan , Logan Vlach , Stephen R Norris , Courtney A Lovejoy , Ruhee Dere , Ryoma Ohi , Peter Ly , Cheryl Lyn Walker , W Kimryn Rathmell

The histone methyltransferase SETD2 regulates HIV expression and latency.

PLoS pathogens

Avec: Cameron R Bussey-Sutton , Airlie Ward , Joshua A Fox , Anne-Marie W Turner , Jackson J Peterson , Ann Emery , Arturo R Longoria , Ismael Gomez-Martinez , Corbin Jones , Austin Hepperla , David M Margolis , Edward P Browne

Molecular insight into interactions between the Taf14, Yng1 and Sas3 subunits of the NuA3 complex.

Nature communications

Avec: Minh Chau Nguyen , Hosein Rostamian , Ana Raman , Pengcheng Wei , Dustin C Becht , Annette H Erbse , Brianna J Klein , Tonya M Gilbert , Gongyi Zhang , M Andres Blanco , Sean D Taverna , Tatiana G Kutateladze

Improved methods for the detection of histone interactions with peptide microarrays.

Scientific reports

Avec: Christopher J Petell , Andrea T Pham , Jessica Skela ,

Mechanically transduced immunosorbent assay to measure protein-protein interactions.

eLife

Avec: Christopher J Petell , Kathyrn Randene , Michael Pappas , Diego Sandoval , Joseph S Harrison , Joshua P Steimel

Recognition of acetylated histone by Yaf9 regulates metabolic cycling of transcription initiation and chromatin regulatory factors.

Genes & development

Avec: Jibo Zhang , Aakanksha Gundu ,

An optogenetic switch for the Set2 methyltransferase provides evidence for transcription-dependent and -independent dynamics of H3K36 methylation.

Genome research

Avec: Andrew M Lerner , Austin J Hepperla , Gregory R Keele , Hashem A Meriesh , Hayretin Yumerefendi , David Restrepo , Seth Zimmerman , James E Bear , Brian Kuhlman , Ian J Davis ,

The ZZ domain of HERC2 is a receptor of arginylated substrates.

Scientific reports

Avec: Adam H Tencer , Jiuyang Liu , Jing Zhu , Nathaniel T Burkholder , Yi Zhang , Wenwen Wu , Tomohiko Ohta , Tatiana G Kutateladze

Combined noncanonical NF-κB agonism and targeted BET bromodomain inhibition reverse HIV latency ex vivo.

The Journal of clinical investigation

Avec: Shane D Falcinelli , Jackson J Peterson , Anne-Marie W Turner , David Irlbeck , Jenna Read , Samuel Lm Raines , Katherine S James , Cameron Sutton , Anthony Sanchez , Ann Emery , Gavin Sampey , Robert Ferris , Brigitte Allard , Simon Ghofrani , Jennifer L Kirchherr , Caroline Baker , JoAnn D Kuruc , Cynthia L Gay , Lindsey I James , Guoxin Wu , Paul Zuck , Inmaculada Rioja , Rebecca C Furze , Rab K Prinjha , Bonnie J Howell , Ronald Swanstrom , Edward P Browne , Richard M Dunham , Nancie M Archin , David M Margolis

An acetylation-mediated chromatin switch governs H3K4 methylation read-write capability.

eLife

Avec: Kanishk Jain , Matthew R Marunde , Jonathan M Burg , Susan L Gloor , Faith M Joseph , Karl F Poncha , Zachary B Gillespie , Keli L Rodriguez , Irina K Popova , Nathan W Hall , Anup Vaidya , Sarah A Howard , Hailey F Taylor , Laylo Mukhsinova , Ugochi C Onuoha , Emily F Patteson , Spencer W Cooke , Bethany C Taylor , Ellen N Weinzapfel , Marcus A Cheek , Matthew J Meiners , Geoffrey C Fox , Kevin E W Namitz , Martis W Cowles , Krzysztof Krajewski , Zu-Wen Sun , Michael S Cosgrove , Nicolas L Young , Michael-Christopher Keogh ,

Correlative single molecule lattice light sheet imaging reveals the dynamic relationship between nucleosomes and the local chromatin environment.

bioRxiv : the preprint server for biology

Avec: Timothy A Daugird , Yu Shi , Katie L Holland , Hosein Rostamian , Zhe Liu , Luke D Lavis , Joseph Rodriguez , Wesley R Legant

Histone H3K18 & H3K23 acetylation directs establishment of MLL-mediated H3K4 methylation.

The Journal of biological chemistry

Avec: Geoffrey C Fox , Karl F Poncha , B Rutledge Smith , Lara N van der Maas , Nathaniel N Robbins , Bria Graham , Jill M Dowen , Nicolas L Young , Kanishk Jain

Neutrophils: back in the thrombosis spotlight.

Blood

Avec: Denis F Noubouossie , Brandi N Reeves , Nigel S Key

Lysine 27 of replication-independent histone H3.3 is required for Polycomb target gene silencing but not for gene activation.

PLoS genetics

Avec: Mary Leatham-Jensen , Christopher M Uyehara , A Gregory Matera , Robert J Duronio , Daniel J McKay

Genetic interaction mapping informs integrative structure determination of protein complexes.

Science (New York, N.Y.)

Avec: Hannes Braberg , Ignacia Echeverria , Stefan Bohn , Peter Cimermancic , Anthony Shiver , Richard Alexander , Jiewei Xu , Michael Shales , Raghuvar Dronamraju , Shuangying Jiang , Gajendradhar Dwivedi , Derek Bogdanoff , Kaitlin K Chaung , Ruth Hüttenhain , Shuyi Wang , David Mavor , Riccardo Pellarin , Dina Schneidman , Joel S Bader , James S Fraser , John Morris , James E Haber , Carol A Gross , Junbiao Dai , Jef D Boeke , Andrej Sali , Nevan J Krogan

The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cells.

Epigenetics & chromatin

Avec: Robert M Vaughan , Ariana Kupai , Caroline A Foley , Cari A Sagum , Bailey M Tibben , Hope E Eden , Rochelle L Tiedemann , Christine A Berryhill , Varun Patel , Kevin M Shaw , Krzysztof Krajewski , Mark T Bedford , Stephen V Frye , Bradley M Dickson , Scott B Rothbart

DNMT1 reads heterochromatic H4K20me3 to reinforce LINE-1 DNA methylation.

Nature communications

Avec: Wendan Ren , Huitao Fan , Sara A Grimm , Jae Jin Kim , Linhui Li , Yiran Guo , Christopher James Petell , Xiao-Feng Tan , Zhi-Min Zhang , John P Coan , Jiekai Yin , Dae In Kim , Linfeng Gao , Ling Cai , Nelli Khudaverdyan , Burak Çetin , Dinshaw J Patel , Yinsheng Wang , Qiang Cui , Or Gozani , Kyle M Miller , Seán E O'Leary , Paul A Wade , Gang Greg Wang , Jikui Song

The bromo-adjacent homology domains of PBRM1 associate with histone tails and contribute to PBAF-mediated gene regulation.

The Journal of biological chemistry

Avec: Christopher J Petell , Nathaniel T Burkholder , Paloma A Ruiz , Jessica Skela , Jake R Foreman , Lauren E Southwell , Brenda R Temple , Krzysztof Krajewski ,

TNRC18 engages H3K9me3 to mediate silencing of endogenous retrotransposons.

Nature

Avec: Shuai Zhao , Jiuwei Lu , Bo Pan , Huitao Fan , Stephanie D Byrum , Chenxi Xu , Arum Kim , Yiran Guo , Krishna L Kanchi , Weida Gong , Tongyu Sun , Aaron J Storey , Nathaniel T Burkholder , Samuel G Mackintosh , Peyton C Kuhlers , Ricky D Edmondson , Yarui Diao , Alan J Tackett , Jesse R Raab , Ling Cai , Jikui Song , Gang Greg Wang

Dual roles of histone H3 lysine-4 in antagonizing Polycomb group function and promoting target gene expression.

bioRxiv : the preprint server for biology

Avec: Cyril S Anyetei-Anum , Mary P Leatham-Jensen , Geoffrey C Fox , B Rutledge Smith , Krzysztof Krajewski , Jill M Dowen , A Gregory Matera , Robert J Duronio , Daniel J McKay

Molecular mechanism of the MORC4 ATPase activation.

Nature communications

Avec: Adam H Tencer , Khan L Cox , Gregory M Wright , Yi Zhang , Christopher J Petell , Brianna J Klein , Joshua C Black , Michael G Poirier , Tatiana G Kutateladze

Selective binding of the PHD6 finger of MLL4 to histone H4K16ac links MLL4 and MOF.

Nature communications

Avec: Yi Zhang , Younghoon Jang , Ji-Eun Lee , JaeWoo Ahn , Longxia Xu , Michael R Holden , Evan M Cornett , Krzysztof Krajewski , Brianna J Klein , Shu-Ping Wang , Yali Dou , Robert G Roeder , Scott B Rothbart , Xiaobing Shi , Kai Ge , Tatiana G Kutateladze

Engineered Reader Proteins for Enhanced Detection of Methylated Lysine on Histones.

ACS chemical biology

Avec: Katherine I Albanese , Mackenzie W Krone , Christopher J Petell , Madison M Parker , Eric M Brustad , Marcey L Waters

Binding to medium and long chain fatty acyls is a common property of HEAT and ARM repeat modules.

Scientific reports

Avec: Tie-Mei Li , John P Coan , Krzysztof Krajewski , Lichao Zhang , Joshua E Elias , Or Gozani , Katrin F Chua

The SAGA continues: The rise of cis- and trans-histone crosstalk pathways.

Biochimica et biophysica acta. Gene regulatory mechanisms

Avec: Scott D Briggs

Réseau de co-auteurs

Krzysztof Krajewski 7 collaborations

Christopher J Petell 5 collaborations

Scott B Rothbart 4 collaborations

Tatiana G Kutateladze 4 collaborations

A Gregory Matera 3 collaborations

Daniel J McKay 3 collaborations

Robert J Duronio 3 collaborations

Huitao Fan 3 collaborations

Yiran Guo 3 collaborations

Ling Cai 3 collaborations

Jikui Song 3 collaborations

Gang Greg Wang 3 collaborations

Brianna J Klein 3 collaborations

Nathaniel T Burkholder 3 collaborations

Yi Zhang 3 collaborations

Geoffrey C Fox 3 collaborations

Raghuvar Dronamraju 2 collaborations

Jiuwei Lu 2 collaborations

Zhi-Min Zhang 2 collaborations

Weida Gong 2 collaborations

Yarui Diao 2 collaborations

Abid Khan 2 collaborations

Katrin F Chua 2 collaborations

Ian J Davis 2 collaborations

Anne-Marie W Turner 2 collaborations

Jackson J Peterson 2 collaborations

Ann Emery 2 collaborations

David M Margolis 2 collaborations

Edward P Browne 2 collaborations

Hosein Rostamian 2 collaborations

Jessica Skela 2 collaborations

Adam H Tencer 2 collaborations

Kanishk Jain 2 collaborations

Karl F Poncha 2 collaborations

Nicolas L Young 2 collaborations

B Rutledge Smith 2 collaborations

Jill M Dowen 2 collaborations

John P Coan 2 collaborations

Or Gozani 2 collaborations

Robin L Armstrong 1 collaboration

Taylor J R Penke 1 collaboration

Samuel K Chao 1 collaboration

Gabrielle M Gentile 1 collaboration

Julia V DiFiore 1 collaboration

Travis S Ptacek 1 collaboration

Yi Wang 1 collaboration

Bing Li 1 collaboration

Jeremy M Simon 1 collaboration

Andrew R Yoblinski 1 collaboration

Seoyoung Chung 1 collaboration

Sophie B Robinson 1 collaboration

Kaitlyn E Forester 1 collaboration

Dongxu Li 1 collaboration

Yi-Hsuan Tsai 1 collaboration

Wen-Chieh Pi 1 collaboration

Jeong Hyun Ahn 1 collaboration

Yu Xiang 1 collaboration

David F Allison 1 collaboration

Huimin Geng 1 collaboration

Shenghui He 1 collaboration

Wei-Yi Chen 1 collaboration

Mariesa J Slaughter 1 collaboration

Erin K Shanle 1 collaboration

Tao Hong 1 collaboration

Lisa D Boxer 1 collaboration

C David Allis 1 collaboration

Steven Z Josefowicz 1 collaboration

Benjamin A Garcia 1 collaboration

Paul Enríquez 1 collaboration

Robert H Dowen 1 collaboration

Robert B Rose 1 collaboration

Frank M Mason 1 collaboration

Emily S Kounlavong 1 collaboration

Anteneh T Tebeje 1 collaboration

Rashmi Dahiya 1 collaboration

Tiffany Guess 1 collaboration

Logan Vlach 1 collaboration

Stephen R Norris 1 collaboration

Courtney A Lovejoy 1 collaboration

Ruhee Dere 1 collaboration

Ryoma Ohi 1 collaboration

Peter Ly 1 collaboration

Cheryl Lyn Walker 1 collaboration

W Kimryn Rathmell 1 collaboration

Cameron R Bussey-Sutton 1 collaboration

Airlie Ward 1 collaboration

Joshua A Fox 1 collaboration

Arturo R Longoria 1 collaboration

Ismael Gomez-Martinez 1 collaboration

Corbin Jones 1 collaboration

Austin Hepperla 1 collaboration

Minh Chau Nguyen 1 collaboration

Ana Raman 1 collaboration

Pengcheng Wei 1 collaboration

Dustin C Becht 1 collaboration

Annette H Erbse 1 collaboration

Tonya M Gilbert 1 collaboration

Gongyi Zhang 1 collaboration

M Andres Blanco 1 collaboration

Sean D Taverna 1 collaboration

Andrea T Pham 1 collaboration

Kathyrn Randene 1 collaboration

Michael Pappas 1 collaboration

Diego Sandoval 1 collaboration

Joseph S Harrison 1 collaboration

Joshua P Steimel 1 collaboration

Jibo Zhang 1 collaboration

Aakanksha Gundu 1 collaboration

Andrew M Lerner 1 collaboration

Austin J Hepperla 1 collaboration

Gregory R Keele 1 collaboration

Hashem A Meriesh 1 collaboration

Hayretin Yumerefendi 1 collaboration

David Restrepo 1 collaboration

Seth Zimmerman 1 collaboration

James E Bear 1 collaboration

Brian Kuhlman 1 collaboration

Jiuyang Liu 1 collaboration

Jing Zhu 1 collaboration

Wenwen Wu 1 collaboration

Tomohiko Ohta 1 collaboration

Shane D Falcinelli 1 collaboration

David Irlbeck 1 collaboration

Jenna Read 1 collaboration

Samuel Lm Raines 1 collaboration

Katherine S James 1 collaboration

Cameron Sutton 1 collaboration

Anthony Sanchez 1 collaboration

Gavin Sampey 1 collaboration

Robert Ferris 1 collaboration

Brigitte Allard 1 collaboration

Simon Ghofrani 1 collaboration

Jennifer L Kirchherr 1 collaboration

Caroline Baker 1 collaboration

JoAnn D Kuruc 1 collaboration

Cynthia L Gay 1 collaboration

Lindsey I James 1 collaboration

Guoxin Wu 1 collaboration

Paul Zuck 1 collaboration

Inmaculada Rioja 1 collaboration

Rebecca C Furze 1 collaboration

Rab K Prinjha 1 collaboration

Bonnie J Howell 1 collaboration

Ronald Swanstrom 1 collaboration

Richard M Dunham 1 collaboration

Nancie M Archin 1 collaboration

Matthew R Marunde 1 collaboration

Jonathan M Burg 1 collaboration

Susan L Gloor 1 collaboration

Faith M Joseph 1 collaboration

Zachary B Gillespie 1 collaboration

Keli L Rodriguez 1 collaboration

Irina K Popova 1 collaboration

Nathan W Hall 1 collaboration

Anup Vaidya 1 collaboration

Sarah A Howard 1 collaboration

Hailey F Taylor 1 collaboration

Laylo Mukhsinova 1 collaboration

Ugochi C Onuoha 1 collaboration

Emily F Patteson 1 collaboration

Spencer W Cooke 1 collaboration

Bethany C Taylor 1 collaboration

Ellen N Weinzapfel 1 collaboration

Marcus A Cheek 1 collaboration

Matthew J Meiners 1 collaboration

Kevin E W Namitz 1 collaboration

Martis W Cowles 1 collaboration

Zu-Wen Sun 1 collaboration

Michael S Cosgrove 1 collaboration

Michael-Christopher Keogh 1 collaboration

Timothy A Daugird 1 collaboration

Yu Shi 1 collaboration

Katie L Holland 1 collaboration

Zhe Liu 1 collaboration

Luke D Lavis 1 collaboration

Joseph Rodriguez 1 collaboration

Wesley R Legant 1 collaboration

Lara N van der Maas 1 collaboration

Nathaniel N Robbins 1 collaboration

Bria Graham 1 collaboration

Denis F Noubouossie 1 collaboration

Brandi N Reeves 1 collaboration

Nigel S Key 1 collaboration

Mary Leatham-Jensen 1 collaboration

Christopher M Uyehara 1 collaboration

Hannes Braberg 1 collaboration

Ignacia Echeverria 1 collaboration

Stefan Bohn 1 collaboration

Peter Cimermancic 1 collaboration

Anthony Shiver 1 collaboration

Richard Alexander 1 collaboration

Jiewei Xu 1 collaboration

Michael Shales 1 collaboration

Shuangying Jiang 1 collaboration

Gajendradhar Dwivedi 1 collaboration

Derek Bogdanoff 1 collaboration

Kaitlin K Chaung 1 collaboration

Ruth Hüttenhain 1 collaboration

Shuyi Wang 1 collaboration

David Mavor 1 collaboration

Riccardo Pellarin 1 collaboration

Dina Schneidman 1 collaboration

Joel S Bader 1 collaboration

James S Fraser 1 collaboration

John Morris 1 collaboration

James E Haber 1 collaboration

Carol A Gross 1 collaboration

Junbiao Dai 1 collaboration

Jef D Boeke 1 collaboration

Andrej Sali 1 collaboration

Nevan J Krogan 1 collaboration

Robert M Vaughan 1 collaboration

Ariana Kupai 1 collaboration

Caroline A Foley 1 collaboration

Cari A Sagum 1 collaboration

Bailey M Tibben 1 collaboration

Hope E Eden 1 collaboration

Rochelle L Tiedemann 1 collaboration

Christine A Berryhill 1 collaboration

Varun Patel 1 collaboration

Kevin M Shaw 1 collaboration

Mark T Bedford 1 collaboration

Stephen V Frye 1 collaboration

Bradley M Dickson 1 collaboration

Wendan Ren 1 collaboration

Sara A Grimm 1 collaboration

Jae Jin Kim 1 collaboration

Linhui Li 1 collaboration

Christopher James Petell 1 collaboration

Xiao-Feng Tan 1 collaboration

Jiekai Yin 1 collaboration

Dae In Kim 1 collaboration

Linfeng Gao 1 collaboration

Nelli Khudaverdyan 1 collaboration

Burak Çetin 1 collaboration

Dinshaw J Patel 1 collaboration

Yinsheng Wang 1 collaboration

Qiang Cui 1 collaboration

Kyle M Miller 1 collaboration

Seán E O'Leary 1 collaboration

Paul A Wade 1 collaboration

Paloma A Ruiz 1 collaboration

Jake R Foreman 1 collaboration

Lauren E Southwell 1 collaboration

Brenda R Temple 1 collaboration

Shuai Zhao 1 collaboration

Bo Pan 1 collaboration

Stephanie D Byrum 1 collaboration

Chenxi Xu 1 collaboration

Arum Kim 1 collaboration

Krishna L Kanchi 1 collaboration

Tongyu Sun 1 collaboration

Aaron J Storey 1 collaboration

Samuel G Mackintosh 1 collaboration

Peyton C Kuhlers 1 collaboration

Ricky D Edmondson 1 collaboration

Alan J Tackett 1 collaboration

Jesse R Raab 1 collaboration

Cyril S Anyetei-Anum 1 collaboration

Mary P Leatham-Jensen 1 collaboration

Khan L Cox 1 collaboration

Gregory M Wright 1 collaboration

Joshua C Black 1 collaboration

Michael G Poirier 1 collaboration

Younghoon Jang 1 collaboration

Ji-Eun Lee 1 collaboration

JaeWoo Ahn 1 collaboration

Longxia Xu 1 collaboration

Michael R Holden 1 collaboration

Evan M Cornett 1 collaboration

Shu-Ping Wang 1 collaboration

Yali Dou 1 collaboration

Robert G Roeder 1 collaboration

Xiaobing Shi 1 collaboration

Kai Ge 1 collaboration

Katherine I Albanese 1 collaboration

Mackenzie W Krone 1 collaboration

Madison M Parker 1 collaboration

Eric M Brustad 1 collaboration

Marcey L Waters 1 collaboration

Tie-Mei Li 1 collaboration

Lichao Zhang 1 collaboration

Joshua E Elias 1 collaboration

Scott D Briggs 1 collaboration