Steven Kyle Higginbottom

Affiliations

Department of Microbiology & Immunology, Stanford University School of Medicine, Stanford, CA 94305, USA.

Publications (15)

Improved mouse models of the small intestine microbiota using region-specific sampling from humans.

bioRxiv : the preprint server for biology

Avec: Rebecca N Culver , Sean Paul Spencer , Arvie Violette , Evelyn Giselle Lemus Silva , Tadashi Takeuchi , Ceena Nafarzadegan , Steven K Higginbottom , Dari Shalon , Justin Sonnenburg , Kerwyn Casey Huang

Butyrate Differentiates Permissiveness to Clostridioides difficile Infection and Influences Growth of Diverse C. difficile Isolates.

Infection and immunity

Avec: Daniel A Pensinger , Andrea T Fisher , Horia A Dobrila , William Van Treuren , Jackson O Gardner , Steven K Higginbottom , Matthew M Carter , Benjamin Schumann , Carolyn R Bertozzi , Victoria Anikst , Cody Martin , Elizabeth V Robilotti , Jo May Chow , Rachael H Buck , Lucy S Tompkins , Justin L Sonnenburg , Andrew J Hryckowian

Mucin-derived O-glycans supplemented to diet mitigate diverse microbiota perturbations.

The ISME journal

Avec: K M Pruss , A Marcobal , A M Southwick , D Dahan , S A Smits , J A Ferreyra , S K Higginbottom , E D Sonnenburg , P C Kashyap , B Choudhury , L Bode , J L Sonnenburg

Quantifying rapid bacterial evolution and transmission within the mouse intestine.

Cell host & microbe

Avec: Kimberly S Vasquez , Lisa Willis , Nate J Cira , Katharine M Ng , Miguel F Pedro , Andrés Aranda-Díaz , Manohary Rajendram , Feiqiao Brian Yu , Steven K Higginbottom , Norma Neff , Gavin Sherlock , Karina B Xavier , Stephen R Quake , Justin L Sonnenburg , Benjamin H Good , Kerwyn Casey Huang

A metabolomics pipeline for the mechanistic interrogation of the gut microbiome.

Nature

Avec: Shuo Han , Will Van Treuren , Curt R Fischer , Bryan D Merrill , Brian C DeFelice , Juan M Sanchez , Steven K Higginbottom , Leah Guthrie , Lalla A Fall , Dylan Dodd , Michael A Fischbach , Justin L Sonnenburg

Host-microbe co-metabolism via MCAD generates circulating metabolites including hippuric acid.

Nature communications

Avec: Kali M Pruss , Haoqing Chen , Yuanyuan Liu , William Van Treuren , Steven K Higginbottom , John B Jarman , Curt R Fischer , Justin Mak , Beverly Wong , Tina M Cowan , Michael A Fischbach , Justin L Sonnenburg , Dylan Dodd

Metabolic diversity in commensal protists regulates intestinal immunity and trans-kingdom competition.

Cell

Avec: Elias R Gerrick , Soumaya Zlitni , Patrick T West , Matthew M Carter , Claire M Mechler , Matthew R Olm , Elisa B Caffrey , Jessica A Li , Steven K Higginbottom , Christopher J Severyn , Frauke Kracke , Alfred M Spormann , Justin L Sonnenburg , Ami S Bhatt , Michael R Howitt

A Metabolic Pathway for Activation of Dietary Glucosinolates by a Human Gut Symbiont.

Cell

Avec: Catherine S Liou , Shannon J Sirk , Camil A C Diaz , Andrew P Klein , Curt R Fischer , Steven K Higginbottom , Amir Erez , Mohamed S Donia , Justin L Sonnenburg , Elizabeth S Sattely

Western diet regulates immune status and the response to LPS-driven sepsis independent of diet-associated microbiome.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Brooke A Napier , Marta Andres-Terre , Liliana M Massis , Andrew J Hryckowian , Steven K Higginbottom , Katherine Cumnock , Kerriann M Casey , Bereketeab Haileselassie , Kyler A Lugo , David S Schneider , Justin L Sonnenburg , Denise M Monack

Recovery of the Gut Microbiota after Antibiotics Depends on Host Diet, Community Context, and Environmental Reservoirs.

Cell host & microbe

Avec: Katharine Michelle Ng , Andrés Aranda-Díaz , Carolina Tropini , Matthew Ryan Frankel , William Van Treuren , Colleen T O'Loughlin , Bryan Douglas Merrill , Feiqiao Brian Yu , Kali M Pruss , Rita Almeida Oliveira , Steven Kyle Higginbottom , Norma F Neff , Michael Andrew Fischbach , Karina Bivar Xavier , Justin Laine Sonnenburg , Kerwyn Casey Huang

Oxidative ornithine metabolism supports non-inflammatory C. difficile colonization.

Nature metabolism

Avec: Kali M Pruss , Fatima Enam , Eric Battaglioli , Mary DeFeo , Oscar R Diaz , Steven K Higginbottom , Curt R Fischer , Andrew J Hryckowian , William Van Treuren , Dylan Dodd , Purna Kashyap , Justin L Sonnenburg

Clostridium sporogenes uses reductive Stickland metabolism in the gut to generate ATP and produce circulating metabolites.

Nature microbiology

Avec: Yuanyuan Liu , Haoqing Chen , William Van Treuren , Bi-Huei Hou , Steven K Higginbottom , Dylan Dodd

Establishment and characterization of stable, diverse, fecal-derived in vitro microbial communities that model the intestinal microbiota.

Cell host & microbe

Avec: Andrés Aranda-Díaz , Katharine Michelle Ng , Tani Thomsen , Imperio Real-Ramírez , Dylan Dahan , Susannah Dittmar , Carlos Gutierrez Gonzalez , Taylor Chavez , Kimberly S Vasquez , Taylor H Nguyen , Feiqiao Brian Yu , Steven K Higginbottom , Norma F Neff , Joshua E Elias , Justin L Sonnenburg , Kerwyn Casey Huang

Hadza

bioRxiv : the preprint server for biology

Avec: Rebecca H Gellman , Matthew R Olm , Nicolas Terrapon , Fatima Enam , Steven K Higginbottom , Justin L Sonnenburg , Erica D Sonnenburg

Hadza

Cell reports

Avec: Rebecca H Gellman , Matthew R Olm , Nicolas Terrapon , Fatima Enam , Steven K Higginbottom , Justin L Sonnenburg , Erica D Sonnenburg

Réseau de co-auteurs

Steven K Higginbottom 13 collaborations

Justin L Sonnenburg 11 collaborations

William Van Treuren 5 collaborations

Kerwyn Casey Huang 4 collaborations

Curt R Fischer 4 collaborations

Dylan Dodd 4 collaborations

Andrew J Hryckowian 3 collaborations

Andrés Aranda-Díaz 3 collaborations

Feiqiao Brian Yu 3 collaborations

Kali M Pruss 3 collaborations

Matthew R Olm 3 collaborations

Fatima Enam 3 collaborations

Matthew M Carter 2 collaborations

Kimberly S Vasquez 2 collaborations

Michael A Fischbach 2 collaborations

Haoqing Chen 2 collaborations

Yuanyuan Liu 2 collaborations

Katharine Michelle Ng 2 collaborations

Norma F Neff 2 collaborations

Rebecca H Gellman 2 collaborations

Nicolas Terrapon 2 collaborations

Erica D Sonnenburg 2 collaborations

Rebecca N Culver 1 collaboration

Sean Paul Spencer 1 collaboration

Arvie Violette 1 collaboration

Evelyn Giselle Lemus Silva 1 collaboration

Tadashi Takeuchi 1 collaboration

Ceena Nafarzadegan 1 collaboration

Dari Shalon 1 collaboration

Justin Sonnenburg 1 collaboration

Daniel A Pensinger 1 collaboration

Andrea T Fisher 1 collaboration

Horia A Dobrila 1 collaboration

Jackson O Gardner 1 collaboration

Benjamin Schumann 1 collaboration

Carolyn R Bertozzi 1 collaboration

Victoria Anikst 1 collaboration

Cody Martin 1 collaboration

Elizabeth V Robilotti 1 collaboration

Jo May Chow 1 collaboration

Rachael H Buck 1 collaboration

Lucy S Tompkins 1 collaboration

K M Pruss 1 collaboration

A Marcobal 1 collaboration

A M Southwick 1 collaboration

D Dahan 1 collaboration

S A Smits 1 collaboration

J A Ferreyra 1 collaboration

S K Higginbottom 1 collaboration

E D Sonnenburg 1 collaboration

P C Kashyap 1 collaboration

B Choudhury 1 collaboration

L Bode 1 collaboration

J L Sonnenburg 1 collaboration

Lisa Willis 1 collaboration

Nate J Cira 1 collaboration

Katharine M Ng 1 collaboration

Miguel F Pedro 1 collaboration

Manohary Rajendram 1 collaboration

Norma Neff 1 collaboration

Gavin Sherlock 1 collaboration

Karina B Xavier 1 collaboration

Stephen R Quake 1 collaboration

Benjamin H Good 1 collaboration

Shuo Han 1 collaboration

Will Van Treuren 1 collaboration

Bryan D Merrill 1 collaboration

Brian C DeFelice 1 collaboration

Juan M Sanchez 1 collaboration

Leah Guthrie 1 collaboration

Lalla A Fall 1 collaboration

John B Jarman 1 collaboration

Justin Mak 1 collaboration

Beverly Wong 1 collaboration

Tina M Cowan 1 collaboration

Elias R Gerrick 1 collaboration

Soumaya Zlitni 1 collaboration

Patrick T West 1 collaboration

Claire M Mechler 1 collaboration

Elisa B Caffrey 1 collaboration

Jessica A Li 1 collaboration

Christopher J Severyn 1 collaboration

Frauke Kracke 1 collaboration

Alfred M Spormann 1 collaboration

Ami S Bhatt 1 collaboration

Michael R Howitt 1 collaboration

Catherine S Liou 1 collaboration

Shannon J Sirk 1 collaboration

Camil A C Diaz 1 collaboration

Andrew P Klein 1 collaboration

Amir Erez 1 collaboration

Mohamed S Donia 1 collaboration

Elizabeth S Sattely 1 collaboration

Brooke A Napier 1 collaboration

Marta Andres-Terre 1 collaboration

Liliana M Massis 1 collaboration

Katherine Cumnock 1 collaboration

Kerriann M Casey 1 collaboration

Bereketeab Haileselassie 1 collaboration

Kyler A Lugo 1 collaboration

David S Schneider 1 collaboration

Denise M Monack 1 collaboration

Carolina Tropini 1 collaboration

Matthew Ryan Frankel 1 collaboration

Colleen T O'Loughlin 1 collaboration

Bryan Douglas Merrill 1 collaboration

Rita Almeida Oliveira 1 collaboration

Michael Andrew Fischbach 1 collaboration

Karina Bivar Xavier 1 collaboration

Justin Laine Sonnenburg 1 collaboration

Eric Battaglioli 1 collaboration

Mary DeFeo 1 collaboration

Oscar R Diaz 1 collaboration

Purna Kashyap 1 collaboration

Bi-Huei Hou 1 collaboration

Tani Thomsen 1 collaboration

Imperio Real-Ramírez 1 collaboration

Dylan Dahan 1 collaboration

Susannah Dittmar 1 collaboration

Carlos Gutierrez Gonzalez 1 collaboration

Taylor Chavez 1 collaboration

Taylor H Nguyen 1 collaboration

Joshua E Elias 1 collaboration