Sophie Helaine

Affiliations

Section of Microbiology, Medical Research Council Centre for Molecular Bacteriology and Infection, Imperial College London, London SW7 2AZ, United Kingdom; email: b.gollan@imperial.ac.uk, grzegorz.grabe10@imperial.ac.uk, c.michaux@imperial.ac.uk, s.helaine@imperial.ac.uk.

Publications (23)

Bacterial Persisters and Infection: Past, Present, and Progressing.

Annual review of microbiology

Avec: Bridget Gollan , Grzegorz Grabe , Charlotte Michaux , Sophie Helaine

Clarifying the Link between Toxin-Antitoxin Modules and Bacterial Persistence.

Journal of molecular biology

Avec: Séverin Ronneau , Sophie Helaine

Stapled Phd Peptides Inhibit Doc Toxin Induced Growth Arrest in

ACS chemical biology

Avec: Dennis J Worm , Grzegorz J Grabe , Guilherme V de Castro , Sofya Rabinovich , Ian Warm , Kira Isherwood , Sophie Helaine , Anna Barnard

A tRNA-Acetylating Toxin and Detoxifying Enzyme in Mycobacterium tuberculosis.

Microbiology spectrum

Avec: Francesca G Tomasi , Alexander M J Hall , Jessica T P Schweber , Charles L Dulberger , Kerry McGowen , Qingyun Liu , Sarah M Fortune , Sophie Helaine , Eric J Rubin

Molecular stripping underpins derepression of a toxin-antitoxin system.

Nature structural & molecular biology

Avec: Grzegorz J Grabe , Rachel T Giorgio , Miłosz Wieczór , Bridget Gollan , Molly Sargen , Modesto Orozco , Stephen A Hare , Sophie Helaine

Host stress drives tolerance and persistence: The bane of anti-microbial therapeutics.

Cell host & microbe

Avec: Sophie Helaine , Brian P Conlon , Kimberly M Davis , David G Russell

GNAT toxins evolve toward narrow tRNA target specificities.

Nucleic acids research

Avec: Dmitry Bikmetov , Alexander M J Hall , Alexei Livenskyi , Bridget Gollan , Stepan Ovchinnikov , Konstantin Gilep , Jenny Y Kim , Gerald Larrouy-Maumus , Viktor Zgoda , Sergei Borukhov , Konstantin Severinov , Sophie Helaine , Svetlana Dubiley

Characterization of the Key Determinants of Phd Antitoxin Mediated Doc Toxin Inactivation in

ACS chemical biology

Avec: Guilherme V de Castro , Dennis J Worm , Grzegorz J Grabe , Fiona C Rowan , Lucy Haggerty , Ana L de la Lastra , Oana Popescu , Sophie Helaine , Anna Barnard

Antibiotic tolerance and persistence have distinct fitness trade-offs.

PLoS pathogens

Avec: Charlotte Michaux , Séverin Ronneau , Rachel T Giorgio , Sophie Helaine

Publisher Correction: Definitions and guidelines for research on antibiotic persistence.

Nature reviews. Microbiology

Avec: Nathalie Q Balaban , Sophie Helaine , Kim Lewis , Martin Ackermann , Bree Aldridge , Dan I Andersson , Mark P Brynildsen , Dirk Bumann , Andrew Camilli , James J Collins , Christoph Dehio , Sarah Fortune , Jean-Marc Ghigo , Wolf-Dietrich Hardt , Alexander Harms , Matthias Heinemann , Deborah T Hung , Urs Jenal , Bruce R Levin , Jan Michiels , Gisela Storz , Man-Wah Tan , Tanel Tenson , Laurence Van Melderen , Annelies Zinkernagel

Antibiotic persistence and tolerance: not just one and the same.

Current opinion in microbiology

Avec: Séverin Ronneau , Peter Ws Hill , Sophie Helaine

The Biological Significance of Pyruvate Sensing and Uptake in

Microorganisms

Avec: Stephanie Paulini , Florian D Fabiani , Anna S Weiss , Ana Laura Moldoveanu , Sophie Helaine , Bärbel Stecher , Kirsten Jung

Decline in nitrosative stress drives antibiotic persister regrowth during infection.

Cell host & microbe

Avec: Séverin Ronneau , Charlotte Michaux , Sophie Helaine

Salmonella-Driven Polarization of Granuloma Macrophages Antagonizes TNF-Mediated Pathogen Restriction during Persistent Infection.

Cell host & microbe

Avec: Trung H M Pham , Susan M Brewer , Teresa Thurston , Liliana M Massis , Jared Honeycutt , Kyler Lugo , Amanda R Jacobson , Jose G Vilches-Moure , Meagan Hamblin , Sophie Helaine , Denise M Monack

Salmonella Effector SteE Converts the Mammalian Serine/Threonine Kinase GSK3 into a Tyrosine Kinase to Direct Macrophage Polarization.

Cell host & microbe

Avec: Ioanna Panagi , Elliott Jennings , Jingkun Zeng , Regina A Günster , Cullum D Stones , Hazel Mak , Enkai Jin , Daphne A C Stapels , Nur Z Subari , Trung H M Pham , Susan M Brewer , Samantha Y Q Ong , Denise M Monack , Sophie Helaine , Teresa L M Thurston

Impact of bacterial persisters on their host.

Current opinion in microbiology

Avec: Ana L Moldoveanu , Julian A Rycroft , Sophie Helaine

Definitions and guidelines for research on antibiotic persistence.

Nature reviews. Microbiology

Studying Antibiotic Persistence During Infection.

Methods in molecular biology (Clifton, N.J.)

Avec: Charlotte Michaux , Séverin Ronneau , Sophie Helaine

The vulnerable versatility of Salmonella antibiotic persisters during infection.

Cell host & microbe

Avec: Peter W S Hill , Ana Laura Moldoveanu , Molly Sargen , Séverin Ronneau , Izabela Glegola-Madejska , Catrin Beetham , Robert A Fisher , Sophie Helaine

Auxiliary interfaces support the evolution of specific toxin-antitoxin pairing.

Nature chemical biology

Avec: Grzegorz J Grabe , Rachel T Giorgio , Alexander M J Hall , Rhodri M L Morgan , Laurent Dubois , Tyler A Sisley , Julian A Rycroft , Stephen A Hare , Sophie Helaine

The RNA-Binding Protein ProQ Promotes Antibiotic Persistence in Salmonella.

mBio

Avec: Alisa Rizvanovic , Charlotte Michaux , Margherita Panza , Zeynep Iloglu , Sophie Helaine , E Gerhart H Wagner , Erik Holmqvist

Intoxication of antibiotic persisters by host RNS inactivates their efflux machinery during infection.

PLoS pathogens

Avec: Séverin Ronneau , Charlotte Michaux , Rachel T Giorgio , Sophie Helaine

Tracking the progeny of bacterial persisters using a CRISPR-based genomic recorder.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Julian Anthony Rycroft , Rachel Teresa Giorgio , Molly Sargen , Sophie Helaine

Réseau de co-auteurs

Séverin Ronneau 7 collaborations

Charlotte Michaux 6 collaborations

Grzegorz J Grabe 4 collaborations

Rachel T Giorgio 4 collaborations

Bridget Gollan 3 collaborations

Alexander M J Hall 3 collaborations

Molly Sargen 3 collaborations

Dennis J Worm 2 collaborations

Guilherme V de Castro 2 collaborations

Anna Barnard 2 collaborations

Stephen A Hare 2 collaborations

Nathalie Q Balaban 2 collaborations

Kim Lewis 2 collaborations

Martin Ackermann 2 collaborations

Bree Aldridge 2 collaborations

Dan I Andersson 2 collaborations

Mark P Brynildsen 2 collaborations

Dirk Bumann 2 collaborations

Andrew Camilli 2 collaborations

James J Collins 2 collaborations

Christoph Dehio 2 collaborations

Sarah Fortune 2 collaborations

Jean-Marc Ghigo 2 collaborations

Wolf-Dietrich Hardt 2 collaborations

Alexander Harms 2 collaborations

Matthias Heinemann 2 collaborations

Deborah T Hung 2 collaborations

Urs Jenal 2 collaborations

Bruce R Levin 2 collaborations

Jan Michiels 2 collaborations

Gisela Storz 2 collaborations

Man-Wah Tan 2 collaborations

Tanel Tenson 2 collaborations

Laurence Van Melderen 2 collaborations

Annelies Zinkernagel 2 collaborations

Ana Laura Moldoveanu 2 collaborations

Trung H M Pham 2 collaborations

Susan M Brewer 2 collaborations

Denise M Monack 2 collaborations

Julian A Rycroft 2 collaborations

Grzegorz Grabe 1 collaboration

Sofya Rabinovich 1 collaboration

Ian Warm 1 collaboration

Kira Isherwood 1 collaboration

Francesca G Tomasi 1 collaboration

Jessica T P Schweber 1 collaboration

Charles L Dulberger 1 collaboration

Kerry McGowen 1 collaboration

Qingyun Liu 1 collaboration

Sarah M Fortune 1 collaboration

Eric J Rubin 1 collaboration

Miłosz Wieczór 1 collaboration

Modesto Orozco 1 collaboration

Brian P Conlon 1 collaboration

Kimberly M Davis 1 collaboration

David G Russell 1 collaboration

Dmitry Bikmetov 1 collaboration

Alexei Livenskyi 1 collaboration

Stepan Ovchinnikov 1 collaboration

Konstantin Gilep 1 collaboration

Jenny Y Kim 1 collaboration

Gerald Larrouy-Maumus 1 collaboration

Viktor Zgoda 1 collaboration

Sergei Borukhov 1 collaboration

Konstantin Severinov 1 collaboration

Svetlana Dubiley 1 collaboration

Fiona C Rowan 1 collaboration

Lucy Haggerty 1 collaboration

Ana L de la Lastra 1 collaboration

Oana Popescu 1 collaboration

Peter Ws Hill 1 collaboration

Stephanie Paulini 1 collaboration

Florian D Fabiani 1 collaboration

Anna S Weiss 1 collaboration

Bärbel Stecher 1 collaboration

Kirsten Jung 1 collaboration

Teresa Thurston 1 collaboration

Liliana M Massis 1 collaboration

Jared Honeycutt 1 collaboration

Kyler Lugo 1 collaboration

Amanda R Jacobson 1 collaboration

Jose G Vilches-Moure 1 collaboration

Meagan Hamblin 1 collaboration

Ioanna Panagi 1 collaboration

Elliott Jennings 1 collaboration

Jingkun Zeng 1 collaboration

Regina A Günster 1 collaboration

Cullum D Stones 1 collaboration

Hazel Mak 1 collaboration

Enkai Jin 1 collaboration

Daphne A C Stapels 1 collaboration

Nur Z Subari 1 collaboration

Samantha Y Q Ong 1 collaboration

Teresa L M Thurston 1 collaboration

Ana L Moldoveanu 1 collaboration

Peter W S Hill 1 collaboration

Izabela Glegola-Madejska 1 collaboration

Catrin Beetham 1 collaboration

Robert A Fisher 1 collaboration

Rhodri M L Morgan 1 collaboration

Laurent Dubois 1 collaboration

Tyler A Sisley 1 collaboration

Alisa Rizvanovic 1 collaboration

Margherita Panza 1 collaboration

Zeynep Iloglu 1 collaboration

E Gerhart H Wagner 1 collaboration

Erik Holmqvist 1 collaboration

Julian Anthony Rycroft 1 collaboration

Rachel Teresa Giorgio 1 collaboration