Sila K Ultanir

Affiliations

The Francis Crick Institute, 1 Midland Road, London NW1 1AT, UK.

Publications (16)

Control of synaptic vesicle release probability via VAMP4 targeting to endolysosomes.

Science advances

Avec: Daniela Ivanova , Katharine L Dobson , Akshada Gajbhiye , Elizabeth C Davenport , Daniela Hacker , Sila K Ultanir , Matthias Trost , Michael A Cousin

The master energy homeostasis regulator PGC-1α exhibits an mRNA nuclear export function.

Nature communications

Avec: Simeon R Mihaylov , Lydia M Castelli , Ya-Hui Lin , Aytac Gül , Nikita Soni , Christopher Hastings , Helen R Flynn , Oana Păun , Mark J Dickman , Ambrosius P Snijders , Robert Goldstone , Oliver Bandmann , Tatyana A Shelkovnikova , Heather Mortiboys , Sila K Ultanir , Guillaume M Hautbergue

YAP1/TAZ drives ependymoma-like tumour formation in mice.

Nature communications

Avec: Noreen Eder , Federico Roncaroli , Marie-Charlotte Domart , Stuart Horswell , Felipe Andreiuolo , Helen R Flynn , Andre T Lopes , Suzanne Claxton , John-Paul Kilday , Lucy Collinson , Jun-Hao Mao , Torsten Pietsch , Barry Thompson , Ambrosius P Snijders , Sila K Ultanir

Author Correction: YAP1/TAZ drives ependymoma-like tumour formation in mice.

Nature communications

A Potent and Selective CDKL5/GSK3 Chemical Probe is Neuroprotective.

bioRxiv : the preprint server for biology

Avec: Han Wee Ong , Yi Liang , William Richardson , Emily R Lowry , Carrow I Wells , Xiangrong Chen , Margaux Silvestre , Kelvin Dempster , Josie A Silvaroli , Jeffery L Smith , Hynek Wichterle , Navjot S Pabla , Sila K Ultanir , Alex N Bullock , David H Drewry , Alison D Axtman

Cell type-specific expression, regulation and compensation of CDKL5 activity in mouse brain.

Molecular psychiatry

Avec: Margaux Silvestre , Kelvin Dempster , Simeon R Mihaylov , Suzanne Claxton , Sila K Ultanir

Phosphorylation of the novel mTOR substrate Unkempt regulates cellular morphogenesis.

The Journal of biological chemistry

Avec: Pranetha Baskaran , Simeon R Mihaylov , Elin Vinsland , Kriti Shah , Lucy Granat , Sila K Ultanir , Andrew R Tee , Jernej Murn , Joseph M Bateman

Discovery of a Potent and Selective CDKL5/GSK3 Chemical Probe That Is Neuroprotective.

ACS chemical neuroscience

Loss of NDR1/2 kinases impairs endomembrane trafficking and autophagy leading to neurodegeneration.

Life science alliance

Avec: Flavia Roşianu , Simeon R Mihaylov , Noreen Eder , Antonie Martiniuc , Suzanne Claxton , Helen R Flynn , Shamsinar Jalal , Marie-Charlotte Domart , Lucy Collinson , Mark Skehel , Ambrosius P Snijders , Matthias Krause , Sharon A Tooze , Sila K Ultanir

Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2.

bioRxiv : the preprint server for biology

Avec: Frances M Bashore , Sophia M Min , Xiangrong Chen , Stefanie Howell , Caroline H Rinderle , Gabriel Morel , Josie A Silvaroli , Carrow I Wells , Bruce A Bunnell , David H Drewry , Navjot S Pabla , Sila K Ultanir , Alex N Bullock , Alison D Axtman

Cyclin-dependent-like kinase 5 is required for pain signaling in human sensory neurons and mouse models.

Science translational medicine

Avec: Paolo La Montanara , Arnau Hervera , Lucas L Baltussen , Thomas H Hutson , Ilaria Palmisano , Francesco De Virgiliis , Guiping Kong , Jessica Chadwick , Yunan Gao , Katalin Bartus , Qasim A Majid , Nikos Gorgoraptis , Kingsley Wong , Jenny Downs , Tommaso Pizzorusso , Sila K Ultanir , Helen Leonard , Hongwei Yu , David S Millar , Nagy Istvan , Nicholas D Mazarakis , Simone Di Giovanni

Epilepsy-linked kinase CDKL5 phosphorylates voltage-gated calcium channel Cav2.3, altering inactivation kinetics and neuronal excitability.

Nature communications

Avec: Marisol Sampedro-Castañeda , Lucas L Baltussen , André T Lopes , Yichen Qiu , Liina Sirvio , Simeon R Mihaylov , Suzanne Claxton , Jill C Richardson , Gabriele Lignani , Sila K Ultanir

Mechanistic target of rapamycin signaling in human nervous system development and disease.

Frontiers in molecular neuroscience

Avec: Marie Girodengo , Sila K Ultanir , Joseph M Bateman

Activity-dependent membrane sculpting deficits in TAOK1-linked neurodevelopmental disease.

Trends in neurosciences

Avec: Marisol Sampedro-Castañeda , Sila K Ultanir

Discovery and characterization of a specific inhibitor of serine-threonine kinase cyclin-dependent kinase-like 5 (CDKL5) demonstrates role in hippocampal CA1 physiology.

eLife

Avec: Anna Castano , Margaux Silvestre , Carrow I Wells , Jennifer L Sanderson , Carla A Ferrer , Han Wee Ong , Yi Lang , William Richardson , Josie A Silvaroli , Frances M Bashore , Jeffery L Smith , Isabelle M Genereux , Kelvin Dempster , David H Drewry , Navlot S Pabla , Alex N Bullock , Tim A Benke , Sila K Ultanir , Alison D Axtman

Discovery and Characterization of a Chemical Probe for Cyclin-Dependent Kinase-Like 2.

ACS medicinal chemistry letters

Réseau de co-auteurs

Simeon R Mihaylov 5 collaborations

Suzanne Claxton 5 collaborations

Carrow I Wells 5 collaborations

Josie A Silvaroli 5 collaborations

Alex N Bullock 5 collaborations

David H Drewry 5 collaborations

Alison D Axtman 5 collaborations

Helen R Flynn 4 collaborations

Ambrosius P Snijders 4 collaborations

Xiangrong Chen 4 collaborations

Margaux Silvestre 4 collaborations

Kelvin Dempster 4 collaborations

Navjot S Pabla 4 collaborations

Noreen Eder 3 collaborations

Marie-Charlotte Domart 3 collaborations

Lucy Collinson 3 collaborations

Han Wee Ong 3 collaborations

William Richardson 3 collaborations

Jeffery L Smith 3 collaborations

Frances M Bashore 3 collaborations

Federico Roncaroli 2 collaborations

Stuart Horswell 2 collaborations

Felipe Andreiuolo 2 collaborations

Andre T Lopes 2 collaborations

John-Paul Kilday 2 collaborations

Jun-Hao Mao 2 collaborations

Torsten Pietsch 2 collaborations

Barry Thompson 2 collaborations

Yi Liang 2 collaborations

Emily R Lowry 2 collaborations

Hynek Wichterle 2 collaborations

Joseph M Bateman 2 collaborations

Sophia M Min 2 collaborations

Stefanie Howell 2 collaborations

Caroline H Rinderle 2 collaborations

Gabriel Morel 2 collaborations

Bruce A Bunnell 2 collaborations

Lucas L Baltussen 2 collaborations

Marisol Sampedro-Castañeda 2 collaborations

Daniela Ivanova 1 collaboration

Katharine L Dobson 1 collaboration

Akshada Gajbhiye 1 collaboration

Elizabeth C Davenport 1 collaboration

Daniela Hacker 1 collaboration

Matthias Trost 1 collaboration

Michael A Cousin 1 collaboration

Lydia M Castelli 1 collaboration

Ya-Hui Lin 1 collaboration

Aytac Gül 1 collaboration

Nikita Soni 1 collaboration

Christopher Hastings 1 collaboration

Oana Păun 1 collaboration

Mark J Dickman 1 collaboration

Robert Goldstone 1 collaboration

Oliver Bandmann 1 collaboration

Tatyana A Shelkovnikova 1 collaboration

Heather Mortiboys 1 collaboration

Guillaume M Hautbergue 1 collaboration

Pranetha Baskaran 1 collaboration

Elin Vinsland 1 collaboration

Kriti Shah 1 collaboration

Lucy Granat 1 collaboration

Andrew R Tee 1 collaboration

Jernej Murn 1 collaboration

Flavia Roşianu 1 collaboration

Antonie Martiniuc 1 collaboration

Shamsinar Jalal 1 collaboration

Mark Skehel 1 collaboration

Matthias Krause 1 collaboration

Sharon A Tooze 1 collaboration

Paolo La Montanara 1 collaboration

Arnau Hervera 1 collaboration

Thomas H Hutson 1 collaboration

Ilaria Palmisano 1 collaboration

Francesco De Virgiliis 1 collaboration

Guiping Kong 1 collaboration

Jessica Chadwick 1 collaboration

Yunan Gao 1 collaboration

Katalin Bartus 1 collaboration

Qasim A Majid 1 collaboration

Nikos Gorgoraptis 1 collaboration

Kingsley Wong 1 collaboration

Jenny Downs 1 collaboration

Tommaso Pizzorusso 1 collaboration

Helen Leonard 1 collaboration

Hongwei Yu 1 collaboration

David S Millar 1 collaboration

Nagy Istvan 1 collaboration

Nicholas D Mazarakis 1 collaboration

Simone Di Giovanni 1 collaboration

André T Lopes 1 collaboration

Yichen Qiu 1 collaboration

Liina Sirvio 1 collaboration

Jill C Richardson 1 collaboration

Gabriele Lignani 1 collaboration

Marie Girodengo 1 collaboration

Anna Castano 1 collaboration

Jennifer L Sanderson 1 collaboration

Carla A Ferrer 1 collaboration

Yi Lang 1 collaboration

Isabelle M Genereux 1 collaboration

Navlot S Pabla 1 collaboration

Tim A Benke 1 collaboration