Robert P Mecham

Affiliations

Department of Cell Biology and Physiology, Washington University School of Medicine, St. Louis, Missouri 63110. Electronic address: bmecham@wustl.edu.

Publications (33)

Identification of the growth factor-binding sequence in the extracellular matrix protein MAGP-1.

The Journal of biological chemistry

Avec: Thomas J Broekelmann , Nicholas K Bodmer , Robert P Mecham

Sodium-activated potassium channels moderate excitability in vascular smooth muscle.

The Journal of physiology

Avec: Ping Li , Carmen M Halabi , Richard Stewart , Alice Butler , Bobbie Brown , Xiaoming Xia , Celia Santi , Sarah England , Juan Ferreira , Robert P Mecham , Lawrence Salkoff

Heterogeneous Cellular Contributions to Elastic Laminae Formation in Arterial Wall Development.

Circulation research

Avec: Chien-Jung Lin , Marius C Staiculescu , Jie Z Hawes , Austin J Cocciolone , Bridget M Hunkins , Robyn A Roth , Chieh-Yu Lin , Robert P Mecham , Jessica E Wagenseil

Elastin haploinsufficiency in mice has divergent effects on arterial remodeling with aging depending on sex.

American journal of physiology. Heart and circulatory physiology

Avec: Jie Z Hawes , Austin J Cocciolone , Amy H Cui , Diana B Griffin , Marius Catalin Staiculescu , Robert P Mecham , Jessica E Wagenseil

Increases in hydraulic conductance and solute permeability in a mouse model of ascending thoracic aortic aneurysm.

Journal of biomechanics

Avec: Christie L Crandall , Sean Y Kim , Jacob Rother , Vivian S Lee , Robert P Mecham , Jessica E Wagenseil

SVEP1 is an endogenous ligand for the orphan receptor PEAR1.

Nature communications

Avec: Jared S Elenbaas , Upasana Pudupakkam , Katrina J Ashworth , Chul Joo Kang , Ved Patel , Katherine Santana , In-Hyuk Jung , Paul C Lee , Kendall H Burks , Junedh M Amrute , Robert P Mecham , Carmen M Halabi , Arturo Alisio , Jorge Di Paola , Nathan O Stitziel

Targeting Epidermal Growth Factor Receptor to Stimulate Elastic Matrix Regenerative Repair.

Tissue engineering. Part A

Avec: Simran Dayal , Thomas Broekelmann , Robert P Mecham , Anand Ramamurthi

Elastic fiber ultrastructure and assembly.

Matrix biology : journal of the International Society for Matrix Biology

Avec: Beth A Kozel , Robert P Mecham

LTBP1 promotes fibrillin incorporation into the extracellular matrix.

Matrix biology : journal of the International Society for Matrix Biology

Avec: Matthias Przyklenk , Veronika S Georgieva , Fabian Metzen , Sebastian Mostert , Birgit Kobbe , Bert Callewaert , Gerhard Sengle , Bent Brachvogel , Robert P Mecham , Mats Paulsson , Raimund Wagener , Manuel Koch , Alvise Schiavinato

Multi-organ phenotypes in mice lacking latent TGFβ binding protein 2 (LTBP2).

Developmental dynamics : an official publication of the American Association of Anatomists

Avec: Nicholas K Bodmer , Russell H Knutsen , Robyn A Roth , Ryan M Castile , Michael D Brodt , Carrie M Gierasch , Thomas J Broekelmann , Mark A Gibson , Jeffrey A Haspel , Spencer P Lake , Jeffrey R Koenitzer , Steven L Brody , Matthew J Silva , Robert P Mecham , David M Ornitz

Progerin induces a phenotypic switch in vascular smooth muscle cells and triggers replication stress and an aging-associated secretory signature.

GeroScience

Avec: Nuria Coll-Bonfill , Urvashi Mahajan , Elena V Shashkova , Chien-Jung Lin , Robert P Mecham , Susana Gonzalo

Polarized localization of phosphatidylserine in the endothelium regulates Kir2.1.

JCI insight

Avec: Claire A Ruddiman , Richard Peckham , Melissa A Luse , Yen-Lin Chen , Maniselvan Kuppusamy , Bruce A Corliss , P Jordan Hall , Chien-Jung Lin , Shayn M Peirce , Swapnil K Sonkusare , Robert P Mecham , Jessica E Wagenseil , Brant E Isakson

Tissue-specific smooth muscle cell subtypes identified by transcriptional profiling.

The international journal of biochemistry & cell biology

Avec: Chien-Jung Lin , Robert P Mecham

Inhibition of NOX1 Mitigates Blood Pressure Increases in Elastin Insufficiency.

Function (Oxford, England)

Avec: Angela Troia , Russell H Knutsen , Carmen M Halabi , Daniela Malide , Zu Xi Yu , Amanda Wardlaw-Pickett , Elise K Kronquist , Kit Man Tsang , Attila Kovacs , Robert P Mecham , Beth A Kozel

Constitutive Modeling Of Mouse Arteries Suggests Changes In Directional Coupling And Extracellular Matrix Remodeling That Depend On Artery Type, Age, Sex And Elastin Amounts.

Journal of biomechanical engineering

Avec: Keshav Kailash , Jie Hawes , Austin Cocciolone , Matthew R Bersi , Robert P Mecham , Jessica E Wagenseil

Captopril treatment during development alleviates mechanically induced aortic remodeling in newborn elastin knockout mice.

Biomechanics and modeling in mechanobiology

Avec: Jungsil Kim , Austin J Cocciolone , Marius C Staiculescu , Robert P Mecham , Jessica E Wagenseil

Intracellular retention of mutant lysyl oxidase leads to aortic dilation in response to increased hemodynamic stress.

JCI insight

Avec: Vivian S Lee , Carmen M Halabi , Thomas J Broekelmann , Philip C Trackman , Nathan O Stitziel , Robert P Mecham

Interleukin-17 Drives Interstitial Entrapment of Tissue Lipoproteins in Experimental Psoriasis.

Cell metabolism

Avec: Li-Hao Huang , Bernd H Zinselmeyer , Chih-Hao Chang , Brian T Saunders , Andrew Elvington , Osamu Baba , Thomas J Broekelmann , Lina Qi , Joseph S Rueve , Melody A Swartz , Brian S Kim , Robert P Mecham , Helge Wiig , Michael J Thomas , Mary G Sorci-Thomas , Gwendalyn J Randolph

Loss of Angiotensin II Type 2 Receptor Improves Blood Pressure in Elastin Insufficiency.

Frontiers in cardiovascular medicine

Avec: Michelle Lin , Robyn A Roth , Beth A Kozel , Robert P Mecham , Carmen M Halabi

Vascular Smooth Muscle Cell Subpopulations and Neointimal Formation in Mouse Models of Elastin Insufficiency.

Arteriosclerosis, thrombosis, and vascular biology

Avec: Chien-Jung Lin , Bridget M Hunkins , Robyn A Roth , Chieh-Yu Lin , Jessica E Wagenseil , Robert P Mecham

Deletion of type VIII collagen reduces blood pressure, increases carotid artery functional distensibility and promotes elastin deposition.

Matrix biology plus

Avec: Amanda L Mohabeer , Jeffrey T Kroetsch , Meghan McFadden , Negin Khosraviani , Thomas J Broekelmann , Guangpei Hou , Hangjun Zhang , Yu-Qing Zhou , Minyao Wang , Anthony O Gramolini , Robert P Mecham , Scott P Heximer , Steffen-Sebastian Bolz , Michelle P Bendeck

Passive biaxial mechanical behavior of newborn mouse aorta with and without elastin.

Journal of the mechanical behavior of biomedical materials

Avec: Jungsil Kim , Austin J Cocciolone , Marius C Staiculescu , Robert P Mecham , Jessica E Wagenseil

SVEP1 is a human coronary artery disease locus that promotes atherosclerosis.

Science translational medicine

Avec: In-Hyuk Jung , Jared S Elenbaas , Arturo Alisio , Katherine Santana , Erica P Young , Chul Joo Kang , Puja Kachroo , Kory J Lavine , Babak Razani , Robert P Mecham , Nathan O Stitziel

A matricellular protein fibulin-4 is essential for the activation of lysyl oxidase.

Science advances

Avec: Kazuo Noda , Kaori Kitagawa , Takao Miki , Masahito Horiguchi , Tomoya O Akama , Takako Taniguchi , Hisaaki Taniguchi , Kazuaki Takahashi , Yasumitsu Ogra , Robert P Mecham , Masahiko Terajima , Mitsuo Yamauchi , Tomoyuki Nakamura

Complex consequences of Cantu syndrome SUR2 variant R1154Q in genetically modified mice.

JCI insight

Avec: Haixia Zhang , Alex Hanson , Tobias Scherf de Almeida , Christopher Emfinger , Conor McClenaghan , Theresa Harter , Zihan Yan , Paige E Cooper , G Schuyler Brown , Eric C Arakel , Robert P Mecham , Atilla Kovacs , Carmen M Halabi , Blanche Schwappach , Maria S Remedi , Colin G Nichols

Biological Preparation and Mechanical Technique for Determining Viscoelastic Properties of Zonular Fibers.

Journal of visualized experiments : JoVE

Avec: Juan Rodriguez , Matthew Reilly , Robert P Mecham , Steven Bassnett

Latent-transforming growth factor beta-binding protein-2 (LTBP-2) is required for longevity but not for development of zonular fibers.

Matrix biology : journal of the International Society for Matrix Biology

Avec: Y Shi , W Jones , W Beatty , Q Tan , R P Mecham , H Kumra , D P Reinhardt , M A Gibson , M A Reilly , J Rodriguez , S Bassnett

Decreased lysyl oxidase level protects against development of retinal vascular lesions in diabetic retinopathy.

Experimental eye research

Avec: Dongjoon Kim , Robert P Mecham , Ngan-Ha Nguyen , Sayon Roy

Whole exome sequencing in patients with Williams-Beuren syndrome followed by disease modeling in mice points to four novel pathways that may modify stenosis risk.

Human molecular genetics

Avec: Phoebe C R Parrish , Delong Liu , Russell H Knutsen , Charles J Billington , Robert P Mecham , Yi-Ping Fu , Beth A Kozel

Stem cell derived extracellular vesicles for vascular elastic matrix regenerative repair.

Acta biomaterialia

Avec: S Sajeesh , Thomas Broekelman , Robert P Mecham , Anand Ramamurthi

Early Aberrant Angiogenesis Due to Elastic Fiber Fragmentation in Aortic Valve Disease.

Journal of cardiovascular development and disease

Avec: Robert B Hinton , Amy L Juraszek , Amy M Opoka , Benjamin J Landis , J Michael Smith , Robert P Mecham , Kevin E Bove

Macrophage secretion of miR-106b-5p causes renin-dependent hypertension.

Nature communications

Avec: J Oh , S J Matkovich , A E Riek , S M Bindom , J S Shao , R D Head , R A Barve , M S Sands , G Carmeliet , P Osei-Owusu , R H Knutsen , H Zhang , K J Blumer , C G Nichols , R P Mecham , Á Baldán , B A Benitez , M L Sequeira-Lopez , R A Gomez , C Bernal-Mizrachi

A new mouse model of elastin haploinsufficiency highlights the importance of elastin to vascular development and blood pressure regulation.

Matrix biology : journal of the International Society for Matrix Biology

Avec: Bridget M Brengle , Michelle Lin , Robyn A Roth , Kara D Jones , Jessica E Wagenseil , Robert P Mecham , Carmen M Halabi

Réseau de co-auteurs

Jessica E Wagenseil 9 collaborations

Carmen M Halabi 7 collaborations

Thomas J Broekelmann 5 collaborations

Chien-Jung Lin 5 collaborations

Robyn A Roth 5 collaborations

Austin J Cocciolone 4 collaborations

Beth A Kozel 4 collaborations

Marius C Staiculescu 3 collaborations

Nathan O Stitziel 3 collaborations

Russell H Knutsen 3 collaborations

Nicholas K Bodmer 2 collaborations

Jie Z Hawes 2 collaborations

Bridget M Hunkins 2 collaborations

Chieh-Yu Lin 2 collaborations

Vivian S Lee 2 collaborations

Jared S Elenbaas 2 collaborations

Chul Joo Kang 2 collaborations

Katherine Santana 2 collaborations

In-Hyuk Jung 2 collaborations

Arturo Alisio 2 collaborations

Anand Ramamurthi 2 collaborations

Jungsil Kim 2 collaborations

Michelle Lin 2 collaborations

R P Mecham 2 collaborations

Ping Li 1 collaboration

Richard Stewart 1 collaboration

Alice Butler 1 collaboration

Bobbie Brown 1 collaboration

Xiaoming Xia 1 collaboration

Celia Santi 1 collaboration

Sarah England 1 collaboration

Juan Ferreira 1 collaboration

Lawrence Salkoff 1 collaboration

Amy H Cui 1 collaboration

Diana B Griffin 1 collaboration

Marius Catalin Staiculescu 1 collaboration

Christie L Crandall 1 collaboration

Sean Y Kim 1 collaboration

Jacob Rother 1 collaboration

Upasana Pudupakkam 1 collaboration

Katrina J Ashworth 1 collaboration

Ved Patel 1 collaboration

Paul C Lee 1 collaboration

Kendall H Burks 1 collaboration

Junedh M Amrute 1 collaboration

Jorge Di Paola 1 collaboration

Simran Dayal 1 collaboration

Thomas Broekelmann 1 collaboration

Matthias Przyklenk 1 collaboration

Veronika S Georgieva 1 collaboration

Fabian Metzen 1 collaboration

Sebastian Mostert 1 collaboration

Birgit Kobbe 1 collaboration

Bert Callewaert 1 collaboration

Gerhard Sengle 1 collaboration

Bent Brachvogel 1 collaboration

Mats Paulsson 1 collaboration

Raimund Wagener 1 collaboration

Manuel Koch 1 collaboration

Alvise Schiavinato 1 collaboration

Ryan M Castile 1 collaboration

Michael D Brodt 1 collaboration

Carrie M Gierasch 1 collaboration

Mark A Gibson 1 collaboration

Jeffrey A Haspel 1 collaboration

Spencer P Lake 1 collaboration

Jeffrey R Koenitzer 1 collaboration

Steven L Brody 1 collaboration

Matthew J Silva 1 collaboration

David M Ornitz 1 collaboration

Nuria Coll-Bonfill 1 collaboration

Urvashi Mahajan 1 collaboration

Elena V Shashkova 1 collaboration

Susana Gonzalo 1 collaboration

Claire A Ruddiman 1 collaboration

Richard Peckham 1 collaboration

Melissa A Luse 1 collaboration

Yen-Lin Chen 1 collaboration

Maniselvan Kuppusamy 1 collaboration

Bruce A Corliss 1 collaboration

P Jordan Hall 1 collaboration

Shayn M Peirce 1 collaboration

Swapnil K Sonkusare 1 collaboration

Brant E Isakson 1 collaboration

Angela Troia 1 collaboration

Daniela Malide 1 collaboration

Zu Xi Yu 1 collaboration

Amanda Wardlaw-Pickett 1 collaboration

Elise K Kronquist 1 collaboration

Kit Man Tsang 1 collaboration

Attila Kovacs 1 collaboration

Keshav Kailash 1 collaboration

Jie Hawes 1 collaboration

Austin Cocciolone 1 collaboration

Matthew R Bersi 1 collaboration

Philip C Trackman 1 collaboration

Li-Hao Huang 1 collaboration

Bernd H Zinselmeyer 1 collaboration

Chih-Hao Chang 1 collaboration

Brian T Saunders 1 collaboration

Andrew Elvington 1 collaboration

Osamu Baba 1 collaboration

Lina Qi 1 collaboration

Joseph S Rueve 1 collaboration

Melody A Swartz 1 collaboration

Brian S Kim 1 collaboration

Helge Wiig 1 collaboration

Michael J Thomas 1 collaboration

Mary G Sorci-Thomas 1 collaboration

Gwendalyn J Randolph 1 collaboration

Amanda L Mohabeer 1 collaboration

Jeffrey T Kroetsch 1 collaboration

Meghan McFadden 1 collaboration

Negin Khosraviani 1 collaboration

Guangpei Hou 1 collaboration

Hangjun Zhang 1 collaboration

Yu-Qing Zhou 1 collaboration

Minyao Wang 1 collaboration

Anthony O Gramolini 1 collaboration

Scott P Heximer 1 collaboration

Steffen-Sebastian Bolz 1 collaboration

Michelle P Bendeck 1 collaboration

Erica P Young 1 collaboration

Puja Kachroo 1 collaboration

Kory J Lavine 1 collaboration

Babak Razani 1 collaboration

Kazuo Noda 1 collaboration

Kaori Kitagawa 1 collaboration

Takao Miki 1 collaboration

Masahito Horiguchi 1 collaboration

Tomoya O Akama 1 collaboration

Takako Taniguchi 1 collaboration

Hisaaki Taniguchi 1 collaboration

Kazuaki Takahashi 1 collaboration

Yasumitsu Ogra 1 collaboration

Masahiko Terajima 1 collaboration

Mitsuo Yamauchi 1 collaboration

Tomoyuki Nakamura 1 collaboration

Haixia Zhang 1 collaboration

Alex Hanson 1 collaboration

Tobias Scherf de Almeida 1 collaboration

Christopher Emfinger 1 collaboration

Conor McClenaghan 1 collaboration

Theresa Harter 1 collaboration

Zihan Yan 1 collaboration

Paige E Cooper 1 collaboration

G Schuyler Brown 1 collaboration

Eric C Arakel 1 collaboration

Atilla Kovacs 1 collaboration

Blanche Schwappach 1 collaboration

Maria S Remedi 1 collaboration

Colin G Nichols 1 collaboration

Juan Rodriguez 1 collaboration

Matthew Reilly 1 collaboration

Steven Bassnett 1 collaboration

Y Shi 1 collaboration

W Jones 1 collaboration

W Beatty 1 collaboration

Q Tan 1 collaboration

H Kumra 1 collaboration

D P Reinhardt 1 collaboration

M A Gibson 1 collaboration

M A Reilly 1 collaboration

J Rodriguez 1 collaboration

S Bassnett 1 collaboration

Dongjoon Kim 1 collaboration

Ngan-Ha Nguyen 1 collaboration

Sayon Roy 1 collaboration

Phoebe C R Parrish 1 collaboration

Delong Liu 1 collaboration

Charles J Billington 1 collaboration

Yi-Ping Fu 1 collaboration

S Sajeesh 1 collaboration

Thomas Broekelman 1 collaboration

Robert B Hinton 1 collaboration

Amy L Juraszek 1 collaboration

Amy M Opoka 1 collaboration

Benjamin J Landis 1 collaboration

J Michael Smith 1 collaboration

Kevin E Bove 1 collaboration

J Oh 1 collaboration

S J Matkovich 1 collaboration

A E Riek 1 collaboration

S M Bindom 1 collaboration

J S Shao 1 collaboration

R D Head 1 collaboration

R A Barve 1 collaboration

M S Sands 1 collaboration

G Carmeliet 1 collaboration

P Osei-Owusu 1 collaboration

R H Knutsen 1 collaboration

H Zhang 1 collaboration

K J Blumer 1 collaboration

C G Nichols 1 collaboration

Á Baldán 1 collaboration

B A Benitez 1 collaboration

M L Sequeira-Lopez 1 collaboration

R A Gomez 1 collaboration

C Bernal-Mizrachi 1 collaboration

Bridget M Brengle 1 collaboration

Kara D Jones 1 collaboration