Paola Arlotta

Affiliations

Department of Stem Cell and Regenerative Biology, Harvard University, Cambridge, MA, USA. paola_arlotta@harvard.edu.
Stanley Center for Psychiatric Research, Broad Institute of MIT and Harvard, Cambridge, MA, USA. paola_arlotta@harvard.edu.

Publications (32)

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex.

Nature

Avec: Silvia Velasco , Amanda J Kedaigle , Sean K Simmons , Allison Nash , Marina Rocha , Giorgia Quadrato , Bruna Paulsen , Lan Nguyen , Xian Adiconis , Aviv Regev , Joshua Z Levin , Paola Arlotta

Cell diversity in the human cerebral cortex: from the embryo to brain organoids.

Current opinion in neurobiology

Avec: Paola Arlotta , Sergiu P Paşca

Autism genes converge on asynchronous development of shared neuron classes.

Nature

Avec: Bruna Paulsen , Silvia Velasco , Amanda J Kedaigle , Martina Pigoni , Giorgia Quadrato , Anthony J Deo , Xian Adiconis , Ana Uzquiano , Rafaela Sartore , Sung Min Yang , Sean K Simmons , Panagiotis Symvoulidis , Kwanho Kim , Kalliopi Tsafou , Archana Podury , Catherine Abbate , Ashley Tucewicz , Samantha N Smith , Alexandre Albanese , Lindy Barrett , Neville E Sanjana , Xi Shi , Kwanghun Chung , Kasper Lage , Edward S Boyden , Aviv Regev , Joshua Z Levin , Paola Arlotta

Cell-type specific defects in PTEN-mutant cortical organoids converge on abnormal circuit activity.

Human molecular genetics

Avec: Martina Pigoni , Ana Uzquiano , Bruna Paulsen , Amanda J Kedaigle , Sung Min Yang , Panagiotis Symvoulidis , Xian Adiconis , Silvia Velasco , Rafaela Sartore , Kwanho Kim , Ashley Tucewicz , Sarah Yoshimi Tropp , Kalliopi Tsafou , Xin Jin , Lindy Barrett , Fei Chen , Edward S Boyden , Aviv Regev , Joshua Z Levin , Paola Arlotta

Transcriptional dynamics orchestrating the development and integration of neurons born in the adult hippocampus.

bioRxiv : the preprint server for biology

Avec: Natalí B Rasetto , Damiana Giacomini , Ariel A Berardino , Tomás Vega Waichman , Maximiliano S Beckel , Daniela J Di Bella , Juliana Brown , M Georgina Davies-Sala , Chiara Gerhardinger , Dieter Chichung Lie , Paola Arlotta , Ariel Chernomoretz , Alejandro F Schinder

Genetic dissection of the glutamatergic neuron system in cerebral cortex.

Nature

Avec: Katherine S Matho , Dhananjay Huilgol , William Galbavy , Miao He , Gukhan Kim , Xu An , Jiangteng Lu , Priscilla Wu , Daniela J Di Bella , Ashwin S Shetty , Ramesh Palaniswamy , Joshua Hatfield , Ricardo Raudales , Arun Narasimhan , Eric Gamache , Jesse M Levine , Jason Tucciarone , Eric Szelenyi , Julie A Harris , Partha P Mitra , Pavel Osten , Paola Arlotta , Z Josh Huang

Dissecting cellular diversity of cortical GABAergic cells across multiple modalities: A turning point in neuronal taxonomy.

Faculty reviews

Avec: Paola Arlotta , Fei Chen , Simona Lodato , Troy W Margrie , Tomasz J Nowakowski , Thoru Pederson , Beatriz Rico

scX: a user-friendly tool for scRNAseq exploration.

Bioinformatics advances

Avec: Tomás V Waichman , M L Vercesi , Ariel A Berardino , Maximiliano S Beckel , Damiana Giacomini , Natalí B Rasetto , Magalí Herrero , Daniela J Di Bella , Paola Arlotta , Alejandro F Schinder , Ariel Chernomoretz

Making Ramón y Cajal proud: Development of cell identity and diversity in the cerebral cortex.

Neuron

Avec: Daniela J Di Bella , Nuria Domínguez-Iturza , Juliana R Brown , Paola Arlotta

Temporally divergent regulatory mechanisms govern neuronal diversification and maturation in the mouse and marmoset neocortex.

Nature neuroscience

Avec: Wen Yuan , Sai Ma , Juliana R Brown , Kwanho Kim , Vanessa Murek , Lucia Trastulla , Alexander Meissner , Simona Lodato , Ashwin S Shetty , Joshua Z Levin , Jason D Buenrostro , Michael J Ziller , Paola Arlotta

Individual Oligodendrocytes Show Bias for Inhibitory Axons in the Neocortex.

Cell reports

Avec: Marzieh Zonouzi , Daniel Berger , Vahbiz Jokhi , Amanda Kedaigle , Jeff Lichtman , Paola Arlotta

Voltage imaging and optogenetics reveal behaviour-dependent changes in hippocampal dynamics.

Nature

Avec: Yoav Adam , Jeong J Kim , Shan Lou , Yongxin Zhao , Michael E Xie , Daan Brinks , Hao Wu , Mohammed A Mostajo-Radji , Simon Kheifets , Vicente Parot , Selmaan Chettih , Katherine J Williams , Benjamin Gmeiner , Samouil L Farhi , Linda Madisen , E Kelly Buchanan , Ian Kinsella , Ding Zhou , Liam Paninski , Christopher D Harvey , Hongkui Zeng , Paola Arlotta , Robert E Campbell , Adam E Cohen

Multiscale 3D phenotyping of human cerebral organoids.

Scientific reports

Avec: Alexandre Albanese , Justin M Swaney , Dae Hee Yun , Nicholas B Evans , Jenna M Antonucci , Silvia Velasco , Chang Ho Sohn , Paola Arlotta , Lee Gehrke , Kwanghun Chung

Neuron class-specific responses govern adaptive myelin remodeling in the neocortex.

Science (New York, N.Y.)

Avec: Sung Min Yang , Katrin Michel , Vahbiz Jokhi , Elly Nedivi , Paola Arlotta

Optogenetic axon guidance in embryonic zebrafish.

STAR protocols

Avec: James M Harris , Andy Yu-Der Wang , Paola Arlotta

Brain organoids: the quest to decipher human-specific features of brain development.

Current opinion in genetics & development

Avec: Ana Uzquiano , Paola Arlotta

A nomenclature consensus for nervous system organoids and assembloids.

Nature

Avec: Sergiu P Pașca , Paola Arlotta , Helen S Bateup , J Gray Camp , Silvia Cappello , Fred H Gage , Jürgen A Knoblich , Arnold R Kriegstein , Madeline A Lancaster , Guo-Li Ming , Alysson R Muotri , In-Hyun Park , Orly Reiner , Hongjun Song , Lorenz Studer , Sally Temple , Giuseppe Testa , Barbara Treutlein , Flora M Vaccarino

Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex.

Cell

Avec: Ana Uzquiano , Amanda J Kedaigle , Martina Pigoni , Bruna Paulsen , Xian Adiconis , Kwanho Kim , Tyler Faits , Surya Nagaraja , Noelia Antón-Bolaños , Chiara Gerhardinger , Ashley Tucewicz , Evan Murray , Xin Jin , Jason Buenrostro , Fei Chen , Silvia Velasco , Aviv Regev , Joshua Z Levin , Paola Arlotta

3D Brain Organoids: Studying Brain Development and Disease Outside the Embryo.

Annual review of neuroscience

Avec: Silvia Velasco , Bruna Paulsen , Paola Arlotta

In vivo Perturb-Seq reveals neuronal and glial abnormalities associated with autism risk genes.

Science (New York, N.Y.)

Avec: Xin Jin , Sean K Simmons , Amy Guo , Ashwin S Shetty , Michelle Ko , Lan Nguyen , Vahbiz Jokhi , Elise Robinson , Paul Oyler , Nathan Curry , Giulio Deangeli , Simona Lodato , Joshua Z Levin , Aviv Regev , Feng Zhang , Paola Arlotta

Highly sensitive spatial transcriptomics at near-cellular resolution with Slide-seqV2.

Nature biotechnology

Avec: Robert R Stickels , Evan Murray , Pawan Kumar , Jilong Li , Jamie L Marshall , Daniela J Di Bella , Paola Arlotta , Evan Z Macosko , Fei Chen

Molecular logic of cellular diversification in the mouse cerebral cortex.

Nature

Avec: Daniela J Di Bella , Ehsan Habibi , Robert R Stickels , Gabriele Scalia , Juliana Brown , Payman Yadollahpour , Sung Min Yang , Catherine Abbate , Tommaso Biancalani , Evan Z Macosko , Fei Chen , Aviv Regev , Paola Arlotta

scX: A user-friendly tool for scRNA-seq exploration.

ArXiv

Avec: Tomás Vega Waichman , M Luz Vercesi , Ariel A Berardino , Maximiliano S Beckel , Damiana Giacomini , Natalí B Rasetto , Magalí Herrero , Daniela J Di Bella , Paola Arlotta , Alejandro F Schinder , Ariel Chernomoretz

Glioblastoma-cortical organoids recapitulate cell state heterogeneity and intercellular transfer.

Cancer discovery

Avec: Vamsi Mangena , Rony Chanoch-Myers , Rafaela Sartore , Bruna Paulsen , Simon Gritsch , Hannah Weisman , Toshiro Hara , Xandra O Breakefield , Koen Breyne , Aviv Regev , Kwanghun Chung , Paola Arlotta , Itay Tirosh , Mario L Suva

FIN-Seq: transcriptional profiling of specific cell types from frozen archived tissue of the human central nervous system.

Nucleic acids research

Avec: Ryoji Amamoto , Emanuela Zuccaro , Nathan C Curry , Sonia Khurana , Hsu-Hsin Chen , Constance L Cepko , Paola Arlotta

Long-Range Optogenetic Control of Axon Guidance Overcomes Developmental Boundaries and Defects.

Developmental cell

Avec: James M Harris , Andy Yu-Der Wang , Jonathan Boulanger-Weill , Cristina Santoriello , Stephan Foianini , Jeff W Lichtman , Leonard I Zon , Paola Arlotta

Pyramidal neuron subtype diversity governs microglia states in the neocortex.

Nature

Avec: Jeffrey A Stogsdill , Kwanho Kim , Loïc Binan , Samouil L Farhi , Joshua Z Levin , Paola Arlotta

Engineering multicellular living systems-a Keystone Symposia report.

Annals of the New York Academy of Sciences

Avec: Jennifer Cable , Paola Arlotta , Kevin Kit Parker , Alex J Hughes , Katharine Goodwin , Christine L Mummery , Roger D Kamm , Sandra J Engle , Danilo A Tagle , Sylvia F Boj , Alice E Stanton , Yoshihiro Morishita , Melissa L Kemp , Dennis A Norfleet , Elebeoba E May , Aric Lu , Rashid Bashir , Adam W Feinberg , Sarah M Hull , Anjelica L Gonzalez , Michael R Blatchley , Núria Montserrat Pulido , Ryuji Morizane , Todd C McDevitt , Deepak Mishra , Adriana Mulero-Russe

A family portrait of human brain cells.

Science (New York, N.Y.)

Avec: Alyssa Weninger , Paola Arlotta

Fetal brain response to maternal inflammation requires microglia.

Development (Cambridge, England)

Avec: Bridget Elaine LaMonica Ostrem , Nuria Domínguez-Iturza , Jeffrey A Stogsdill , Tyler Faits , Kwanho Kim , Joshua Z Levin , Paola Arlotta

Brain Chimeroids reveal individual susceptibility to neurotoxic triggers.

Nature

Avec: Noelia Antón-Bolaños , Irene Faravelli , Tyler Faits , Sophia Andreadis , Rahel Kastli , Sebastiano Trattaro , Xian Adiconis , Anqi Wei , Abhishek Sampath Kumar , Daniela J Di Bella , Matthew Tegtmeyer , Ralda Nehme , Joshua Z Levin , Aviv Regev , Paola Arlotta

Transcriptional dynamics orchestrating the development and integration of neurons born in the adult hippocampus.

Science advances

Réseau de co-auteurs

Joshua Z Levin 9 collaborations

Daniela J Di Bella 9 collaborations

Aviv Regev 8 collaborations

Silvia Velasco 6 collaborations

Bruna Paulsen 6 collaborations

Kwanho Kim 6 collaborations

Xian Adiconis 5 collaborations

Fei Chen 5 collaborations

Amanda J Kedaigle 4 collaborations

Ana Uzquiano 4 collaborations

Sung Min Yang 4 collaborations

Natalí B Rasetto 4 collaborations

Damiana Giacomini 4 collaborations

Ariel A Berardino 4 collaborations

Maximiliano S Beckel 4 collaborations

Ariel Chernomoretz 4 collaborations

Alejandro F Schinder 4 collaborations

Sean K Simmons 3 collaborations

Martina Pigoni 3 collaborations

Rafaela Sartore 3 collaborations

Ashley Tucewicz 3 collaborations

Kwanghun Chung 3 collaborations

Xin Jin 3 collaborations

Tomás Vega Waichman 3 collaborations

Juliana Brown 3 collaborations

Chiara Gerhardinger 3 collaborations

Ashwin S Shetty 3 collaborations

Simona Lodato 3 collaborations

Vahbiz Jokhi 3 collaborations

Tyler Faits 3 collaborations

Giorgia Quadrato 2 collaborations

Lan Nguyen 2 collaborations

Panagiotis Symvoulidis 2 collaborations

Kalliopi Tsafou 2 collaborations

Catherine Abbate 2 collaborations

Alexandre Albanese 2 collaborations

Lindy Barrett 2 collaborations

Edward S Boyden 2 collaborations

M Georgina Davies-Sala 2 collaborations

Dieter Chichung Lie 2 collaborations

Magalí Herrero 2 collaborations

Nuria Domínguez-Iturza 2 collaborations

Juliana R Brown 2 collaborations

Samouil L Farhi 2 collaborations

James M Harris 2 collaborations

Andy Yu-Der Wang 2 collaborations

Noelia Antón-Bolaños 2 collaborations

Evan Murray 2 collaborations

Robert R Stickels 2 collaborations

Evan Z Macosko 2 collaborations

Jeffrey A Stogsdill 2 collaborations

Allison Nash 1 collaboration

Marina Rocha 1 collaboration

Sergiu P Paşca 1 collaboration

Anthony J Deo 1 collaboration

Archana Podury 1 collaboration

Samantha N Smith 1 collaboration

Neville E Sanjana 1 collaboration

Xi Shi 1 collaboration

Kasper Lage 1 collaboration

Sarah Yoshimi Tropp 1 collaboration

Katherine S Matho 1 collaboration

Dhananjay Huilgol 1 collaboration

William Galbavy 1 collaboration

Miao He 1 collaboration

Gukhan Kim 1 collaboration

Xu An 1 collaboration

Jiangteng Lu 1 collaboration

Priscilla Wu 1 collaboration

Ramesh Palaniswamy 1 collaboration

Joshua Hatfield 1 collaboration

Ricardo Raudales 1 collaboration

Arun Narasimhan 1 collaboration

Eric Gamache 1 collaboration

Jesse M Levine 1 collaboration

Jason Tucciarone 1 collaboration

Eric Szelenyi 1 collaboration

Julie A Harris 1 collaboration

Partha P Mitra 1 collaboration

Pavel Osten 1 collaboration

Z Josh Huang 1 collaboration

Troy W Margrie 1 collaboration

Tomasz J Nowakowski 1 collaboration

Thoru Pederson 1 collaboration

Beatriz Rico 1 collaboration

Tomás V Waichman 1 collaboration

M L Vercesi 1 collaboration

Wen Yuan 1 collaboration

Sai Ma 1 collaboration

Vanessa Murek 1 collaboration

Lucia Trastulla 1 collaboration

Alexander Meissner 1 collaboration

Jason D Buenrostro 1 collaboration

Michael J Ziller 1 collaboration

Marzieh Zonouzi 1 collaboration

Daniel Berger 1 collaboration

Amanda Kedaigle 1 collaboration

Jeff Lichtman 1 collaboration

Yoav Adam 1 collaboration

Jeong J Kim 1 collaboration

Shan Lou 1 collaboration

Yongxin Zhao 1 collaboration

Michael E Xie 1 collaboration

Daan Brinks 1 collaboration

Hao Wu 1 collaboration

Mohammed A Mostajo-Radji 1 collaboration

Simon Kheifets 1 collaboration

Vicente Parot 1 collaboration

Selmaan Chettih 1 collaboration

Katherine J Williams 1 collaboration

Benjamin Gmeiner 1 collaboration

Linda Madisen 1 collaboration

E Kelly Buchanan 1 collaboration

Ian Kinsella 1 collaboration

Ding Zhou 1 collaboration

Liam Paninski 1 collaboration

Christopher D Harvey 1 collaboration

Hongkui Zeng 1 collaboration

Robert E Campbell 1 collaboration

Adam E Cohen 1 collaboration

Justin M Swaney 1 collaboration

Dae Hee Yun 1 collaboration

Nicholas B Evans 1 collaboration

Jenna M Antonucci 1 collaboration

Chang Ho Sohn 1 collaboration

Lee Gehrke 1 collaboration

Katrin Michel 1 collaboration

Elly Nedivi 1 collaboration

Sergiu P Pașca 1 collaboration

Helen S Bateup 1 collaboration

J Gray Camp 1 collaboration

Silvia Cappello 1 collaboration

Fred H Gage 1 collaboration

Jürgen A Knoblich 1 collaboration

Arnold R Kriegstein 1 collaboration

Madeline A Lancaster 1 collaboration

Guo-Li Ming 1 collaboration

Alysson R Muotri 1 collaboration

In-Hyun Park 1 collaboration

Orly Reiner 1 collaboration

Hongjun Song 1 collaboration

Lorenz Studer 1 collaboration

Sally Temple 1 collaboration

Giuseppe Testa 1 collaboration

Barbara Treutlein 1 collaboration

Flora M Vaccarino 1 collaboration

Surya Nagaraja 1 collaboration

Jason Buenrostro 1 collaboration

Amy Guo 1 collaboration

Michelle Ko 1 collaboration

Elise Robinson 1 collaboration

Paul Oyler 1 collaboration

Nathan Curry 1 collaboration

Giulio Deangeli 1 collaboration

Feng Zhang 1 collaboration

Pawan Kumar 1 collaboration

Jilong Li 1 collaboration

Jamie L Marshall 1 collaboration

Ehsan Habibi 1 collaboration

Gabriele Scalia 1 collaboration

Payman Yadollahpour 1 collaboration

Tommaso Biancalani 1 collaboration

M Luz Vercesi 1 collaboration

Vamsi Mangena 1 collaboration

Rony Chanoch-Myers 1 collaboration

Simon Gritsch 1 collaboration

Hannah Weisman 1 collaboration

Toshiro Hara 1 collaboration

Xandra O Breakefield 1 collaboration

Koen Breyne 1 collaboration

Itay Tirosh 1 collaboration

Mario L Suva 1 collaboration

Ryoji Amamoto 1 collaboration

Emanuela Zuccaro 1 collaboration

Nathan C Curry 1 collaboration

Sonia Khurana 1 collaboration

Hsu-Hsin Chen 1 collaboration

Constance L Cepko 1 collaboration

Jonathan Boulanger-Weill 1 collaboration

Cristina Santoriello 1 collaboration

Stephan Foianini 1 collaboration

Jeff W Lichtman 1 collaboration

Leonard I Zon 1 collaboration

Loïc Binan 1 collaboration

Jennifer Cable 1 collaboration

Kevin Kit Parker 1 collaboration

Alex J Hughes 1 collaboration

Katharine Goodwin 1 collaboration

Christine L Mummery 1 collaboration

Roger D Kamm 1 collaboration

Sandra J Engle 1 collaboration

Danilo A Tagle 1 collaboration

Sylvia F Boj 1 collaboration

Alice E Stanton 1 collaboration

Yoshihiro Morishita 1 collaboration

Melissa L Kemp 1 collaboration

Dennis A Norfleet 1 collaboration

Elebeoba E May 1 collaboration

Aric Lu 1 collaboration

Rashid Bashir 1 collaboration

Adam W Feinberg 1 collaboration

Sarah M Hull 1 collaboration

Anjelica L Gonzalez 1 collaboration

Michael R Blatchley 1 collaboration

Núria Montserrat Pulido 1 collaboration

Ryuji Morizane 1 collaboration

Todd C McDevitt 1 collaboration

Deepak Mishra 1 collaboration

Adriana Mulero-Russe 1 collaboration

Alyssa Weninger 1 collaboration

Bridget Elaine LaMonica Ostrem 1 collaboration

Irene Faravelli 1 collaboration

Sophia Andreadis 1 collaboration

Rahel Kastli 1 collaboration

Sebastiano Trattaro 1 collaboration

Anqi Wei 1 collaboration

Abhishek Sampath Kumar 1 collaboration

Matthew Tegtmeyer 1 collaboration

Ralda Nehme 1 collaboration