Amanda J Kedaigle

Affiliations

Broad Institute of MIT and Harvard, Cambridge, MA, USA.

ORCID: http://orcid.org/0000-0001-6156-5046

Publications (9)

Systematic comparison of single-cell and single-nucleus RNA-sequencing methods.

Nature biotechnology

Avec: Jiarui Ding , Xian Adiconis , Sean K Simmons , Monika S Kowalczyk , Cynthia C Hession , Nemanja D Marjanovic , Travis K Hughes , Marc H Wadsworth , Tyler Burks , Lan T Nguyen , John Y H Kwon , Boaz Barak , William Ge , Shaina Carroll , Shuqiang Li , Nir Hacohen , Orit Rozenblatt-Rosen , Alex K Shalek , Alexandra-Chloé Villani , Aviv Regev , Joshua Z Levin

Treatment with JQ1, a BET bromodomain inhibitor, is selectively detrimental to R6/2 Huntington's disease mice.

Human molecular genetics

Avec: Jack C Reidling , Ryan G Lim , Miriam Adam , Jie Wu , Brook Wassie , Jennifer T Stocksdale , Malcolm S Casale , Ernest Fraenkel , Leslie M Thompson

Author Correction: Systematic comparison of single-cell and single-nucleus RNA-sequencing methods.

Nature biotechnology

Avec: Jiarui Ding , Xian Adiconis , Sean K Simmons , Monika S Kowalczyk , Cynthia C Hession , Nemanja D Marjanovic , Travis K Hughes , Marc H Wadsworth , Tyler Burks , Lan T Nguyen , John Y H Kwon , Boaz Barak , William Ge , Shaina Carroll , Shuqiang Li , Nir Hacohen , Orit Rozenblatt-Rosen , Alex K Shalek , Alexandra-Chloé Villani , Aviv Regev , Joshua Z Levin

Immortalized striatal precursor neurons from Huntington's disease patient-derived iPS cells as a platform for target identification and screening for experimental therapeutics.

Human molecular genetics

Avec: Sergey S Akimov , Mali Jiang , Nicolas Arbez , Leonard O Marque , Chelsy R Eddings , Paul T Ranum , Emma Whelan , Anthony Tang , Ronald Wang , Lauren R DeVine , Conover C Talbot , Robert N Cole , Tamara Ratovitski , Beverly L Davidson , Ernest Fraenkel , Christopher A Ross

Proper acquisition of cell class identity in organoids allows definition of fate specification programs of the human cerebral cortex.

Cell

Avec: Ana Uzquiano , Martina Pigoni , Bruna Paulsen , Xian Adiconis , Kwanho Kim , Tyler Faits , Surya Nagaraja , Noelia Antón-Bolaños , Chiara Gerhardinger , Ashley Tucewicz , Evan Murray , Xin Jin , Jason Buenrostro , Fei Chen , Silvia Velasco , Aviv Regev , Joshua Z Levin , Paola Arlotta

Individual brain organoids reproducibly form cell diversity of the human cerebral cortex.

Nature

Avec: Silvia Velasco , Sean K Simmons , Allison Nash , Marina Rocha , Giorgia Quadrato , Bruna Paulsen , Lan Nguyen , Xian Adiconis , Aviv Regev , Joshua Z Levin , Paola Arlotta

Skin-resident innate lymphoid cells converge on a pathogenic effector state.

Nature

Avec: Piotr Bielecki , Samantha J Riesenfeld , Jan-Christian Hütter , Elena Torlai Triglia , Monika S Kowalczyk , Roberto R Ricardo-Gonzalez , Mi Lian , Maria C Amezcua Vesely , Lina Kroehling , Hao Xu , Michal Slyper , Christoph Muus , Leif S Ludwig , Elena Christian , Liming Tao , Holly R Steach , Autumn G York , Mathias H Skadow , Parastou Yaghoubi , Danielle Dionne , Abigail Jarret , Heather M McGee , Caroline B M Porter , Paula Licona-Limón , Will Bailis , Ruaidhrí Jackson , Nicola Gagliani , Georg Gasteiger , Richard M Locksley , Aviv Regev , Richard A Flavell

Autism genes converge on asynchronous development of shared neuron classes.

Nature

Avec: Bruna Paulsen , Silvia Velasco , Martina Pigoni , Giorgia Quadrato , Anthony J Deo , Xian Adiconis , Ana Uzquiano , Rafaela Sartore , Sung Min Yang , Sean K Simmons , Panagiotis Symvoulidis , Kwanho Kim , Kalliopi Tsafou , Archana Podury , Catherine Abbate , Ashley Tucewicz , Samantha N Smith , Alexandre Albanese , Lindy Barrett , Neville E Sanjana , Xi Shi , Kwanghun Chung , Kasper Lage , Edward S Boyden , Aviv Regev , Joshua Z Levin , Paola Arlotta

Cell-type specific defects in PTEN-mutant cortical organoids converge on abnormal circuit activity.

Human molecular genetics

Avec: Martina Pigoni , Ana Uzquiano , Bruna Paulsen , Sung Min Yang , Panagiotis Symvoulidis , Xian Adiconis , Silvia Velasco , Rafaela Sartore , Kwanho Kim , Ashley Tucewicz , Sarah Yoshimi Tropp , Kalliopi Tsafou , Xin Jin , Lindy Barrett , Fei Chen , Edward S Boyden , Aviv Regev , Joshua Z Levin , Paola Arlotta

Réseau de co-auteurs

Aviv Regev 7 collaborations

Xian Adiconis 6 collaborations

Joshua Z Levin 6 collaborations

Sean K Simmons 4 collaborations

Bruna Paulsen 4 collaborations

Silvia Velasco 4 collaborations

Paola Arlotta 4 collaborations

Monika S Kowalczyk 3 collaborations

Ana Uzquiano 3 collaborations

Martina Pigoni 3 collaborations

Kwanho Kim 3 collaborations

Ashley Tucewicz 3 collaborations

Jiarui Ding 2 collaborations

Cynthia C Hession 2 collaborations

Nemanja D Marjanovic 2 collaborations

Travis K Hughes 2 collaborations

Marc H Wadsworth 2 collaborations

Tyler Burks 2 collaborations

Lan T Nguyen 2 collaborations

John Y H Kwon 2 collaborations

Boaz Barak 2 collaborations

William Ge 2 collaborations

Shaina Carroll 2 collaborations

Shuqiang Li 2 collaborations

Nir Hacohen 2 collaborations

Orit Rozenblatt-Rosen 2 collaborations

Alex K Shalek 2 collaborations

Alexandra-Chloé Villani 2 collaborations

Ernest Fraenkel 2 collaborations

Xin Jin 2 collaborations

Fei Chen 2 collaborations

Giorgia Quadrato 2 collaborations

Rafaela Sartore 2 collaborations

Sung Min Yang 2 collaborations

Panagiotis Symvoulidis 2 collaborations

Kalliopi Tsafou 2 collaborations

Lindy Barrett 2 collaborations

Edward S Boyden 2 collaborations

Jack C Reidling 1 collaboration

Ryan G Lim 1 collaboration

Miriam Adam 1 collaboration

Jie Wu 1 collaboration

Brook Wassie 1 collaboration

Jennifer T Stocksdale 1 collaboration

Malcolm S Casale 1 collaboration

Leslie M Thompson 1 collaboration

Sergey S Akimov 1 collaboration

Mali Jiang 1 collaboration

Nicolas Arbez 1 collaboration

Leonard O Marque 1 collaboration

Chelsy R Eddings 1 collaboration

Paul T Ranum 1 collaboration

Emma Whelan 1 collaboration

Anthony Tang 1 collaboration

Ronald Wang 1 collaboration

Lauren R DeVine 1 collaboration

Conover C Talbot 1 collaboration

Robert N Cole 1 collaboration

Tamara Ratovitski 1 collaboration

Beverly L Davidson 1 collaboration

Christopher A Ross 1 collaboration

Tyler Faits 1 collaboration

Surya Nagaraja 1 collaboration

Noelia Antón-Bolaños 1 collaboration

Chiara Gerhardinger 1 collaboration

Evan Murray 1 collaboration

Jason Buenrostro 1 collaboration

Allison Nash 1 collaboration

Marina Rocha 1 collaboration

Lan Nguyen 1 collaboration

Piotr Bielecki 1 collaboration

Samantha J Riesenfeld 1 collaboration

Jan-Christian Hütter 1 collaboration

Elena Torlai Triglia 1 collaboration

Roberto R Ricardo-Gonzalez 1 collaboration

Mi Lian 1 collaboration

Maria C Amezcua Vesely 1 collaboration

Lina Kroehling 1 collaboration

Hao Xu 1 collaboration

Michal Slyper 1 collaboration

Christoph Muus 1 collaboration

Leif S Ludwig 1 collaboration

Elena Christian 1 collaboration

Liming Tao 1 collaboration

Holly R Steach 1 collaboration

Autumn G York 1 collaboration

Mathias H Skadow 1 collaboration

Parastou Yaghoubi 1 collaboration

Danielle Dionne 1 collaboration

Abigail Jarret 1 collaboration

Heather M McGee 1 collaboration

Caroline B M Porter 1 collaboration

Paula Licona-Limón 1 collaboration

Will Bailis 1 collaboration

Ruaidhrí Jackson 1 collaboration

Nicola Gagliani 1 collaboration

Georg Gasteiger 1 collaboration

Richard M Locksley 1 collaboration

Richard A Flavell 1 collaboration

Anthony J Deo 1 collaboration

Archana Podury 1 collaboration

Catherine Abbate 1 collaboration

Samantha N Smith 1 collaboration

Alexandre Albanese 1 collaboration

Neville E Sanjana 1 collaboration

Xi Shi 1 collaboration

Kwanghun Chung 1 collaboration

Kasper Lage 1 collaboration

Sarah Yoshimi Tropp 1 collaboration