Leszek J Klimczak

Affiliations

Integrative Bioinformatics Support Group, National Institute of Environmental Health Sciences, US National Institutes of Health, North Carolina, United States of America.

Publications (15)

Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation.

PLoS biology

Avec: Cynthia J Sakofsky , Natalie Saini , Leszek J Klimczak , Kin Chan , Ewa P Malc , Piotr A Mieczkowski , Adam B Burkholder , David Fargo , Dmitry A Gordenin

Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic.

bioRxiv : the preprint server for biology

Avec: Leszek J Klimczak , Thomas A Randall , Natalie Saini , Jian-Liang Li , Dmitry A Gordenin

The repertoire of mutational signatures in human cancer.

Nature

Avec: Ludmil B Alexandrov , Jaegil Kim , Nicholas J Haradhvala , Mi Ni Huang , Alvin Wei Tian Ng , Yang Wu , Arnoud Boot , Kyle R Covington , Dmitry A Gordenin , Erik N Bergstrom , S M Ashiqul Islam , Nuria Lopez-Bigas , Leszek J Klimczak , John R McPherson , Sandro Morganella , Radhakrishnan Sabarinathan , David A Wheeler , Ville Mustonen , Auteur inconnu , Gad Getz , Steven G Rozen , Michael R Stratton , Auteur inconnu

Infectious vaccine-derived rubella viruses emerge, persist, and evolve in cutaneous granulomas of children with primary immunodeficiencies.

PLoS pathogens

Avec: Ludmila Perelygina , Min-Hsin Chen , Suganthi Suppiah , Adebola Adebayo , Emily Abernathy , Morna Dorsey , Lionel Bercovitch , Kenneth Paris , Kevin P White , Alfons Krol , Julie Dhossche , Ivan Y Torshin , Natalie Saini , Leszek J Klimczak , Dmitry A Gordenin , Andrey Zharkikh , Stanley Plotkin , Kathleen E Sullivan , Joseph Icenogle

UV-exposure, endogenous DNA damage, and DNA replication errors shape the spectra of genome changes in human skin.

PLoS genetics

Avec: Natalie Saini , Camille K Giacobone , Leszek J Klimczak , Brian N Papas , Adam B Burkholder , Jian-Liang Li , David C Fargo , Re Bai , Kevin Gerrish , Cynthia L Innes , Shepherd H Schurman , Dmitry A Gordenin

Somatic mutation distributions in cancer genomes vary with three-dimensional chromatin structure.

Nature genetics

Avec: Kadir C Akdemir , Victoria T Le , Justin M Kim , Sarah Killcoyne , Devin A King , Ya-Ping Lin , Yanyan Tian , Akira Inoue , Samirkumar B Amin , Frederick S Robinson , Manjunath Nimmakayalu , Rafael E Herrera , Erica J Lynn , Kin Chan , Sahil Seth , Leszek J Klimczak , Moritz Gerstung , Dmitry A Gordenin , John O'Brien , Lei Li , Yonathan Lissanu Deribe , Roel G Verhaak , Peter J Campbell , Rebecca Fitzgerald , Ashby J Morrison , Jesse R Dixon , P Andrew Futreal

Hypomorphic mutation in the large subunit of replication protein A affects mutagenesis by human APOBEC cytidine deaminases in yeast.

bioRxiv : the preprint server for biology

Avec: Matthew S Dennen , Zachary W Kockler , Steven A Roberts , Adam B Burkholder , Leszek J Klimczak , Dmitry A Gordenin

Mutational signatures of redox stress in yeast single-strand DNA and of aging in human mitochondrial DNA share a common feature.

PLoS biology

Avec: Natalya P Degtyareva , Natalie Saini , Joan F Sterling , Victoria C Placentra , Leszek J Klimczak , Dmitry A Gordenin , Paul W Doetsch

Comprehensive analysis of chromothripsis in 2,658 human cancers using whole-genome sequencing.

Nature genetics

Avec: Isidro Cortés-Ciriano , Jake June-Koo Lee , Ruibin Xi , Dhawal Jain , Youngsook L Jung , Lixing Yang , Dmitry Gordenin , Leszek J Klimczak , Cheng-Zhong Zhang , David S Pellman , Auteur inconnu , Peter J Park , Auteur inconnu

APOBEC shapes tumor evolution and age at onset of lung cancer in smokers.

bioRxiv : the preprint server for biology

Avec: Tongwu Zhang , Jian Sang , Phuc H Hoang , Wei Zhao , Jennifer Rosenbaum , Kofi Ennu Johnson , Leszek J Klimczak , John McElderry , Alyssa Klein , Christopher Wirth , Erik N Bergstrom , Marcos Díaz-Gay , Raviteja Vangara , Frank Colon-Matos , Amy Hutchinson , Scott M Lawrence , Nathan Cole , Bin Zhu , Teresa M Przytycka , Jianxin Shi , Neil E Caporaso , Robert Homer , Angela C Pesatori , Dario Consonni , Marcin Imielinski , Stephen J Chanock , David C Wedge , Dmitry A Gordenin , Ludmil B Alexandrov , Reuben S Harris , Maria Teresa Landi

Glycidamide-induced hypermutation in yeast single-stranded DNA reveals a ubiquitous clock-like mutational motif in humans.

Nucleic acids research

Avec: Kathleen M Hudson , Leszek J Klimczak , Joan F Sterling , Adam B Burkholder , Marat D Kazanov , Natalie Saini , Piotr A Mieczkowski , Dmitry A Gordenin

APOBEC3-dependent kataegis and TREX1-driven chromothripsis during telomere crisis.

Nature genetics

Avec: John Maciejowski , Aikaterini Chatzipli , Alexandra Dananberg , Kevan Chu , Eleonore Toufektchan , Leszek J Klimczak , Dmitry A Gordenin , Peter J Campbell , Titia de Lange

Analysis of APOBEC-induced mutations in yeast strains with low levels of replicative DNA polymerases.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Yang Sui , Lei Qi , Ke Zhang , Natalie Saini , Leszek J Klimczak , Cynthia J Sakofsky , Dmitry A Gordenin , Thomas D Petes , Dao-Qiong Zheng

Correction: Repair of multiple simultaneous double-strand breaks causes bursts of genome-wide clustered hypermutation.

PLoS biology

Avec: Cynthia J Sakofsky , Natalie Saini , Leszek J Klimczak , Kin Chan , Ewa P Malc , Piotr A Mieczkowski , Adam B Burkholder , David Fargo , Dmitry A Gordenin

Similarity between mutation spectra in hypermutated genomes of rubella virus and in SARS-CoV-2 genomes accumulated during the COVID-19 pandemic.

PloS one

Avec: Leszek J Klimczak , Thomas A Randall , Natalie Saini , Jian-Liang Li , Dmitry A Gordenin

Réseau de co-auteurs

Dmitry A Gordenin 14 collaborations

Natalie Saini 9 collaborations

Adam B Burkholder 5 collaborations

None None 4 collaborations

Cynthia J Sakofsky 3 collaborations

Kin Chan 3 collaborations

Piotr A Mieczkowski 3 collaborations

Jian-Liang Li 3 collaborations

Ewa P Malc 2 collaborations

David Fargo 2 collaborations

Thomas A Randall 2 collaborations

Ludmil B Alexandrov 2 collaborations

Erik N Bergstrom 2 collaborations

Peter J Campbell 2 collaborations

Joan F Sterling 2 collaborations

Jaegil Kim 1 collaboration

Nicholas J Haradhvala 1 collaboration

Mi Ni Huang 1 collaboration

Alvin Wei Tian Ng 1 collaboration

Yang Wu 1 collaboration

Arnoud Boot 1 collaboration

Kyle R Covington 1 collaboration

S M Ashiqul Islam 1 collaboration

Nuria Lopez-Bigas 1 collaboration

John R McPherson 1 collaboration

Sandro Morganella 1 collaboration

Radhakrishnan Sabarinathan 1 collaboration

David A Wheeler 1 collaboration

Ville Mustonen 1 collaboration

Gad Getz 1 collaboration

Steven G Rozen 1 collaboration

Michael R Stratton 1 collaboration

Ludmila Perelygina 1 collaboration

Min-Hsin Chen 1 collaboration

Suganthi Suppiah 1 collaboration

Adebola Adebayo 1 collaboration

Emily Abernathy 1 collaboration

Morna Dorsey 1 collaboration

Lionel Bercovitch 1 collaboration

Kenneth Paris 1 collaboration

Kevin P White 1 collaboration

Alfons Krol 1 collaboration

Julie Dhossche 1 collaboration

Ivan Y Torshin 1 collaboration

Andrey Zharkikh 1 collaboration

Stanley Plotkin 1 collaboration

Kathleen E Sullivan 1 collaboration

Joseph Icenogle 1 collaboration

Camille K Giacobone 1 collaboration

Brian N Papas 1 collaboration

David C Fargo 1 collaboration

Re Bai 1 collaboration

Kevin Gerrish 1 collaboration

Cynthia L Innes 1 collaboration

Shepherd H Schurman 1 collaboration

Kadir C Akdemir 1 collaboration

Victoria T Le 1 collaboration

Justin M Kim 1 collaboration

Sarah Killcoyne 1 collaboration

Devin A King 1 collaboration

Ya-Ping Lin 1 collaboration

Yanyan Tian 1 collaboration

Akira Inoue 1 collaboration

Samirkumar B Amin 1 collaboration

Frederick S Robinson 1 collaboration

Manjunath Nimmakayalu 1 collaboration

Rafael E Herrera 1 collaboration

Erica J Lynn 1 collaboration

Sahil Seth 1 collaboration

Moritz Gerstung 1 collaboration

John O'Brien 1 collaboration

Lei Li 1 collaboration

Yonathan Lissanu Deribe 1 collaboration

Roel G Verhaak 1 collaboration

Rebecca Fitzgerald 1 collaboration

Ashby J Morrison 1 collaboration

Jesse R Dixon 1 collaboration

P Andrew Futreal 1 collaboration

Matthew S Dennen 1 collaboration

Zachary W Kockler 1 collaboration

Steven A Roberts 1 collaboration

Natalya P Degtyareva 1 collaboration

Victoria C Placentra 1 collaboration

Paul W Doetsch 1 collaboration

Isidro Cortés-Ciriano 1 collaboration

Jake June-Koo Lee 1 collaboration

Ruibin Xi 1 collaboration

Dhawal Jain 1 collaboration

Youngsook L Jung 1 collaboration

Lixing Yang 1 collaboration

Dmitry Gordenin 1 collaboration

Cheng-Zhong Zhang 1 collaboration

David S Pellman 1 collaboration

Peter J Park 1 collaboration

Tongwu Zhang 1 collaboration

Jian Sang 1 collaboration

Phuc H Hoang 1 collaboration

Wei Zhao 1 collaboration

Jennifer Rosenbaum 1 collaboration

Kofi Ennu Johnson 1 collaboration

John McElderry 1 collaboration

Alyssa Klein 1 collaboration

Christopher Wirth 1 collaboration

Marcos Díaz-Gay 1 collaboration

Raviteja Vangara 1 collaboration

Frank Colon-Matos 1 collaboration

Amy Hutchinson 1 collaboration

Scott M Lawrence 1 collaboration

Nathan Cole 1 collaboration

Bin Zhu 1 collaboration

Teresa M Przytycka 1 collaboration

Jianxin Shi 1 collaboration

Neil E Caporaso 1 collaboration

Robert Homer 1 collaboration

Angela C Pesatori 1 collaboration

Dario Consonni 1 collaboration

Marcin Imielinski 1 collaboration

Stephen J Chanock 1 collaboration

David C Wedge 1 collaboration

Reuben S Harris 1 collaboration

Maria Teresa Landi 1 collaboration

Kathleen M Hudson 1 collaboration

Marat D Kazanov 1 collaboration

John Maciejowski 1 collaboration

Aikaterini Chatzipli 1 collaboration

Alexandra Dananberg 1 collaboration

Kevan Chu 1 collaboration

Eleonore Toufektchan 1 collaboration

Titia de Lange 1 collaboration

Yang Sui 1 collaboration

Lei Qi 1 collaboration

Ke Zhang 1 collaboration

Thomas D Petes 1 collaboration

Dao-Qiong Zheng 1 collaboration