Larry H Matherly

Affiliations

Department of Oncology, Wayne State University School of Medicine/Karmanos Cancer Institute, Detroit, Michigan (A.S.D., J.F., A.W.-P., C.O., Z.H., S.K., L.H.M.); Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, Pittsburgh, Pennsylvania (M.J.N., K.S., A.G.); Center for Molecular Medicine and Genetics (H.K., M.H.) and Department of Pharmacology (L.H.M.), Wayne State University School of Medicine, Detroit, Michigan; Biochemistry and Molecular Biology, Jilin University, Changchun, Jilin Province, China (C.N.); and Molecular Therapeutics Program, Barbara Ann Karmanos Cancer Institute, Detroit, Michigan (Z.H., S.K., M.H., L.H.M.) matherly@karmanos.org.

Publications (29)

Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-

Molecular pharmacology

Avec: Aamod S Dekhne , Changwen Ning , Md Junayed Nayeen , Khushbu Shah , Hasini Kalpage , Josephine Frühauf , Adrianne Wallace-Povirk , Carrie O'Connor , Zhanjun Hou , Seongho Kim , Maik Hüttemann , Aleem Gangjee , Larry H Matherly

Folate receptors and transporters: biological role and diagnostic/therapeutic targets in cancer and other diseases.

Journal of experimental & clinical cancer research : CR

Avec: Barbara Frigerio , Claudia Bizzoni , Gerrit Jansen , Christopher P Leamon , Godefridus J Peters , Philip S Low , Larry H Matherly , Mariangela Figini

Enhancing anti-AML activity of venetoclax by isoflavone ME-344 through suppression of OXPHOS and/or purine biosynthesis in vitro.

Biochemical pharmacology

Avec: Katie H Hurrish , Yongwei Su , Shraddha Patel , Cassandra L Ramage , Jianlei Zhao , Brianna R Temby , Jenna L Carter , Holly Edwards , Steven A Buck , Sandra E Wiley , Maik Hüttemann , Lisa Polin , Juiwanna Kushner , Sijana H Dzinic , Kathryn White , Xun Bao , Jing Li , Jay Yang , Julie Boerner , Zhanjun Hou , Gheath Al-Atrash , Sergej N Konoplev , Jonathan Busquets , Stefano Tiziani , Larry H Matherly , Jeffrey W Taub , Marina Konopleva , Yubin Ge , Natalia Baran

Exposure of Larval Zebrafish to the Insecticide Propoxur Induced Developmental Delays that Correlate with Behavioral Abnormalities and Altered Expression of

Toxics

Avec: Jeremiah N Shields , Eric C Hales , Lillian E Ranspach , Xixia Luo , Steven Orr , Donna Runft , Alan Dombkowski , Melody N Neely , Larry H Matherly , Jeffrey Taub , Tracie R Baker , Ryan Thummel

Novel Pyrrolo[3,2-

Molecular cancer therapeutics

Avec: Aamod S Dekhne , Khushbu Shah , Gregory S Ducker , Jade M Katinas , Jennifer Wong-Roushar , Md Junayed Nayeen , Arpit Doshi , Changwen Ning , Xun Bao , Josephine Frühauf , Jenney Liu , Adrianne Wallace-Povirk , Carrie O'Connor , Sijana H Dzinic , Kathryn White , Juiwanna Kushner , Seongho Kim , Maik Hüttemann , Lisa Polin , Joshua D Rabinowitz , Jing Li , Zhanjun Hou , Charles E Dann , Aleem Gangjee , Larry H Matherly

Folate transporter dynamics and therapy with classic and tumor-targeted antifolates.

Scientific reports

Avec: Carrie O'Connor , Adrianne Wallace-Povirk , Changwen Ning , Josephine Frühauf , Nian Tong , Aleem Gangjee , Larry H Matherly , Zhanjun Hou

Multitargeted 6-Substituted Thieno[2,3-

ACS pharmacology & translational science

Avec: Nian Tong , Jennifer Wong-Roushar , Adrianne Wallace-Povirk , Yesha Shah , Morgan C Nyman , Jade M Katinas , Mathew Schneider , Carrie O'Connor , Xun Bao , Seongho Kim , Jing Li , Zhanjun Hou , Larry H Matherly , Charles E Dann , Aleem Gangjee

Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria.

Journal of medicinal chemistry

Avec: Md Junayed Nayeen , Jade M Katinas , Tejashree Magdum , Khushbu Shah , Jennifer E Wong , Carrie E O'Connor , Alexandra N Fifer , Adrianne Wallace-Povirk , Zhanjun Hou , Larry H Matherly , Charles E Dann , Aleem Gangjee

The evolution and history of Vinca alkaloids: From the Big Bang to the treatment of pediatric acute leukemia.

Pediatric blood & cancer

Avec: Jeffrey W Taub , Steven A Buck , Ana C Xavier , Holly Edwards , Larry H Matherly , Yubin Ge

Lipid metabolism reprogramming in renal cell carcinoma.

Cancer metastasis reviews

Avec: Gioia Heravi , Omid Yazdanpanah , Izabela Podgorski , Larry H Matherly , Wanqing Liu

Pattern Analysis of Organellar Maps for Interpretation of Proteomic Data.

Proteomes

Avec: Jordan B Burton , Nicholas J Carruthers , Zhanjun Hou , Larry H Matherly , Paul M Stemmer

Folate Transport and One-Carbon Metabolism in Targeted Therapies of Epithelial Ovarian Cancer.

Cancers

Avec: Adrianne Wallace-Povirk , Zhanjun Hou , Md Junayed Nayeen , Aleem Gangjee , Larry H Matherly

Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment.

Scientific reports

Avec: Adrianne Wallace-Povirk , Lisa Rubinsak , Agnes Malysa , Sijana H Dzinic , Manasa Ravindra , Mathew Schneider , James Glassbrook , Carrie O'Connor , Zhanjun Hou , Seongho Kim , Jessica Back , Lisa Polin , Robert T Morris , Aleem Gangjee , Heather Gibson , Larry H Matherly

Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport.

ACS medicinal chemistry letters

Avec: Krishna Kaku , Manasa P Ravindra , Nian Tong , Shruti Choudhary , Xinxin Li , Jianming Yu , Mohammad Karim , Madelyn Brzezinski , Carrie O'Connor , Zhanjun Hou , Larry H Matherly , Aleem Gangjee

Structural Characterization of 5-Substituted Pyrrolo[3,2-

Biochemistry

Avec: Jade M Katinas , Md Junayed Nayeen , Mathew Schneider , Khushbu Shah , Alexandra N Fifer , Lily M Klapper , Abhishekh Sharma , Kishore Thalluri , Michael S Van Nieuwenhze , Zhanjun Hou , Aleem Gangjee , Larry H Matherly , Charles E Dann

RX-3117 (Fluorocyclopentenyl-Cytosine)-Mediated Down-Regulation of DNA Methyltransferase 1 Leads to Protein Expression of Tumor-Suppressor Genes and Increased Functionality of the Proton-Coupled Folate Carrier.

International journal of molecular sciences

Avec: Dzjemma Sarkisjan , Joris R Julsing , Btissame El Hassouni , Richard J Honeywell , Ietje Kathmann , Larry H Matherly , Young B Lee , Deog J Kim , Godefridus J Peters

Regulation of differential proton-coupled folate transporter gene expression in human tumors: transactivation by KLF15 with NRF-1 and the role of Sp1.

The Biochemical journal

Avec: Zhanjun Hou , Carrie O'Connor , Josephine Frühauf , Steve Orr , Seongho Kim , Aleem Gangjee , Larry H Matherly

Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.

Bioorganic & medicinal chemistry

Avec: Adrianne Wallace-Povirk , Nian Tong , Jennifer Wong-Roushar , Carrie O'Connor , Xilin Zhou , Zhanjun Hou , Xun Bao , Gloria E Garcia , Jing Li , Seongho Kim , Charles E Dann , Larry H Matherly , Aleem Gangjee

Mitochondrial and cytosolic one-carbon metabolism is a targetable metabolic vulnerability in cisplatin-resistant ovarian cancer.

Molecular cancer therapeutics

Avec: Adrianne Wallace-Povirk , Carrie O'Connor , Aamod S Dekhne , Xun Bao , Md Junayed Nayeen , Mathew Schneider , Jade M Katinas , Jennifer Wong-Roushar , Seongho Kim , Lisa Polin , Jing Li , Jessica B Back , Charles E Dann , Aleem Gangjee , Zhanjun Hou , Larry H Matherly

Enhancing anti-AML activity of venetoclax by isoflavone ME-344 through suppression of OXPHOS and/or purine biosynthesis.

Research square

Avec: Katie H Hurrish , Yongwei Su , Shraddha Patel , Cassandra L Ramage , Jenna L Carter , Holly Edwards , Steven A Buck , Sandra E Wiley , Maik Hüttemann , Lisa Polin , Juiwanna Kushner , Sijana H Dzinic , Kathryn White , Xun Bao , Jing Li , Jay Yang , Julie Boerner , Zhanjun Hou , Gheath Al-Atrash , Sergej N Konoplev , Jonathan Busquets , Stefano Tiziani , Larry H Matherly , Jeffrey W Taub , Marina Konopleva , Yubin Ge , Natalia Baran

Molecular pharmacology

Avec: Carrie O'Connor , Mathew Schneider , Jade M Katinas , Md Junayed Nayeen , Khushbu Shah , Tejashree Magdum , Abhishekh Sharma , Seongho Kim , Xun Bao , Jing Li , Charles E Dann , Aleem Gangjee , Larry H Matherly , Zhanjun Hou

Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.

Bioorganic & medicinal chemistry

Avec: Weiguo Xiang , Aamod Dekhne , Arpit Doshi , Carrie O'Connor , Zhanjun Hou , Larry H Matherly , Aleem Gangjee

Serum folate receptor α (sFR) in ovarian cancer diagnosis and surveillance.

Cancer medicine

Avec: Batoul Farran , Samet Albayrak , Judith Abrams , Michael A Tainsky , Nancy K Levin , Robert Morris , Larry H Matherly , Manohar Ratnam , Ira Winer

Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer.

Molecular cancer therapeutics

Avec: Aamod S Dekhne , Zhanjun Hou , Aleem Gangjee , Larry H Matherly

Impact of hypoxia on chemoresistance of mesothelioma mediated by the proton-coupled folate transporter, and preclinical activity of new anti-LDH-A compounds.

British journal of cancer

Avec: Giovanna Li Petri , Btissame El Hassouni , Rocco Sciarrillo , Niccola Funel , Giulia Mantini , Eveline A Zeeuw van der Laan , Stella Cascioferro , Amir Avan , Paolo Andrea Zucali , Nadia Zaffaroni , Tonny Lagerweij , Barbara Parrino , Kees Smid , Marcello Deraco , Carlotta Granchi , Alicja Braczko , Ryszard T Smolenski , Larry H Matherly , Gerrit Jansen , Yehuda G Assaraf , Patrizia Diana , Jacqueline Cloos , Godefridus J Peters , Filippo Minutolo , Elisa Giovannetti

Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier.

Bioorganic & medicinal chemistry

Avec: Lalit K Golani , Farhana Islam , Carrie O'Connor , Aamod S Dekhne , Zhanjun Hou , Larry H Matherly , Aleem Gangjee

The evolving biology of the proton-coupled folate transporter: New insights into regulation, structure, and mechanism.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Zhanjun Hou , Aleem Gangjee , Larry H Matherly

Biology and therapeutic applications of the proton-coupled folate transporter.

Expert opinion on drug metabolism & toxicology

Avec: Larry H Matherly , Mathew Schneider , Aleem Gangjee , Zhanjun Hou

BRCA status dictates Wnt responsiveness in epithelial ovarian cancer.

Cancer research communications

Avec: Hussein Chehade , Radhika Gogoi , Nicholas K Adzibolosu , Sandra Galoforo , Rouba-Ali Fehmi , Mira Kheil , Alexandra Fox , Seongho Kim , Ramandeep Rattan , Zhanjun Hou , Robert T Morris , Larry H Matherly , Gil Mor , Ayesha B Alvero

Réseau de co-auteurs

Zhanjun Hou 22 collaborations

Aleem Gangjee 18 collaborations

Carrie O'Connor 12 collaborations

Adrianne Wallace-Povirk 9 collaborations

Seongho Kim 9 collaborations

Md Junayed Nayeen 7 collaborations

Xun Bao 7 collaborations

Jing Li 7 collaborations

Charles E Dann 7 collaborations

Jade M Katinas 6 collaborations

Mathew Schneider 6 collaborations

Aamod S Dekhne 5 collaborations

Khushbu Shah 5 collaborations

Lisa Polin 5 collaborations

Josephine Frühauf 4 collaborations

Maik Hüttemann 4 collaborations

Sijana H Dzinic 4 collaborations

Jennifer Wong-Roushar 4 collaborations

Nian Tong 4 collaborations

Changwen Ning 3 collaborations

Godefridus J Peters 3 collaborations

Holly Edwards 3 collaborations

Steven A Buck 3 collaborations

Juiwanna Kushner 3 collaborations

Kathryn White 3 collaborations

Jeffrey W Taub 3 collaborations

Yubin Ge 3 collaborations

Gerrit Jansen 2 collaborations

Katie H Hurrish 2 collaborations

Yongwei Su 2 collaborations

Shraddha Patel 2 collaborations

Cassandra L Ramage 2 collaborations

Jenna L Carter 2 collaborations

Sandra E Wiley 2 collaborations

Jay Yang 2 collaborations

Julie Boerner 2 collaborations

Gheath Al-Atrash 2 collaborations

Sergej N Konoplev 2 collaborations

Jonathan Busquets 2 collaborations

Stefano Tiziani 2 collaborations

Marina Konopleva 2 collaborations

Natalia Baran 2 collaborations

Arpit Doshi 2 collaborations

Tejashree Magdum 2 collaborations

Alexandra N Fifer 2 collaborations

Robert T Morris 2 collaborations

Abhishekh Sharma 2 collaborations

Btissame El Hassouni 2 collaborations

Hasini Kalpage 1 collaboration

Barbara Frigerio 1 collaboration

Claudia Bizzoni 1 collaboration

Christopher P Leamon 1 collaboration

Philip S Low 1 collaboration

Mariangela Figini 1 collaboration

Jianlei Zhao 1 collaboration

Brianna R Temby 1 collaboration

Jeremiah N Shields 1 collaboration

Eric C Hales 1 collaboration

Lillian E Ranspach 1 collaboration

Xixia Luo 1 collaboration

Steven Orr 1 collaboration

Donna Runft 1 collaboration

Alan Dombkowski 1 collaboration

Melody N Neely 1 collaboration

Jeffrey Taub 1 collaboration

Tracie R Baker 1 collaboration

Ryan Thummel 1 collaboration

Gregory S Ducker 1 collaboration

Jenney Liu 1 collaboration

Joshua D Rabinowitz 1 collaboration

Yesha Shah 1 collaboration

Morgan C Nyman 1 collaboration

Jennifer E Wong 1 collaboration

Carrie E O'Connor 1 collaboration

Ana C Xavier 1 collaboration

Gioia Heravi 1 collaboration

Omid Yazdanpanah 1 collaboration

Izabela Podgorski 1 collaboration

Wanqing Liu 1 collaboration

Jordan B Burton 1 collaboration

Nicholas J Carruthers 1 collaboration

Paul M Stemmer 1 collaboration

Lisa Rubinsak 1 collaboration

Agnes Malysa 1 collaboration

Manasa Ravindra 1 collaboration

James Glassbrook 1 collaboration

Jessica Back 1 collaboration

Heather Gibson 1 collaboration

Krishna Kaku 1 collaboration

Manasa P Ravindra 1 collaboration

Shruti Choudhary 1 collaboration

Xinxin Li 1 collaboration

Jianming Yu 1 collaboration

Mohammad Karim 1 collaboration

Madelyn Brzezinski 1 collaboration

Lily M Klapper 1 collaboration

Kishore Thalluri 1 collaboration

Michael S Van Nieuwenhze 1 collaboration

Dzjemma Sarkisjan 1 collaboration

Joris R Julsing 1 collaboration

Richard J Honeywell 1 collaboration

Ietje Kathmann 1 collaboration

Young B Lee 1 collaboration

Deog J Kim 1 collaboration

Steve Orr 1 collaboration

Xilin Zhou 1 collaboration

Gloria E Garcia 1 collaboration

Jessica B Back 1 collaboration

Weiguo Xiang 1 collaboration

Aamod Dekhne 1 collaboration

Batoul Farran 1 collaboration

Samet Albayrak 1 collaboration

Judith Abrams 1 collaboration

Michael A Tainsky 1 collaboration

Nancy K Levin 1 collaboration

Robert Morris 1 collaboration

Manohar Ratnam 1 collaboration

Ira Winer 1 collaboration

Giovanna Li Petri 1 collaboration

Rocco Sciarrillo 1 collaboration

Niccola Funel 1 collaboration

Giulia Mantini 1 collaboration

Eveline A Zeeuw van der Laan 1 collaboration

Stella Cascioferro 1 collaboration

Amir Avan 1 collaboration

Paolo Andrea Zucali 1 collaboration

Nadia Zaffaroni 1 collaboration

Tonny Lagerweij 1 collaboration

Barbara Parrino 1 collaboration

Kees Smid 1 collaboration

Marcello Deraco 1 collaboration

Carlotta Granchi 1 collaboration

Alicja Braczko 1 collaboration

Ryszard T Smolenski 1 collaboration

Yehuda G Assaraf 1 collaboration

Patrizia Diana 1 collaboration

Jacqueline Cloos 1 collaboration

Filippo Minutolo 1 collaboration

Elisa Giovannetti 1 collaboration

Lalit K Golani 1 collaboration

Farhana Islam 1 collaboration

Hussein Chehade 1 collaboration

Radhika Gogoi 1 collaboration

Nicholas K Adzibolosu 1 collaboration

Sandra Galoforo 1 collaboration

Rouba-Ali Fehmi 1 collaboration

Mira Kheil 1 collaboration

Alexandra Fox 1 collaboration

Ramandeep Rattan 1 collaboration

Gil Mor 1 collaboration

Ayesha B Alvero 1 collaboration