Aleem Gangjee

Affiliations

Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, United States. Electronic address: gangjee@duq.edu.

Publications (24)

The 3-D conformational shape of N-naphthyl-cyclopenta[d]pyrimidines affects their potency as microtubule targeting agents and their antitumor activity.

Bioorganic & medicinal chemistry

Avec: Weiguo Xiang , Tasdique M Quadery , Ernest Hamel , Lerin R Luckett-Chastain , Michael A Ihnat , Susan L Mooberry , Aleem Gangjee

Development of substituted pyrido[3,2-d]pyrimidines as potent and selective dihydrofolate reductase inhibitors for pneumocystis pneumonia infection.

Bioorganic & medicinal chemistry letters

Avec: Khushbu Shah , Sherry Queener , Vivian Cody , Jim Pace , Aleem Gangjee

Cellular Pharmacodynamics of a Novel Pyrrolo[3,2-

Molecular pharmacology

Avec: Aamod S Dekhne , Changwen Ning , Md Junayed Nayeen , Khushbu Shah , Hasini Kalpage , Josephine Frühauf , Adrianne Wallace-Povirk , Carrie O'Connor , Zhanjun Hou , Seongho Kim , Maik Hüttemann , Aleem Gangjee , Larry H Matherly

Simple monocyclic pyrimidine analogs as microtubule targeting agents binding to the colchicine site.

Bioorganic & medicinal chemistry

Avec: Shruti Choudhary , Krishna Kaku , Andrew J Robles , Ernest Hamel , Susan L Mooberry , Aleem Gangjee

Novel Pyrrolo[3,2-

Molecular cancer therapeutics

Avec: Aamod S Dekhne , Khushbu Shah , Gregory S Ducker , Jade M Katinas , Jennifer Wong-Roushar , Md Junayed Nayeen , Arpit Doshi , Changwen Ning , Xun Bao , Josephine Frühauf , Jenney Liu , Adrianne Wallace-Povirk , Carrie O'Connor , Sijana H Dzinic , Kathryn White , Juiwanna Kushner , Seongho Kim , Maik Hüttemann , Lisa Polin , Joshua D Rabinowitz , Jing Li , Zhanjun Hou , Charles E Dann , Aleem Gangjee , Larry H Matherly

Folate transporter dynamics and therapy with classic and tumor-targeted antifolates.

Scientific reports

Avec: Carrie O'Connor , Adrianne Wallace-Povirk , Changwen Ning , Josephine Frühauf , Nian Tong , Aleem Gangjee , Larry H Matherly , Zhanjun Hou

Multitargeted 6-Substituted Thieno[2,3-

ACS pharmacology & translational science

Avec: Nian Tong , Jennifer Wong-Roushar , Adrianne Wallace-Povirk , Yesha Shah , Morgan C Nyman , Jade M Katinas , Mathew Schneider , Carrie O'Connor , Xun Bao , Seongho Kim , Jing Li , Zhanjun Hou , Larry H Matherly , Charles E Dann , Aleem Gangjee

Structure-Based Design of Transport-Specific Multitargeted One-Carbon Metabolism Inhibitors in Cytosol and Mitochondria.

Journal of medicinal chemistry

Avec: Md Junayed Nayeen , Jade M Katinas , Tejashree Magdum , Khushbu Shah , Jennifer E Wong , Carrie E O'Connor , Alexandra N Fifer , Adrianne Wallace-Povirk , Zhanjun Hou , Larry H Matherly , Charles E Dann , Aleem Gangjee

Novel pyrazolo[4,3-d]pyrimidine microtubule targeting agents (MTAs): Synthesis, structure-activity relationship, in vitro and in vivo evaluation as antitumor agents.

Bioorganic & medicinal chemistry letters

Avec: Farhana Islam , Tasdique M Quadery , Ruoli Bai , Lerin R Luckett-Chastain , Ernest Hamel , Michael A Ihnat , Aleem Gangjee

Folate Transport and One-Carbon Metabolism in Targeted Therapies of Epithelial Ovarian Cancer.

Cancers

Avec: Adrianne Wallace-Povirk , Zhanjun Hou , Md Junayed Nayeen , Aleem Gangjee , Larry H Matherly

Targeted therapy of pyrrolo[2,3-d]pyrimidine antifolates in a syngeneic mouse model of high grade serous ovarian cancer and the impact on the tumor microenvironment.

Scientific reports

Avec: Adrianne Wallace-Povirk , Lisa Rubinsak , Agnes Malysa , Sijana H Dzinic , Manasa Ravindra , Mathew Schneider , James Glassbrook , Carrie O'Connor , Zhanjun Hou , Seongho Kim , Jessica Back , Lisa Polin , Robert T Morris , Aleem Gangjee , Heather Gibson , Larry H Matherly

Discovery of Tumor-Targeted 6-Methyl Substituted Pemetrexed and Related Antifolates with Selective Loss of RFC Transport.

ACS medicinal chemistry letters

Avec: Krishna Kaku , Manasa P Ravindra , Nian Tong , Shruti Choudhary , Xinxin Li , Jianming Yu , Mohammad Karim , Madelyn Brzezinski , Carrie O'Connor , Zhanjun Hou , Larry H Matherly , Aleem Gangjee

Structural Characterization of 5-Substituted Pyrrolo[3,2-

Biochemistry

Avec: Jade M Katinas , Md Junayed Nayeen , Mathew Schneider , Khushbu Shah , Alexandra N Fifer , Lily M Klapper , Abhishekh Sharma , Kishore Thalluri , Michael S Van Nieuwenhze , Zhanjun Hou , Aleem Gangjee , Larry H Matherly , Charles E Dann

Regulation of differential proton-coupled folate transporter gene expression in human tumors: transactivation by KLF15 with NRF-1 and the role of Sp1.

The Biochemical journal

Avec: Zhanjun Hou , Carrie O'Connor , Josephine Frühauf , Steve Orr , Seongho Kim , Aleem Gangjee , Larry H Matherly

Discovery of 6-substituted thieno[2,3-d]pyrimidine analogs as dual inhibitors of glycinamide ribonucleotide formyltransferase and 5-aminoimidazole-4-carboxamide ribonucleotide formyltransferase in de novo purine nucleotide biosynthesis in folate receptor expressing human tumors.

Bioorganic & medicinal chemistry

Avec: Adrianne Wallace-Povirk , Nian Tong , Jennifer Wong-Roushar , Carrie O'Connor , Xilin Zhou , Zhanjun Hou , Xun Bao , Gloria E Garcia , Jing Li , Seongho Kim , Charles E Dann , Larry H Matherly , Aleem Gangjee

Potential of substituted quinazolines to interact with multiple targets in the treatment of cancer.

Bioorganic & medicinal chemistry

Avec: Shruti Choudhary , Arpit Doshi , Lerin Luckett-Chastain , Michael Ihnat , Ernest Hamel , Susan L Mooberry , Aleem Gangjee

Mitochondrial and cytosolic one-carbon metabolism is a targetable metabolic vulnerability in cisplatin-resistant ovarian cancer.

Molecular cancer therapeutics

Avec: Adrianne Wallace-Povirk , Carrie O'Connor , Aamod S Dekhne , Xun Bao , Md Junayed Nayeen , Mathew Schneider , Jade M Katinas , Jennifer Wong-Roushar , Seongho Kim , Lisa Polin , Jing Li , Jessica B Back , Charles E Dann , Aleem Gangjee , Zhanjun Hou , Larry H Matherly

Molecular pharmacology

Avec: Carrie O'Connor , Mathew Schneider , Jade M Katinas , Md Junayed Nayeen , Khushbu Shah , Tejashree Magdum , Abhishekh Sharma , Seongho Kim , Xun Bao , Jing Li , Charles E Dann , Aleem Gangjee , Larry H Matherly , Zhanjun Hou

Discovery of amide-bridged pyrrolo[2,3-d]pyrimidines as tumor targeted classical antifolates with selective uptake by folate receptor α and inhibition of de novo purine nucleotide biosynthesis.

Bioorganic & medicinal chemistry

Avec: Weiguo Xiang , Aamod Dekhne , Arpit Doshi , Carrie O'Connor , Zhanjun Hou , Larry H Matherly , Aleem Gangjee

Therapeutic Targeting of Mitochondrial One-Carbon Metabolism in Cancer.

Molecular cancer therapeutics

Avec: Aamod S Dekhne , Zhanjun Hou , Aleem Gangjee , Larry H Matherly

Design, synthesis and biological evaluation of novel pyrrolo[2,3-d]pyrimidine as tumor-targeting agents with selectivity for tumor uptake by high affinity folate receptors over the reduced folate carrier.

Bioorganic & medicinal chemistry

Avec: Lalit K Golani , Farhana Islam , Carrie O'Connor , Aamod S Dekhne , Zhanjun Hou , Larry H Matherly , Aleem Gangjee

The evolving biology of the proton-coupled folate transporter: New insights into regulation, structure, and mechanism.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Zhanjun Hou , Aleem Gangjee , Larry H Matherly

Design, Synthesis, and Biological Evaluation of 5,6,7,8-Tetrahydrobenzo[4,5]thieno[2,3-

Molecules (Basel, Switzerland)

Avec: Farhana Islam , Arpit Doshi , Andrew J Robles , Tasdique M Quadery , Xin Zhang , Xilin Zhou , Ernest Hamel , Susan L Mooberry , Aleem Gangjee

Biology and therapeutic applications of the proton-coupled folate transporter.

Expert opinion on drug metabolism & toxicology

Avec: Larry H Matherly , Mathew Schneider , Aleem Gangjee , Zhanjun Hou

Réseau de co-auteurs

Zhanjun Hou 18 collaborations

Larry H Matherly 18 collaborations

Carrie O'Connor 12 collaborations

Adrianne Wallace-Povirk 9 collaborations

Seongho Kim 8 collaborations

Md Junayed Nayeen 7 collaborations

Charles E Dann 7 collaborations

Khushbu Shah 6 collaborations

Jade M Katinas 6 collaborations

Mathew Schneider 6 collaborations

Ernest Hamel 5 collaborations

Aamod S Dekhne 5 collaborations

Xun Bao 5 collaborations

Jing Li 5 collaborations

Susan L Mooberry 4 collaborations

Josephine Frühauf 4 collaborations

Jennifer Wong-Roushar 4 collaborations

Arpit Doshi 4 collaborations

Nian Tong 4 collaborations

Tasdique M Quadery 3 collaborations

Changwen Ning 3 collaborations

Shruti Choudhary 3 collaborations

Lisa Polin 3 collaborations

Farhana Islam 3 collaborations

Weiguo Xiang 2 collaborations

Lerin R Luckett-Chastain 2 collaborations

Michael A Ihnat 2 collaborations

Maik Hüttemann 2 collaborations

Krishna Kaku 2 collaborations

Andrew J Robles 2 collaborations

Sijana H Dzinic 2 collaborations

Tejashree Magdum 2 collaborations

Alexandra N Fifer 2 collaborations

Abhishekh Sharma 2 collaborations

Xilin Zhou 2 collaborations

Sherry Queener 1 collaboration

Vivian Cody 1 collaboration

Jim Pace 1 collaboration

Hasini Kalpage 1 collaboration

Gregory S Ducker 1 collaboration

Jenney Liu 1 collaboration

Kathryn White 1 collaboration

Juiwanna Kushner 1 collaboration

Joshua D Rabinowitz 1 collaboration

Yesha Shah 1 collaboration

Morgan C Nyman 1 collaboration

Jennifer E Wong 1 collaboration

Carrie E O'Connor 1 collaboration

Ruoli Bai 1 collaboration

Lisa Rubinsak 1 collaboration

Agnes Malysa 1 collaboration

Manasa Ravindra 1 collaboration

James Glassbrook 1 collaboration

Jessica Back 1 collaboration

Robert T Morris 1 collaboration

Heather Gibson 1 collaboration

Manasa P Ravindra 1 collaboration

Xinxin Li 1 collaboration

Jianming Yu 1 collaboration

Mohammad Karim 1 collaboration

Madelyn Brzezinski 1 collaboration

Lily M Klapper 1 collaboration

Kishore Thalluri 1 collaboration

Michael S Van Nieuwenhze 1 collaboration

Steve Orr 1 collaboration

Gloria E Garcia 1 collaboration

Lerin Luckett-Chastain 1 collaboration

Michael Ihnat 1 collaboration

Jessica B Back 1 collaboration

Aamod Dekhne 1 collaboration

Lalit K Golani 1 collaboration

Xin Zhang 1 collaboration