Kazuhiko Seya

Affiliations

Department of Vascular Biology, Hirosaki University Graduate School of Medicine, Hirosaki, Japan.

ORCID: https://orcid.org/0000-0001-5866-7148

Publications (37)

Effect of sera from lupus patients on the glomerular endothelial fibrinolysis system.

Pediatrics international : official journal of the Japan Pediatric Society

Avec: Riko Sato , Tomomi Aizawa , Tadaatsu Imaizumi , Koji Tsugawa , Shogo Kawaguchi , Kazuhiko Seya , Kiminori Terui , Hiroshi Tanaka

Elucidation of the inhibitory effect of (+)-hopeaphenol on polyinosinic-polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells.

Journal of pharmacological sciences

Avec: Liu Xu , Zaiqiang Yu , Yoshinori Uekusa , Shogo Kawaguchi , Haruhisa Kikuchi , Kazuyuki Daitoku , Masahito Minakawa , Shigeru Motomura , Ken-Ichi Furukawa , Yoshiteru Oshima , Kazuhiko Seya , Tadaatsu Imaizumi

Glomerular endothelial expression of type I IFN-stimulated gene, DExD/H-Box helicase 60 via toll-like receptor 3 signaling: possible involvement in the pathogenesis of lupus nephritis.

Renal failure

Avec: Takao Karasawa , Riko Sato , Tadaatsu Imaizumi , Shun Hashimoto , Masashi Fujita , Tomomi Aizawa , Koji Tsugawa , Shogo Kawaguchi , Kazuhiko Seya , Kiminori Terui , Hiroshi Tanaka

Expression of interferon-stimulated gene 20 (ISG20), an antiviral effector protein, in glomerular endothelial cells: possible involvement of ISG20 in lupus nephritis.

Renal failure

Avec: Takao Karasawa , Riko Sato , Tadaatsu Imaizumi , Masashi Fujita , Tomomi Aizawa , Koji Tsugawa , Deborah Mattinzoli , Shogo Kawaguchi , Kazuhiko Seya , Kiminori Terui , Kensuke Joh , Hiroshi Tanaka

Interferon-stimulated gene 56 positively regulates Toll-like receptor 3-mediated CXCL10 expression in human renal proximal tubular epithelial cells.

FEBS open bio

Avec: Mayuki Tachizaki , Sho Sakamoto , Yuri Kobori , Yoshiya Asano , Shogo Kawaguchi , Kazuhiko Seya , Hiroshi Tanaka , Eiji Morita , Tadaatsu Imaizumi

Cytosolic Sensors of Viral RNA Are Involved in the Production of Interleukin-6 via Toll-Like Receptor 3 Signaling in Human Glomerular Endothelial Cells.

Kidney & blood pressure research

Avec: Qiang Liu , Tadaatsu Imaizumi , Tomomi Aizawa , Koji Hirono , Shogo Kawaguchi , Shojiro Watanabe , Koji Tsugawa , Tomoh Matsumiya , Kazuhiko Seya , Hidemi Yoshida , Hiroshi Tanaka

Interferon-induced transmembrane protein 1 and Myxovirus resistance protein 1 are induced by polyinosinic-polycytidylic acid in cultured hCMEC/D3 human cerebral microvascular endothelial cells.

Journal of neuroimmunology

Avec: Tadaatsu Imaizumi , Urara Satake , Ruri Miyashita , Shogo Kawaguchi , Tomoh Matsumiya , Kazuhiko Seya , Jiangli Ding , Hiroshi Tanaka

Hepatic Macrophages Express Melanoma Differentiation-Associated Gene 5 in Nonalcoholic Steatohepatitis.

Inflammation

Avec: Shogo Kawaguchi , Hirotake Sakuraba , Momone Horiuchi , Jiangli Ding , Tomoh Matsumiya , Kazuhiko Seya , Chikara Iino , Tetsu Endo , Hidezumi Kikuchi , Shukuko Yoshida , Hiroto Hiraga , Shinsaku Fukuda , Tadaatsu Imaizumi

Expression of IFN-induced transmembrane protein 1 in glomerular endothelial cells.

Pediatrics international : official journal of the Japan Pediatric Society

Avec: Shun Hashimoto , Tadaatsu Imaizumi , Shojiro Watanabe , Tomomi Aizawa , Koji Tsugawa , Shogo Kawaguchi , Kazuhiko Seya , Tomoh Matsumiya , Hiroshi Tanaka

Daily Brazilian green propolis intake elevates blood artepillin C levels in humans.

Journal of the science of food and agriculture

Avec: Jiangli Ding , Tomoh Matsumiya , Ryo Hayakari , Yuko Shiba , Shogo Kawaguchi , Kazuhiko Seya , Kayo Ueno , Tadaatsu Imaizumi

The inhibitory effect of DIF-3 on polyinosinic-polycytidylic acid-induced innate immunity activation in human cerebral microvascular endothelial cells.

Journal of pharmacological sciences

Avec: Ryusei Araya , Shihu Men , Yoshinori Uekusa , Zaiqiang Yu , Haruhisa Kikuchi , Kazuyuki Daitoku , Masahito Minakawa , Shogo Kawaguchi , Ken-Ichi Furukawa , Yoshiteru Oshima , Tadaatsu Imaizumi , Kazuhiko Seya

Experimental and therapeutic medicine

Avec: Shogo Kawaguchi , Hirotake Sakuraba , Hidezumi Kikuchi , Kota Matsuki , Yudai Hayashi , Jiangli Ding , Yusuke Tanaka , Kazuhiko Seya , Tomoh Matsumiya , Hiroto Hiraga , Shinsaku Fukuda , Kenroh Sasaki , Tadaatsu Imaizumi

Expression of Zinc-Finger Antiviral Protein in hCMEC/D3 Human Cerebral Microvascular Endothelial Cells: Effect of a Toll-Like Receptor 3 Agonist.

Neuroimmunomodulation

Avec: Mako Okudera , Minami Odawara , Masashi Arakawa , Shogo Kawaguchi , Kazuhiko Seya , Tomoh Matsumiya , Riko Sato , Jiangli Ding , Eiji Morita , Tadaatsu Imaizumi

Porphyromonas gingivalis lipopolysaccharide induces interleukin-6 and c-c motif chemokine ligand 2 expression in cultured hCMEC/D3 human brain microvascular endothelial cells.

Gerodontology

Avec: Natsu Sato , Takeshi Matsumoto , Shogo Kawaguchi , Kazuhiko Seya , Tomoh Matsumiya , Jiangli Ding , Tomomi Aizawa , Tadaatsu Imaizumi

Inhibitory effect of anti-malarial agents on the expression of proinflammatory chemokines via Toll-like receptor 3 signaling in human glomerular endothelial cells.

Renal failure

Avec: Riko Sato , Tadaatsu Imaizumi , Tomomi Aizawa , Shojiro Watanabe , Koji Tsugawa , Shogo Kawaguchi , Kazuhiko Seya , Tomoh Matsumiya , Hiroshi Tanaka

Ketamine Does Not Change Natural Killer Cell Cytotoxicity in Patients Undergoing Cancer Surgery: Basic Experiment and Clinical Trial.

Journal of oncology

Avec: Mirei Kubota , Hidetomo Niwa , Kazuhiko Seya , Jun Kawaguchi , Tetsuya Kushikata , Kazuyoshi Hirota

Tryptanthrin attenuates TLR3-mediated STAT1 activation in THP-1 cells.

Immunologic research

Avec: Noriyuki Numao , Shogo Kawaguchi , Jiangli Ding , Takao Karasawa , Kazuhiko Seya , Tomoh Matsumiya , Hidezumi Kikuchi , Hirotake Sakuraba , Shinsaku Fukuda , Tadaatsu Imaizumi

ER export signals mediate plasma membrane localization of transmembrane protein TMEM72.

The FEBS journal

Avec: Jiangli Ding , Tomoh Matsumiya , Yasuo Miki , Ryo Hayakari , Yuko Shiba , Shogo Kawaguchi , Kazuhiko Seya , Tadaatsu Imaizumi

Resiquimod Induces C-C Motif Chemokine Ligand 2 Via Nuclear Factor-Kappa B in SH-SY5Y Human Neuroblastoma Cells.

Neuromolecular medicine

Avec: Masatoshi Kaizuka , Shogo Kawaguchi , Tetsuya Tatsuta , Mayuki Tachizaki , Yuri Kobori , Yusuke Tanaka , Kazuhiko Seya , Tomoh Matsumiya , Tadaatsu Imaizumi , Hirotake Sakuraba

Role of CD34 in calcification of human aortic valve interstitial cells from patients with aortic valve stenosis.

Journal of pharmacological sciences

Avec: Shihu Men , Zaiqiang Yu , Xu Liu , Kazuyuki Daitoku , Mayuki Tachizaki , Shogo Kawaguchi , Tadaatsu Imaizumi , Masahito Minakawa , Kazuhiko Seya

Role of MDA5 in regulating CXCL10 expression induced by TLR3 signaling in human rheumatoid fibroblast-like synoviocytes.

Molecular biology reports

Avec: Tatsuro Saruga , Tadaatsu Imaizumi , Shogo Kawaguchi , Kazuhiko Seya , Tomoh Matsumiya , Eiji Sasaki , Norihiro Sasaki , Ryoko Uesato , Yasuyuki Ishibashi

Tryptanthrin suppresses double-stranded RNA-induced CXCL10 expression via inhibiting the phosphorylation of STAT1 in human umbilical vein endothelial cells.

Molecular immunology

Avec: Shogo Kawaguchi , Hirotake Sakuraba , Hidezumi Kikuchi , Noriyuki Numao , Taka Asari , Hiroto Hiraga , Jiangli Ding , Tomoh Matsumiya , Kazuhiko Seya , Shinsaku Fukuda , Tadaatsu Imaizumi

Correction to: Warfarin calcifies human aortic valve interstitial cells at high-phosphate conditions via pregnane X receptor.

Journal of bone and mineral metabolism

Avec: Zaiqiang Yu , Kazuhiko Seya , Mari Chiyoya , Kazuyuki Daitoku , Shigeru Motomura , Tadaatsu Imaizumi , Ikuo Fukuda , Ken-Ichi Furukawa

Polyinosinic-Polycytidylic Acid Induces CXCL1 Expression in Cultured hCMEC/D3 Human Cerebral Microvascular Endothelial Cells.

Neuroimmunomodulation

Avec: Yuchen Li , Tadaatsu Imaizumi , Tomoh Matsumiya , Kazuhiko Seya , Shogo Kawaguchi , Jiangli Ding , Hiroki Ohkuma

Cylindromatosis lysine 63 deubiquitinase (CYLD) suppress TLR3-mediated CCL5 expression in human renal proximal tubular epithelial cells.

Molecular biology reports

Avec: Mayuki Tachizaki , Yuri Kobori , Shogo Kawaguchi , Kazuhiko Seya , Hiroshi Tanaka , Tadaatsu Imaizumi

The double-stranded RNA-dependent protein kinase PKR negatively regulates the protein expression of IFN-β induced by RIG-I signaling.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Tomoh Matsumiya , Yuko Shiba , Jiangli Ding , Shogo Kawaguchi , Kazuhiko Seya , Tadaatsu Imaizumi

Possible involvement of DExD/H box helicase 60 in synovial inflammation of rheumatoid arthritis: role of toll-like receptor 3 signaling.

Molecular biology reports

Avec: Yuzuru Nakamura , Hikaru Kristi Ishibashi , Tatsuro Saruga , Tadaatsu Imaizumi , Akira Kurose , Mayuki Tachizaki , Shogo Kawaguchi , Kazuhiko Seya , Eiji Sasaki , Yasuyuki Ishibashi

Menaquinone-4 Accelerates Calcification of Human Aortic Valve Interstitial Cells in High-Phosphate Medium through PXR.

The Journal of pharmacology and experimental therapeutics

Avec: Wei Yang , Zaiqiang Yu , Mari Chiyoya , Xu Liu , Kazuyuki Daitoku , Shigeru Motomura , Tadaatsu Imaizumi , Ikuo Fukuda , Ken-Ichi Furukawa , Motonori Tsuji , Kazuhiko Seya

Melanoma Differentiation-Associated Gene 5 Positively Modulates TNF-α-Induced CXCL10 Expression in Cultured HuH-7 and HLE Cells.

Inflammation

Avec: Shogo Kawaguchi , Hirotake Sakuraba , Toshihiro Haga , Tomoh Matsumiya , Kazuhiko Seya , Tetsu Endo , Naoya Sawada , Chikara Iino , Hidezumi Kikuchi , Hiroto Hiraga , Shinsaku Fukuda , Tadaatsu Imaizumi

Warfarin calcifies human aortic valve interstitial cells at high-phosphate conditions via pregnane X receptor.

Journal of bone and mineral metabolism

Avec: Zaiqiang Yu , Kazuhiko Seya , Mari Chiyoya , Kazuyuki Daitoku , Shigeru Motomura , Tadaatsu Imaizumi , Ikuo Fukuda , Ken-Ichi Furukawa

Interleukin-6 via Toll-Like Receptor 3 Signaling Attenuates the Expression of Proinflammatory Chemokines in Human Podocytes.

Kidney & blood pressure research

Avec: Hidenori Umetsu , Shojiro Watanabe , Tadaatsu Imaizumi , Tomomi Aizawa , Koji Tsugawa , Shogo Kawaguchi , Kazuhiko Seya , Tomoh Matsumiya , Hiroshi Tanaka

Human aortic valve interstitial cells obtained from patients with aortic valve stenosis are vascular endothelial growth factor receptor 2 positive and contribute to ectopic calcification.

Journal of pharmacological sciences

Avec: Xu Liu , Zaiqiang Yu , Kazuyuki Daitoku , Ikuo Fukuda , Shigeru Motomura , Tomoh Matsumiya , Tadaatsu Imaizumi , Ken-Ichi Furukawa , Kazuhiko Seya

IFIT Proteins Are Involved in CXCL10 Expression in Human Glomerular Endothelial Cells Treated with a Toll-Like Receptor 3 Agonist.

Kidney & blood pressure research

Avec: Tadaatsu Imaizumi , Shun Hashimoto , Riko Sato , Hidenori Umetsu , Tomomi Aizawa , Shojiro Watanabe , Shogo Kawaguchi , Tomoh Matsumiya , Kazuhiko Seya , Jiangli Ding , Hiroshi Tanaka

Toll-like receptor 3 signaling induces interferon-induced transmembrane protein 1 in BEAS-2B cells.

Experimental biology and medicine (Maywood, N.J.)

Avec: Masaki Dobashi , Toshihiro Shiratori , Tadaatsu Imaizumi , Shun Hashimoto , Shogo Kawaguchi , Kazuhiko Seya , Sadatomo Tasaka

TMEM2 suppresses TLR3-mediated IFN-β/ISG56/CXCL10 expression in BEAS-2B bronchial epithelial cells.

Molecular biology reports

Avec: Yuri Kobori , Mayuki Tachizaki , Tadaatsu Imaizumi , Yusuke Tanaka , Kazuhiko Seya , Yasuo Miki , Shogo Kawaguchi , Tomoh Matsumiya , Yuki Tobisawa , Chikara Ohyama , Sadatomo Tasaka

Expression of ISG60 is induced by TLR3 signaling in BEAS‑2B bronchial epithelial cells: Possible involvement in CXCL10 expression.

Molecular medicine reports

Avec: Yusuke Tanaka , Tadaatsu Imaizumi , Yuri Kobori , Mayuki Tachizaki , Toshihiro Shiratori , Masaki Dobashi , Mami Sato , Shogo Kawaguchi , Kazuhiko Seya , Sadatomo Tasaka

TLR3 signaling-induced interferon-stimulated gene 56 plays a role in the pathogenesis of rheumatoid arthritis.

Experimental biology and medicine (Maywood, N.J.)

Avec: Hikaru Kristi Ishibashi , Yuzuru Nakamura , Tatsuro Saruga , Tadaatsu Imaizumi , Akira Kurose , Shogo Kawaguchi , Kazuhiko Seya , Eiji Sasaki , Yasuyuki Ishibashi

Réseau de co-auteurs

Tadaatsu Imaizumi 36 collaborations

Shogo Kawaguchi 32 collaborations

Tomoh Matsumiya 21 collaborations

Jiangli Ding 12 collaborations

Hiroshi Tanaka 11 collaborations

Tomomi Aizawa 9 collaborations

Koji Tsugawa 7 collaborations

Zaiqiang Yu 7 collaborations

Kazuyuki Daitoku 7 collaborations

Mayuki Tachizaki 7 collaborations

Riko Sato 6 collaborations

Ken-Ichi Furukawa 6 collaborations

Hirotake Sakuraba 6 collaborations

Shigeru Motomura 5 collaborations

Yuri Kobori 5 collaborations

Shojiro Watanabe 5 collaborations

Hidezumi Kikuchi 5 collaborations

Shinsaku Fukuda 5 collaborations

Shun Hashimoto 4 collaborations

Hiroto Hiraga 4 collaborations

Yusuke Tanaka 4 collaborations

Ikuo Fukuda 4 collaborations

Kiminori Terui 3 collaborations

Masahito Minakawa 3 collaborations

Takao Karasawa 3 collaborations

Yuko Shiba 3 collaborations

Xu Liu 3 collaborations

Tatsuro Saruga 3 collaborations

Eiji Sasaki 3 collaborations

Yasuyuki Ishibashi 3 collaborations

Mari Chiyoya 3 collaborations

Sadatomo Tasaka 3 collaborations

Yoshinori Uekusa 2 collaborations

Haruhisa Kikuchi 2 collaborations

Yoshiteru Oshima 2 collaborations

Masashi Fujita 2 collaborations

Eiji Morita 2 collaborations

Chikara Iino 2 collaborations

Tetsu Endo 2 collaborations

Ryo Hayakari 2 collaborations

Shihu Men 2 collaborations

Noriyuki Numao 2 collaborations

Yasuo Miki 2 collaborations

Yuzuru Nakamura 2 collaborations

Hikaru Kristi Ishibashi 2 collaborations

Akira Kurose 2 collaborations

Hidenori Umetsu 2 collaborations

Masaki Dobashi 2 collaborations

Toshihiro Shiratori 2 collaborations

Liu Xu 1 collaboration

Deborah Mattinzoli 1 collaboration

Kensuke Joh 1 collaboration

Sho Sakamoto 1 collaboration

Yoshiya Asano 1 collaboration

Qiang Liu 1 collaboration

Koji Hirono 1 collaboration

Hidemi Yoshida 1 collaboration

Urara Satake 1 collaboration

Ruri Miyashita 1 collaboration

Momone Horiuchi 1 collaboration

Shukuko Yoshida 1 collaboration

Kayo Ueno 1 collaboration

Ryusei Araya 1 collaboration

Kota Matsuki 1 collaboration

Yudai Hayashi 1 collaboration

Kenroh Sasaki 1 collaboration

Mako Okudera 1 collaboration

Minami Odawara 1 collaboration

Masashi Arakawa 1 collaboration

Natsu Sato 1 collaboration

Takeshi Matsumoto 1 collaboration

Mirei Kubota 1 collaboration

Hidetomo Niwa 1 collaboration

Jun Kawaguchi 1 collaboration

Tetsuya Kushikata 1 collaboration

Kazuyoshi Hirota 1 collaboration

Masatoshi Kaizuka 1 collaboration

Tetsuya Tatsuta 1 collaboration

Norihiro Sasaki 1 collaboration

Ryoko Uesato 1 collaboration

Taka Asari 1 collaboration

Yuchen Li 1 collaboration

Hiroki Ohkuma 1 collaboration

Wei Yang 1 collaboration

Motonori Tsuji 1 collaboration

Toshihiro Haga 1 collaboration

Naoya Sawada 1 collaboration

Yuki Tobisawa 1 collaboration

Chikara Ohyama 1 collaboration

Mami Sato 1 collaboration