Johanna Myllyharju

Affiliations

Oulu Center for Cell-Matrix Research, University of Oulu, PO Box 5400, 90014, Oulu, Finland. johanna.myllyharju@oulu.fi.
Biocenter Oulu and Faculty of Biochemistry and Molecular Medicine, University of Oulu, 90014, Oulu, Finland. johanna.myllyharju@oulu.fi.

ORCID: http://orcid.org/0000-0001-7772-1250

Publications (29)

A long hypoxia-inducible factor 3 isoform 2 is a transcription activator that regulates erythropoietin.

Cellular and molecular life sciences : CMLS

Avec: Jussi-Pekka Tolonen , Minna Heikkilä , Marjo Malinen , Hang-Mao Lee , Jorma J Palvimo , Gong-Hong Wei , Johanna Myllyharju

Type I and type V procollagen triple helix uses different subsets of the molecular ensemble for lysine posttranslational modifications in the rER.

The Journal of biological chemistry

Avec: Yoshihiro Ishikawa , Yuki Taga , Keith Zientek , Nobuyo Mizuno , Antti M Salo , Olesya Semenova , Sara F Tufa , Douglas R Keene , Paul Holden , Kazunori Mizuno , Douglas B Gould , Johanna Myllyharju , Hans Peter Bächinger

Inactivation of mouse transmembrane prolyl 4-hydroxylase increases blood brain barrier permeability and ischemia-induced cerebral neuroinflammation.

The Journal of biological chemistry

Avec: Nadiya Byts , Subodh Sharma , Tarja Malm , Mika Kaakinen , Paula Korhonen , Laura Jaakkonen , Meike Keuters , Mikko Huuskonen , Ilkka Pietilä , Jari Koistinaho , Peppi Koivunen , Johanna Myllyharju

HIF-P4H-2 inhibition enhances intestinal fructose metabolism and induces thermogenesis protecting against NAFLD.

Journal of molecular medicine (Berlin, Germany)

Avec: Anna Laitakari , Joona Tapio , Kari A Mäkelä , Karl-Heinz Herzig , Franziska Dengler , Helena Gylling , Gail Walkinshaw , Johanna Myllyharju , Elitsa Y Dimova , Raisa Serpi , Peppi Koivunen

Systemic long-term inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 ameliorates aging-induced changes in mice without affecting their life span.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Anna Laitakari , Riikka Huttunen , Paula Kuvaja , Pauliina Hannuksela , Zoltan Szabo , Minna Heikkilä , Risto Kerkelä , Johanna Myllyharju , Elitsa Y Dimova , Raisa Serpi , Peppi Koivunen

Role of prolyl hydroxylation in the molecular interactions of collagens.

Essays in biochemistry

Avec: Pekka Rappu , Antti M Salo , Johanna Myllyharju , Jyrki Heino

Deletion of hypoxia-inducible factor prolyl 4-hydroxylase 2 in FoxD1-lineage mesenchymal cells leads to congenital truncal alopecia.

The Journal of biological chemistry

Avec: Ann-Helen Rosendahl , Mia Monnius , Anu Laitala , Antti Railo , Ilkka Miinalainen , Ritva Heljasvaara , Joni M Mäki , Johanna Myllyharju

Lack of activity of recombinant HIF prolyl hydroxylases (PHDs) on reported non-HIF substrates.

eLife

Avec: Matthew E Cockman , Kerstin Lippl , Ya-Min Tian , Hamish B Pegg , William D Figg , Martine I Abboud , Raphael Heilig , Roman Fischer , Johanna Myllyharju , Christopher J Schofield , Peter J Ratcliffe

Genetic Ablation of Transmembrane Prolyl 4-Hydroxylase Reduces Atherosclerotic Plaques in Mice.

Arteriosclerosis, thrombosis, and vascular biology

Avec: Jenni Määttä , Raisa Serpi , Sohvi Hörkkö , Valerio Izzi , Johanna Myllyharju , Elitsa Y Dimova , Peppi Koivunen

Expression and Roles of Individual HIF Prolyl 4-Hydroxylase Isoenzymes in the Regulation of the Hypoxia Response Pathway along the Murine Gastrointestinal Epithelium.

International journal of molecular sciences

Avec: Franziska Dengler , Sofia Sova , Antti M Salo , Joni M Mäki , Peppi Koivunen , Johanna Myllyharju

Reduced Bone Mass in Collagen Prolyl 4-Hydroxylase

JBMR plus

Avec: Jussi-Pekka Tolonen , Antti M Salo , Mikko Finnilä , Ellinoora Aro , Emma Karjalainen , Veli-Pekka Ronkainen , Kati Drushinin , Christophe Merceron , Valerio Izzi , Ernestina Schipani , Johanna Myllyharju

Activation of the hypoxia response protects mice from amyloid-β accumulation.

Cellular and molecular life sciences : CMLS

Avec: Teemu Ollonen , Margareta Kurkela , Anna Laitakari , Samuli Sakko , Henna Koivisto , Johanna Myllyharju , Heikki Tanila , Raisa Serpi , Peppi Koivunen

Contribution of collagen XIII to lung function and development of pulmonary fibrosis.

BMJ open respiratory research

Avec: Oula Norman , Jarkko Koivunen , Riitta Kaarteenaho , Antti M Salo , Joni M Mäki , Johanna Myllyharju , Taina Pihlajaniemi , Anne Heikkinen

Interactions between lysyl oxidases and ADAMTS proteins suggest a novel crosstalk between two extracellular matrix families.

Matrix biology : journal of the International Society for Matrix Biology

Avec: Rohtem Aviram , Shelly Zaffryar-Eilot , Dirk Hubmacher , Hagar Grunwald , Joni M Mäki , Johanna Myllyharju , Suneel S Apte , Peleg Hasson

Null mutation in P4h-tm leads to decreased fear and anxiety and increased social behavior in mice.

Neuropharmacology

Avec: Henri Leinonen , Hennariikka Koivisto , Henna-Riikka Lipponen , Anna Matilainen , Antti M Salo , Elitsa Y Dimova , Elina Hämäläinen , Saara Stavén , Pasi Miettinen , Johanna Myllyharju , Peppi Koivunen , Heikki Tanila

PHD2 deletion in endothelial or arterial smooth muscle cells reveals vascular cell type-specific responses in pulmonary hypertension and fibrosis.

Angiogenesis

Avec: Harri Elamaa , Mika Kaakinen , Marjut Nätynki , Zoltan Szabo , Veli-Pekka Ronkainen , Ville Äijälä , Joni M Mäki , Risto Kerkelä , Johanna Myllyharju , Lauri Eklund

The glucose-sensing transcription factor ChREBP is targeted by proline hydroxylation.

The Journal of biological chemistry

Avec: Steffi Heidenreich , Pamela Weber , Heike Stephanowitz , Konstantin M Petricek , Till Schütte , Moritz Oster , Antti M Salo , Miriam Knauer , Isabel Goehring , Na Yang , Nicole Witte , Anne Schumann , Manuela Sommerfeld , Matthias Muenzner , Johanna Myllyharju , Eberhard Krause , Michael Schupp

Crystal structure of the collagen prolyl 4-hydroxylase (C-P4H) catalytic domain complexed with PDI: Toward a model of the C-P4H α

The Journal of biological chemistry

Avec: Abhinandan V Murthy , Ramita Sulu , Andrey Lebedev , Antti M Salo , Kati Korhonen , Rajaram Venkatesan , Hongmin Tu , Ulrich Bergmann , Janne Jänis , Mikko Laitaoja , Lloyd W Ruddock , Johanna Myllyharju , M Kristian Koski , Rik K Wierenga

Metabolic characteristics of transmembrane prolyl 4-hydroxylase (P4H-TM) deficient mice.

Pflugers Archiv : European journal of physiology

Avec: Tuulia Ala-Nisula , Riikka Halmetoja , Henri Leinonen , Margareta Kurkela , Henna-Riikka Lipponen , Samuli Sakko , Mikko Karpale , Antti M Salo , Niina Sissala , Tapio Röning , Ghulam S Raza , Kari A Mäkelä , Jérôme Thevenot , Karl-Heinz Herzig , Raisa Serpi , Johanna Myllyharju , Heikki Tanila , Peppi Koivunen , Elitsa Y Dimova

Collagen prolyl 4-hydroxylase isoenzymes I and II have sequence specificity towards different X-Pro-Gly triplets.

Matrix biology : journal of the International Society for Matrix Biology

Avec: Antti M Salo , Pekka Rappu , M Kristian Koski , Emma Karjalainen , Valerio Izzi , Kati Drushinin , Ilkka Miinalainen , Jarmo Käpylä , Jyrki Heino , Johanna Myllyharju

HIF2α-dependent Dock4/Rac1-signaling regulates formation of adherens junctions and cell polarity in normoxia.

Scientific reports

Avec: I Raykhel , V-P Ronkainen , J Myllyharju , A Manninen

Structure of transmembrane prolyl 4-hydroxylase reveals unique organization of EF and dioxygenase domains.

The Journal of biological chemistry

Avec: Matti Myllykoski , Aleksi Sutinen , M Kristian Koski , Juha P Kallio , Arne Raasakka , Johanna Myllyharju , Rik K Wierenga , Peppi Koivunen

Transmembrane Prolyl 4-Hydroxylase is a Novel Regulator of Calcium Signaling in Astrocytes.

eNeuro

Avec: Nadiya Byts , Subodh Sharma , Jenny Laurila , Prodeep Paudel , Ilkka Miinalainen , Veli-Pekka Ronkainen , Reetta Hinttala , Kid Törnquist , Peppi Koivunen , Johanna Myllyharju

Loss of Cln5 leads to altered Gad1 expression and deficits in interneuron development in mice.

Human molecular genetics

Avec: Yajuvinder Singh , Henri Leinonen , Feroze Fazaludeen , Merja Jaronen , Debbie Guest , Noel Buckley , Nadiya Byts , Petra Oksa , Kari Jalkanen , Imran Iqbal , Mikko Huuskonen , Ekaterina Savchenko , Velta Keksa-Goldsteine , Sweelin Chew , Johanna Myllyharju , Heikki Tanila , Lezanne Ooi , Jari Koistinaho , Katja M Kanninen , Tarja Malm

Systemic inactivation of hypoxia-inducible factor prolyl 4-hydroxylase 2 in mice protects from alcohol-induced fatty liver disease.

Redox biology

Avec: Anna Laitakari , Teemu Ollonen , Thomas Kietzmann , Gail Walkinshaw , Daniela Mennerich , Valerio Izzi , Kirsi-Maria Haapasaari , Johanna Myllyharju , Raisa Serpi , Elitsa Y Dimova , Peppi Koivunen

Prolyl hydroxylase domain 2 reduction enhances skeletal muscle tissue regeneration after soft tissue trauma in mice.

PloS one

Avec: Stephan Settelmeier , Timm Schreiber , Joni Mäki , Nadiya Byts , Peppi Koivunen , Johanna Myllyharju , Joachim Fandrey , Sandra Winning

Prolyl and lysyl hydroxylases in collagen synthesis.

Experimental dermatology

Avec: Antti M Salo , Johanna Myllyharju

Activation of the hypoxia response pathway protects against age-induced cardiac hypertrophy.

Journal of molecular and cellular cardiology

Avec: Tapio Röning , Johanna Magga , Anna Laitakari , Riikka Halmetoja , Joona Tapio , Elitsa Y Dimova , Zoltan Szabo , Lea Rahtu-Korpela , Anna Kemppi , Gail Walkinshaw , Johanna Myllyharju , Risto Kerkelä , Peppi Koivunen , Raisa Serpi

Contribution of HIF-P4H isoenzyme inhibition to metabolism indicates major beneficial effects being conveyed by HIF-P4H-2 antagonism.

The Journal of biological chemistry

Avec: Joona Tapio , Riikka Halmetoja , Elitsa Y Dimova , Joni M Mäki , Anu Laitala , Gail Walkinshaw , Johanna Myllyharju , Raisa Serpi , Peppi Koivunen

Réseau de co-auteurs

Peppi Koivunen 14 collaborations

Antti M Salo 11 collaborations

Elitsa Y Dimova 8 collaborations

Raisa Serpi 8 collaborations

Joni M Mäki 6 collaborations

Anna Laitakari 5 collaborations

Nadiya Byts 4 collaborations

Gail Walkinshaw 4 collaborations

Valerio Izzi 4 collaborations

Heikki Tanila 4 collaborations

Joona Tapio 3 collaborations

Zoltan Szabo 3 collaborations

Risto Kerkelä 3 collaborations

Ilkka Miinalainen 3 collaborations

Veli-Pekka Ronkainen 3 collaborations

Henri Leinonen 3 collaborations

M Kristian Koski 3 collaborations

Riikka Halmetoja 3 collaborations

Jussi-Pekka Tolonen 2 collaborations

Minna Heikkilä 2 collaborations

Subodh Sharma 2 collaborations

Tarja Malm 2 collaborations

Mika Kaakinen 2 collaborations

Mikko Huuskonen 2 collaborations

Jari Koistinaho 2 collaborations

Kari A Mäkelä 2 collaborations

Karl-Heinz Herzig 2 collaborations

Franziska Dengler 2 collaborations

Pekka Rappu 2 collaborations

Jyrki Heino 2 collaborations

Anu Laitala 2 collaborations

Emma Karjalainen 2 collaborations

Kati Drushinin 2 collaborations

Teemu Ollonen 2 collaborations

Margareta Kurkela 2 collaborations

Samuli Sakko 2 collaborations

Henna-Riikka Lipponen 2 collaborations

Rik K Wierenga 2 collaborations

Tapio Röning 2 collaborations

Marjo Malinen 1 collaboration

Hang-Mao Lee 1 collaboration

Jorma J Palvimo 1 collaboration

Gong-Hong Wei 1 collaboration

Yoshihiro Ishikawa 1 collaboration

Yuki Taga 1 collaboration

Keith Zientek 1 collaboration

Nobuyo Mizuno 1 collaboration

Olesya Semenova 1 collaboration

Sara F Tufa 1 collaboration

Douglas R Keene 1 collaboration

Paul Holden 1 collaboration

Kazunori Mizuno 1 collaboration

Douglas B Gould 1 collaboration

Hans Peter Bächinger 1 collaboration

Paula Korhonen 1 collaboration

Laura Jaakkonen 1 collaboration

Meike Keuters 1 collaboration

Ilkka Pietilä 1 collaboration

Helena Gylling 1 collaboration

Riikka Huttunen 1 collaboration

Paula Kuvaja 1 collaboration

Pauliina Hannuksela 1 collaboration

Ann-Helen Rosendahl 1 collaboration

Mia Monnius 1 collaboration

Antti Railo 1 collaboration

Ritva Heljasvaara 1 collaboration

Matthew E Cockman 1 collaboration

Kerstin Lippl 1 collaboration

Ya-Min Tian 1 collaboration

Hamish B Pegg 1 collaboration

William D Figg 1 collaboration

Martine I Abboud 1 collaboration

Raphael Heilig 1 collaboration

Roman Fischer 1 collaboration

Christopher J Schofield 1 collaboration

Peter J Ratcliffe 1 collaboration

Jenni Määttä 1 collaboration

Sohvi Hörkkö 1 collaboration

Sofia Sova 1 collaboration

Mikko Finnilä 1 collaboration

Ellinoora Aro 1 collaboration

Christophe Merceron 1 collaboration

Ernestina Schipani 1 collaboration

Henna Koivisto 1 collaboration

Oula Norman 1 collaboration

Jarkko Koivunen 1 collaboration

Riitta Kaarteenaho 1 collaboration

Taina Pihlajaniemi 1 collaboration

Anne Heikkinen 1 collaboration

Rohtem Aviram 1 collaboration

Shelly Zaffryar-Eilot 1 collaboration

Dirk Hubmacher 1 collaboration

Hagar Grunwald 1 collaboration

Suneel S Apte 1 collaboration

Peleg Hasson 1 collaboration

Hennariikka Koivisto 1 collaboration

Anna Matilainen 1 collaboration

Elina Hämäläinen 1 collaboration

Saara Stavén 1 collaboration

Pasi Miettinen 1 collaboration

Harri Elamaa 1 collaboration

Marjut Nätynki 1 collaboration

Ville Äijälä 1 collaboration

Lauri Eklund 1 collaboration

Steffi Heidenreich 1 collaboration

Pamela Weber 1 collaboration

Heike Stephanowitz 1 collaboration

Konstantin M Petricek 1 collaboration

Till Schütte 1 collaboration

Moritz Oster 1 collaboration

Miriam Knauer 1 collaboration

Isabel Goehring 1 collaboration

Na Yang 1 collaboration

Nicole Witte 1 collaboration

Anne Schumann 1 collaboration

Manuela Sommerfeld 1 collaboration

Matthias Muenzner 1 collaboration

Eberhard Krause 1 collaboration

Michael Schupp 1 collaboration

Abhinandan V Murthy 1 collaboration

Ramita Sulu 1 collaboration

Andrey Lebedev 1 collaboration

Kati Korhonen 1 collaboration

Rajaram Venkatesan 1 collaboration

Hongmin Tu 1 collaboration

Ulrich Bergmann 1 collaboration

Janne Jänis 1 collaboration

Mikko Laitaoja 1 collaboration

Lloyd W Ruddock 1 collaboration

Tuulia Ala-Nisula 1 collaboration

Mikko Karpale 1 collaboration

Niina Sissala 1 collaboration

Ghulam S Raza 1 collaboration

Jérôme Thevenot 1 collaboration

Jarmo Käpylä 1 collaboration

I Raykhel 1 collaboration

V-P Ronkainen 1 collaboration

J Myllyharju 1 collaboration

A Manninen 1 collaboration

Matti Myllykoski 1 collaboration

Aleksi Sutinen 1 collaboration

Juha P Kallio 1 collaboration

Arne Raasakka 1 collaboration

Jenny Laurila 1 collaboration

Prodeep Paudel 1 collaboration

Reetta Hinttala 1 collaboration

Kid Törnquist 1 collaboration

Yajuvinder Singh 1 collaboration

Feroze Fazaludeen 1 collaboration

Merja Jaronen 1 collaboration

Debbie Guest 1 collaboration

Noel Buckley 1 collaboration

Petra Oksa 1 collaboration

Kari Jalkanen 1 collaboration

Imran Iqbal 1 collaboration

Ekaterina Savchenko 1 collaboration

Velta Keksa-Goldsteine 1 collaboration

Sweelin Chew 1 collaboration

Lezanne Ooi 1 collaboration

Katja M Kanninen 1 collaboration

Thomas Kietzmann 1 collaboration

Daniela Mennerich 1 collaboration

Kirsi-Maria Haapasaari 1 collaboration

Stephan Settelmeier 1 collaboration

Timm Schreiber 1 collaboration

Joni Mäki 1 collaboration

Joachim Fandrey 1 collaboration

Sandra Winning 1 collaboration

Johanna Magga 1 collaboration

Lea Rahtu-Korpela 1 collaboration

Anna Kemppi 1 collaboration