Isidro Hötzel

Affiliations

a Department of Antibody Engineering , Genentech , South San Francisco , CA , USA.

Publications (14)

Immune repertoire mining for rapid affinity optimization of mouse monoclonal antibodies.

mAbs

Avec: Yi-Chun Hsiao , Yonglei Shang , Danielle M DiCara , Angie Yee , Joyce Lai , Si Hyun Kim , Diego Ellerman , Racquel Corpuz , Yongmei Chen , Sharmila Rajan , Hao Cai , Yan Wu , Dhaya Seshasayee , Isidro Hötzel

Domain Organization of Lentiviral and Betaretroviral Surface Envelope Glycoproteins Modeled with AlphaFold.

Journal of virology

Avec: Isidro Hötzel

Neutral or detrimental effects of TREM2 agonist antibodies in preclinical models of Alzheimer's Disease and Multiple Sclerosis.

The Journal of neuroscience : the official journal of the Society for Neuroscience

Avec: Ainhoa Etxeberria , Yun-An A Shen , Steve Vito , Sean Silverman , Jose Imperio , Guita Lalehzadeh , Allison Soung , Changchun Du , Luke Xie , Man Kin Choy , Yi-Chun Hsiao , Hai Ngu , Chang Hoon Cho , Soumitra Ghosh , Gloriia Novikova , Mitchell G Rezzonico , Rebecca Leahey , Martin Weber , Alvin Gogineni , Justin Elstrott , Monica Xiong , Jacob J Greene , Kimberly L Stark , Pamela Chan , Gillie A Roth , Max Adrian , Qingling Li , Meena Choi , Weng Ruh Wong , Wendy Sandoval , Oded Foreman , Alicia A Nugent , Brad A Friedman , Shraddha Sadekar , Isidro Hötzel , David V Hansen , Ben Chih , Tracy J Yuen , Robby M Weimer , Amy Easton , William J Meilandt , Christopher J Bohlen

High titer expression of antibodies using linear expression cassettes for early-stage functional screening.

Protein engineering, design & selection : PEDS

Avec: Shuang Wu , Joni Tsukuda , Nancy Chiang , Hao To , Yongmei Chen , Isidro Hötzel , Sowmya Balasubramanian , Gerald Nakamura , Ryan L Kelly

Structural definition of babesial RAP-1 proteins identifies a novel protein superfamily across Apicomplexa.

Scientific reports

Avec: Isidro Hötzel , Carlos E Suarez

Rapid affinity optimization of an anti-TREM2 clinical lead antibody by cross-lineage immune repertoire mining.

Nature communications

Avec: Yi-Chun Hsiao , Heidi Ackerly Wallweber , Robert G Alberstein , Zhonghua Lin , Changchun Du , Ainhoa Etxeberria , Theint Aung , Yonglei Shang , Dhaya Seshasayee , Franziska Seeger , Andrew M Watkins , David V Hansen , Christopher J Bohlen , Peter L Hsu , Isidro Hötzel

Massively parallel single-cell B-cell receptor sequencing enables rapid discovery of diverse antigen-reactive antibodies.

Communications biology

Avec: Leonard D Goldstein , Ying-Jiun J Chen , Jia Wu , Subhra Chaudhuri , Yi-Chun Hsiao , Kellen Schneider , Kam Hon Hoi , Zhonghua Lin , Steve Guerrero , Bijay S Jaiswal , Jeremy Stinson , Aju Antony , Kanika Bajaj Pahuja , Dhaya Seshasayee , Zora Modrusan , Isidro Hötzel , Somasekar Seshagiri

Antibody semorinemab reduces tau pathology in a transgenic mouse model and engages tau in patients with Alzheimer's disease.

Science translational medicine

Avec: Gai Ayalon , Seung-Hye Lee , Oskar Adolfsson , Corinne Foo-Atkins , Jasvinder K Atwal , Mira Blendstrup , Helen Booler , Joseph Bravo , Robert Brendza , Flavia Brunstein , Ruby Chan , Priya Chandra , Jessica A Couch , Akash Datwani , Barthélemy Demeule , Danielle DiCara , Rich Erickson , James A Ernst , Oded Foreman , Dongping He , Isidro Hötzel , Michael Keeley , Michael C M Kwok , Julien Lafrance-Vanasse , Han Lin , Yanmei Lu , Wilman Luk , Paul Manser , Andreas Muhs , Hai Ngu , Andrea Pfeifer , Maria Pihlgren , Gautham K Rao , Kimberly Scearce-Levie , Stephen P Schauer , William B Smith , Hilda Solanoy , Edmond Teng , Kristin R Wildsmith , Daniela Bumbaca Yadav , Yong Ying , Reina N Fuji , Geoffrey A Kerchner

Deep-Time Structural Evolution of Retroviral and Filoviral Surface Envelope Proteins.

Journal of virology

Avec: Isidro Hötzel

Restricted epitope specificity determined by variable region germline segment pairing in rodent antibody repertoires.

mAbs

Avec: Yi-Chun Hsiao , Ying-Jiun J Chen , Leonard D Goldstein , Jia Wu , Zhonghua Lin , Kellen Schneider , Subhra Chaudhuri , Aju Antony , Kanika Bajaj Pahuja , Zora Modrusan , Dhaya Seshasayee , Somasekar Seshagiri , Isidro Hötzel

Loss of the intracellular enzyme QPCTL limits chemokine function and reshapes myeloid infiltration to augment tumor immunity.

Nature immunology

Avec: Rosa Barreira da Silva , Ricardo M Leitao , Ximo Pechuan-Jorge , Scott Werneke , Jason Oeh , Vincent Javinal , Yingyun Wang , Wilson Phung , Christine Everett , Jim Nonomiya , David Arnott , Cheng Lu , Yi-Chun Hsiao , James T Koerber , Isidro Hötzel , James Ziai , Zora Modrusan , Thomas H Pillow , Merone Roose-Girma , Jill M Schartner , Mark Merchant , Sascha Rutz , Céline Eidenschenk , Ira Mellman , Matthew L Albert

Primate cerebrospinal fluid CHI3L1 reflects brain TREM2 agonism.

Alzheimer's & dementia : the journal of the Alzheimer's Association

Avec: Stephen P Schauer , Chang Hoon Cho , Gloriia Novikova , Gillie A Roth , Julie Lee , Anup D Sharma , Alejandro R Foley , Carl Ng , Philip Shen , Meena Choi , Taylur P Ma , Lilian Phu , Hanna G Budayeva , Tommy K Cheung , Guita Lalehzadeh , Jose Imperio , Hai Ngu , Ainhoa Etxeberria , Yuxin Liang , Mitchell G Rezzonico , Michelle Dourado , Kevin Huang , Zijuan Lai , Martha Hokom , Nikhil J Pandya , Dwight Newton , Alyaa M Abdel-Haleem , Pamela Chan , Donna Lee , Nardos G Tassew , Dewakar Sangaraju , Deborah O'Connor , Isidro Hötzel , Kimberly L Stark , Carolina Chou , Oded Foreman , Amy Easton , Kristin R Wildsmith , Gizette Sperinde , Christopher M Rose , Brad A Friedman , Reina N Fuji , Robby M Weimer , William J Meilandt , Shraddha Sadekar , Alicia A Nugent , Anne Biever

Dynamics of heavy chain junctional length biases in antibody repertoires.

Communications biology

Avec: Kannan Sankar , Kam Hon Hoi , Isidro Hötzel

Anti-α-synuclein c-terminal antibodies block PFF uptake and accumulation of phospho-synuclein in preclinical models of Parkinson's disease.

Neurobiology of disease

Avec: Robert Brendza , Xiaoying Gao , Kimberly L Stark , Han Lin , Seung-Hye Lee , Changyun Hu , Hao Cai , Danielle DiCara , Yi-Chun Hsiao , Hai Ngu , Oded Foreman , Miriam Baca , Monika Dohse , Jean-Phillipe Fortin , Racquel Corpuz , Dhaya Seshasayee , Amy Easton , Gai Ayalon , Isidro Hötzel , Ben Chih

Réseau de co-auteurs

Yi-Chun Hsiao 7 collaborations

Dhaya Seshasayee 5 collaborations

Hai Ngu 4 collaborations

Oded Foreman 4 collaborations

Ainhoa Etxeberria 3 collaborations

Kimberly L Stark 3 collaborations

Amy Easton 3 collaborations

Zhonghua Lin 3 collaborations

Zora Modrusan 3 collaborations

Yonglei Shang 2 collaborations

Racquel Corpuz 2 collaborations

Yongmei Chen 2 collaborations

Hao Cai 2 collaborations

Jose Imperio 2 collaborations

Guita Lalehzadeh 2 collaborations

Changchun Du 2 collaborations

Chang Hoon Cho 2 collaborations

Gloriia Novikova 2 collaborations

Mitchell G Rezzonico 2 collaborations

Pamela Chan 2 collaborations

Gillie A Roth 2 collaborations

Meena Choi 2 collaborations

Alicia A Nugent 2 collaborations

Brad A Friedman 2 collaborations

Shraddha Sadekar 2 collaborations

David V Hansen 2 collaborations

Ben Chih 2 collaborations

Robby M Weimer 2 collaborations

William J Meilandt 2 collaborations

Christopher J Bohlen 2 collaborations

Leonard D Goldstein 2 collaborations

Ying-Jiun J Chen 2 collaborations

Jia Wu 2 collaborations

Subhra Chaudhuri 2 collaborations

Kellen Schneider 2 collaborations

Kam Hon Hoi 2 collaborations

Aju Antony 2 collaborations

Kanika Bajaj Pahuja 2 collaborations

Somasekar Seshagiri 2 collaborations

Gai Ayalon 2 collaborations

Seung-Hye Lee 2 collaborations

Robert Brendza 2 collaborations

Danielle DiCara 2 collaborations

Han Lin 2 collaborations

Stephen P Schauer 2 collaborations

Kristin R Wildsmith 2 collaborations

Reina N Fuji 2 collaborations

Danielle M DiCara 1 collaboration

Angie Yee 1 collaboration

Joyce Lai 1 collaboration

Si Hyun Kim 1 collaboration

Diego Ellerman 1 collaboration

Sharmila Rajan 1 collaboration

Yan Wu 1 collaboration

Yun-An A Shen 1 collaboration

Steve Vito 1 collaboration

Sean Silverman 1 collaboration

Allison Soung 1 collaboration

Luke Xie 1 collaboration

Man Kin Choy 1 collaboration

Soumitra Ghosh 1 collaboration

Rebecca Leahey 1 collaboration

Martin Weber 1 collaboration

Alvin Gogineni 1 collaboration

Justin Elstrott 1 collaboration

Monica Xiong 1 collaboration

Jacob J Greene 1 collaboration

Max Adrian 1 collaboration

Qingling Li 1 collaboration

Weng Ruh Wong 1 collaboration

Wendy Sandoval 1 collaboration

Tracy J Yuen 1 collaboration

Shuang Wu 1 collaboration

Joni Tsukuda 1 collaboration

Nancy Chiang 1 collaboration

Hao To 1 collaboration

Sowmya Balasubramanian 1 collaboration

Gerald Nakamura 1 collaboration

Ryan L Kelly 1 collaboration

Carlos E Suarez 1 collaboration

Heidi Ackerly Wallweber 1 collaboration

Robert G Alberstein 1 collaboration

Theint Aung 1 collaboration

Franziska Seeger 1 collaboration

Andrew M Watkins 1 collaboration

Peter L Hsu 1 collaboration

Steve Guerrero 1 collaboration

Bijay S Jaiswal 1 collaboration

Jeremy Stinson 1 collaboration

Oskar Adolfsson 1 collaboration

Corinne Foo-Atkins 1 collaboration

Jasvinder K Atwal 1 collaboration

Mira Blendstrup 1 collaboration

Helen Booler 1 collaboration

Joseph Bravo 1 collaboration

Flavia Brunstein 1 collaboration

Ruby Chan 1 collaboration

Priya Chandra 1 collaboration

Jessica A Couch 1 collaboration

Akash Datwani 1 collaboration

Barthélemy Demeule 1 collaboration

Rich Erickson 1 collaboration

James A Ernst 1 collaboration

Dongping He 1 collaboration

Michael Keeley 1 collaboration

Michael C M Kwok 1 collaboration

Julien Lafrance-Vanasse 1 collaboration

Yanmei Lu 1 collaboration

Wilman Luk 1 collaboration

Paul Manser 1 collaboration

Andreas Muhs 1 collaboration

Andrea Pfeifer 1 collaboration

Maria Pihlgren 1 collaboration

Gautham K Rao 1 collaboration

Kimberly Scearce-Levie 1 collaboration

William B Smith 1 collaboration

Hilda Solanoy 1 collaboration

Edmond Teng 1 collaboration

Daniela Bumbaca Yadav 1 collaboration

Yong Ying 1 collaboration

Geoffrey A Kerchner 1 collaboration

Rosa Barreira da Silva 1 collaboration

Ricardo M Leitao 1 collaboration

Ximo Pechuan-Jorge 1 collaboration

Scott Werneke 1 collaboration

Jason Oeh 1 collaboration

Vincent Javinal 1 collaboration

Yingyun Wang 1 collaboration

Wilson Phung 1 collaboration

Christine Everett 1 collaboration

Jim Nonomiya 1 collaboration

David Arnott 1 collaboration

Cheng Lu 1 collaboration

James T Koerber 1 collaboration

James Ziai 1 collaboration

Thomas H Pillow 1 collaboration

Merone Roose-Girma 1 collaboration

Jill M Schartner 1 collaboration

Mark Merchant 1 collaboration

Sascha Rutz 1 collaboration

Céline Eidenschenk 1 collaboration

Ira Mellman 1 collaboration

Matthew L Albert 1 collaboration

Julie Lee 1 collaboration

Anup D Sharma 1 collaboration

Alejandro R Foley 1 collaboration

Carl Ng 1 collaboration

Philip Shen 1 collaboration

Taylur P Ma 1 collaboration

Lilian Phu 1 collaboration

Hanna G Budayeva 1 collaboration

Tommy K Cheung 1 collaboration

Yuxin Liang 1 collaboration

Michelle Dourado 1 collaboration

Kevin Huang 1 collaboration

Zijuan Lai 1 collaboration

Martha Hokom 1 collaboration

Nikhil J Pandya 1 collaboration

Dwight Newton 1 collaboration

Alyaa M Abdel-Haleem 1 collaboration

Donna Lee 1 collaboration

Nardos G Tassew 1 collaboration

Dewakar Sangaraju 1 collaboration

Deborah O'Connor 1 collaboration

Carolina Chou 1 collaboration

Gizette Sperinde 1 collaboration

Christopher M Rose 1 collaboration

Anne Biever 1 collaboration

Kannan Sankar 1 collaboration

Xiaoying Gao 1 collaboration

Changyun Hu 1 collaboration

Miriam Baca 1 collaboration

Monika Dohse 1 collaboration

Jean-Phillipe Fortin 1 collaboration