Heidi M Haikala

Affiliations

Lowe Center for Thoracic Oncology, Department of Medical Oncology, Dana-Farber Cancer Institute, Boston, Massachusetts.
Harvard Medical School, Boston, Massachusetts.

Publications (14)

EGFR Inhibition Enhances the Cellular Uptake and Antitumor-Activity of the HER3 Antibody-Drug Conjugate HER3-DXd.

Cancer research

Avec: Heidi M Haikala , Timothy Lopez , Jens Köhler , Pinar O Eser , Man Xu , Qing Zeng , Tyler J Teceno , Kenneth Ngo , Yutong Zhao , Elena V Ivanova , Arrien A Bertram , Brittaney A Leeper , Emily S Chambers , Anika E Adeni , Luke J Taus , Mari Kuraguchi , Paul T Kirschmeier , Channing Yu , Yoshinobu Shiose , Yasuki Kamai , Yang Qiu , Cloud P Paweletz , Prafulla C Gokhale , Pasi A Jänne

Cancer research

Avec: Xi Qiao , Ying Liu , Maria Llamazares Prada , Aravind K Mohan , Abhishekh Gupta , Alok Jaiswal , Mukund Sharma , Joni Merisaari , Heidi M Haikala , Kati Talvinen , Laxman Yetukuri , Joanna W Pylvänäinen , Juha Klefström , Pauliina Kronqvist , Annika Meinander , Tero Aittokallio , Ville Hietakangas , Martin Eilers , Jukka Westermarck

Sortilin-related receptor is a druggable therapeutic target in breast cancer.

Molecular oncology

Avec: Hussein Al-Akhrass , Mika Pietilä , Johanna Lilja , Ella-Maria Vesilahti , Johanna M Anttila , Heidi M Haikala , Pauliina M Munne , Juha Klefström , Emilia Peuhu , Johanna Ivaska

Thirty Years of HER3: From Basic Biology to Therapeutic Interventions.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Heidi M Haikala , Pasi A Jänne

Publisher Correction: Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy.

Nature communications

Avec: Heidi M Haikala , Johanna M Anttila , Elsa Marques , Tiina Raatikainen , Mette Ilander , Henna Hakanen , Hanna Ala-Hongisto , Mariel Savelius , Diego Balboa , Bjoern Von Eyss , Vilja Eskelinen , Pauliina Munne , Anni I Nieminen , Timo Otonkoski , Julia Schüler , Teemu D Laajala , Tero Aittokallio , Harri Sihto , Johanna Mattson , Päivi Heikkilä , Marjut Leidenius , Heikki Joensuu , Satu Mustjoki , Panu Kovanen , Martin Eilers , Joel D Leverson , Juha Klefström

Novel therapeutic approaches for pleural mesothelioma identified by functional ex vivo drug sensitivity testing.

Lung cancer (Amsterdam, Netherlands)

Avec: Hely Ollila-Raj , Astrid Murumägi , Teijo Pellinen , Mariliina Arjama , Eva Sutinen , Kirsi Volmonen , Heidi M Haikala , Olli Kallioniemi , Mikko I Mäyränpää , Ilkka Ilonen

Inhibition of CDK12 elevates cancer cell dependence on P-TEFb by stimulation of RNA polymerase II pause release.

Nucleic acids research

Avec: Zhijia Wang , Samu V Himanen , Heidi M Haikala , Caroline C Friedel , Anniina Vihervaara , Matjaž Barborič

Ex vivo modeling of precision immuno-oncology responses in lung cancer.

Science advances

Avec: Bassel Alsaed , Johannes Smolander , Hanna Laitinen , Linh Lin , Nina Bobik , Lilja Lahtinen , Mikko Räsänen , Shadi Jansouz , Karita Peltonen , Emmi Jokinen , Jay Klievink , Keerthana Ganesh , Mari Ainola , Eva Sutinen , Mikko Rönty , Elli Narvi , Anil Thotakura , Pipsa Saharinen , Satu Mustjoki , Ilkka Ilonen , Heidi M Haikala

Treatment-Induced Tumor Dormancy through YAP-Mediated Transcriptional Reprogramming of the Apoptotic Pathway.

Cancer cell

Avec: Kari J Kurppa , Yao Liu , Ciric To , Tinghu Zhang , Mengyang Fan , Amir Vajdi , Erik H Knelson , Yingtian Xie , Klothilda Lim , Paloma Cejas , Andrew Portell , Patrick H Lizotte , Scott B Ficarro , Shuai Li , Ting Chen , Heidi M Haikala , Haiyun Wang , Magda Bahcall , Yang Gao , Sophia Shalhout , Steffen Boettcher , Bo Hee Shin , Tran Thai , Margaret K Wilkens , Michelle L Tillgren , Mierzhati Mushajiang , Man Xu , Jihyun Choi , Arrien A Bertram , Benjamin L Ebert , Rameen Beroukhim , Pratiti Bandopadhayay , Mark M Awad , Prafulla C Gokhale , Paul T Kirschmeier , Jarrod A Marto , Fernando D Camargo , Rizwan Haq , Cloud P Paweletz , Kwok-Kin Wong , David A Barbie , Henry W Long , Nathanael S Gray , Pasi A Jänne

Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy.

Nature communications

An allosteric inhibitor against the therapy-resistant mutant forms of EGFR in non-small cell lung cancer.

Nature cancer

Avec: Ciric To , Tyler S Beyett , Jaebong Jang , William W Feng , Magda Bahcall , Heidi M Haikala , Bo H Shin , David E Heppner , Jaimin K Rana , Brittaney A Leeper , Kara M Soroko , Michael J Poitras , Prafulla C Gokhale , Yoshihisa Kobayashi , Kamal Wahid , Kari J Kurppa , Thomas W Gero , Michael D Cameron , Atsuko Ogino , Mierzhati Mushajiang , Chunxiao Xu , Yanxi Zhang , David A Scott , Michael J Eck , Nathanael S Gray , Pasi A Jänne

Comparative Analysis and Isoform-Specific Therapeutic Vulnerabilities of KRAS Mutations in Non-Small Cell Lung Cancer.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Biagio Ricciuti , Jieun Son , Jeffrey J Okoro , Alessia Mira , Enrico Patrucco , Yoonji Eum , Xinan Wang , Raymond Paranal , Haiyun Wang , Mika Lin , Heidi M Haikala , Jiaqi Li , Yue Xu , Joao Victor Alessi , Chhayheng Chhoeu , Amanda J Redig , Jens Köhler , Kshiti H Dholakia , Yunhan Chen , Elodie Richard , Marie-Julie Nokin , David Santamaria , Prafulla C Gokhale , Mark M Awad , Pasi A Jänne , Chiara Ambrogio

A Novel HER2-Selective Kinase Inhibitor Is Effective in HER2 Mutant and Amplified Non-Small Cell Lung Cancer.

Cancer research

Avec: Jieun Son , Jaebong Jang , Tyler S Beyett , Yoonji Eum , Heidi M Haikala , Alyssa Verano , Mika Lin , John M Hatcher , Nicholas P Kwiatkowski , Pinar Ö Eser , Michael J Poitras , Stephen Wang , Man Xu , Prafulla C Gokhale , Michael D Cameron , Michael J Eck , Nathanael S Gray , Pasi A Jänne

Oncogenic switch and single-agent MET inhibitor sensitivity in a subset of

Science translational medicine

Avec: Pınar Özden Eser , Raymond M Paranal , Jieun Son , Elena Ivanova , Yanan Kuang , Heidi M Haikala , Ciric To , Jeffrey J Okoro , Kshiti H Dholakia , Jihyun Choi , Yoonji Eum , Atsuko Ogino , Pavlos Missios , Dalia Ercan , Man Xu , Michael J Poitras , Stephen Wang , Kenneth Ngo , Michael Dills , Masahiko Yanagita , Timothy Lopez , Mika Lin , Jeanelle Tsai , Nicolas Floch , Emily S Chambers , Jennifer Heng , Rana Anjum , Alison D Santucci , Kesi Michael , Alwin G Schuller , Darren Cross , Paul D Smith , Geoffrey R Oxnard , David A Barbie , Lynette M Sholl , Magda Bahcall , Sangeetha Palakurthi , Prafulla C Gokhale , Cloud P Paweletz , George Q Daley , Pasi A Jänne

Réseau de co-auteurs

Pasi A Jänne 7 collaborations

Prafulla C Gokhale 6 collaborations

Man Xu 4 collaborations

Juha Klefström 4 collaborations

Cloud P Paweletz 3 collaborations

Tero Aittokallio 3 collaborations

Martin Eilers 3 collaborations

Johanna M Anttila 3 collaborations

Satu Mustjoki 3 collaborations

Ciric To 3 collaborations

Magda Bahcall 3 collaborations

Nathanael S Gray 3 collaborations

Michael J Poitras 3 collaborations

Jieun Son 3 collaborations

Yoonji Eum 3 collaborations

Mika Lin 3 collaborations

Timothy Lopez 2 collaborations

Jens Köhler 2 collaborations

Kenneth Ngo 2 collaborations

Arrien A Bertram 2 collaborations

Brittaney A Leeper 2 collaborations

Emily S Chambers 2 collaborations

Paul T Kirschmeier 2 collaborations

Elsa Marques 2 collaborations

Tiina Raatikainen 2 collaborations

Mette Ilander 2 collaborations

Henna Hakanen 2 collaborations

Hanna Ala-Hongisto 2 collaborations

Mariel Savelius 2 collaborations

Diego Balboa 2 collaborations

Bjoern Von Eyss 2 collaborations

Vilja Eskelinen 2 collaborations

Pauliina Munne 2 collaborations

Anni I Nieminen 2 collaborations

Timo Otonkoski 2 collaborations

Julia Schüler 2 collaborations

Teemu D Laajala 2 collaborations

Harri Sihto 2 collaborations

Johanna Mattson 2 collaborations

Päivi Heikkilä 2 collaborations

Marjut Leidenius 2 collaborations

Heikki Joensuu 2 collaborations

Panu Kovanen 2 collaborations

Joel D Leverson 2 collaborations

Eva Sutinen 2 collaborations

Ilkka Ilonen 2 collaborations

Kari J Kurppa 2 collaborations

Haiyun Wang 2 collaborations

Mierzhati Mushajiang 2 collaborations

Jihyun Choi 2 collaborations

Mark M Awad 2 collaborations

David A Barbie 2 collaborations

Tyler S Beyett 2 collaborations

Jaebong Jang 2 collaborations

Michael D Cameron 2 collaborations

Atsuko Ogino 2 collaborations

Michael J Eck 2 collaborations

Jeffrey J Okoro 2 collaborations

Kshiti H Dholakia 2 collaborations

Stephen Wang 2 collaborations

Pinar O Eser 1 collaboration

Qing Zeng 1 collaboration

Tyler J Teceno 1 collaboration

Yutong Zhao 1 collaboration

Elena V Ivanova 1 collaboration

Anika E Adeni 1 collaboration

Luke J Taus 1 collaboration

Mari Kuraguchi 1 collaboration

Channing Yu 1 collaboration

Yoshinobu Shiose 1 collaboration

Yasuki Kamai 1 collaboration

Yang Qiu 1 collaboration

Xi Qiao 1 collaboration

Ying Liu 1 collaboration

Maria Llamazares Prada 1 collaboration

Aravind K Mohan 1 collaboration

Abhishekh Gupta 1 collaboration

Alok Jaiswal 1 collaboration

Mukund Sharma 1 collaboration

Joni Merisaari 1 collaboration

Kati Talvinen 1 collaboration

Laxman Yetukuri 1 collaboration

Joanna W Pylvänäinen 1 collaboration

Pauliina Kronqvist 1 collaboration

Annika Meinander 1 collaboration

Ville Hietakangas 1 collaboration

Jukka Westermarck 1 collaboration

Hussein Al-Akhrass 1 collaboration

Mika Pietilä 1 collaboration

Johanna Lilja 1 collaboration

Ella-Maria Vesilahti 1 collaboration

Pauliina M Munne 1 collaboration

Emilia Peuhu 1 collaboration

Johanna Ivaska 1 collaboration

Hely Ollila-Raj 1 collaboration

Astrid Murumägi 1 collaboration

Teijo Pellinen 1 collaboration

Mariliina Arjama 1 collaboration

Kirsi Volmonen 1 collaboration

Olli Kallioniemi 1 collaboration

Mikko I Mäyränpää 1 collaboration

Zhijia Wang 1 collaboration

Samu V Himanen 1 collaboration

Caroline C Friedel 1 collaboration

Anniina Vihervaara 1 collaboration

Matjaž Barborič 1 collaboration

Bassel Alsaed 1 collaboration

Johannes Smolander 1 collaboration

Hanna Laitinen 1 collaboration

Linh Lin 1 collaboration

Nina Bobik 1 collaboration

Lilja Lahtinen 1 collaboration

Mikko Räsänen 1 collaboration

Shadi Jansouz 1 collaboration

Karita Peltonen 1 collaboration

Emmi Jokinen 1 collaboration

Jay Klievink 1 collaboration

Keerthana Ganesh 1 collaboration

Mari Ainola 1 collaboration

Mikko Rönty 1 collaboration

Elli Narvi 1 collaboration

Anil Thotakura 1 collaboration

Pipsa Saharinen 1 collaboration

Yao Liu 1 collaboration

Tinghu Zhang 1 collaboration

Mengyang Fan 1 collaboration

Amir Vajdi 1 collaboration

Erik H Knelson 1 collaboration

Yingtian Xie 1 collaboration

Klothilda Lim 1 collaboration

Paloma Cejas 1 collaboration

Andrew Portell 1 collaboration

Patrick H Lizotte 1 collaboration

Scott B Ficarro 1 collaboration

Shuai Li 1 collaboration

Ting Chen 1 collaboration

Yang Gao 1 collaboration

Sophia Shalhout 1 collaboration

Steffen Boettcher 1 collaboration

Bo Hee Shin 1 collaboration

Tran Thai 1 collaboration

Margaret K Wilkens 1 collaboration

Michelle L Tillgren 1 collaboration

Benjamin L Ebert 1 collaboration

Rameen Beroukhim 1 collaboration

Pratiti Bandopadhayay 1 collaboration

Jarrod A Marto 1 collaboration

Fernando D Camargo 1 collaboration

Rizwan Haq 1 collaboration

Kwok-Kin Wong 1 collaboration

Henry W Long 1 collaboration

William W Feng 1 collaboration

Bo H Shin 1 collaboration

David E Heppner 1 collaboration

Jaimin K Rana 1 collaboration

Kara M Soroko 1 collaboration

Yoshihisa Kobayashi 1 collaboration

Kamal Wahid 1 collaboration

Thomas W Gero 1 collaboration

Chunxiao Xu 1 collaboration

Yanxi Zhang 1 collaboration

David A Scott 1 collaboration

Biagio Ricciuti 1 collaboration

Alessia Mira 1 collaboration

Enrico Patrucco 1 collaboration

Xinan Wang 1 collaboration

Raymond Paranal 1 collaboration

Jiaqi Li 1 collaboration

Yue Xu 1 collaboration

Joao Victor Alessi 1 collaboration

Chhayheng Chhoeu 1 collaboration

Amanda J Redig 1 collaboration

Yunhan Chen 1 collaboration

Elodie Richard 1 collaboration

Marie-Julie Nokin 1 collaboration

David Santamaria 1 collaboration

Chiara Ambrogio 1 collaboration

Alyssa Verano 1 collaboration

John M Hatcher 1 collaboration

Nicholas P Kwiatkowski 1 collaboration

Pinar Ö Eser 1 collaboration

Pınar Özden Eser 1 collaboration

Raymond M Paranal 1 collaboration

Elena Ivanova 1 collaboration

Yanan Kuang 1 collaboration

Pavlos Missios 1 collaboration

Dalia Ercan 1 collaboration

Michael Dills 1 collaboration

Masahiko Yanagita 1 collaboration

Jeanelle Tsai 1 collaboration

Nicolas Floch 1 collaboration

Jennifer Heng 1 collaboration

Rana Anjum 1 collaboration

Alison D Santucci 1 collaboration

Kesi Michael 1 collaboration

Alwin G Schuller 1 collaboration

Darren Cross 1 collaboration

Paul D Smith 1 collaboration

Geoffrey R Oxnard 1 collaboration

Lynette M Sholl 1 collaboration

Sangeetha Palakurthi 1 collaboration

George Q Daley 1 collaboration