Gary Kleiger

Affiliations

Department of Chemistry and Biochemistry, University of Nevada, Las Vegas, Las Vegas, NV, U.S.A.

ORCID: 0000-0003-3924-1680

Publications (12)

Catalysis of non-canonical protein ubiquitylation by the ARIH1 ubiquitin ligase.

The Biochemical journal

Avec: Nicholas Purser , Ishita Tripathi-Giesgen , Jerry Li , Daniel C Scott , Daniel Horn-Ghetko , Kheewoong Baek , Brenda A Schulman , Arno F Alpi , Gary Kleiger

Linkage-specific ubiquitin chain formation depends on a lysine hydrocarbon ruler.

Nature chemical biology

Avec: Joanna Liwocha , David T Krist , Gerbrand J van der Heden van Noort , Fynn M Hansen , Vinh H Truong , Ozge Karayel , Nicholas Purser , Daniel Houston , Nicole Burton , Mark J Bostock , Michael Sattler , Matthias Mann , Joseph S Harrison , Gary Kleiger , Huib Ovaa , Brenda A Schulman

Multisite phosphorylation dictates selective E2-E3 pairing as revealed by Ubc8/UBE2H-GID/CTLH assemblies.

Molecular cell

Avec: Jakub Chrustowicz , Dawafuti Sherpa , Jerry Li , Christine R Langlois , Eleftheria C Papadopoulou , D Tung Vu , Laura A Hehl , Özge Karayel , Viola Beier , Susanne von Gronau , Judith Müller , J Rajan Prabu , Matthias Mann , Gary Kleiger , Arno F Alpi , Brenda A Schulman

The extent of Ssa1/Ssa2 Hsp70 chaperone involvement in nuclear protein quality control degradation varies with the substrate.

Molecular biology of the cell

Avec: Ramon D Jones , Charisma Enam , Rebeca Ibarra , Heather R Borror , Kaitlyn E Mostoller , Eric K Fredrickson , JiaBei Lin , Edward Chuang , Zachary March , James Shorter , Tommer Ravid , Gary Kleiger , Richard G Gardner

Robust cullin-RING ligase function is established by a multiplicity of poly-ubiquitylation pathways.

eLife

Avec: Spencer Hill , Kurt Reichermeier , Daniel C Scott , Lorena Samentar , Jasmin Coulombe-Huntington , Luisa Izzi , Xiaojing Tang , Rebeca Ibarra , Thierry Bertomeu , Annie Moradian , Michael J Sweredoski , Nora Caberoy , Brenda A Schulman , Frank Sicheri , Mike Tyers , Gary Kleiger

NEDD8 nucleates a multivalent cullin-RING-UBE2D ubiquitin ligation assembly.

Nature

Avec: Kheewoong Baek , David T Krist , J Rajan Prabu , Spencer Hill , Maren Klügel , Lisa-Marie Neumaier , Susanne von Gronau , Gary Kleiger , Brenda A Schulman

The San1 Ubiquitin Ligase Avidly Recognizes Misfolded Proteins through Multiple Substrate Binding Sites.

Biomolecules

Avec: Rebeca Ibarra , Heather R Borror , Bryce Hart , Richard G Gardner , Gary Kleiger

Ubiquitin ligation to F-box protein targets by SCF-RBR E3-E3 super-assembly.

Nature

Avec: Daniel Horn-Ghetko , David T Krist , J Rajan Prabu , Kheewoong Baek , Monique P C Mulder , Maren Klügel , Daniel C Scott , Huib Ovaa , Gary Kleiger , Brenda A Schulman

Cullin-RING ligases employ geometrically optimized catalytic partners for substrate targeting.

Molecular cell

Avec: Jerry Li , Nicholas Purser , Joanna Liwocha , Daniel C Scott , Holly A Byers , Barbara Steigenberger , Spencer Hill , Ishita Tripathi-Giesgen , Trent Hinkle , Fynn M Hansen , J Rajan Prabu , Senthil K Radhakrishnan , Donald S Kirkpatrick , Kurt M Reichermeier , Brenda A Schulman , Gary Kleiger

Mechanism of millisecond Lys48-linked poly-ubiquitin chain formation by cullin-RING ligases.

Nature structural & molecular biology

Avec: Joanna Liwocha , Jerry Li , Nicholas Purser , Chutima Rattanasopa , Samuel Maiwald , David T Krist , Daniel C Scott , Barbara Steigenberger , J Rajan Prabu , Brenda A Schulman , Gary Kleiger

E3 ligase autoinhibition by C-degron mimicry maintains C-degron substrate fidelity.

Molecular cell

Avec: Daniel C Scott , Moeko T King , Kheewoong Baek , Clifford T Gee , Ravi Kalathur , Jerry Li , Nicholas Purser , Amanda Nourse , Sergio C Chai , Sivaraja Vaithiyalingam , Taosheng Chen , Richard E Lee , Stephen J Elledge , Gary Kleiger , Brenda A Schulman

Design of linked-domain protein inhibitors of UBE2D as tools to study cellular ubiquitination.

bioRxiv : the preprint server for biology

Avec: Zara Bukhari , Li Gu , Anneroos E Nederstigt , Logan J Cope , Derek L Bolhuis , Kim Harvey , Tristan Allen , Spencer Hill , Yujie Yang , Guy Lawson , Cai Lu , Tommy Tran , Leah Pineda , Leanne Low , Andrew Chiang , Jason Song , Michelle V Fong , Vanessa M Rangel , William K Chan , Gary Kleiger , Dennis Goldfarb , Craig A Vierra , Nicholas G Brown , Joseph S Harrison

Réseau de co-auteurs

Brenda A Schulman 9 collaborations

Daniel C Scott 6 collaborations

Nicholas Purser 5 collaborations

Jerry Li 5 collaborations

J Rajan Prabu 5 collaborations

Kheewoong Baek 4 collaborations

David T Krist 4 collaborations

Spencer Hill 4 collaborations

Joanna Liwocha 3 collaborations

Rebeca Ibarra 3 collaborations

Ishita Tripathi-Giesgen 2 collaborations

Daniel Horn-Ghetko 2 collaborations

Arno F Alpi 2 collaborations

Fynn M Hansen 2 collaborations

Matthias Mann 2 collaborations

Joseph S Harrison 2 collaborations

Huib Ovaa 2 collaborations

Susanne von Gronau 2 collaborations

Heather R Borror 2 collaborations

Richard G Gardner 2 collaborations

Maren Klügel 2 collaborations

Barbara Steigenberger 2 collaborations

Gerbrand J van der Heden van Noort 1 collaboration

Vinh H Truong 1 collaboration

Ozge Karayel 1 collaboration

Daniel Houston 1 collaboration

Nicole Burton 1 collaboration

Mark J Bostock 1 collaboration

Michael Sattler 1 collaboration

Jakub Chrustowicz 1 collaboration

Dawafuti Sherpa 1 collaboration

Christine R Langlois 1 collaboration

Eleftheria C Papadopoulou 1 collaboration

D Tung Vu 1 collaboration

Laura A Hehl 1 collaboration

Özge Karayel 1 collaboration

Viola Beier 1 collaboration

Judith Müller 1 collaboration

Ramon D Jones 1 collaboration

Charisma Enam 1 collaboration

Kaitlyn E Mostoller 1 collaboration

Eric K Fredrickson 1 collaboration

JiaBei Lin 1 collaboration

Edward Chuang 1 collaboration

Zachary March 1 collaboration

James Shorter 1 collaboration

Tommer Ravid 1 collaboration

Kurt Reichermeier 1 collaboration

Lorena Samentar 1 collaboration

Jasmin Coulombe-Huntington 1 collaboration

Luisa Izzi 1 collaboration

Xiaojing Tang 1 collaboration

Thierry Bertomeu 1 collaboration

Annie Moradian 1 collaboration

Michael J Sweredoski 1 collaboration

Nora Caberoy 1 collaboration

Frank Sicheri 1 collaboration

Mike Tyers 1 collaboration

Lisa-Marie Neumaier 1 collaboration

Bryce Hart 1 collaboration

Monique P C Mulder 1 collaboration

Holly A Byers 1 collaboration

Trent Hinkle 1 collaboration

Senthil K Radhakrishnan 1 collaboration

Donald S Kirkpatrick 1 collaboration

Kurt M Reichermeier 1 collaboration

Chutima Rattanasopa 1 collaboration

Samuel Maiwald 1 collaboration

Moeko T King 1 collaboration

Clifford T Gee 1 collaboration

Ravi Kalathur 1 collaboration

Amanda Nourse 1 collaboration

Sergio C Chai 1 collaboration

Sivaraja Vaithiyalingam 1 collaboration

Taosheng Chen 1 collaboration

Richard E Lee 1 collaboration

Stephen J Elledge 1 collaboration

Zara Bukhari 1 collaboration

Li Gu 1 collaboration

Anneroos E Nederstigt 1 collaboration

Logan J Cope 1 collaboration

Derek L Bolhuis 1 collaboration

Kim Harvey 1 collaboration

Tristan Allen 1 collaboration

Yujie Yang 1 collaboration

Guy Lawson 1 collaboration

Cai Lu 1 collaboration

Tommy Tran 1 collaboration

Leah Pineda 1 collaboration

Leanne Low 1 collaboration

Andrew Chiang 1 collaboration

Jason Song 1 collaboration

Michelle V Fong 1 collaboration

Vanessa M Rangel 1 collaboration

William K Chan 1 collaboration

Dennis Goldfarb 1 collaboration

Craig A Vierra 1 collaboration

Nicholas G Brown 1 collaboration