Donald S Backos

Affiliations

Department of Pharmaceutical Sciences, Skaggs School of Pharmacy and Pharmaceutical Sciences, University of Colorado Anschutz Medical Campus, 12850 East Montview Boulevard, Aurora, CO, 80045, USA.

Publications (16)

Molecular docking of substituted pteridinones and pyrimidines to the ATP-binding site of the N-terminal domain of RSK2 and associated MM/GBSA and molecular field datasets.

Data in brief

Avec: Kimberly A Casalvieri , Christopher J Matheson , Donald S Backos , Philip Reigan

Evaluation of Thymidine Phosphorylase Inhibitors in Glioblastoma and Their Capacity for Temozolomide Potentiation.

ACS chemical neuroscience

Avec: Becka M Warfield , Christopher J Matheson , Debbie G McArthur , Donald S Backos , Philip Reigan

4-Hydroxy-2-nonenal attenuates 8-oxoguanine DNA glycosylase 1 activity.

Journal of cellular biochemistry

Avec: Guodong Pan , Mandar Deshpande , Haiyan Pang , Paul M Stemmer , Nicholas J Carruthers , Colin T Shearn , Donald S Backos , Suresh S Palaniyandi

Persistent, Progressive Pulmonary Fibrosis and Epithelial Remodeling in Mice.

American journal of respiratory cell and molecular biology

Avec: Elizabeth F Redente , Bart P Black , Donald S Backos , Ali N Bahadur , Stephen M Humphries , David A Lynch , Rubin M Tuder , Rachel L Zemans , David W H Riches

Deglutarylation of glutaryl-CoA dehydrogenase by deacylating enzyme SIRT5 promotes lysine oxidation in mice.

The Journal of biological chemistry

Avec: Dhaval P Bhatt , C Allie Mills , Kristin A Anderson , Bárbara J Henriques , Tânia G Lucas , Sara Francisco , Juan Liu , Olga R Ilkayeva , Alexander E Adams , Shreyas R Kulkarni , Donald S Backos , Michael B Major , Paul A Grimsrud , Cláudio M Gomes , Matthew D Hirschey

10-Alkoxy-anthracenyl-isoxazole analogs have sub-micromolar activity against a Glioblastoma multiforme cell line.

Bioorganic & medicinal chemistry

Avec: Nathan S Duncan , Michael J Campbell , Donald S Backos , Chun Li , Kevin C Rider , Sascha Stump , Matthew J Weaver , Mariusz P Gajewski , Howard D Beall , Philip Reigan , Nicholas R Natale

The Lateral Metalation of Isoxazolo[3,4-

Molecules (Basel, Switzerland)

Avec: Christina A Gates , Donald S Backos , Philip Reigan , Nicholas R Natale

Characterization and Optimization of the Novel Transient Receptor Potential Melastatin 2 Antagonist tatM2NX.

Molecular pharmacology

Avec: I Cruz-Torres , D S Backos , P S Herson

N-Substituted pyrrolopyrimidines and purines as p90 ribosomal S6 protein kinase-2 (RSK2) inhibitors.

Bioorganic & medicinal chemistry

Avec: Kimberly A Casalvieri , Christopher J Matheson , Becka M Warfield , Donald S Backos , Philip Reigan

Statin therapy inhibits fatty acid synthase via dynamic protein modifications.

Nature communications

Avec: Alec G Trub , Gregory R Wagner , Kristin A Anderson , Scott B Crown , Guo-Fang Zhang , J Will Thompson , Olga R Ilkayeva , Robert D Stevens , Paul A Grimsrud , Rhushikesh A Kulkarni , Donald S Backos , Jordan L Meier , Matthew D Hirschey

Iloprost requires the Frizzled-9 receptor to prevent lung cancer.

iScience

Avec: Kayla Sompel , Lori D Dwyer-Nield , Alex J Smith , Alamelu Elango , Don S Backos , Bicheng Zhang , James Gross , Kristina Ternyak , Jennifer L Matsuda , Katrina Kopf , Robert L Keith , Meredith A Tennis

10-N-heterocylic aryl-isoxazole-amides (AIMs) have robust anti-tumor activity against breast and brain cancer cell lines and useful fluorescence properties.

Bioorganic & medicinal chemistry

Avec: Matthew J Weaver , Sascha Stump , Michael J Campbell , Donald S Backos , Chun Li , Philip Reigan , Earle Adams , Howard D Beall , Nicholas R Natale

Computational Modeling of NLRP3 Identifies Enhanced ATP Binding and Multimerization in Cryopyrin-Associated Periodic Syndromes.

Frontiers in immunology

Avec: Jenny Mae Samson , Dinoop Ravindran Menon , Prasanna K Vaddi , Nazanin Kalani Williams , Joanne Domenico , Zili Zhai , Donald S Backos , Mayumi Fujita

Substituted pteridinones as p90 ribosomal S6 protein kinase (RSK) inhibitors: A structure-activity study.

Bioorganic & medicinal chemistry

Avec: Kimberly A Casalvieri , Christopher J Matheson , Donald S Backos , Philip Reigan

Substituted oxindol-3-ylidenes as AMP-activated protein kinase (AMPK) inhibitors.

European journal of medicinal chemistry

Avec: Christopher J Matheson , Kimberly A Casalvieri , Donald S Backos , Mohammed Minhajuddin , Craig T Jordan , Philip Reigan

Substituted pteridinones, pyrimidines, pyrrolopyrimidines, and purines as p90 ribosomal S6 protein kinase-2 (RSK2) inhibitors: Pharmacophore modeling data.

Data in brief

Avec: Becka M Warfield , Kimberly A Casalvieri , Christopher J Matheson , Donald S Backos , Philip Reigan

Réseau de co-auteurs

Philip Reigan 9 collaborations

Christopher J Matheson 6 collaborations

Kimberly A Casalvieri 5 collaborations

Becka M Warfield 3 collaborations

Nicholas R Natale 3 collaborations

Kristin A Anderson 2 collaborations

Olga R Ilkayeva 2 collaborations

Paul A Grimsrud 2 collaborations

Matthew D Hirschey 2 collaborations

Michael J Campbell 2 collaborations

Chun Li 2 collaborations

Sascha Stump 2 collaborations

Matthew J Weaver 2 collaborations

Howard D Beall 2 collaborations

Debbie G McArthur 1 collaboration

Guodong Pan 1 collaboration

Mandar Deshpande 1 collaboration

Haiyan Pang 1 collaboration

Paul M Stemmer 1 collaboration

Nicholas J Carruthers 1 collaboration

Colin T Shearn 1 collaboration

Suresh S Palaniyandi 1 collaboration

Elizabeth F Redente 1 collaboration

Bart P Black 1 collaboration

Ali N Bahadur 1 collaboration

Stephen M Humphries 1 collaboration

David A Lynch 1 collaboration

Rubin M Tuder 1 collaboration

Rachel L Zemans 1 collaboration

David W H Riches 1 collaboration

Dhaval P Bhatt 1 collaboration

C Allie Mills 1 collaboration

Bárbara J Henriques 1 collaboration

Tânia G Lucas 1 collaboration

Sara Francisco 1 collaboration

Juan Liu 1 collaboration

Alexander E Adams 1 collaboration

Shreyas R Kulkarni 1 collaboration

Michael B Major 1 collaboration

Cláudio M Gomes 1 collaboration

Nathan S Duncan 1 collaboration

Kevin C Rider 1 collaboration

Mariusz P Gajewski 1 collaboration

Christina A Gates 1 collaboration

I Cruz-Torres 1 collaboration

D S Backos 1 collaboration

P S Herson 1 collaboration

Alec G Trub 1 collaboration

Gregory R Wagner 1 collaboration

Scott B Crown 1 collaboration

Guo-Fang Zhang 1 collaboration

J Will Thompson 1 collaboration

Robert D Stevens 1 collaboration

Rhushikesh A Kulkarni 1 collaboration

Jordan L Meier 1 collaboration

Kayla Sompel 1 collaboration

Lori D Dwyer-Nield 1 collaboration

Alex J Smith 1 collaboration

Alamelu Elango 1 collaboration

Don S Backos 1 collaboration

Bicheng Zhang 1 collaboration

James Gross 1 collaboration

Kristina Ternyak 1 collaboration

Jennifer L Matsuda 1 collaboration

Katrina Kopf 1 collaboration

Robert L Keith 1 collaboration

Meredith A Tennis 1 collaboration

Earle Adams 1 collaboration

Jenny Mae Samson 1 collaboration

Dinoop Ravindran Menon 1 collaboration

Prasanna K Vaddi 1 collaboration

Nazanin Kalani Williams 1 collaboration

Joanne Domenico 1 collaboration

Zili Zhai 1 collaboration

Mayumi Fujita 1 collaboration

Mohammed Minhajuddin 1 collaboration

Craig T Jordan 1 collaboration