Daniel P Rakiec

Affiliations

Oncology, Novartis Institutes for BioMedical Research, Cambridge, Massachusetts.

Publications (7)

RAF-Mutant Melanomas Differentially Depend on ERK2 Over ERK1 to Support Aberrant MAPK Pathway Activation and Cell Proliferation.

Molecular cancer research : MCR

Avec: Matthew S Crowe , Tatiana Zavorotinskaya , Charles F Voliva , Matthew D Shirley , Yanqun Wang , David A Ruddy , Daniel P Rakiec , Jeffery A Engelman , Darrin D Stuart , Alyson K Freeman

A Proof of Concept for Biomarker-Guided Targeted Therapy against Ovarian Cancer Based on Patient-Derived Tumor Xenografts.

Cancer research

Avec: Adam C Palmer , Deborah Plana , Hui Gao , Joshua M Korn , Guizhi Yang , John Green , Xiamei Zhang , Roberto Velazquez , Margaret E McLaughlin , David A Ruddy , Colleen Kowal , Julie Muszynski , Caroline Bullock , Stacy Rivera , Daniel P Rakiec , GiNell Elliott , Paul Fordjour , Ronald Meyer , Alice Loo , Esther Kurth , Jeffrey A Engelman , Hans Bitter , William R Sellers , Juliet A Williams , Peter K Sorger

Targeting FGFR overcomes EMT-mediated resistance in EGFR mutant non-small cell lung cancer.

Oncogene

Avec: Sana Raoof , Iain J Mulford , Heidie Frisco-Cabanos , Varuna Nangia , Daria Timonina , Emma Labrot , Nafeeza Hafeez , Samantha J Bilton , Yotam Drier , Fei Ji , Max Greenberg , August Williams , Krystina Kattermann , Leah Damon , Sosathya Sovath , Daniel P Rakiec , Joshua M Korn , David A Ruddy , Cyril H Benes , Peter S Hammerman , Zofia Piotrowska , Lecia V Sequist , Matthew J Niederst , Jordi Barretina , Jeffrey A Engelman , Aaron N Hata

Distinct Transcriptional Programming Drive Response to MAPK Inhibition in

Molecular cancer therapeutics

Avec: Tianshu Feng , Javad Golji , Ailing Li , Xiamei Zhang , David A Ruddy , Daniel P Rakiec , Felipe C Geyer , Jane Gu , Hui Gao , Juliet A Williams , Darrin D Stuart , Matthew J Meyer

The Lineage Determining Factor GRHL2 Collaborates with FOXA1 to Establish a Targetable Pathway in Endocrine Therapy-Resistant Breast Cancer.

Cell reports

Avec: Kimberly J Cocce , Jeff S Jasper , Taylor K Desautels , Logan Everett , Suzanne Wardell , Thomas Westerling , Robert Baldi , Tricia M Wright , Kendall Tavares , Alex Yllanes , Yeeun Bae , Jeremy T Blitzer , Craig Logsdon , Daniel P Rakiec , David A Ruddy , Tiancong Jiang , Gloria Broadwater , Terry Hyslop , Allison Hall , Muriel Laine , Linda Phung , Geoffrey L Greene , Lesley-Ann Martin , Sunil Pancholi , Mitch Dowsett , Simone Detre , Jeffrey R Marks , Gregory E Crawford , Myles Brown , John D Norris , Ching-Yi Chang , Donald P McDonnell

Hyperactivation of MAPK Signaling Is Deleterious to RAS/RAF-mutant Melanoma.

Molecular cancer research : MCR

Avec: Grace P Leung , Tianshu Feng , Frederic D Sigoillot , Felipe C Geyer , Matthew D Shirley , David A Ruddy , Daniel P Rakiec , Alyson K Freeman , Jeffrey A Engelman , Mariela Jaskelioff , Darrin D Stuart

Tumor-derived IFN triggers chronic pathway agonism and sensitivity to ADAR loss.

Nature medicine

Avec: Huayang Liu , Javad Golji , Lauren K Brodeur , Franklin S Chung , Julie T Chen , Rosalie S deBeaumont , Caroline P Bullock , Michael D Jones , Grainne Kerr , Li Li , Daniel P Rakiec , Michael R Schlabach , Sosathya Sovath , Joseph D Growney , Raymond A Pagliarini , David A Ruddy , Kenzie D MacIsaac , Joshua M Korn , E Robert McDonald

Réseau de co-auteurs

David A Ruddy 7 collaborations

Darrin D Stuart 3 collaborations

Joshua M Korn 3 collaborations

Jeffrey A Engelman 3 collaborations

Matthew D Shirley 2 collaborations

Alyson K Freeman 2 collaborations

Hui Gao 2 collaborations

Xiamei Zhang 2 collaborations

Juliet A Williams 2 collaborations

Sosathya Sovath 2 collaborations

Tianshu Feng 2 collaborations

Javad Golji 2 collaborations

Felipe C Geyer 2 collaborations

Matthew S Crowe 1 collaboration

Tatiana Zavorotinskaya 1 collaboration

Charles F Voliva 1 collaboration

Yanqun Wang 1 collaboration

Jeffery A Engelman 1 collaboration

Adam C Palmer 1 collaboration

Deborah Plana 1 collaboration

Guizhi Yang 1 collaboration

John Green 1 collaboration

Roberto Velazquez 1 collaboration

Margaret E McLaughlin 1 collaboration

Colleen Kowal 1 collaboration

Julie Muszynski 1 collaboration

Caroline Bullock 1 collaboration

Stacy Rivera 1 collaboration

GiNell Elliott 1 collaboration

Paul Fordjour 1 collaboration

Ronald Meyer 1 collaboration

Alice Loo 1 collaboration

Esther Kurth 1 collaboration

Hans Bitter 1 collaboration

William R Sellers 1 collaboration

Peter K Sorger 1 collaboration

Sana Raoof 1 collaboration

Iain J Mulford 1 collaboration

Heidie Frisco-Cabanos 1 collaboration

Varuna Nangia 1 collaboration

Daria Timonina 1 collaboration

Emma Labrot 1 collaboration

Nafeeza Hafeez 1 collaboration

Samantha J Bilton 1 collaboration

Yotam Drier 1 collaboration

Fei Ji 1 collaboration

Max Greenberg 1 collaboration

August Williams 1 collaboration

Krystina Kattermann 1 collaboration

Leah Damon 1 collaboration

Cyril H Benes 1 collaboration

Peter S Hammerman 1 collaboration

Zofia Piotrowska 1 collaboration

Lecia V Sequist 1 collaboration

Matthew J Niederst 1 collaboration

Jordi Barretina 1 collaboration

Aaron N Hata 1 collaboration

Ailing Li 1 collaboration

Jane Gu 1 collaboration

Matthew J Meyer 1 collaboration

Kimberly J Cocce 1 collaboration

Jeff S Jasper 1 collaboration

Taylor K Desautels 1 collaboration

Logan Everett 1 collaboration

Suzanne Wardell 1 collaboration

Thomas Westerling 1 collaboration

Robert Baldi 1 collaboration

Tricia M Wright 1 collaboration

Kendall Tavares 1 collaboration

Alex Yllanes 1 collaboration

Yeeun Bae 1 collaboration

Jeremy T Blitzer 1 collaboration

Craig Logsdon 1 collaboration

Tiancong Jiang 1 collaboration

Gloria Broadwater 1 collaboration

Terry Hyslop 1 collaboration

Allison Hall 1 collaboration

Muriel Laine 1 collaboration

Linda Phung 1 collaboration

Geoffrey L Greene 1 collaboration

Lesley-Ann Martin 1 collaboration

Sunil Pancholi 1 collaboration

Mitch Dowsett 1 collaboration

Simone Detre 1 collaboration

Jeffrey R Marks 1 collaboration

Gregory E Crawford 1 collaboration

Myles Brown 1 collaboration

John D Norris 1 collaboration

Ching-Yi Chang 1 collaboration

Donald P McDonnell 1 collaboration

Grace P Leung 1 collaboration

Frederic D Sigoillot 1 collaboration

Mariela Jaskelioff 1 collaboration

Huayang Liu 1 collaboration

Lauren K Brodeur 1 collaboration

Franklin S Chung 1 collaboration

Julie T Chen 1 collaboration

Rosalie S deBeaumont 1 collaboration

Caroline P Bullock 1 collaboration

Michael D Jones 1 collaboration

Grainne Kerr 1 collaboration

Li Li 1 collaboration

Michael R Schlabach 1 collaboration

Joseph D Growney 1 collaboration

Raymond A Pagliarini 1 collaboration

Kenzie D MacIsaac 1 collaboration

E Robert McDonald 1 collaboration