Charles D Imbusch

Affiliations

Division of Applied Bioinformatics, German Cancer Research Center (DKFZ), Im Neuenheimer Feld 280, 69120 Heidelberg, Germany.

Publications (17)

Chronic chromosome instability induced by Plk1 results in immune suppression in breast cancer.

Cell reports

Avec: Sridhar Kandala , Maria Ramos , Lena Voith von Voithenberg , Alberto Diaz-Jimenez , Sara Chocarro , Johanna Keding , Benedikt Brors , Charles D Imbusch , Rocio Sotillo

Single-cell chromatin accessibility and transposable element landscapes reveal shared features of tissue-residing immune cells.

Immunity

Avec: Malte Simon , Philipp Stüve , Lisa Schmidleithner , Sebastian Bittner , Niklas Beumer , Nicholas Strieder , Christian Schmidl , Asmita Pant , Claudia Gebhard , Andreas Eigenberger , Michael Rehli , Lukas Prantl , Thomas Hehlgans , Benedikt Brors , Charles D Imbusch , Michael Delacher , Markus Feuerer

Aggressive PDACs Show Hypomethylation of Repetitive Elements and the Execution of an Intrinsic IFN Program Linked to a Ductal Cell of Origin.

Cancer discovery

Avec: Elisa Espinet , Zuguang Gu , Charles D Imbusch , Nathalia A Giese , Magdalena Büscher , Mariam Safavi , Silke Weisenburger , Corinna Klein , Vanessa Vogel , Mattia Falcone , Jacob Insua-Rodríguez , Manuel Reitberger , Vera Thiel , Steffi O Kossi , Alexander Muckenhuber , Karnjit Sarai , Alex Y L Lee , Elyne Backx , Soheila Zarei , Matthias M Gaida , Manuel Rodríguez-Paredes , Elisa Donato , Hsi-Yu Yen , Roland Eils , Matthias Schlesner , Nicole Pfarr , Thilo Hackert , Christoph Plass , Benedikt Brors , Katja Steiger , Dieter Weichenhan , H Efsun Arda , Ilse Rooman , Janel L Kopp , Oliver Strobel , Wilko Weichert , Martin R Sprick , Andreas Trumpp

Rbpj expression in regulatory T cells is critical for restraining T

Nature communications

Avec: Michael Delacher , Christian Schmidl , Yonatan Herzig , Minka Breloer , Wiebke Hartmann , Fabian Brunk , Danny Kägebein , Ulrike Träger , Ann-Cathrin Hofer , Sebastian Bittner , Dieter Weichenhan , Charles D Imbusch , Agnes Hotz-Wagenblatt , Thomas Hielscher , Achim Breiling , Giuseppina Federico , Hermann-Josef Gröne , Roland M Schmid , Michael Rehli , Jakub Abramson , Markus Feuerer

Integrated single-cell profiling dissects cell-state-specific enhancer landscapes of human tumor-infiltrating CD8

Molecular cell

Avec: Dania Riegel , Elena Romero-Fernández , Malte Simon , Akinbami Raphael Adenugba , Katrin Singer , Roman Mayr , Florian Weber , Mark Kleemann , Charles D Imbusch , Marina Kreutz , Benedikt Brors , Ines Ugele , Jens M Werner , Peter J Siska , Christian Schmidl

Precursors for Nonlymphoid-Tissue Treg Cells Reside in Secondary Lymphoid Organs and Are Programmed by the Transcription Factor BATF.

Immunity

Avec: Michael Delacher , Charles D Imbusch , Agnes Hotz-Wagenblatt , Jan-Philipp Mallm , Katharina Bauer , Malte Simon , Dania Riegel , André F Rendeiro , Sebastian Bittner , Lieke Sanderink , Asmita Pant , Lisa Schmidleithner , Kathrin L Braband , Bernd Echtenachter , Alexander Fischer , Valentina Giunchiglia , Petra Hoffmann , Matthias Edinger , Christoph Bock , Michael Rehli , Benedikt Brors , Christian Schmidl , Markus Feuerer

Single-cell chromatin accessibility landscape identifies tissue repair program in human regulatory T cells.

Immunity

Avec: Michael Delacher , Malte Simon , Lieke Sanderink , Agnes Hotz-Wagenblatt , Marina Wuttke , Kathrin Schambeck , Lisa Schmidleithner , Sebastian Bittner , Asmita Pant , Uwe Ritter , Thomas Hehlgans , Dania Riegel , Verena Schneider , Florian Kai Groeber-Becker , Andreas Eigenberger , Claudia Gebhard , Nicholas Strieder , Alexander Fischer , Michael Rehli , Petra Hoffmann , Matthias Edinger , Till Strowig , Jochen Huehn , Christian Schmidl , Jens M Werner , Lukas Prantl , Benedikt Brors , Charles D Imbusch , Markus Feuerer

Lorlatinib Induces Durable Disease Stabilization in a Pancreatic Cancer Patient with a ROS1 p.L1950F Mutation: Case Report.

Oncology research and treatment

Avec: Janna-Lisa Velthaus , Peter Iglauer , Ronald Simon , Carsten Bokemeyer , Peter Bannas , Niklas Beumer , Charles D Imbusch , Eray Goekkurt , Sonja Loges

Pathologic responses in oligometastatic NSCLC patients treated with neoadjuvant immune checkpoint blockade with and without chemotherapy followed by surgery.

Lung cancer (Amsterdam, Netherlands)

Avec: Tobias Boch , Nikolaj Frost , Linna Sommer , Tobias R Overbeck , Christoph T Michaeli , Chrisoph J Szuszies , Lisa-Marie Rieckmann , Niklas Beumer , Charles D Imbusch , Hauke Winter , Michael Thomas , Julia Roeper , Melanie Janning , Frank Griesinger , Martin Wermke , Sonja Loges

The effector program of human CD8 T cells supports tissue remodeling.

The Journal of experimental medicine

Avec: Michael Delacher , Lisa Schmidleithner , Malte Simon , Philipp Stüve , Lieke Sanderink , Agnes Hotz-Wagenblatt , Marina Wuttke , Kathrin Schambeck , Brigitte Ruhland , Veronika Hofmann , Sebastian Bittner , Uwe Ritter , Asmita Pant , Sara Salome Helbich , Morten Voss , Niels A Lemmermann , Lisa Bessiri-Schake , Toszka Bohn , Andreas Eigenberger , Ayse Nur Menevse , Claudia Gebhard , Nicholas Strieder , Hinrich Abken , Michael Rehli , Jochen Huehn , Philipp Beckhove , Thomas Hehlgans , Henrik Junger , Edward K Geissler , Lukas Prantl , Jens M Werner , Christian Schmidl , Benedikt Brors , Charles D Imbusch , Markus Feuerer

Quantitative Proteomics Identifies TCF1 as a Negative Regulator of Foxp3 Expression in Conventional T Cells.

iScience

Avec: Michael Delacher , Melanie M Barra , Yonatan Herzig , Katrin Eichelbaum , Mahmoud-Reza Rafiee , David M Richards , Ulrike Träger , Ann-Cathrin Hofer , Alexander Kazakov , Kathrin L Braband , Marina Gonzalez , Lukas Wöhrl , Kathrin Schambeck , Charles D Imbusch , Jakub Abramson , Jeroen Krijgsveld , Markus Feuerer

Generation of Whole Genome Bisulfite Sequencing Libraries from Very Low DNA Input.

Methods in molecular biology (Clifton, N.J.)

Avec: Dieter Weichenhan , Charles D Imbusch , Qi Wang , Benedikt Brors , Christoph Plass

Deconvolution of sarcoma methylomes reveals varying degrees of immune cell infiltrates with association to genomic aberrations.

Journal of translational medicine

Avec: Malte Simon , Sadaf S Mughal , Peter Horak , Sebastian Uhrig , Jonas Buchloh , Bogac Aybey , Albrecht Stenzinger , Hanno Glimm , Stefan Fröhling , Benedikt Brors , Charles D Imbusch

Spatially Resolved Multi-Omics Single-Cell Analyses Inform Mechanisms of Immune Dysfunction in Pancreatic Cancer.

Gastroenterology

Avec: Suhail Yousuf , Mengjie Qiu , Lena Voith von Voithenberg , Johannes Hulkkonen , Igor Macinkovic , Axel R Schulz , Domenic Hartmann , Florian Mueller , Margarete Mijatovic , David Ibberson , Karam T AlHalabi , Jenny Hetzer , Simon Anders , Bernhard Brüne , Henrik E Mei , Charles D Imbusch , Benedikt Brors , Mathias Heikenwälder , Matthias M Gaida , Markus W Büchler , Andreas Weigert , Thilo Hackert , Susanne Roth

High-resolution transcriptomic and epigenetic profiling identifies novel regulators of COPD.

The EMBO journal

Avec: Uwe Schwartz , Maria Llamazares Prada , Stephanie T Pohl , Mandy Richter , Raluca Tamas , Michael Schuler , Corinna Keller , Vedrana Mijosek , Thomas Muley , Marc A Schneider , Karsten Quast , Joschka Hey , Claus P Heußel , Arne Warth , Hauke Winter , Özdemirhan Serçin , Harry Karmouty-Quintana , Soma Sk Jyothula , Manish K Patel , Felix Herth , Ina Koch , Giuseppe Petrosino , Alexandru Titimeaua , Balca R Mardin , Dieter Weichenhan , Tomasz P Jurkowski , Charles D Imbusch , Benedikt Brors , Vladimir Benes , Birgit Jung , David Wyatt , Heiko F Stahl , Christoph Plass , Renata Z Jurkowska

Diagnostic leukapheresis reveals distinct phenotypes of NSCLC circulating tumor cells.

Molecular cancer

Avec: Lisa-Marie Rieckmann , Michael Spohn , Lisa Ruff , David Agorku , Lisa Becker , Alina Borchers , Jenny Krause , Roisin O'Reilly , Jurek Hille , Janna-Lisa Velthaus-Rusik , Niklas Beumer , Armin Günther , Lena Willnow , Charles D Imbusch , Peter Iglauer , Ronald Simon , Sören Franzenburg , Hauke Winter , Michael Thomas , Carsten Bokemeyer , Nicola Gagliani , Christian F Krebs , Martin Sprick , Olaf Hardt , Sabine Riethdorf , Andreas Trumpp , Nikolas H Stoecklein , Sven Peine , Philipp Rosenstiel , Klaus Pantel , Sonja Loges , Melanie Janning

SOX10 mediates glioblastoma cell-state plasticity.

EMBO reports

Avec: Ka-Hou Man , Yonghe Wu , Zhenjiang Gao , Anna-Sophie Spreng , Johanna Keding , Jasmin Mangei , Pavle Boskovic , Jan-Philipp Mallm , Hai-Kun Liu , Charles D Imbusch , Peter Lichter , Bernhard Radlwimmer

Réseau de co-auteurs

Benedikt Brors 11 collaborations

Malte Simon 6 collaborations

Christian Schmidl 6 collaborations

Michael Delacher 6 collaborations

Markus Feuerer 6 collaborations

Sebastian Bittner 5 collaborations

Michael Rehli 5 collaborations

Lisa Schmidleithner 4 collaborations

Niklas Beumer 4 collaborations

Asmita Pant 4 collaborations

Dieter Weichenhan 4 collaborations

Agnes Hotz-Wagenblatt 4 collaborations

Nicholas Strieder 3 collaborations

Claudia Gebhard 3 collaborations

Andreas Eigenberger 3 collaborations

Lukas Prantl 3 collaborations

Thomas Hehlgans 3 collaborations

Christoph Plass 3 collaborations

Dania Riegel 3 collaborations

Jens M Werner 3 collaborations

Lieke Sanderink 3 collaborations

Kathrin Schambeck 3 collaborations

Sonja Loges 3 collaborations

Hauke Winter 3 collaborations

Lena Voith von Voithenberg 2 collaborations

Johanna Keding 2 collaborations

Philipp Stüve 2 collaborations

Matthias M Gaida 2 collaborations

Thilo Hackert 2 collaborations

Andreas Trumpp 2 collaborations

Yonatan Herzig 2 collaborations

Ulrike Träger 2 collaborations

Ann-Cathrin Hofer 2 collaborations

Jakub Abramson 2 collaborations

Jan-Philipp Mallm 2 collaborations

Kathrin L Braband 2 collaborations

Alexander Fischer 2 collaborations

Petra Hoffmann 2 collaborations

Matthias Edinger 2 collaborations

Marina Wuttke 2 collaborations

Uwe Ritter 2 collaborations

Jochen Huehn 2 collaborations

Peter Iglauer 2 collaborations

Ronald Simon 2 collaborations

Carsten Bokemeyer 2 collaborations

Lisa-Marie Rieckmann 2 collaborations

Michael Thomas 2 collaborations

Melanie Janning 2 collaborations

Sridhar Kandala 1 collaboration

Maria Ramos 1 collaboration

Alberto Diaz-Jimenez 1 collaboration

Sara Chocarro 1 collaboration

Rocio Sotillo 1 collaboration

Elisa Espinet 1 collaboration

Zuguang Gu 1 collaboration

Nathalia A Giese 1 collaboration

Magdalena Büscher 1 collaboration

Mariam Safavi 1 collaboration

Silke Weisenburger 1 collaboration

Corinna Klein 1 collaboration

Vanessa Vogel 1 collaboration

Mattia Falcone 1 collaboration

Jacob Insua-Rodríguez 1 collaboration

Manuel Reitberger 1 collaboration

Vera Thiel 1 collaboration

Steffi O Kossi 1 collaboration

Alexander Muckenhuber 1 collaboration

Karnjit Sarai 1 collaboration

Alex Y L Lee 1 collaboration

Elyne Backx 1 collaboration

Soheila Zarei 1 collaboration

Manuel Rodríguez-Paredes 1 collaboration

Elisa Donato 1 collaboration

Hsi-Yu Yen 1 collaboration

Roland Eils 1 collaboration

Matthias Schlesner 1 collaboration

Nicole Pfarr 1 collaboration

Katja Steiger 1 collaboration

H Efsun Arda 1 collaboration

Ilse Rooman 1 collaboration

Janel L Kopp 1 collaboration

Oliver Strobel 1 collaboration

Wilko Weichert 1 collaboration

Martin R Sprick 1 collaboration

Minka Breloer 1 collaboration

Wiebke Hartmann 1 collaboration

Fabian Brunk 1 collaboration

Danny Kägebein 1 collaboration

Thomas Hielscher 1 collaboration

Achim Breiling 1 collaboration

Giuseppina Federico 1 collaboration

Hermann-Josef Gröne 1 collaboration

Roland M Schmid 1 collaboration

Elena Romero-Fernández 1 collaboration

Akinbami Raphael Adenugba 1 collaboration

Katrin Singer 1 collaboration

Roman Mayr 1 collaboration

Florian Weber 1 collaboration

Mark Kleemann 1 collaboration

Marina Kreutz 1 collaboration

Ines Ugele 1 collaboration

Peter J Siska 1 collaboration

Katharina Bauer 1 collaboration

André F Rendeiro 1 collaboration

Bernd Echtenachter 1 collaboration

Valentina Giunchiglia 1 collaboration

Christoph Bock 1 collaboration

Verena Schneider 1 collaboration

Florian Kai Groeber-Becker 1 collaboration

Till Strowig 1 collaboration

Janna-Lisa Velthaus 1 collaboration

Peter Bannas 1 collaboration

Eray Goekkurt 1 collaboration

Tobias Boch 1 collaboration

Nikolaj Frost 1 collaboration

Linna Sommer 1 collaboration

Tobias R Overbeck 1 collaboration

Christoph T Michaeli 1 collaboration

Chrisoph J Szuszies 1 collaboration

Julia Roeper 1 collaboration

Frank Griesinger 1 collaboration

Martin Wermke 1 collaboration

Brigitte Ruhland 1 collaboration

Veronika Hofmann 1 collaboration

Sara Salome Helbich 1 collaboration

Morten Voss 1 collaboration

Niels A Lemmermann 1 collaboration

Lisa Bessiri-Schake 1 collaboration

Toszka Bohn 1 collaboration

Ayse Nur Menevse 1 collaboration

Hinrich Abken 1 collaboration

Philipp Beckhove 1 collaboration

Henrik Junger 1 collaboration

Edward K Geissler 1 collaboration

Melanie M Barra 1 collaboration

Katrin Eichelbaum 1 collaboration

Mahmoud-Reza Rafiee 1 collaboration

David M Richards 1 collaboration

Alexander Kazakov 1 collaboration

Marina Gonzalez 1 collaboration

Lukas Wöhrl 1 collaboration

Jeroen Krijgsveld 1 collaboration

Qi Wang 1 collaboration

Sadaf S Mughal 1 collaboration

Peter Horak 1 collaboration

Sebastian Uhrig 1 collaboration

Jonas Buchloh 1 collaboration

Bogac Aybey 1 collaboration

Albrecht Stenzinger 1 collaboration

Hanno Glimm 1 collaboration

Stefan Fröhling 1 collaboration

Suhail Yousuf 1 collaboration

Mengjie Qiu 1 collaboration

Johannes Hulkkonen 1 collaboration

Igor Macinkovic 1 collaboration

Axel R Schulz 1 collaboration

Domenic Hartmann 1 collaboration

Florian Mueller 1 collaboration

Margarete Mijatovic 1 collaboration

David Ibberson 1 collaboration

Karam T AlHalabi 1 collaboration

Jenny Hetzer 1 collaboration

Simon Anders 1 collaboration

Bernhard Brüne 1 collaboration

Henrik E Mei 1 collaboration

Mathias Heikenwälder 1 collaboration

Markus W Büchler 1 collaboration

Andreas Weigert 1 collaboration

Susanne Roth 1 collaboration

Uwe Schwartz 1 collaboration

Maria Llamazares Prada 1 collaboration

Stephanie T Pohl 1 collaboration

Mandy Richter 1 collaboration

Raluca Tamas 1 collaboration

Michael Schuler 1 collaboration

Corinna Keller 1 collaboration

Vedrana Mijosek 1 collaboration

Thomas Muley 1 collaboration

Marc A Schneider 1 collaboration

Karsten Quast 1 collaboration

Joschka Hey 1 collaboration

Claus P Heußel 1 collaboration

Arne Warth 1 collaboration

Özdemirhan Serçin 1 collaboration

Harry Karmouty-Quintana 1 collaboration

Soma Sk Jyothula 1 collaboration

Manish K Patel 1 collaboration

Felix Herth 1 collaboration

Ina Koch 1 collaboration

Giuseppe Petrosino 1 collaboration

Alexandru Titimeaua 1 collaboration

Balca R Mardin 1 collaboration

Tomasz P Jurkowski 1 collaboration

Vladimir Benes 1 collaboration

Birgit Jung 1 collaboration

David Wyatt 1 collaboration

Heiko F Stahl 1 collaboration

Renata Z Jurkowska 1 collaboration

Michael Spohn 1 collaboration

Lisa Ruff 1 collaboration

David Agorku 1 collaboration

Lisa Becker 1 collaboration

Alina Borchers 1 collaboration

Jenny Krause 1 collaboration

Roisin O'Reilly 1 collaboration

Jurek Hille 1 collaboration

Janna-Lisa Velthaus-Rusik 1 collaboration

Armin Günther 1 collaboration

Lena Willnow 1 collaboration

Sören Franzenburg 1 collaboration

Nicola Gagliani 1 collaboration

Christian F Krebs 1 collaboration

Martin Sprick 1 collaboration

Olaf Hardt 1 collaboration

Sabine Riethdorf 1 collaboration

Nikolas H Stoecklein 1 collaboration

Sven Peine 1 collaboration

Philipp Rosenstiel 1 collaboration

Klaus Pantel 1 collaboration

Ka-Hou Man 1 collaboration

Yonghe Wu 1 collaboration

Zhenjiang Gao 1 collaboration

Anna-Sophie Spreng 1 collaboration

Jasmin Mangei 1 collaboration

Pavle Boskovic 1 collaboration

Hai-Kun Liu 1 collaboration

Peter Lichter 1 collaboration

Bernhard Radlwimmer 1 collaboration