Arda Halu

Affiliations
  • Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
ORCID: https://orcid.org/0000-0001-6217-790X

Publications (20)

Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1.

eLife
Avec: Ayse Kilic , Arda Halu , Margherita De Marzio , Enrico Maiorino , Melody G Duvall , Thayse Brueggemann , Joselyn J Rojas Quintero , Robert Chase , Hooman Mirzakhani , Ayse Özge Sungur , Janine Koepke , Taiji Nakano , Hong Yong Peh , Nandini Krishnamoorthy , Raja-Elie Abdulnour , Katia Georgopoulos , Augusto A Litonjua , Marie Demay , Harald Renz , Bruce D Levy , Scott T Weiss

Obesity and age are transmission risk factors for SARS-CoV-2 infection among exposed individuals.

PNAS nexus
Avec: Joan T Matamalas , Sarvesh Chelvanambi , Julius L Decano , Raony F França , Arda Halu , Diego V Santinelli-Pestana , Elena Aikawa , Rajeev Malhotra , Masanori Aikawa

Systems Approach to Discovery of Therapeutic Targets for Vein Graft Disease: PPARα Pivotally Regulates Metabolism, Activation, and Heterogeneity of Macrophages and Lesion Development.

Circulation
Avec: Julius L Decano , Sasha A Singh , Cauê Gasparotto Bueno , Lang Ho Lee , Arda Halu , Sarvesh Chelvanambi , Joan T Matamalas , Hengmin Zhang , Andrew K Mlynarchik , Jiao Qiao , Amitabh Sharma , Shin Mukai , Jianguo Wang , Daniel G Anderson , C Keith Ozaki , Peter Libby , Elena Aikawa , Masanori Aikawa

XINA: A Workflow for the Integration of Multiplexed Proteomics Kinetics Data with Network Analysis.

Journal of proteome research
Avec: Lang Ho Lee , Arda Halu , Stephanie Morgan , Hiroshi Iwata , Masanori Aikawa , Sasha A Singh

The multiplex network of human diseases.

NPJ systems biology and applications
Avec: Arda Halu , Manlio De Domenico , Alex Arenas , Amitabh Sharma

Uremic Toxin Indoxyl Sulfate Promotes Proinflammatory Macrophage Activation Via the Interplay of OATP2B1 and Dll4-Notch Signaling.

Circulation
Avec: Toshiaki Nakano , Shunsuke Katsuki , Mingxian Chen , Julius L Decano , Arda Halu , Lang Ho Lee , Diego V S Pestana , Angelo S T Kum , Rodrigo K Kuromoto , Whitney S Golden , Mario S Boff , Gabriel C Guimaraes , Hideyuki Higashi , Kevin J Kauffman , Takashi Maejima , Takehiro Suzuki , Hiroshi Iwata , Albert-László Barabási , Jon C Aster , Daniel G Anderson , Amitabh Sharma , Sasha A Singh , Elena Aikawa , Masanori Aikawa

A disease-driver population within interstitial cells of human calcific aortic valves identified via single-cell and proteomic profiling.

Cell reports
Avec: Julius L Decano , Yukio Iwamoto , Shinji Goto , Janey Y Lee , Joan T Matamalas , Arda Halu , Mark Blaser , Lang Ho Lee , Brett Pieper , Sarvesh Chelvanambi , Jessica Silva-Nicolau , Francesca Bartoli-Leonard , Hideyuki Higashi , Haruki Shibata , Payal Vyas , Jianguo Wang , Elena Gostjeva , Simon C Body , Sasha A Singh , Masanori Aikawa , Elena Aikawa

Detecting and dissecting signaling crosstalk via the multilayer network integration of signaling and regulatory interactions.

Nucleic acids research
Avec: Leonardo Martini , Seung Han Baek , Ian Lo , Benjamin A Raby , Edwin K Silverman , Scott T Weiss , Kimberly Glass , Arda Halu

Multiomics of Tissue Extracellular Vesicles Identifies Unique Modulators of Atherosclerosis and Calcific Aortic Valve Stenosis.

Circulation
Avec: Mark C Blaser , Fabrizio Buffolo , Arda Halu , Mandy E Turner , Florian Schlotter , Hideyuki Higashi , Lorena Pantano , Cassandra L Clift , Louis A Saddic , Samantha K Atkins , Maximillian A Rogers , Tan Pham , Amélie Vromman , Eugenia Shvartz , Galina K Sukhova , Silvia Monticone , Giovanni Camussi , Simon C Robson , Simon C Body , Jochen D Muehlschlegel , Sasha A Singh , Masanori Aikawa , Elena Aikawa

Multiorgan Systems Study Reveals Igfbp7 as a Suppressor of Gluconeogenesis after Gastric Bypass Surgery.

Journal of proteome research
Avec: Naoaki Arima , Yusuke Sasaki , Lang Ho Lee , Hengmin Zhang , Jose-Luiz Figueiredo , Andrew K Mlynarchik , Jiao Qiao , Iwao Yamada , Hideyuki Higashi , Anna H Ha , Arda Halu , Ken Mizuno , Sasha A Singh , Yukiyoshi Yamazaki , Masanori Aikawa

CROT (Carnitine O-Octanoyltransferase) Is a Novel Contributing Factor in Vascular Calcification via Promoting Fatty Acid Metabolism and Mitochondrial Dysfunction.

Arteriosclerosis, thrombosis, and vascular biology
Avec: Takehito Okui , Masaya Iwashita , Maximillian A Rogers , Arda Halu , Samantha K Atkins , Shiori Kuraoka , Ilyes Abdelhamid , Hideyuki Higashi , Ashisha Ramsaroop , Masanori Aikawa , Sasha A Singh , Elena Aikawa

Gene Expression Profiling Reveals the Shared and Distinct Transcriptional Signatures in Human Lung Epithelial Cells Infected With SARS-CoV-2, MERS-CoV, or SARS-CoV: Potential Implications in Cardiovascular Complications of COVID-19.

Frontiers in cardiovascular medicine
Avec: Prabhash Kumar Jha , Aatira Vijay , Arda Halu , Shizuka Uchida , Masanori Aikawa

Dynamin-related protein 1 inhibition reduces hepatic PCSK9 secretion.

Cardiovascular research
Avec: Maximillian A Rogers , Joshua D Hutcheson , Takehito Okui , Claudia Goettsch , Sasha A Singh , Arda Halu , Florian Schlotter , Hideyuki Higashi , Lixiang Wang , Mary C Whelan , Andrew K Mlynarchik , Alan Daugherty , Masatoshi Nomura , Masanori Aikawa , Elena Aikawa

Proprotein Convertase Subtilisin/Kexin 9 (PCSK9) Promotes Macrophage Activation via LDL Receptor-Independent Mechanisms.

Circulation research
Avec: Shunsuke Katsuki , Prabhash K Jha , Adrien Lupieri , Toshiaki Nakano , Livia S A Passos , Maximillian A Rogers , Dakota Becker-Greene , Thanh-Dat Le , Julius L Decano , Lang Ho Lee , Gabriel C Guimaraes , Ilyes Abdelhamid , Arda Halu , Alessandro Muscoloni , Carlo V Cannistraci , Hideyuki Higashi , Hengmin Zhang , Amélie Vromman , Peter Libby , C Keith Ozaki , Amitabh Sharma , Sasha A Singh , Elena Aikawa , Masanori Aikawa

Exploring the cross-phenotype network region of disease modules reveals concordant and discordant pathways between chronic obstructive pulmonary disease and idiopathic pulmonary fibrosis.

Human molecular genetics
Avec: Arda Halu , Shikang Liu , Seung Han Baek , Brian D Hobbs , Gary M Hunninghake , Michael H Cho , Edwin K Silverman , Amitabh Sharma

ApoC-III is a novel inducer of calcification in human aortic valves.

The Journal of biological chemistry
Avec: Florian Schlotter , Renata C C de Freitas , Maximillian A Rogers , Mark C Blaser , Pin-Jou Wu , Hideyuki Higashi , Arda Halu , Farwah Iqbal , Allison B Andraski , Cayla N Rodia , Shiori Kuraoka , Jennifer R Wen , Michael Creager , Tan Pham , Joshua D Hutcheson , Simon C Body , Alison B Kohan , Frank M Sacks , Masanori Aikawa , Sasha A Singh , Elena Aikawa

Robustness and lethality in multilayer biological molecular networks.

Nature communications
Avec: Xueming Liu , Enrico Maiorino , Arda Halu , Kimberly Glass , Rashmi B Prasad , Joseph Loscalzo , Jianxi Gao , Amitabh Sharma

Annexin A1-dependent tethering promotes extracellular vesicle aggregation revealed with single-extracellular vesicle analysis.

Science advances
Avec: Maximillian A Rogers , Fabrizio Buffolo , Florian Schlotter , Samantha K Atkins , Lang H Lee , Arda Halu , Mark C Blaser , Elena Tsolaki , Hideyuki Higashi , Kristin Luther , George Daaboul , Carlijn V C Bouten , Simon C Body , Sasha A Singh , Sergio Bertazzo , Peter Libby , Masanori Aikawa , Elena Aikawa

Identifying novel mechanisms of abdominal aortic aneurysm

Frontiers in cardiovascular medicine
Avec: Stephanie Morgan , Lang Ho Lee , Arda Halu , Jessica S Nicolau , Hideyuki Higashi , Anna H Ha , Jennifer R Wen , Alan Daugherty , Peter Libby , Scott J Cameron , Doran Mix , Elena Aikawa , A Phillip Owens , Sasha A Singh , Masanori Aikawa

Sortilin enhances fibrosis and calcification in aortic valve disease by inducing interstitial cell heterogeneity.

European heart journal
Avec: Farwah Iqbal , Florian Schlotter , Dakota Becker-Greene , Adrien Lupieri , Claudia Goettsch , Joshua D Hutcheson , Maximillian A Rogers , Shinsuke Itoh , Arda Halu , Lang Ho Lee , Mark C Blaser , Andrew K Mlynarchik , Sumihiko Hagita , Shiori Kuraoka , Hao Yu Chen , James C Engert , Livia S A Passos , Prabhash K Jha , Eric A Osborn , Farouc A Jaffer , Simon C Body , Simon C Robson , George Thanassoulis , Masanori Aikawa , Sasha A Singh , Abhijeet R Sonawane , Elena Aikawa

Réseau de co-auteurs

Masanori Aikawa 15 collaborations
Sasha A Singh 13 collaborations
Elena Aikawa 12 collaborations
Hideyuki Higashi 10 collaborations
Lang Ho Lee 8 collaborations
Maximillian A Rogers 7 collaborations
Amitabh Sharma 6 collaborations
Julius L Decano 5 collaborations
Simon C Body 5 collaborations
Florian Schlotter 5 collaborations
Andrew K Mlynarchik 4 collaborations
Peter Libby 4 collaborations
Mark C Blaser 4 collaborations
Joan T Matamalas 3 collaborations
Sarvesh Chelvanambi 3 collaborations
Hengmin Zhang 3 collaborations
Samantha K Atkins 3 collaborations
Shiori Kuraoka 3 collaborations
Joshua D Hutcheson 3 collaborations
Enrico Maiorino 2 collaborations
Scott T Weiss 2 collaborations
Jiao Qiao 2 collaborations
Jianguo Wang 2 collaborations
Daniel G Anderson 2 collaborations
C Keith Ozaki 2 collaborations
Stephanie Morgan 2 collaborations
Hiroshi Iwata 2 collaborations
Toshiaki Nakano 2 collaborations
Shunsuke Katsuki 2 collaborations
Gabriel C Guimaraes 2 collaborations
Seung Han Baek 2 collaborations
Edwin K Silverman 2 collaborations
Kimberly Glass 2 collaborations
Fabrizio Buffolo 2 collaborations
Tan Pham 2 collaborations
Amélie Vromman 2 collaborations
Simon C Robson 2 collaborations
Anna H Ha 2 collaborations
Takehito Okui 2 collaborations
Ilyes Abdelhamid 2 collaborations
Claudia Goettsch 2 collaborations
Alan Daugherty 2 collaborations
Prabhash K Jha 2 collaborations
Adrien Lupieri 2 collaborations
Livia S A Passos 2 collaborations
Dakota Becker-Greene 2 collaborations
Farwah Iqbal 2 collaborations
Jennifer R Wen 2 collaborations
Ayse Kilic 1 collaboration
Margherita De Marzio 1 collaboration
Melody G Duvall 1 collaboration
Thayse Brueggemann 1 collaboration
Joselyn J Rojas Quintero 1 collaboration
Robert Chase 1 collaboration
Hooman Mirzakhani 1 collaboration
Ayse Özge Sungur 1 collaboration
Janine Koepke 1 collaboration
Taiji Nakano 1 collaboration
Hong Yong Peh 1 collaboration
Nandini Krishnamoorthy 1 collaboration
Raja-Elie Abdulnour 1 collaboration
Katia Georgopoulos 1 collaboration
Augusto A Litonjua 1 collaboration
Marie Demay 1 collaboration
Harald Renz 1 collaboration
Bruce D Levy 1 collaboration
Raony F França 1 collaboration
Diego V Santinelli-Pestana 1 collaboration
Rajeev Malhotra 1 collaboration
Cauê Gasparotto Bueno 1 collaboration
Shin Mukai 1 collaboration
Manlio De Domenico 1 collaboration
Alex Arenas 1 collaboration
Mingxian Chen 1 collaboration
Diego V S Pestana 1 collaboration
Angelo S T Kum 1 collaboration
Rodrigo K Kuromoto 1 collaboration
Whitney S Golden 1 collaboration
Mario S Boff 1 collaboration
Kevin J Kauffman 1 collaboration
Takashi Maejima 1 collaboration
Takehiro Suzuki 1 collaboration
Albert-László Barabási 1 collaboration
Jon C Aster 1 collaboration
Yukio Iwamoto 1 collaboration
Shinji Goto 1 collaboration
Janey Y Lee 1 collaboration
Mark Blaser 1 collaboration
Brett Pieper 1 collaboration
Jessica Silva-Nicolau 1 collaboration
Francesca Bartoli-Leonard 1 collaboration
Haruki Shibata 1 collaboration
Payal Vyas 1 collaboration
Elena Gostjeva 1 collaboration
Leonardo Martini 1 collaboration
Ian Lo 1 collaboration
Benjamin A Raby 1 collaboration
Mandy E Turner 1 collaboration
Lorena Pantano 1 collaboration
Cassandra L Clift 1 collaboration
Louis A Saddic 1 collaboration
Eugenia Shvartz 1 collaboration
Galina K Sukhova 1 collaboration
Silvia Monticone 1 collaboration
Giovanni Camussi 1 collaboration
Jochen D Muehlschlegel 1 collaboration
Naoaki Arima 1 collaboration
Yusuke Sasaki 1 collaboration
Jose-Luiz Figueiredo 1 collaboration
Iwao Yamada 1 collaboration
Ken Mizuno 1 collaboration
Yukiyoshi Yamazaki 1 collaboration
Masaya Iwashita 1 collaboration
Ashisha Ramsaroop 1 collaboration
Prabhash Kumar Jha 1 collaboration
Aatira Vijay 1 collaboration
Shizuka Uchida 1 collaboration
Lixiang Wang 1 collaboration
Mary C Whelan 1 collaboration
Masatoshi Nomura 1 collaboration
Thanh-Dat Le 1 collaboration
Alessandro Muscoloni 1 collaboration
Carlo V Cannistraci 1 collaboration
Shikang Liu 1 collaboration
Brian D Hobbs 1 collaboration
Gary M Hunninghake 1 collaboration
Michael H Cho 1 collaboration
Renata C C de Freitas 1 collaboration
Pin-Jou Wu 1 collaboration
Allison B Andraski 1 collaboration
Cayla N Rodia 1 collaboration
Michael Creager 1 collaboration
Alison B Kohan 1 collaboration
Frank M Sacks 1 collaboration
Xueming Liu 1 collaboration
Rashmi B Prasad 1 collaboration
Joseph Loscalzo 1 collaboration
Jianxi Gao 1 collaboration
Lang H Lee 1 collaboration
Elena Tsolaki 1 collaboration
Kristin Luther 1 collaboration
George Daaboul 1 collaboration
Carlijn V C Bouten 1 collaboration
Sergio Bertazzo 1 collaboration
Jessica S Nicolau 1 collaboration
Scott J Cameron 1 collaboration
Doran Mix 1 collaboration
A Phillip Owens 1 collaboration
Shinsuke Itoh 1 collaboration
Sumihiko Hagita 1 collaboration
Hao Yu Chen 1 collaboration
James C Engert 1 collaboration
Eric A Osborn 1 collaboration
Farouc A Jaffer 1 collaboration
George Thanassoulis 1 collaboration
Abhijeet R Sonawane 1 collaboration