Vitamin D constrains inflammation by modulating the expression of key genes on Chr17q12-21.1.

asthma genetics genomics human immunology inflammation mouse vitamin D receptor

Journal

eLife
ISSN: 2050-084X
Titre abrégé: Elife
Pays: England
ID NLM: 101579614

Informations de publication

Date de publication:
03 Apr 2024
Historique:
medline: 3 4 2024
pubmed: 3 4 2024
entrez: 3 4 2024
Statut: epublish

Résumé

Vitamin D possesses immunomodulatory functions and vitamin D deficiency has been associated with the rise in chronic inflammatory diseases, including asthma (Litonjua and Weiss, 2007). Vitamin D supplementation studies do not provide insight into the molecular genetic mechanisms of vitamin D-mediated immunoregulation. Here, we provide evidence for vitamin D regulation of two human chromosomal loci, Chr17q12-21.1 and Chr17q21.2, reliably associated with autoimmune and chronic inflammatory diseases. We demonstrate increased vitamin D receptor (

Identifiants

DOI: 10.7554/eLife.89270 PMID: 38567749
pubmed: 38567749
doi: 10.7554/eLife.89270
pii: 89270
doi:
pii:

Banques de données

GEO
['GSE89431', 'GSE22484']

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NHLBI NIH HHS
ID : 5P01HL132825
Pays : United States
Organisme : NHLBI NIH HHS
ID : 5UH3OD023268
Pays : United States
Organisme : NHLBI NIH HHS
ID : 5K25HL150336
Pays : United States
Organisme : NHLBI NIH HHS
ID : 1K25HL168157
Pays : United States
Organisme : NHLBI NIH HHS
ID : 1K01HL166705
Pays : United States
Organisme : NHLBI NIH HHS
ID : 1R01HL171141
Pays : United States

Informations de copyright

© 2023, Kilic, Halu et al.

Déclaration de conflit d'intérêts

AK, AH, MD, EM, MD, TB, JR, RC, HM, AS, JK, TN, HP, NK, RA, KG, AL, MD, HR, BL No competing interests declared, SW receives royalties from UpToDate and is an investor in Histolix

Auteurs

Ayse Kilic (A)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
ORCID: 0000-0001-5362-2127

Arda Halu (A)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
ORCID: 0000-0001-6217-790X

Margherita De Marzio (M)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
Department of Environmental Health, Harvard TH Chan School of Public Health, Boston, United States.
ORCID: 0000-0003-1821-208X

Enrico Maiorino (E)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.

Melody G Duvall (MG)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
ORCID: 0000-0002-4173-3628

Thayse Brueggemann (T)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.

Joselyn J Rojas Quintero (JJ)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.

Robert Chase (R)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.

Hooman Mirzakhani (H)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.

Ayse Özge Sungur (AÖ)

Behavioral Neuroscience, Experimental and Biological Psychology, Philipps-University, Marburg, Germany.
Excellence Cluster Cardio-Pulmonary System (ECCPS), Justus Liebig University Giessen, Giessen, Germany.
ORCID: 0000-0002-9272-9717

Janine Koepke (J)

Excellence Cluster Cardio-Pulmonary System (ECCPS), Justus Liebig University Giessen, Giessen, Germany.

Taiji Nakano (T)

Department of Pediatrics, Graduate School of Medicine, Chiba University, Chiba, Japan.

Hong Yong Peh (HY)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.
ORCID: 0000-0001-6098-9381

Nandini Krishnamoorthy (N)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.

Raja-Elie Abdulnour (RE)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.

Katia Georgopoulos (K)

Cutaneous Biology Research Center, Massachusetts General Hospital and Harvard Medical School, Boston, United States.

Augusto A Litonjua (AA)

Division of Pediatric Pulmonary Medicine, Golisano Children's Hospital at Strong, University of Rochester Medical Center, Rochester, United States.

Marie Demay (M)

Endocrine Unit, Massachusetts General Hospital and Harvard Medical School, Boston, United States.

Harald Renz (H)

Institute of Laboratory Medicine and Pathobiochemistry, Molecular Diagnostics, Philipps University of Marburg and German Center for Lung Research (DZL), Marburg, Germany.
Department of Clinical Immunology and Allergology, Laboratory of Immunopathology Sechenov University, Moscow, Russian Federation.

Bruce D Levy (BD)

Division of Pulmonary and Critical Care Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.

Scott T Weiss (ST)

Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, United States.

Classifications MeSH