Andreas Brech

Affiliations

Department of Molecular Cell Biology, Institute for Cancer Research, Oslo University Hospital, Oslo, Norway.
Centre for Cancer Cell Reprogramming, Institute of Clinical Medicine, Faculty of Medicine, University of Oslo, Oslo, Norway.

ORCID: http://orcid.org/0000-0002-9803-1774

Publications (30)

Wetting regulates autophagy of phase-separated compartments and the cytosol.

Nature

Avec: Jaime Agudo-Canalejo , Sebastian W Schultz , Haruka Chino , Simona M Migliano , Chieko Saito , Ikuko Koyama-Honda , Harald Stenmark , Andreas Brech , Alexander I May , Noboru Mizushima , Roland L Knorr

Remodeling of secretory lysosomes during education tunes functional potential in NK cells.

Nature communications

Avec: Jodie P Goodridge , Benedikt Jacobs , Michelle L Saetersmoen , Dennis Clement , Quirin Hammer , Trevor Clancy , Ellen Skarpen , Andreas Brech , Johannes Landskron , Christian Grimm , Aline Pfefferle , Leonardo Meza-Zepeda , Susanne Lorenz , Merete Thune Wiiger , William E Louch , Eivind Heggernes Ask , Lisa L Liu , Vincent Yi Sheng Oei , Una Kjällquist , Sten Linnarsson , Sandip Patel , Kjetil Taskén , Harald Stenmark , Karl-Johan Malmberg

Adaptation to hypoxia in

Autophagy

Avec: Ayelén Valko , Sebastián Perez-Pandolfo , Eleonora Sorianello , Andreas Brech , Pablo Wappner , Mariana Melani

Host autophagy mediates organ wasting and nutrient mobilization for tumor growth.

The EMBO journal

Avec: Rojyar Khezri , Petter Holland , Todd Andrew Schoborg , Ifat Abramovich , Szabolcs Takáts , Caroline Dillard , Ashish Jain , Fergal O'Farrell , Sebastian Wolfgang Schultz , William M Hagopian , Eduardo Martin Quintana , Rachel Ng , Nadja Sandra Katheder , Mohammed Mahidur Rahman , José Gerardo Teles Reis , Andreas Brech , Heinrich Jasper , Nasser M Rusan , Anne Hope Jahren , Eyal Gottlieb , Tor Erik Rusten

Intercellular transfer of cancer cell invasiveness via endosome-mediated protease shedding.

Nature communications

Avec: Eva Maria Wenzel , Nina Marie Pedersen , Liv Anker Elfmark , Ling Wang , Ingrid Kjos , Espen Stang , Lene Malerød , Andreas Brech , Harald Stenmark , Camilla Raiborg

ESCRT-mediated phagophore sealing during mitophagy.

Autophagy

Avec: Yan Zhen , Hélène Spangenberg , Michael J Munson , Andreas Brech , Kay O Schink , Kia-Wee Tan , Vigdis Sørensen , Eva Maria Wenzel , Maja Radulovic , Nikolai Engedal , Anne Simonsen , Camilla Raiborg , Harald Stenmark

Cholesterol transfer via endoplasmic reticulum contacts mediates lysosome damage repair.

The EMBO journal

Avec: Maja Radulovic , Eva Maria Wenzel , Sania Gilani , Lya Kk Holland , Alf Håkon Lystad , Santosh Phuyal , Vesa M Olkkonen , Andreas Brech , Marja Jäättelä , Kenji Maeda , Camilla Raiborg , Harald Stenmark

siRNA screening reveals that SNAP29 contributes to exosome release.

Cellular and molecular life sciences : CMLS

Avec: Nina Pettersen Hessvik , Krizia Sagini , Silvana Romero , Manuel Ramirez-Garrastacho , Marta Rodriguez , Astrid Elisabeth V Tutturen , Audun Kvalvaag , Espen Stang , Andreas Brech , Kirsten Sandvig , Alicia Llorente

Vesicle-mediated transport of ALIX and ESCRT-III to the intercellular bridge during cytokinesis.

Cellular and molecular life sciences : CMLS

Avec: Sascha Pust , Andreas Brech , Catherine Sem Wegner , Harald Stenmark , Kaisa Haglund

Unrestrained ESCRT-III drives micronuclear catastrophe and chromosome fragmentation.

Nature cell biology

Avec: Marina Vietri , Sebastian W Schultz , Aurélie Bellanger , Carl M Jones , Louise I Petersen , Camilla Raiborg , Ellen Skarpen , Christeen Ramane J Pedurupillay , Ingrid Kjos , Eline Kip , Romy Timmer , Ashish Jain , Philippe Collas , Roland L Knorr , Sushma N Grellscheid , Halim Kusumaatmaja , Andreas Brech , Francesca Micci , Harald Stenmark , Coen Campsteijn

Selective autophagy maintains centrosome integrity and accurate mitosis by turnover of centriolar satellites.

Nature communications

Avec: Søs Grønbæk Holdgaard , Valentina Cianfanelli , Emanuela Pupo , Matteo Lambrughi , Michal Lubas , Julie C Nielsen , Susana Eibes , Emiliano Maiani , Lea M Harder , Nicole Wesch , Mads Møller Foged , Kenji Maeda , Francesca Nazio , Laura R de la Ballina , Volker Dötsch , Andreas Brech , Lisa B Frankel , Marja Jäättelä , Franco Locatelli , Marin Barisic , Jens S Andersen , Simon Bekker-Jensen , Anders H Lund , Vladimir V Rogov , Elena Papaleo , Letizia Lanzetti , Daniela De Zio , Francesco Cecconi

Protein crowding mediates membrane remodeling in upstream ESCRT-induced formation of intraluminal vesicles.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Susanne Liese , Eva Maria Wenzel , Ingrid Kjos , Rossana Rojas Molina , Sebastian W Schultz , Andreas Brech , Harald Stenmark , Camilla Raiborg , Andreas Carlson

Photodynamic Effects with 5-Aminolevulinic Acid on Cytokines and Exosomes in Human Peripheral Blood Mononuclear Cells.

Biomedicines

Avec: Kristian Espeland , Andrius Kleinauskas , Petras Juzenas , Andreas Brech , Sagar Darvekar , Vlada Vasovic , Trond Warloe , Eidi Christensen , Jørgen Jahnsen , Qian Peng

The Lysosomal Calcium Channel TRPML1 Maintains Mitochondrial Fitness in NK Cells through Interorganelle Cross-Talk.

Journal of immunology (Baltimore, Md. : 1950)

Avec: Dennis Clement , Edina K Szabo , Silje Zandstra Krokeide , Merete Thune Wiiger , Marianna Vincenti , Daniel Palacios , Young-Tae Chang , Christian Grimm , Sandip Patel , Harald Stenmark , Andreas Brech , Rakesh Kumar Majhi , Karl-Johan Malmberg

The E3 ubiquitin ligase ITCH negatively regulates intercellular communication via gap junctions by targeting connexin43 for lysosomal degradation.

Cellular and molecular life sciences : CMLS

Avec: Max Zachrisson Totland , Lars Mørland Knudsen , Nikoline Lander Rasmussen , Yasufumi Omori , Vigdis Sørensen , Vilde C Wivestad Elster , Jakob Mørkved Stenersen , Mathias Larsen , Caroline Lunder Jensen , Anna A Zickfeldt Lade , Emilie Bruusgaard , Sebastian Basing , Kushtrim Kryeziu , Andreas Brech , Trond Aasen , Ragnhild A Lothe , Edward Leithe

Structural basis of p62/SQSTM1 helical filaments and their role in cellular cargo uptake.

Nature communications

Avec: Arjen J Jakobi , Stefan T Huber , Simon A Mortensen , Sebastian W Schultz , Anthimi Palara , Tanja Kuhm , Birendra Kumar Shrestha , Trond Lamark , Wim J H Hagen , Matthias Wilmanns , Terje Johansen , Andreas Brech , Carsten Sachse

The kinase PERK and the transcription factor ATF4 play distinct and essential roles in autophagy resulting from tunicamycin-induced ER stress.

The Journal of biological chemistry

Avec: Morten Luhr , Maria Lyngaas Torgersen , Paula Szalai , Adnan Hashim , Andreas Brech , Judith Staerk , Nikolai Engedal

Endosomal microautophagy is an integrated part of the autophagic response to amino acid starvation.

Autophagy

Avec: Hallvard L Olsvik , Steingrim Svenning , Yakubu Princely Abudu , Andreas Brech , Harald Stenmark , Terje Johansen , Jakob Mejlvang

Optic Atrophy 1 Controls Human Neuronal Development by Preventing Aberrant Nuclear DNA Methylation.

iScience

Avec: Safak Caglayan , Adnan Hashim , Artur Cieslar-Pobuda , Vidar Jensen , Sidney Behringer , Burcu Talug , Dinh Toi Chu , Christian Pecquet , Marie Rogne , Andreas Brech , Sverre Henning Brorson , Erlend Arnulf Nagelhus , Luciana Hannibal , Antonella Boschi , Kjetil Taskén , Judith Staerk

The phosphatidylinositol 3-phosphate-binding protein SNX4 controls ATG9A recycling and autophagy.

Journal of cell science

Avec: Anthony Ravussin , Andreas Brech , Sharon A Tooze , Harald Stenmark

JIP4 is recruited by the phosphoinositide-binding protein Phafin2 to promote recycling tubules on macropinosomes.

Journal of cell science

Avec: Kia Wee Tan , Viola Nähse , Coen Campsteijn , Andreas Brech , Kay Oliver Schink , Harald Stenmark

TRIM27 is an autophagy substrate facilitating mitochondria clustering and mitophagy via phosphorylated TBK1.

The FEBS journal

Avec: Juncal Garcia-Garcia , Anne Kristin McLaren Berge , Katrine Stange Overå , Kenneth Bowitz Larsen , Zambarlal Bhujabal , Andreas Brech , Yakubu Princely Abudu , Trond Lamark , Terje Johansen , Eva Sjøttem

Endocytic trafficking of connexins in cancer pathogenesis.

Biochimica et biophysica acta. Molecular basis of disease

Avec: Max Zachrisson Totland , Yasufumi Omori , Vigdis Sørensen , Kushtrim Kryeziu , Trond Aasen , Andreas Brech , Edward Leithe

The FMRpolyGlycine Protein Mediates Aggregate Formation and Toxicity Independent of the CGG mRNA Hairpin in a Cellular Model for FXTAS.

Frontiers in genetics

Avec: Gry Hoem , Kenneth Bowitz Larsen , Aud Øvervatn , Andreas Brech , Trond Lamark , Eva Sjøttem , Terje Johansen

Genotoxic effects of intermediate frequency magnetic fields on blood leukocytes in vitro.

Mutation research. Genetic toxicology and environmental mutagenesis

Avec: Annamária Brech , Györgyi Kubinyi , Zsuzsanna Németh , József Bakos , Serena Fiocchi , György Thuróczy

RabX1 Organizes a Late Endosomal Compartment that Forms Tubular Connections to Lysosomes Consistent with a "Kiss and Run" Mechanism.

Current biology : CB

Avec: Sara Laiouar , Nicola Berns , Andreas Brech , Veit Riechmann

Inhibiting autophagy increases the efficacy of low-dose photodynamic therapy.

Biochemical pharmacology

Avec: Sabine Weisheit , Catherine S Wegner , Ieva Ailte , Maja Radulovic , Anette Weyergang , Pål Kristian Selbo , Andreas Brech

Should I bend or should I grow: the mechanisms of droplet-mediated autophagosome formation.

Autophagy

Avec: Sebastian W Schultz , Jaime Agudo-Canalejo , Haruka Chino , Simona M Migliano , Chieko Saito , Ikuko Koyama-Honda , Harald Stenmark , Andreas Brech , Noboru Mizushima , Roland L Knorr , Alexander I May

BIN1, Myotubularin, and Dynamin-2 Coordinate T-Tubule Growth in Cardiomyocytes.

Circulation research

Avec: Harmonie Perdreau-Dahl , David B Lipsett , Michael Frisk , Fatemeh Kermani , Cathrine R Carlson , Andreas Brech , Xin Shen , Anna Bergan-Dahl , Yufeng Hou , Tomi Tuomainen , Pasi Tavi , Peter P Jones , Marianne Lunde , J Andrew Wasserstrom , Jocelyn Laporte , Nina D Ullrich , Geir Christensen , J Preben Morth , William E Louch

Modulation of lytic molecules restrain serial killing in γδ T lymphocytes.

Nature communications

Avec: Patrick A Sandoz , Kyra Kuhnigk , Edina K Szabo , Sarah Thunberg , Elina Erikson , Niklas Sandström , Quentin Verron , Andreas Brech , Carsten Watzl , Arnika K Wagner , Evren Alici , Karl-Johan Malmberg , Michael Uhlin , Björn Önfelt

Réseau de co-auteurs

Harald Stenmark 13 collaborations

Sebastian W Schultz 5 collaborations

Camilla Raiborg 5 collaborations

Eva Maria Wenzel 4 collaborations

Terje Johansen 4 collaborations

Roland L Knorr 3 collaborations

Karl-Johan Malmberg 3 collaborations

Ingrid Kjos 3 collaborations

Vigdis Sørensen 3 collaborations

Maja Radulovic 3 collaborations

Trond Lamark 3 collaborations

Jaime Agudo-Canalejo 2 collaborations

Haruka Chino 2 collaborations

Simona M Migliano 2 collaborations

Chieko Saito 2 collaborations

Ikuko Koyama-Honda 2 collaborations

Alexander I May 2 collaborations

Noboru Mizushima 2 collaborations

Dennis Clement 2 collaborations

Ellen Skarpen 2 collaborations

Christian Grimm 2 collaborations

Merete Thune Wiiger 2 collaborations

William E Louch 2 collaborations

Sandip Patel 2 collaborations

Kjetil Taskén 2 collaborations

Ashish Jain 2 collaborations

Espen Stang 2 collaborations

Nikolai Engedal 2 collaborations

Marja Jäättelä 2 collaborations

Kenji Maeda 2 collaborations

Coen Campsteijn 2 collaborations

Edina K Szabo 2 collaborations

Max Zachrisson Totland 2 collaborations

Yasufumi Omori 2 collaborations

Kushtrim Kryeziu 2 collaborations

Trond Aasen 2 collaborations

Edward Leithe 2 collaborations

Adnan Hashim 2 collaborations

Judith Staerk 2 collaborations

Yakubu Princely Abudu 2 collaborations

Kenneth Bowitz Larsen 2 collaborations

Eva Sjøttem 2 collaborations

Jodie P Goodridge 1 collaboration

Benedikt Jacobs 1 collaboration

Michelle L Saetersmoen 1 collaboration

Quirin Hammer 1 collaboration

Trevor Clancy 1 collaboration

Johannes Landskron 1 collaboration

Aline Pfefferle 1 collaboration

Leonardo Meza-Zepeda 1 collaboration

Susanne Lorenz 1 collaboration

Eivind Heggernes Ask 1 collaboration

Lisa L Liu 1 collaboration

Vincent Yi Sheng Oei 1 collaboration

Una Kjällquist 1 collaboration

Sten Linnarsson 1 collaboration

Ayelén Valko 1 collaboration

Sebastián Perez-Pandolfo 1 collaboration

Eleonora Sorianello 1 collaboration

Pablo Wappner 1 collaboration

Mariana Melani 1 collaboration

Rojyar Khezri 1 collaboration

Petter Holland 1 collaboration

Todd Andrew Schoborg 1 collaboration

Ifat Abramovich 1 collaboration

Szabolcs Takáts 1 collaboration

Caroline Dillard 1 collaboration

Fergal O'Farrell 1 collaboration

Sebastian Wolfgang Schultz 1 collaboration

William M Hagopian 1 collaboration

Eduardo Martin Quintana 1 collaboration

Rachel Ng 1 collaboration

Nadja Sandra Katheder 1 collaboration

Mohammed Mahidur Rahman 1 collaboration

José Gerardo Teles Reis 1 collaboration

Heinrich Jasper 1 collaboration

Nasser M Rusan 1 collaboration

Anne Hope Jahren 1 collaboration

Eyal Gottlieb 1 collaboration

Tor Erik Rusten 1 collaboration

Nina Marie Pedersen 1 collaboration

Liv Anker Elfmark 1 collaboration

Ling Wang 1 collaboration

Lene Malerød 1 collaboration

Yan Zhen 1 collaboration

Hélène Spangenberg 1 collaboration

Michael J Munson 1 collaboration

Kay O Schink 1 collaboration

Kia-Wee Tan 1 collaboration

Anne Simonsen 1 collaboration

Sania Gilani 1 collaboration

Lya Kk Holland 1 collaboration

Alf Håkon Lystad 1 collaboration

Santosh Phuyal 1 collaboration

Vesa M Olkkonen 1 collaboration

Nina Pettersen Hessvik 1 collaboration

Krizia Sagini 1 collaboration

Silvana Romero 1 collaboration

Manuel Ramirez-Garrastacho 1 collaboration

Marta Rodriguez 1 collaboration

Astrid Elisabeth V Tutturen 1 collaboration

Audun Kvalvaag 1 collaboration

Kirsten Sandvig 1 collaboration

Alicia Llorente 1 collaboration

Sascha Pust 1 collaboration

Catherine Sem Wegner 1 collaboration

Kaisa Haglund 1 collaboration

Marina Vietri 1 collaboration

Aurélie Bellanger 1 collaboration

Carl M Jones 1 collaboration

Louise I Petersen 1 collaboration

Christeen Ramane J Pedurupillay 1 collaboration

Eline Kip 1 collaboration

Romy Timmer 1 collaboration

Philippe Collas 1 collaboration

Sushma N Grellscheid 1 collaboration

Halim Kusumaatmaja 1 collaboration

Francesca Micci 1 collaboration

Søs Grønbæk Holdgaard 1 collaboration

Valentina Cianfanelli 1 collaboration

Emanuela Pupo 1 collaboration

Matteo Lambrughi 1 collaboration

Michal Lubas 1 collaboration

Julie C Nielsen 1 collaboration

Susana Eibes 1 collaboration

Emiliano Maiani 1 collaboration

Lea M Harder 1 collaboration

Nicole Wesch 1 collaboration

Mads Møller Foged 1 collaboration

Francesca Nazio 1 collaboration

Laura R de la Ballina 1 collaboration

Volker Dötsch 1 collaboration

Lisa B Frankel 1 collaboration

Franco Locatelli 1 collaboration

Marin Barisic 1 collaboration

Jens S Andersen 1 collaboration

Simon Bekker-Jensen 1 collaboration

Anders H Lund 1 collaboration

Vladimir V Rogov 1 collaboration

Elena Papaleo 1 collaboration

Letizia Lanzetti 1 collaboration

Daniela De Zio 1 collaboration

Francesco Cecconi 1 collaboration

Susanne Liese 1 collaboration

Rossana Rojas Molina 1 collaboration

Andreas Carlson 1 collaboration

Kristian Espeland 1 collaboration

Andrius Kleinauskas 1 collaboration

Petras Juzenas 1 collaboration

Sagar Darvekar 1 collaboration

Vlada Vasovic 1 collaboration

Trond Warloe 1 collaboration

Eidi Christensen 1 collaboration

Jørgen Jahnsen 1 collaboration

Qian Peng 1 collaboration

Silje Zandstra Krokeide 1 collaboration

Marianna Vincenti 1 collaboration

Daniel Palacios 1 collaboration

Young-Tae Chang 1 collaboration

Rakesh Kumar Majhi 1 collaboration

Lars Mørland Knudsen 1 collaboration

Nikoline Lander Rasmussen 1 collaboration

Vilde C Wivestad Elster 1 collaboration

Jakob Mørkved Stenersen 1 collaboration

Mathias Larsen 1 collaboration

Caroline Lunder Jensen 1 collaboration

Anna A Zickfeldt Lade 1 collaboration

Emilie Bruusgaard 1 collaboration

Sebastian Basing 1 collaboration

Ragnhild A Lothe 1 collaboration

Arjen J Jakobi 1 collaboration

Stefan T Huber 1 collaboration

Simon A Mortensen 1 collaboration

Anthimi Palara 1 collaboration

Tanja Kuhm 1 collaboration

Birendra Kumar Shrestha 1 collaboration

Wim J H Hagen 1 collaboration

Matthias Wilmanns 1 collaboration

Carsten Sachse 1 collaboration

Morten Luhr 1 collaboration

Maria Lyngaas Torgersen 1 collaboration

Paula Szalai 1 collaboration

Hallvard L Olsvik 1 collaboration

Steingrim Svenning 1 collaboration

Jakob Mejlvang 1 collaboration

Safak Caglayan 1 collaboration

Artur Cieslar-Pobuda 1 collaboration

Vidar Jensen 1 collaboration

Sidney Behringer 1 collaboration

Burcu Talug 1 collaboration

Dinh Toi Chu 1 collaboration

Christian Pecquet 1 collaboration

Marie Rogne 1 collaboration

Sverre Henning Brorson 1 collaboration

Erlend Arnulf Nagelhus 1 collaboration

Luciana Hannibal 1 collaboration

Antonella Boschi 1 collaboration

Anthony Ravussin 1 collaboration

Sharon A Tooze 1 collaboration

Kia Wee Tan 1 collaboration

Viola Nähse 1 collaboration

Kay Oliver Schink 1 collaboration

Juncal Garcia-Garcia 1 collaboration

Anne Kristin McLaren Berge 1 collaboration

Katrine Stange Overå 1 collaboration

Zambarlal Bhujabal 1 collaboration

Gry Hoem 1 collaboration

Aud Øvervatn 1 collaboration

Annamária Brech 1 collaboration

Györgyi Kubinyi 1 collaboration

Zsuzsanna Németh 1 collaboration

József Bakos 1 collaboration

Serena Fiocchi 1 collaboration

György Thuróczy 1 collaboration

Sara Laiouar 1 collaboration

Nicola Berns 1 collaboration

Veit Riechmann 1 collaboration

Sabine Weisheit 1 collaboration

Catherine S Wegner 1 collaboration

Ieva Ailte 1 collaboration

Anette Weyergang 1 collaboration

Pål Kristian Selbo 1 collaboration

Harmonie Perdreau-Dahl 1 collaboration

David B Lipsett 1 collaboration

Michael Frisk 1 collaboration

Fatemeh Kermani 1 collaboration

Cathrine R Carlson 1 collaboration

Xin Shen 1 collaboration

Anna Bergan-Dahl 1 collaboration

Yufeng Hou 1 collaboration

Tomi Tuomainen 1 collaboration

Pasi Tavi 1 collaboration

Peter P Jones 1 collaboration

Marianne Lunde 1 collaboration

J Andrew Wasserstrom 1 collaboration

Jocelyn Laporte 1 collaboration

Nina D Ullrich 1 collaboration

Geir Christensen 1 collaboration

J Preben Morth 1 collaboration

Patrick A Sandoz 1 collaboration

Kyra Kuhnigk 1 collaboration

Sarah Thunberg 1 collaboration

Elina Erikson 1 collaboration

Niklas Sandström 1 collaboration

Quentin Verron 1 collaboration

Carsten Watzl 1 collaboration

Arnika K Wagner 1 collaboration

Evren Alici 1 collaboration

Michael Uhlin 1 collaboration

Björn Önfelt 1 collaboration