Alina Guna

Affiliations

Division of Biology and Biological Engineering, California Institute of Technology, 1200 E. California Ave, Pasadena, CA, 91125, USA.
Whitehead Institute for Biomedical Research, Massachusetts Institute of Technology, Cambridge, MA, 02142, USA.

Publications (16)

A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens.

BMC genomics

Avec: Alina Guna , Katharine R Page , Joseph M Replogle , Theodore K Esantsi , Maxine L Wang , Jonathan S Weissman , Rebecca M Voorhees

Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins.

Molecular cell

Avec: Katharine R Page , Vy N Nguyen , Tino Pleiner , Giovani Pinton Tomaleri , Maxine L Wang , Alina Guna , Masami Hazu , Ting-Yu Wang , Tsui-Fen Chou , Rebecca M Voorhees

A TAle of Two Pathways: Tail-Anchored Protein Insertion at the Endoplasmic Reticulum.

Cold Spring Harbor perspectives in biology

Avec: Alina Guna , Masami Hazu , Giovani Pinton Tomaleri , Rebecca M Voorhees

Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.

bioRxiv : the preprint server for biology

Avec: Gayathri Muthukumar , Taylor A Stevens , Alison J Inglis , Theodore K Esantsi , Reuben A Saunders , Fabian Schulte , Rebecca M Voorhees , Alina Guna , Jonathan S Weissman

Differential Modes of Orphan Subunit Recognition for the WRB/CAML Complex.

Cell reports

Avec: Alison J Inglis , Katharine R Page , Alina Guna , Rebecca M Voorhees

Mapping information-rich genotype-phenotype landscapes with genome-scale Perturb-seq.

Cell

Avec: Joseph M Replogle , Reuben A Saunders , Angela N Pogson , Jeffrey A Hussmann , Alexander Lenail , Alina Guna , Lauren Mascibroda , Eric J Wagner , Karen Adelman , Gila Lithwick-Yanai , Nika Iremadze , Florian Oberstrass , Doron Lipson , Jessica L Bonnar , Marco Jost , Thomas M Norman , Jonathan S Weissman

MTCH2 is a mitochondrial outer membrane protein insertase.

Science (New York, N.Y.)

Avec: Alina Guna , Taylor A Stevens , Alison J Inglis , Joseph M Replogle , Theodore K Esantsi , Gayathri Muthukumar , Kelly C L Shaffer , Maxine L Wang , Angela N Pogson , Jeff J Jones , Brett Lomenick , Tsui-Fen Chou , Jonathan S Weissman , Rebecca M Voorhees

Compensatory ion transport buffers daily protein rhythms to regulate osmotic balance and cellular physiology.

Nature communications

Avec: Alessandra Stangherlin , Joseph L Watson , David C S Wong , Silvia Barbiero , Aiwei Zeng , Estere Seinkmane , Sew Peak Chew , Andrew D Beale , Edward A Hayter , Alina Guna , Alison J Inglis , Marrit Putker , Eline Bartolami , Stefan Matile , Nicolas Lequeux , Thomas Pons , Jason Day , Gerben van Ooijen , Rebecca M Voorhees , David A Bechtold , Emmanuel Derivery , Rachel S Edgar , Peter Newham , John S O'Neill

Triaging of α-helical proteins to the mitochondrial outer membrane by distinct chaperone machinery based on substrate topology.

Molecular cell

Avec: Gayathri Muthukumar , Taylor A Stevens , Alison J Inglis , Theodore K Esantsi , Reuben A Saunders , Fabian Schulte , Rebecca M Voorhees , Alina Guna , Jonathan S Weissman

Macromolecular condensation buffers intracellular water potential.

Nature

Avec: Joseph L Watson , Estere Seinkmane , Christine T Styles , Andrei Mihut , Lara K Krüger , Kerrie E McNally , Vicente Jose Planelles-Herrero , Michal Dudek , Patrick M McCall , Silvia Barbiero , Michael Vanden Oever , Sew Yeu Peak-Chew , Benjamin T Porebski , Aiwei Zeng , Nina M Rzechorzek , David C S Wong , Andrew D Beale , Alessandra Stangherlin , Margot Riggi , Janet Iwasa , Jörg Morf , Christos Miliotis , Alina Guna , Alison J Inglis , Jan Brugués , Rebecca M Voorhees , Joseph E Chambers , Qing-Jun Meng , John S O'Neill , Rachel S Edgar , Emmanuel Derivery

WNK1 is an assembly factor for the human ER membrane protein complex.

Molecular cell

Avec: Tino Pleiner , Masami Hazu , Giovani Pinton Tomaleri , Kurt Januszyk , Robert S Oania , Michael J Sweredoski , Annie Moradian , Alina Guna , Rebecca M Voorhees

Role of a holo-insertase complex in the biogenesis of biophysically diverse ER membrane proteins.

bioRxiv : the preprint server for biology

Avec: Katharine R Page , Vy N Nguyen , Tino Pleiner , Giovani Pinton Tomaleri , Maxine L Wang , Alina Guna , Ting-Yu Wang , Tsui-Fen Chou , Rebecca M Voorhees

A dual sgRNA library design to probe genetic modifiers using genome-wide CRISPRi screens.

bioRxiv : the preprint server for biology

Avec: Alina Guna , Katharine R Page , Joseph M Replogle , Theodore K Esantsi , Maxine L Wang , Jonathan S Weissman , Rebecca M Voorhees

A genome-wide optical pooled screen reveals regulators of cellular antiviral responses.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Rebecca J Carlson , Michael D Leiken , Alina Guna , Nir Hacohen , Paul C Blainey

Coupled protein quality control during nonsense-mediated mRNA decay.

Journal of cell science

Avec: Alison J Inglis , Alina Guna , Ángel Gálvez-Merchán , Akshaye Pal , Theodore K Esantsi , Heather R Keys , Evgeni M Frenkel , Robert Oania , Jonathan S Weissman , Rebecca M Voorhees

Maximizing CRISPRi efficacy and accessibility with dual-sgRNA libraries and optimal effectors.

eLife

Avec: Joseph M Replogle , Jessica L Bonnar , Angela N Pogson , Christina R Liem , Nolan K Maier , Yufang Ding , Baylee J Russell , Xingren Wang , Kun Leng , Alina Guna , Thomas M Norman , Ryan A Pak , Daniel M Ramos , Michael E Ward , Luke A Gilbert , Martin Kampmann , Jonathan S Weissman , Marco Jost

Réseau de co-auteurs

Rebecca M Voorhees 13 collaborations

Jonathan S Weissman 8 collaborations

Alison J Inglis 7 collaborations

Theodore K Esantsi 6 collaborations

Katharine R Page 5 collaborations

Joseph M Replogle 5 collaborations

Maxine L Wang 5 collaborations

Giovani Pinton Tomaleri 4 collaborations

Tino Pleiner 3 collaborations

Masami Hazu 3 collaborations

Tsui-Fen Chou 3 collaborations

Gayathri Muthukumar 3 collaborations

Taylor A Stevens 3 collaborations

Reuben A Saunders 3 collaborations

Angela N Pogson 3 collaborations

Vy N Nguyen 2 collaborations

Ting-Yu Wang 2 collaborations

Fabian Schulte 2 collaborations

Jessica L Bonnar 2 collaborations

Marco Jost 2 collaborations

Thomas M Norman 2 collaborations

Alessandra Stangherlin 2 collaborations

Joseph L Watson 2 collaborations

David C S Wong 2 collaborations

Silvia Barbiero 2 collaborations

Aiwei Zeng 2 collaborations

Estere Seinkmane 2 collaborations

Andrew D Beale 2 collaborations

Emmanuel Derivery 2 collaborations

Rachel S Edgar 2 collaborations

John S O'Neill 2 collaborations

Jeffrey A Hussmann 1 collaboration

Alexander Lenail 1 collaboration

Lauren Mascibroda 1 collaboration

Eric J Wagner 1 collaboration

Karen Adelman 1 collaboration

Gila Lithwick-Yanai 1 collaboration

Nika Iremadze 1 collaboration

Florian Oberstrass 1 collaboration

Doron Lipson 1 collaboration

Kelly C L Shaffer 1 collaboration

Jeff J Jones 1 collaboration

Brett Lomenick 1 collaboration

Sew Peak Chew 1 collaboration

Edward A Hayter 1 collaboration

Marrit Putker 1 collaboration

Eline Bartolami 1 collaboration

Stefan Matile 1 collaboration

Nicolas Lequeux 1 collaboration

Thomas Pons 1 collaboration

Jason Day 1 collaboration

Gerben van Ooijen 1 collaboration

David A Bechtold 1 collaboration

Peter Newham 1 collaboration

Christine T Styles 1 collaboration

Andrei Mihut 1 collaboration

Lara K Krüger 1 collaboration

Kerrie E McNally 1 collaboration

Vicente Jose Planelles-Herrero 1 collaboration

Michal Dudek 1 collaboration

Patrick M McCall 1 collaboration

Michael Vanden Oever 1 collaboration

Sew Yeu Peak-Chew 1 collaboration

Benjamin T Porebski 1 collaboration

Nina M Rzechorzek 1 collaboration

Margot Riggi 1 collaboration

Janet Iwasa 1 collaboration

Jörg Morf 1 collaboration

Christos Miliotis 1 collaboration

Jan Brugués 1 collaboration

Joseph E Chambers 1 collaboration

Qing-Jun Meng 1 collaboration

Kurt Januszyk 1 collaboration

Robert S Oania 1 collaboration

Michael J Sweredoski 1 collaboration

Annie Moradian 1 collaboration

Rebecca J Carlson 1 collaboration

Michael D Leiken 1 collaboration

Nir Hacohen 1 collaboration

Paul C Blainey 1 collaboration

Ángel Gálvez-Merchán 1 collaboration

Akshaye Pal 1 collaboration

Heather R Keys 1 collaboration

Evgeni M Frenkel 1 collaboration

Robert Oania 1 collaboration

Christina R Liem 1 collaboration

Nolan K Maier 1 collaboration

Yufang Ding 1 collaboration

Baylee J Russell 1 collaboration

Xingren Wang 1 collaboration

Kun Leng 1 collaboration

Ryan A Pak 1 collaboration

Daniel M Ramos 1 collaboration

Michael E Ward 1 collaboration

Luke A Gilbert 1 collaboration

Martin Kampmann 1 collaboration