Wenzel M Hackeng

Affiliations

Department of Pathology, University Medical Center Utrecht, Utrecht, The Netherlands.

ORCID: 0000-0001-6795-179X

Publications (22)

Aggressive versus indolent insulinomas: new clinicopathological insights.

Endocrine-related cancer

Avec: Lodewijk A A Brosens , Koen M A Dreijerink

Well-differentiated Pancreatic Neuroendocrine Tumor in a Patient With Familial Atypical Multiple Mole Melanoma Syndrome (FAMMM).

The American journal of surgical pathology

Avec: Michaël Noë , Wendy W J de Leng , Menno Vergeer , Frank P Vleggaar , Folkert H M Morsink , Laura D Wood , Ralph H Hruban , G Johan A Offerhaus , Lodewijk A A Brosens

Subtype heterogeneity and epigenetic convergence in neuroendocrine prostate cancer.

Nature communications

Avec: Paloma Cejas , Yingtian Xie , Alba Font-Tello , Klothilda Lim , Sudeepa Syamala , Xintao Qiu , Alok K Tewari , Neel Shah , Holly M Nguyen , Radhika A Patel , Lisha Brown , Ilsa Coleman , Lodewijk Brosens , Koen M A Dreijerink , Leigh Ellis , Sarah Abou Alaiwi , Ji-Heui Seo , Sylvan Baca , Himisha Beltran , Francesca Khani , Mark Pomerantz , Alessandra Dall'Agnese , Jett Crowdis , Eliezer M Van Allen , Joaquim Bellmunt , Colm Morrisey , Peter S Nelson , James DeCaprio , Anna Farago , Nicholas Dyson , Benjamin Drapkin , X Shirley Liu , Matthew Freedman , Michael C Haffner , Eva Corey , Myles Brown , Henry W Long

Non-functional pancreatic neuroendocrine tumours: ATRX/DAXX and alternative lengthening of telomeres (ALT) are prognostically independent from ARX/PDX1 expression and tumour size.

Gut

Avec: Lodewijk A A Brosens , Joo Young Kim , Roderick O'Sullivan , You-Na Sung , Ta-Chiang Liu , Dengfeng Cao , Michelle Heayn , Jacqueline Brosnan-Cashman , Soyeon An , Folkert H M Morsink , Charlotte M Heidsma , Gerlof D Valk , Menno R Vriens , Els Nieveen van Dijkum , G Johan A Offerhaus , Koen M A Dreijerink , Herbert Zeh , Amer H Zureikat , Melissa Hogg , Kenneth Lee , David Geller , J Wallis Marsh , Alessandro Paniccia , Melanie Ongchin , James F Pingpank , Nathan Bahary , Muaz Aijazi , Randall Brand , Jennifer Chennat , Rohit Das , Kenneth E Fasanella , Asif Khalid , Kevin McGrath , Savreet Sarkaria , Harkirat Singh , Adam Slivka , Michael Nalesnik , Xiaoli Han , Marina N Nikiforova , Rita Teresa Lawlor , Andrea Mafficini , Boris Rusev , Vincenzo Corbo , Claudio Luchini , Samantha Bersani , Antonio Pea , Sara Cingarlini , Luca Landoni , Roberto Salvia , Massimo Milione , Michele Milella , Aldo Scarpa , Seung-Mo Hong , Christopher M Heaphy , Aatur D Singhi

The Management of Neuroendocrine Tumors of the Lung in MEN1: Results From the Dutch MEN1 Study Group.

The Journal of clinical endocrinology and metabolism

Avec: Medard F M van den Broek , Joanne M de Laat , Rachel S van Leeuwaarde , Annenienke C van de Ven , Wouter W de Herder , Olaf M Dekkers , Madeleine L Drent , Michiel N Kerstens , Peter H Bisschop , Bas Havekes , Lodewijk A A Brosens , Menno R Vriens , Wieneke A Buikhuisen , Gerlof D Valk

Clear cell chondrosarcoma in Von Hippel-Lindau disease.

Familial cancer

Avec: Koen M A Dreijerink , Rachel S van Leeuwaarde , Rachel H Giles , Wendy W J de Leng , Paul C Jutte , Albert J H Suurmeijer , Bernadette P M van Nesselrooij , Lodewijk A A Brosens

Pseudomyxoma Peritonei After a Total Pancreatectomy for Intraductal Papillary Mucinous Neoplasm With Colloid Carcinoma in Lynch Syndrome.

Pancreas

Avec: Livia E V M de Guerre , Karel C Kuypers , Alexander M Snoek , Folkert H Morsink , G Johan A Offerhaus , Lodewijk A A Brosens

Diagnostic Utility of Menin Immunohistochemistry in Patients With Multiple Endocrine Neoplasia Type 1 Syndrome.

The American journal of surgical pathology

Avec: Anna Vera D Verschuur , Aranxa S M Kok , Folkert H M Morsink , Wendy W J de Leng , Medard F M van den Broek , Marco J Koudijs , Johan A Offerhaus , Gerlof D Valk , Menno R Vriens , Bernadette P M van Nesselrooij , Lodewijk A A Brosens

Druggable growth dependencies and tumor evolution analysis in patient-derived organoids of neuroendocrine neoplasms from multiple body sites.

Cancer cell

Avec: Talya L Dayton , Nicolas Alcala , Laura Moonen , Lisanne den Hartigh , Veerle Geurts , Lise Mangiante , Lisa Lap , Antonella F M Dost , Joep Beumer , Sonja Levy , Rachel S van Leeuwaarde , Kris Samsom , Catherine Voegele , Alexandra Sexton-Oates , Harry Begthel , Jeroen Korving , Lisa Hillen , Lodewijk A A Brosens , Sylvie Lantuejoul , Sridevi Jaksani , Niels F M Kok , Koen J Hartemink , Houke M Klomp , Inne H M Borel Rinkes , Anne-Marie Dingemans , Gerlof D Valk , Menno R Vriens , Wieneke Buikhuisen , José van den Berg , Margot Tesselaar , Jules Derks , Ernst Jan Speel , Matthieu Foll , Lynnette Fernández-Cuesta , Hans Clevers

Genomic characterization of malignant progression in neoplastic pancreatic cysts.

Nature communications

Avec: Michaël Noë , Noushin Niknafs , Catherine G Fischer , Violeta Beleva Guthrie , Waki Hosoda , Marija Debeljak , Eniko Papp , Vilmos Adleff , James R White , Claudio Luchini , Antonio Pea , Aldo Scarpa , Giovanni Butturini , Giuseppe Zamboni , Paola Castelli , Seung-Mo Hong , Shinichi Yachida , Nobuyoshi Hiraoka , Anthony J Gill , Jaswinder S Samra , G Johan A Offerhaus , Anne Hoorens , Joanne Verheij , Casper Jansen , N Volkan Adsay , Wei Jiang , Jordan Winter , Jorge Albores-Saavedra , Benoit Terris , Elizabeth D Thompson , Nicholas J Roberts , Ralph H Hruban , Rachel Karchin , Robert B Scharpf , Lodewijk A A Brosens , Victor E Velculescu , Laura D Wood

Comprehensive Genomic Profiling of Neuroendocrine Carcinomas of the Gastrointestinal System.

Cancer discovery

Avec: Shinichi Yachida , Yasushi Totoki , Michaël Noë , Yoichiro Nakatani , Masafumi Horie , Kenta Kawasaki , Hiromi Nakamura , Mihoko Saito-Adachi , Masami Suzuki , Erina Takai , Natsuko Hama , Ryota Higuchi , Seiko Hirono , Satoshi Shiba , Mamoru Kato , Eisaku Furukawa , Yasuhito Arai , Hirofumi Rokutan , Taiki Hashimoto , Shuichi Mitsunaga , Mitsuro Kanda , Hidenori Tanaka , So Takata , Ayaka Shimomura , Minoru Oshima , Tomoyuki Okumura , Keiichi Okano , Masakazu Yamamoto , Hiroki Yamaue , Chigusa Morizane , Koji Arihiro , Toru Furukawa , Toshiro Sato , Tohru Kiyono , Lodewijk A A Brosens , Laura D Wood , Ralph H Hruban , Tatsuhiro Shibata

Genome Methylation Accurately Predicts Neuroendocrine Tumor Origin: An Online Tool.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Koen M A Dreijerink , Wendy W J de Leng , Folkert H M Morsink , Gerlof D Valk , Menno R Vriens , G Johan A Offerhaus , Christoph Geisenberger , Lodewijk A A Brosens

Metastatic Patterns of Duodenopancreatic Neuroendocrine Tumors in Patients With Multiple Endocrine Neoplasia Type 1.

The American journal of surgical pathology

Avec: Dirk-Jan van Beek , Aranxa S M Kok , Madelon van Emst , Folkert H M Morsink , Mark J C van Treijen , Inne H M Borel Rinkes , Koen M A Dreijerink , G Johan A Offerhaus , Gerlof D Valk , Menno R Vriens , Lodewijk A A Brosens

DNA Methylation Profiling Enables Accurate Classification of Nonductal Primary Pancreatic Neoplasms.

Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association

Avec: Anna Vera D Verschuur , Florine Westerbeke , Jamal K Benhamida , Olca Basturk , Pier Selenica , G Mihaela Raicu , I Quintus Molenaar , Hjalmar C van Santvoort , Lois A Daamen , David S Klimstra , Shinichi Yachida , Claudio Luchini , Aatur D Singhi , Christoph Geisenberger , Lodewijk A A Brosens

Glucagon-Producing Pancreatic Neuroendocrine Tumors (Glucagonomas) are Enriched in Aggressive Neoplasms with ARX and PDX1 Co-expression, DAXX/ATRX Mutations, and ALT (Alternative Lengthening of Telomeres).

Endocrine pathology

Avec: Paola Mattiolo , Michele Bevere , Andrea Mafficini , Anna Vera D Verschuur , Martina Calicchia , Michele Simbolo , Salvatore Paiella , Koen M A Dreijerink , Luca Landoni , Serena Pedron , Sara Cingarlini , Roberto Salvia , Michele Milella , Rita T Lawlor , Gerlof D Valk , Menno R Vriens , Aldo Scarpa , Lodewijk A Brosens , Claudio Luchini

The decisive role of molecular pathology in presumed somatic metastases of type II testicular germ cell tumors: report of 2 cases.

Diagnostic pathology

Avec: Mariëtte E G Kranendonk , G Johan A Offerhaus , Folkert H M Morsink , Geertruida N Jonges , Gerard Groenewegen , Pieter-Jaap Krijtenburg , Heinz-Josef Klümpen , Wendy W J de Leng , Leendert H J Looijenga , Lodewijk A A Brosens

Assessment of ARX expression, a novel biomarker for metastatic risk in pancreatic neuroendocrine tumors, in endoscopic ultrasound fine-needle aspiration.

Diagnostic cytopathology

Avec: Folkert H M Morsink , Leon M G Moons , Christopher M Heaphy , G Johan A Offerhaus , Koen M A Dreijerink , Lodewijk A A Brosens

Alternative Lengthening of Telomeres and Differential Expression of Endocrine Transcription Factors Distinguish Metastatic and Non-metastatic Insulinomas.

Endocrine pathology

Avec: Willemien Schelhaas , Folkert H M Morsink , Charlotte M Heidsma , Susanne van Eeden , Gerlof D Valk , Menno R Vriens , Christopher M Heaphy , Els J M Nieveen van Dijkum , G Johan A Offerhaus , Koen M A Dreijerink , Lodewijk A A Brosens

Clinical implications of cell-of-origin epigenetic characteristics in non-functional pancreatic neuroendocrine tumors.

The Journal of pathology

Avec: Koen Ma Dreijerink , Aatur D Singhi , Christopher M Heaphy , Lodewijk Aa Brosens

The Impact of Clinical and Pathological Features on Intraductal Papillary Mucinous Neoplasm Recurrence After Surgical Resection: Long-Term Follow-Up Analysis.

Annals of surgery

Avec: Michael J Pflüger , James F Griffin , Satomi Kawamoto , Jun Yu , Peter Chianchiano , Eunice Shin , Gemma Lionheart , Hua-Ling Tsai , Hao Wang , Neda Rezaee , Richard A Burkhart , John L Cameron , Elizabeth D Thompson , Christopher L Wolfgang , Jin He , Lodewijk A A Brosens , Laura D Wood

A Parathyroid-Gut Axis: Hypercalcemia and the Pathogenesis of Gastrinoma in Multiple Endocrine Neoplasia 1.

Molecular cancer research : MCR

Avec: Koen M A Dreijerink , G Johan A Offerhaus , Lodewijk A A Brosens

Prognostic and Predictive Biomarkers for Pancreatic Neuroendocrine Tumors.

Surgical pathology clinics

Avec: Hussein A Assi , Florine H M Westerbeke , Lodewijk A A Brosens , Christopher M Heaphy

Réseau de co-auteurs

Lodewijk A A Brosens 19 collaborations

Koen M A Dreijerink 10 collaborations

G Johan A Offerhaus 10 collaborations

Folkert H M Morsink 8 collaborations

Gerlof D Valk 8 collaborations

Menno R Vriens 8 collaborations

Wendy W J de Leng 5 collaborations

Christopher M Heaphy 5 collaborations

Laura D Wood 4 collaborations

Claudio Luchini 4 collaborations

Michaël Noë 3 collaborations

Ralph H Hruban 3 collaborations

Aldo Scarpa 3 collaborations

Aatur D Singhi 3 collaborations

Rachel S van Leeuwaarde 3 collaborations

Anna Vera D Verschuur 3 collaborations

Shinichi Yachida 3 collaborations

Charlotte M Heidsma 2 collaborations

Andrea Mafficini 2 collaborations

Antonio Pea 2 collaborations

Sara Cingarlini 2 collaborations

Luca Landoni 2 collaborations

Roberto Salvia 2 collaborations

Michele Milella 2 collaborations

Seung-Mo Hong 2 collaborations

Medard F M van den Broek 2 collaborations

Bernadette P M van Nesselrooij 2 collaborations

Aranxa S M Kok 2 collaborations

Inne H M Borel Rinkes 2 collaborations

Elizabeth D Thompson 2 collaborations

Christoph Geisenberger 2 collaborations

Menno Vergeer 1 collaboration

Frank P Vleggaar 1 collaboration

Paloma Cejas 1 collaboration

Yingtian Xie 1 collaboration

Alba Font-Tello 1 collaboration

Klothilda Lim 1 collaboration

Sudeepa Syamala 1 collaboration

Xintao Qiu 1 collaboration

Alok K Tewari 1 collaboration

Neel Shah 1 collaboration

Holly M Nguyen 1 collaboration

Radhika A Patel 1 collaboration

Lisha Brown 1 collaboration

Ilsa Coleman 1 collaboration

Lodewijk Brosens 1 collaboration

Leigh Ellis 1 collaboration

Sarah Abou Alaiwi 1 collaboration

Ji-Heui Seo 1 collaboration

Sylvan Baca 1 collaboration

Himisha Beltran 1 collaboration

Francesca Khani 1 collaboration

Mark Pomerantz 1 collaboration

Alessandra Dall'Agnese 1 collaboration

Jett Crowdis 1 collaboration

Eliezer M Van Allen 1 collaboration

Joaquim Bellmunt 1 collaboration

Colm Morrisey 1 collaboration

Peter S Nelson 1 collaboration

James DeCaprio 1 collaboration

Anna Farago 1 collaboration

Nicholas Dyson 1 collaboration

Benjamin Drapkin 1 collaboration

X Shirley Liu 1 collaboration

Matthew Freedman 1 collaboration

Michael C Haffner 1 collaboration

Eva Corey 1 collaboration

Myles Brown 1 collaboration

Henry W Long 1 collaboration

Joo Young Kim 1 collaboration

Roderick O'Sullivan 1 collaboration

You-Na Sung 1 collaboration

Ta-Chiang Liu 1 collaboration

Dengfeng Cao 1 collaboration

Michelle Heayn 1 collaboration

Jacqueline Brosnan-Cashman 1 collaboration

Soyeon An 1 collaboration

Els Nieveen van Dijkum 1 collaboration

Herbert Zeh 1 collaboration

Amer H Zureikat 1 collaboration

Melissa Hogg 1 collaboration

Kenneth Lee 1 collaboration

David Geller 1 collaboration

J Wallis Marsh 1 collaboration

Alessandro Paniccia 1 collaboration

Melanie Ongchin 1 collaboration

James F Pingpank 1 collaboration

Nathan Bahary 1 collaboration

Muaz Aijazi 1 collaboration

Randall Brand 1 collaboration

Jennifer Chennat 1 collaboration

Rohit Das 1 collaboration

Kenneth E Fasanella 1 collaboration

Asif Khalid 1 collaboration

Kevin McGrath 1 collaboration

Savreet Sarkaria 1 collaboration

Harkirat Singh 1 collaboration

Adam Slivka 1 collaboration

Michael Nalesnik 1 collaboration

Xiaoli Han 1 collaboration

Marina N Nikiforova 1 collaboration

Rita Teresa Lawlor 1 collaboration

Boris Rusev 1 collaboration

Vincenzo Corbo 1 collaboration

Samantha Bersani 1 collaboration

Massimo Milione 1 collaboration

Joanne M de Laat 1 collaboration

Annenienke C van de Ven 1 collaboration

Wouter W de Herder 1 collaboration

Olaf M Dekkers 1 collaboration

Madeleine L Drent 1 collaboration

Michiel N Kerstens 1 collaboration

Peter H Bisschop 1 collaboration

Bas Havekes 1 collaboration

Wieneke A Buikhuisen 1 collaboration

Rachel H Giles 1 collaboration

Paul C Jutte 1 collaboration

Albert J H Suurmeijer 1 collaboration

Livia E V M de Guerre 1 collaboration

Karel C Kuypers 1 collaboration

Alexander M Snoek 1 collaboration

Folkert H Morsink 1 collaboration

Marco J Koudijs 1 collaboration

Johan A Offerhaus 1 collaboration

Talya L Dayton 1 collaboration

Nicolas Alcala 1 collaboration

Laura Moonen 1 collaboration

Lisanne den Hartigh 1 collaboration

Veerle Geurts 1 collaboration

Lise Mangiante 1 collaboration

Lisa Lap 1 collaboration

Antonella F M Dost 1 collaboration

Joep Beumer 1 collaboration

Sonja Levy 1 collaboration

Kris Samsom 1 collaboration

Catherine Voegele 1 collaboration

Alexandra Sexton-Oates 1 collaboration

Harry Begthel 1 collaboration

Jeroen Korving 1 collaboration

Lisa Hillen 1 collaboration

Sylvie Lantuejoul 1 collaboration

Sridevi Jaksani 1 collaboration

Niels F M Kok 1 collaboration

Koen J Hartemink 1 collaboration

Houke M Klomp 1 collaboration

Anne-Marie Dingemans 1 collaboration

Wieneke Buikhuisen 1 collaboration

José van den Berg 1 collaboration

Margot Tesselaar 1 collaboration

Jules Derks 1 collaboration

Ernst Jan Speel 1 collaboration

Matthieu Foll 1 collaboration

Lynnette Fernández-Cuesta 1 collaboration

Hans Clevers 1 collaboration

Noushin Niknafs 1 collaboration

Catherine G Fischer 1 collaboration

Violeta Beleva Guthrie 1 collaboration

Waki Hosoda 1 collaboration

Marija Debeljak 1 collaboration

Eniko Papp 1 collaboration

Vilmos Adleff 1 collaboration

James R White 1 collaboration

Giovanni Butturini 1 collaboration

Giuseppe Zamboni 1 collaboration

Paola Castelli 1 collaboration

Nobuyoshi Hiraoka 1 collaboration

Anthony J Gill 1 collaboration

Jaswinder S Samra 1 collaboration

Anne Hoorens 1 collaboration

Joanne Verheij 1 collaboration

Casper Jansen 1 collaboration

N Volkan Adsay 1 collaboration

Wei Jiang 1 collaboration

Jordan Winter 1 collaboration

Jorge Albores-Saavedra 1 collaboration

Benoit Terris 1 collaboration

Nicholas J Roberts 1 collaboration

Rachel Karchin 1 collaboration

Robert B Scharpf 1 collaboration

Victor E Velculescu 1 collaboration

Yasushi Totoki 1 collaboration

Yoichiro Nakatani 1 collaboration

Masafumi Horie 1 collaboration

Kenta Kawasaki 1 collaboration

Hiromi Nakamura 1 collaboration

Mihoko Saito-Adachi 1 collaboration

Masami Suzuki 1 collaboration

Erina Takai 1 collaboration

Natsuko Hama 1 collaboration

Ryota Higuchi 1 collaboration

Seiko Hirono 1 collaboration

Satoshi Shiba 1 collaboration

Mamoru Kato 1 collaboration

Eisaku Furukawa 1 collaboration

Yasuhito Arai 1 collaboration

Hirofumi Rokutan 1 collaboration

Taiki Hashimoto 1 collaboration

Shuichi Mitsunaga 1 collaboration

Mitsuro Kanda 1 collaboration

Hidenori Tanaka 1 collaboration

So Takata 1 collaboration

Ayaka Shimomura 1 collaboration

Minoru Oshima 1 collaboration

Tomoyuki Okumura 1 collaboration

Keiichi Okano 1 collaboration

Masakazu Yamamoto 1 collaboration

Hiroki Yamaue 1 collaboration

Chigusa Morizane 1 collaboration

Koji Arihiro 1 collaboration

Toru Furukawa 1 collaboration

Toshiro Sato 1 collaboration

Tohru Kiyono 1 collaboration

Tatsuhiro Shibata 1 collaboration

Dirk-Jan van Beek 1 collaboration

Madelon van Emst 1 collaboration

Mark J C van Treijen 1 collaboration

Florine Westerbeke 1 collaboration

Jamal K Benhamida 1 collaboration

Olca Basturk 1 collaboration

Pier Selenica 1 collaboration

G Mihaela Raicu 1 collaboration

I Quintus Molenaar 1 collaboration

Hjalmar C van Santvoort 1 collaboration

Lois A Daamen 1 collaboration

David S Klimstra 1 collaboration

Paola Mattiolo 1 collaboration

Michele Bevere 1 collaboration

Martina Calicchia 1 collaboration

Michele Simbolo 1 collaboration

Salvatore Paiella 1 collaboration

Serena Pedron 1 collaboration

Rita T Lawlor 1 collaboration

Lodewijk A Brosens 1 collaboration

Mariëtte E G Kranendonk 1 collaboration

Geertruida N Jonges 1 collaboration

Gerard Groenewegen 1 collaboration

Pieter-Jaap Krijtenburg 1 collaboration

Heinz-Josef Klümpen 1 collaboration

Leendert H J Looijenga 1 collaboration

Leon M G Moons 1 collaboration

Willemien Schelhaas 1 collaboration

Susanne van Eeden 1 collaboration

Els J M Nieveen van Dijkum 1 collaboration

Koen Ma Dreijerink 1 collaboration

Lodewijk Aa Brosens 1 collaboration

Michael J Pflüger 1 collaboration

James F Griffin 1 collaboration

Satomi Kawamoto 1 collaboration

Jun Yu 1 collaboration

Peter Chianchiano 1 collaboration

Eunice Shin 1 collaboration

Gemma Lionheart 1 collaboration

Hua-Ling Tsai 1 collaboration

Hao Wang 1 collaboration

Neda Rezaee 1 collaboration

Richard A Burkhart 1 collaboration

John L Cameron 1 collaboration

Christopher L Wolfgang 1 collaboration

Jin He 1 collaboration

Hussein A Assi 1 collaboration

Florine H M Westerbeke 1 collaboration