Tristan Rawling

Affiliations

Faculty of Medicine and Health, The University of Sydney, Sydney, Australia (B.S.W., J.P.-O., A.G., S.E., C.A., S.N.M, M.J.C., R.J.V., S.A.M.) and School of Mathematical and Physical Sciences, University of Technology, Sydney, Australia (S.S., T.R.).

Publications (39)

Peripheral Administration of Selective Glycine Transporter-2 Inhibitor, Oleoyl-

The Journal of pharmacology and experimental therapeutics

Avec: Bruce S Wilson , Julian Peiser-Oliver , Alexander Gillis , Sally Evans , Claudia Alamein , Shannon N Mostyn , Susan Shimmon , MacDonald J Christie , Robert J Vandenberg , Sarasa A Mohammadi

Expanding the π-system of fatty acid-anion transporter conjugates modulates their mechanism of proton transport and mitochondrial uncoupling activity.

Chemistry (Weinheim an der Bergstrasse, Germany)

Avec: Edward York , Daniel A McNaughton , David S Gertner , Philip A Gale , Michael Murray ,

Amphetamine-like Deferiprone and Clioquinol Derivatives as Iron Chelating Agents.

Molecules (Basel, Switzerland)

Avec: Mahmoud El Safadi , Katie A Wilson , Indigo J Strudwicke , Megan L O'Mara , Mohan Bhadbhade , Andrew M McDonagh

Mitochondrial uncoupler SHC517 reverses obesity in mice without affecting food intake.

Metabolism: clinical and experimental

Avec: Sing-Young Chen , Martina Beretta , Stephanie J Alexopoulos , Divya P Shah , Ellen M Olzomer , Stefan R Hargett , Elizabeth S Childress , Joseph M Salamoun , Isabella Aleksovska , Ariane Roseblade , Charles Cranfield , Kate G R Quinlan , Margaret J Morris , Simon P Tucker , Webster L Santos , Kyle L Hoehn

l-3,4-dihydroxyphenylalanine (l-DOPA) modulates brain iron, dopaminergic neurodegeneration and motor dysfunction in iron overload and mutant alpha-synuclein mouse models of Parkinson's disease.

Journal of neurochemistry

Avec: Jessica L Billings , Sarah L Gordon , Philip A Doble , Ashley I Bush , Paul A Adlard , David I Finkelstein , Dominic J Hare

Aryl-urea fatty acids that activate the p38 MAP kinase and down-regulate multiple cyclins decrease the viability of MDA-MB-231 breast cancer cells.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences

Avec: Yassir Al-Zubaidi , Curtis Pazderka , Nooshin Koolaji , Md Khalilur Rahman , Hassan Choucair , Bala Umashankar , Kirsi Bourget , Yongjuan Chen , Michael Murray

PTU, a novel ureido-fatty acid, inhibits MDA-MB-231 cell invasion and dissemination by modulating Wnt5a secretion and cytoskeletal signaling.

Biochemical pharmacology

Avec: Yassir Al-Zubaidi , Yongjuan Chen , Md Khalilur Rahman , Bala Umashankar , Hassan Choucair , Kirsi Bourget , Long Chung , Yanfei Qi , Paul K Witting , Robin L Anderson , Geraldine M O'Neill , Colin R Dunstan , Michael Murray

The aryl-ureido fatty acid CTU activates endoplasmic reticulum stress and PERK/NOXA-mediated apoptosis in tumor cells by a dual mitochondrial-targeting mechanism.

Cancer letters

Avec: Hassan Choucair , Md Khalilur Rahman , Balasubrahmanyam Umashankar , Yassir Al-Zubaidi , Kirsi Bourget , Yongjuan Chen , Colin Dunstan , Michael Murray

Methods for negating the impact of zinc contamination to allow characterization of positive allosteric modulators of glycine receptors.

Frontiers in molecular neuroscience

Avec: Casey I Gallagher , David P Bishop , Thomas E Lockwood , Robert J Vandenberg

Structure-Activity Relationship and Mechanistic Studies of Bisaryl Urea Anticancer Agents Indicate Mitochondrial Uncoupling by a Fatty Acid-Activated Mechanism.

ACS chemical biology

Avec: Edward York , Daniel A McNaughton , Ariane Roseblade , Charles G Cranfield , Philip A Gale ,

Organic & biomolecular chemistry

Avec: Daniel A McNaughton , Edward York , Philip A Gale

Triphenylphosphonium-Conjugated Palmitic Acid for Mitochondrial Targeting of Pancreatic Cancer Cells: Proteomic and Molecular Evidence.

International journal of molecular sciences

Avec: Giuliana Siragusa , Jessica Brandi , Michael Murray , Daniela Cecconi

Effects of cationic head group structure on cytotoxicity and mitochondrial actions of amphiphilic ionic liquids.

Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association

Avec: Ritik Roy , Edward York , Ethan Pacchini ,

4-Chloroisocoumarins as Chlamydial Protease Inhibitors and Anti-Chlamydial Agents.

Molecules (Basel, Switzerland)

Avec: Matthew J A Phillips , Wilhelmina M Huston , Andrew M McDonagh ,

Identification of an allosteric binding site on the human glycine transporter, GlyT2, for bioactive lipid analgesics.

eLife

Avec: Shannon N Mostyn , Katie A Wilson , Alexandra Schumann-Gillett , Zachary J Frangos , Susan Shimmon , Renae M Ryan , Megan L O'Mara , Robert J Vandenberg

Omega-3 Polyunsaturated Fatty Acid Derived Lipid Mediators and their Application in Drug Discovery.

Current medicinal chemistry

Avec: Curtis W Pazderka , Brian Oliver , Michael Murray ,

Differential inhibition of human CYP2C8 and molecular docking interactions elicited by sorafenib and its major N-oxide metabolite.

Chemico-biological interactions

Avec: Pramod C Nair , Tina B Gillani , Michael Murray

Cytotoxicity of acridinium-based ionic liquids: structure-activity relationship and mechanistic studies.

Chemico-biological interactions

Avec: Ritik Roy , Phoenix Chick , Edward York ,

Sorafenib plus intensive chemotherapy in newly diagnosed FLT3-ITD AML: a randomized, placebo-controlled study by the ALLG.

Blood

Avec: Sun Loo , Andrew W Roberts , Natasha S Anstee , Glen A Kennedy , Simon He , Anthony P Schwarer , Anoop K Enjeti , James D'Rozario , Paula Marlton , Ian A Bilmon , John Taper , Gavin Cull , Campbell Tiley , Emma Verner , Uwe Hahn , Devendra K Hiwase , Harry J Iland , Nick Murphy , Sundra Ramanathan , John Reynolds , Doen Ming Ong , Ing Soo Tiong , Meaghan Wall , Michael Murray , Joanna Leadbetter , Leesa Rowley , Maya Latimer , Sam Yuen , Stephen B Ting , Chun Yew Fong , Kirk Morris , Ashish Bajel , John F Seymour , Mark J Levis , Andrew H Wei

An update on inflammation in uveal melanoma.

Biochimie

Avec: Sebastian Liau , Janney Z Wang , Ethan Zagarella , Paus Paulus , Nguyen Huong Que Hiep Dang , Michael Murray , Fanfan Zhou

Protonophoric and mitochondrial uncoupling activity of aryl-carbamate substituted fatty acids.

Organic & biomolecular chemistry

Avec: Hugo MacDermott-Opeskin , Callum Clarke , Xin Wu , Ariane Roseblade , Edward York , Ethan Pacchini , Ritik Roy , Charles Cranfield , Philip A Gale , Megan L O'Mara , Michael Murray ,

Inhibition of Hepatic CYP2D6 by the Active N-Oxide Metabolite of Sorafenib.

The AAPS journal

Avec: Michael Murray , Tina B Gillani , Pramod C Nair

Carbon Chain Length Modulates MDA-MB-231 Breast Cancer Cell Killing Mechanisms by Mitochondrially Targeted Aryl-Urea Fatty Acids.

ChemMedChem

Avec: Michael Murray , Ariane Roseblade , Yongjuan Chen , Kirsi Bourget ,

Antiproliferative activities of tricyclic amides derived from β-caryophyllene

RSC medicinal chemistry

Avec: XiXi Xu , Ariane Roseblade , Alison T Ung

The Role of Autophagy in Human Uveal Melanoma and the Development of Potential Disease Biomarkers and Novel Therapeutic Paradigms.

Biomedicines

Avec: Janney Z Wang , Paus Paulus , Yihe Niu , Ling Zhu , Christophe Morisseau , Michael Murray , Bruce D Hammock , Fanfan Zhou

The inositol-requiring enzyme 1 (IRE1) endoplasmic reticulum stress pathway promotes MDA-MB-231 cell survival and renewal in response to the aryl-ureido fatty acid CTU.

The international journal of biochemistry & cell biology

Avec: Md Khalilur Rahman , Balasubrahmanyam Umashankar , Hassan Choucair , Kirsi Bourget , Michael Murray

Inclusion of the in-chain sulfur in 3-thiaCTU increases the efficiency of mitochondrial targeting and cell killing by anticancer aryl-urea fatty acids.

European journal of pharmacology

Avec: Md Khalilur Rahman , Balasubrahmanyam Umashankar , Hassan Choucair , Curtis Pazderka , Kirsi Bourget , Yongjuan Chen , Colin R Dunstan , Michael Murray

Fatty Acid-Activated Proton Transport by Bisaryl Anion Transporters Depolarises Mitochondria and Reduces the Viability of MDA-MB-231 Breast Cancer Cells.

Biomolecules

Avec: Edward York , Daniel A McNaughton , Meryem-Nur Duman , Philip A Gale ,

Identification of N-acyl amino acids that are positive allosteric modulators of glycine receptors.

Biochemical pharmacology

Avec: Casey I Gallagher , Diba Sheipouri , Susan Shimmon , Robert J Vandenberg

Expansion of the structure-activity relationship of branched chain fatty acids: Effect of unsaturation and branching group size on anticancer activity.

Chemistry and physics of lipids

Avec: Ritik Roy , Ariane Roseblade ,

Photoswitchable ORG25543 Congener Enables Optical Control of Glycine Transporter 2.

ACS chemical neuroscience

Avec: Shannon N Mostyn , Subhodeep Sarker , Parthasarathy Muthuraman , Arun Raja , Susan Shimmon , Christopher L Cioffi , Robert J Vandenberg

Development of an N-Acyl Amino Acid That Selectively Inhibits the Glycine Transporter 2 To Produce Analgesia in a Rat Model of Chronic Pain.

Journal of medicinal chemistry

Avec: Shannon N Mostyn , Sarasa Mohammadi , Susan Shimmon , Zachary J Frangos , Subhodeep Sarker , Arsalan Yousuf , Irina Vetter , Renae M Ryan , Macdonald J Christie , Robert J Vandenberg

Sorafenib N-Oxide Is an Inhibitor of Human Hepatic CYP3A4.

The AAPS journal

Avec: Sussan Ghassabian , Tina B Gillani , Severine Crettol , Pramod C Nair , Michael Murray

The allosteric inhibition of glycine transporter 2 by bioactive lipid analgesics is controlled by penetration into a deep lipid cavity.

The Journal of biological chemistry

Avec: Katie A Wilson , Shannon N Mostyn , Zachary J Frangos , Susan Shimmon , Robert J Vandenberg , Megan L O'Mara

A System for Assessing Dual Action Modulators of Glycine Transporters and Glycine Receptors.

Biomolecules

Avec: Diba Sheipouri , Casey I Gallagher , Susan Shimmon , Robert J Vandenberg

Aryl urea substituted fatty acids: a new class of protonophoric mitochondrial uncoupler that utilises a synthetic anion transporter.

Chemical science

Avec: Hugo MacDermott-Opeskin , Ariane Roseblade , Curtis Pazderka , Callum Clarke , Kirsi Bourget , Xin Wu , William Lewis , Benjamin Noble , Philip A Gale , Megan L O'Mara , Charles Cranfield , Michael Murray

Novel Phenylene Lipids That Are Positive Allosteric Modulators of Glycine Receptors and Inhibitors of Glycine Transporter 2.

ACS chemical neuroscience

Avec: Casey I Gallagher , Zachary J Frangos , Diba Sheipouri , Susan Shimmon , Meryem-Nur Duman , Srinivasan Jayakumar , Christopher L Cioffi , Robert J Vandenberg

Carbon chain length in a novel anticancer aryl-urea fatty acid modulates mitochondrial targeting, reactive oxygen species production and cell killing.

ChemMedChem

Avec: Michael Murray , Yasmin Elmaghrabi , Ariane Roseblade , Md Khalilur Rahman ,

The Novel Anticancer Aryl-Ureido Fatty Acid CTU Increases Reactive Oxygen Species Production That Impairs Mitochondrial Fusion Mechanisms and Promotes MDA-MB-231 Cell Death.

International journal of molecular sciences

Avec: Stanton Tam , Balasubrahmanyam Umashankar , Md Khalilur Rahman , Hassan Choucair , Michael Murray

Réseau de co-auteurs

Michael Murray 19 collaborations

Robert J Vandenberg 9 collaborations

Susan Shimmon 8 collaborations

Ariane Roseblade 8 collaborations

Edward York 7 collaborations

Md Khalilur Rahman 7 collaborations

Kirsi Bourget 7 collaborations

Philip A Gale 6 collaborations

Hassan Choucair 6 collaborations

Shannon N Mostyn 5 collaborations

Megan L O'Mara 5 collaborations

Yongjuan Chen 5 collaborations

Daniel A McNaughton 4 collaborations

Balasubrahmanyam Umashankar 4 collaborations

Casey I Gallagher 4 collaborations

Ritik Roy 4 collaborations

Zachary J Frangos 4 collaborations

Katie A Wilson 3 collaborations

Charles Cranfield 3 collaborations

Yassir Al-Zubaidi 3 collaborations

Curtis Pazderka 3 collaborations

Pramod C Nair 3 collaborations

Tina B Gillani 3 collaborations

Diba Sheipouri 3 collaborations

Andrew M McDonagh 2 collaborations

Bala Umashankar 2 collaborations

Colin R Dunstan 2 collaborations

Ethan Pacchini 2 collaborations

Renae M Ryan 2 collaborations

Janney Z Wang 2 collaborations

Paus Paulus 2 collaborations

Fanfan Zhou 2 collaborations

Hugo MacDermott-Opeskin 2 collaborations

Callum Clarke 2 collaborations

Xin Wu 2 collaborations

Meryem-Nur Duman 2 collaborations

Subhodeep Sarker 2 collaborations

Christopher L Cioffi 2 collaborations

Bruce S Wilson 1 collaboration

Julian Peiser-Oliver 1 collaboration

Alexander Gillis 1 collaboration

Sally Evans 1 collaboration

Claudia Alamein 1 collaboration

MacDonald J Christie 1 collaboration

Sarasa A Mohammadi 1 collaboration

David S Gertner 1 collaboration

Mahmoud El Safadi 1 collaboration

Indigo J Strudwicke 1 collaboration

Mohan Bhadbhade 1 collaboration

Sing-Young Chen 1 collaboration

Martina Beretta 1 collaboration

Stephanie J Alexopoulos 1 collaboration

Divya P Shah 1 collaboration

Ellen M Olzomer 1 collaboration

Stefan R Hargett 1 collaboration

Elizabeth S Childress 1 collaboration

Joseph M Salamoun 1 collaboration

Isabella Aleksovska 1 collaboration

Kate G R Quinlan 1 collaboration

Margaret J Morris 1 collaboration

Simon P Tucker 1 collaboration

Webster L Santos 1 collaboration

Kyle L Hoehn 1 collaboration

Jessica L Billings 1 collaboration

Sarah L Gordon 1 collaboration

Philip A Doble 1 collaboration

Ashley I Bush 1 collaboration

Paul A Adlard 1 collaboration

David I Finkelstein 1 collaboration

Dominic J Hare 1 collaboration

Nooshin Koolaji 1 collaboration

Long Chung 1 collaboration

Yanfei Qi 1 collaboration

Paul K Witting 1 collaboration

Robin L Anderson 1 collaboration

Geraldine M O'Neill 1 collaboration

Colin Dunstan 1 collaboration

David P Bishop 1 collaboration

Thomas E Lockwood 1 collaboration

Charles G Cranfield 1 collaboration

Giuliana Siragusa 1 collaboration

Jessica Brandi 1 collaboration

Daniela Cecconi 1 collaboration

Matthew J A Phillips 1 collaboration

Wilhelmina M Huston 1 collaboration

Alexandra Schumann-Gillett 1 collaboration

Curtis W Pazderka 1 collaboration

Brian Oliver 1 collaboration

Phoenix Chick 1 collaboration

Sun Loo 1 collaboration

Andrew W Roberts 1 collaboration

Natasha S Anstee 1 collaboration

Glen A Kennedy 1 collaboration

Simon He 1 collaboration

Anthony P Schwarer 1 collaboration

Anoop K Enjeti 1 collaboration

James D'Rozario 1 collaboration

Paula Marlton 1 collaboration

Ian A Bilmon 1 collaboration

John Taper 1 collaboration

Gavin Cull 1 collaboration

Campbell Tiley 1 collaboration

Emma Verner 1 collaboration

Uwe Hahn 1 collaboration

Devendra K Hiwase 1 collaboration

Harry J Iland 1 collaboration

Nick Murphy 1 collaboration

Sundra Ramanathan 1 collaboration

John Reynolds 1 collaboration

Doen Ming Ong 1 collaboration

Ing Soo Tiong 1 collaboration

Meaghan Wall 1 collaboration

Joanna Leadbetter 1 collaboration

Leesa Rowley 1 collaboration

Maya Latimer 1 collaboration

Sam Yuen 1 collaboration

Stephen B Ting 1 collaboration

Chun Yew Fong 1 collaboration

Kirk Morris 1 collaboration

Ashish Bajel 1 collaboration

John F Seymour 1 collaboration

Mark J Levis 1 collaboration

Andrew H Wei 1 collaboration

Sebastian Liau 1 collaboration

Ethan Zagarella 1 collaboration

Nguyen Huong Que Hiep Dang 1 collaboration

XiXi Xu 1 collaboration

Alison T Ung 1 collaboration

Yihe Niu 1 collaboration

Ling Zhu 1 collaboration

Christophe Morisseau 1 collaboration

Bruce D Hammock 1 collaboration

Parthasarathy Muthuraman 1 collaboration

Arun Raja 1 collaboration

Sarasa Mohammadi 1 collaboration

Arsalan Yousuf 1 collaboration

Irina Vetter 1 collaboration

Macdonald J Christie 1 collaboration

Sussan Ghassabian 1 collaboration

Severine Crettol 1 collaboration

William Lewis 1 collaboration

Benjamin Noble 1 collaboration

Srinivasan Jayakumar 1 collaboration

Yasmin Elmaghrabi 1 collaboration

Stanton Tam 1 collaboration