T Hyötyläinen

Affiliations
  • MTM Research Centre, School of Science and Technology, Örebro University, Örebro 702 81, Sweden.

Publications (84)

Circulating metabolites in progression to islet autoimmunity and type 1 diabetes.

Diabetologia
Avec: Santosh Lamichhane , Esko Kemppainen , Kajetan Trošt , Heli Siljander , Heikki Hyöty , Jorma Ilonen , Jorma Toppari , Riitta Veijola , Tuulia Hyötyläinen , Mikael Knip , Matej Orešič

Simultaneous determination of perfluoroalkyl substances and bile acids in human serum using ultra-high-performance liquid chromatography-tandem mass spectrometry.

Analytical and bioanalytical chemistry
Avec: Samira Salihović , Alex M Dickens , Ida Schoultz , Frida Fart , Lisanna Sinisalu , Tuomas Lindeman , Jonas Halfvarson , Matej Orešič , Tuulia Hyötyläinen

Perfluorooctanoic acid induces liver and serum dyslipidemia in humanized PPARα mice fed an American diet.

Toxicology and applied pharmacology
Avec: J J Schlezinger , T Sinioja , C Boston , H Puckett , J Oliver , W Heiger-Bernays , T F Webster

Metabolomics and lipidomics in NAFLD: biomarkers and non-invasive diagnostic tests.

Nature reviews. Gastroenterology & hepatology
Avec: Mojgan Masoodi , Amalia Gastaldelli , Tuulia Hyötyläinen , Enara Arretxe , Cristina Alonso , Melania Gaggini , Julia Brosnan , Quentin M Anstee , Oscar Millet , Pablo Ortiz , Jose M Mato , Jean-Francois Dufour , Matej Orešič

Overfeeding Saturated Fat Increases LDL (Low-Density Lipoprotein) Aggregation Susceptibility While Overfeeding Unsaturated Fat Decreases Proteoglycan-Binding of Lipoproteins.

Arteriosclerosis, thrombosis, and vascular biology
Avec: Maija Ruuth , Mari Lahelma , Panu K Luukkonen , Martina B Lorey , Sami Qadri , Sanja Sädevirta , Tuulia Hyötyläinen , Petri T Kovanen , Leanne Hodson , Hannele Yki-Järvinen , Katariina Öörni

Perfluoroalkyl substances are increased in patients with late-onset ulcerative colitis and induce intestinal barrier defects

Scandinavian journal of gastroenterology
Avec: Frida Fart , Samira Salihović , Aidan McGlinchey , Melanie G Gareau , Matej Orešič , Jonas Halfvarson , Tuulia Hyötyläinen , Ida Schoultz

Potential Transdiagnostic Lipid Mediators of Inflammatory Activity in Individuals With Serious Mental Illness.

Frontiers in psychiatry
Avec: Ulrika Hylén , Aidan McGlinchey , Matej Orešič , Susanne Bejerot , Mats B Humble , Eva Särndahl , Tuulia Hyötyläinen , Daniel Eklund

Impact of Extensively Hydrolyzed Infant Formula on Circulating Lipids During Early Life.

Frontiers in nutrition
Avec: Santosh Lamichhane , Heli Siljander , Marja Salonen , Terhi Ruohtula , Suvi M Virtanen , Jorma Ilonen , Tuulia Hyötyläinen , Mikael Knip , Matej Orešič

Prenatal exposure to environmental contaminants and cord serum metabolite profiles in future immune-mediated diseases.

Journal of exposure science & environmental epidemiology
Avec: Bagavathy Shanmugam Karthikeyan , Tuulia Hyötyläinen , Tannaz Ghaffarzadegan , Eric Triplett , Matej Orešič , Johnny Ludvigsson

Quantitative modeling of human liver reveals dysregulation of glycosphingolipid pathways in nonalcoholic fatty liver disease.

iScience
Avec: Partho Sen , Olivier Govaere , Tim Sinioja , Aidan McGlinchey , Dawei Geng , Vlad Ratziu , Elisabetta Bugianesi , Jörn M Schattenberg , Antonio Vidal-Puig , Michael Allison , Simon Cockell , Ann K Daly , Tuulia Hyötyläinen , Quentin M Anstee , Matej Orešič

Dynamics of the Lipidome in a Colon Simulator.

Metabolites
Avec: Matilda Kråkström , Alex M Dickens , Marina Amaral Alves , Sofia D Forssten , Arthur C Ouwehand , Tuulia Hyötyläinen , Matej Orešič , Santosh Lamichhane

Human PNPLA3-I148M variant increases hepatic retention of polyunsaturated fatty acids.

JCI insight
Avec: Panu K Luukkonen , Auli Nick , Maarit Hölttä-Vuori , Christoph Thiele , Elina Isokuortti , Susanna Lallukka-Brück , You Zhou , Antti Hakkarainen , Nina Lundbom , Markku Peltonen , Marju Orho-Melander , Matej Orešič , Tuulia Hyötyläinen , Leanne Hodson , Elina Ikonen , Hannele Yki-Järvinen

Integrated Lipidomics and Proteomics Point to Early Blood-Based Changes in Childhood Preceding Later Development of Psychotic Experiences: Evidence From the Avon Longitudinal Study of Parents and Children.

Biological psychiatry
Avec: Francisco Madrid-Gambin , Melanie Föcking , Sophie Sabherwal , Meike Heurich , Jane A English , Aoife O'Gorman , Tommi Suvitaival , Linda Ahonen , Mary Cannon , Glyn Lewis , Ismo Mattila , Caitriona Scaife , Sean Madden , Tuulia Hyötyläinen , Matej Orešič , Stanley Zammit , Gerard Cagney , David R Cotter , Lorraine Brennan

Effect of perfluorooctanesulfonic acid (PFOS) on the liver lipid metabolism of the developing chicken embryo.

Ecotoxicology and environmental safety
Avec: Dawei Geng , Ayan Au Musse , Viktoria Wigh , Cecilia Carlsson , Magnus Engwall , Matej Orešič , Nikolai Scherbak , Tuulia Hyötyläinen

Correlations between microbiota and metabolites after faecal microbiota transfer in irritable bowel syndrome.

Beneficial microbes
Avec: S Holster , D Repsilber , D Geng , A Salonen , C M Lindqvist , S K Rajan , W M de Vos , R J Brummer , J König

Human and preclinical studies of the host-gut microbiome co-metabolite hippurate as a marker and mediator of metabolic health.

Gut
Avec: François Brial , Julien Chilloux , Trine Nielsen , Sara Vieira-Silva , Gwen Falony , Petros Andrikopoulos , Michael Olanipekun , Lesley Hoyles , Fatima Djouadi , Ana L Neves , Andrea Rodriguez-Martinez , Ghiwa Ishac Mouawad , Nicolas Pons , Sofia Forslund , Emmanuelle Le-Chatelier , Aurélie Le Lay , Jeremy Nicholson , Torben Hansen , Tuulia Hyötyläinen , Karine Clément , Matej Oresic , Peer Bork , Stanislav Dusko Ehrlich , Jeroen Raes , Oluf Borbye Pedersen , Dominique Gauguier , Marc-Emmanuel Dumas

Dysregulated Lipid Metabolism Precedes Onset of Psychosis.

Biological psychiatry
Avec: Alex M Dickens , Partho Sen , Matthew J Kempton , Neus Barrantes-Vidal , Conrad Iyegbe , Merete Nordentoft , Thomas Pollak , Anita Riecher-Rössler , Stephan Ruhrmann , Gabriele Sachs , Rodrigo Bressan , Marie-Odile Krebs , G Paul Amminger , Lieuwe de Haan , Mark van der Gaag , Lucia Valmaggia , Tuulia Hyötyläinen , Auteur inconnu , Matej Orešič , Philip McGuire

Glucosylceramide synthase deficiency in the heart compromises β1-adrenergic receptor trafficking.

European heart journal
Avec: Linda Andersson , Mathieu Cinato , Ismena Mardani , Azra Miljanovic , Muhammad Arif , Ara Koh , Malin Lindbom , Marion Laudette , Entela Bollano , Elmir Omerovic , Martina Klevstig , Marcus Henricsson , Per Fogelstrand , Karl Swärd , Matias Ekstrand , Max Levin , Johannes Wikström , Stephen Doran , Tuulia Hyötyläinen , Lisanna Sinisalu , Matej Orešič , Åsa Tivesten , Martin Adiels , Martin O Bergo , Richard Proia , Adil Mardinoglu , Anders Jeppsson , Jan Borén , Malin C Levin

Metabolic changes in cucumber leaves are enhanced by blue light but differentially affected by UV interactions with light signalling pathways in the visible spectrum.

Plant science : an international journal of experimental plant biology
Avec: Carolina Falcato Fialho Palma , Victor Castro-Alves , Luis Orlando Morales , Eva Rosenqvist , Carl-Otto Ottosen , Tuulia Hyötyläinen , Åke Strid

From farm to fork… and beyond! UV enhances Aryl hydrocarbon receptor-mediated activity of cruciferous vegetables in human intestinal cells upon colonic fermentation.

Food chemistry
Avec: P Seeburger , H Forsman , G Bevilacqua , T M Marques , L O Morales , S B R Prado , Å Strid , V Castro-Alves

Impact of exposure to per- and polyfluoroalkyl substances on fecal microbiota composition in mother-infant dyads.

Environment international
Avec: Santosh Lamichhane , Taina Härkönen , Tommi Vatanen , Tuulia Hyötyläinen , Mikael Knip , Matej Orešič

The human liver lipidome is significantly related to the lipid composition and aggregation susceptibility of low-density lipoprotein (LDL) particles.

Atherosclerosis
Avec: Mari Lahelma , Sami Qadri , Noora Ahlholm , Kimmo Porthan , Maija Ruuth , Anne Juuti , Matej Orešič , Tuulia Hyötyläinen , Katariina Öörni , Hannele Yki-Järvinen

A Novel Nanosafety Approach Using Cell Painting, Metabolomics, and Lipidomics Captures the Cellular and Molecular Phenotypes Induced by the Unintentionally Formed Metal-Based (Nano)Particles.

Cells
Avec: Andi Alijagic , Nikolai Scherbak , Oleksandr Kotlyar , Patrik Karlsson , Xuying Wang , Inger Odnevall , Oldřich Benada , Ali Amiryousefi , Lena Andersson , Alexander Persson , Jenny Felth , Henrik Andersson , Maria Larsson , Alexander Hedbrant , Samira Salihovic , Tuulia Hyötyläinen , Dirk Repsilber , Eva Särndahl , Magnus Engwall

Identification and validation of a blood- based diagnostic lipidomic signature of pediatric inflammatory bowel disease.

Nature communications
Avec: Samira Salihovic , Niklas Nyström , Charlotte Bache-Wiig Mathisen , Robert Kruse , Christine Olbjørn , Svend Andersen , Alexandra J Noble , Maria Dorn-Rasmussen , Igor Bazov , Gøri Perminow , Randi Opheim , Trond Espen Detlie , Gert Huppertz-Hauss , Charlotte R H Hedin , Marie Carlson , Lena Öhman , Maria K Magnusson , Åsa V Keita , Johan D Söderholm , Mauro D'Amato , Matej Orešič , Vibeke Wewer , Jack Satsangi , Carl Mårten Lindqvist , Johan Burisch , Holm H Uhlig , Dirk Repsilber , Tuulia Hyötyläinen , Marte Lie Høivik , Jonas Halfvarson

The PNPLA3-I148M variant increases polyunsaturated triglycerides in human adipose tissue.

Liver international : official journal of the International Association for the Study of the Liver
Avec: Sami Qadri , Susanna Lallukka-Brück , Panu K Luukkonen , You Zhou , Amalia Gastaldelli , Marju Orho-Melander , Henna Sammalkorpi , Anne Juuti , Anne K Penttilä , Julia Perttilä , Antti Hakkarainen , Tiina E Lehtimäki , Matej Orešič , Tuulia Hyötyläinen , Leanne Hodson , Vesa M Olkkonen , Hannele Yki-Järvinen

Prenatal exposure to perfluoroalkyl substances modulates neonatal serum phospholipids, increasing risk of type 1 diabetes.

Environment international
Avec: Aidan McGlinchey , Tim Sinioja , Santosh Lamichhane , Partho Sen , Johanna Bodin , Heli Siljander , Alex M Dickens , Dawei Geng , Cecilia Carlsson , Daniel Duberg , Jorma Ilonen , Suvi M Virtanen , Hubert Dirven , Hanne Friis Berntsen , Karin Zimmer , Unni C Nygaard , Matej Orešič , Mikael Knip , Tuulia Hyötyläinen

Early-life exposure to perfluorinated alkyl substances modulates lipid metabolism in progression to celiac disease.

Environmental research
Avec: Lisanna Sinisalu , Partho Sen , Samira Salihović , Suvi M Virtanen , Heikki Hyöty , Jorma Ilonen , Jorma Toppari , Riitta Veijola , Matej Orešič , Mikael Knip , Tuulia Hyötyläinen

Persistent Alterations in Plasma Lipid Profiles Before Introduction of Gluten in the Diet Associated With Progression to Celiac Disease.

Clinical and translational gastroenterology
Avec: Partho Sen , Cecilia Carlsson , Suvi M Virtanen , Satu Simell , Heikki Hyöty , Jorma Ilonen , Jorma Toppari , Riitta Veijola , Tuulia Hyötyläinen , Mikael Knip , Matej Orešič

Identification of metabolic profiles associated with human exposure to perfluoroalkyl substances.

Journal of exposure science & environmental epidemiology
Avec: Samira Salihovic , Tove Fall , Andrea Ganna , Corey D Broeckling , Jessica E Prenni , Tuulia Hyötyläinen , Anna Kärrman , P Monica Lind , Erik Ingelsson , Lars Lind

Cord-Blood Lipidome in Progression to Islet Autoimmunity and Type 1 Diabetes.

Biomolecules
Avec: Santosh Lamichhane , Linda Ahonen , Thomas Sparholt Dyrlund , Alex M Dickens , Heli Siljander , Heikki Hyöty , Jorma Ilonen , Jorma Toppari , Riitta Veijola , Tuulia Hyötyläinen , Mikael Knip , Matej Oresic

Lipidomic Analyses Reveal Modulation of Lipid Metabolism by the PFAS Perfluoroundecanoic Acid (PFUnDA) in Non-Obese Diabetic Mice.

Frontiers in genetics
Avec: Tuulia Hyötyläinen , Johanna Bodin , Daniel Duberg , Hubert Dirven , Unni C Nygaard , Matej Orešič

Integrative Analysis of Circulating Metabolite Profiles and Magnetic Resonance Imaging Metrics in Patients with Traumatic Brain Injury.

International journal of molecular sciences
Avec: Ilias Thomas , Alex M Dickens , Jussi P Posti , Mehrbod Mohammadian , Christian Ledig , Riikka S K Takala , Tuulia Hyötyläinen , Olli Tenovuo , Matej Orešič

Hydroxysteroid 17-β dehydrogenase 13 variant increases phospholipids and protects against fibrosis in nonalcoholic fatty liver disease.

JCI insight
Avec: Panu K Luukkonen , Taru Tukiainen , Anne Juuti , Henna Sammalkorpi , P A Nidhina Haridas , Onni Niemelä , Johanna Arola , Marju Orho-Melander , Antti Hakkarainen , Petri T Kovanen , Om Dwivedi , Leif Groop , Leanne Hodson , Amalia Gastaldelli , Tuulia Hyötyläinen , Matej Orešič , Hannele Yki-Järvinen

Conjugated C-6 hydroxylated bile acids in serum relate to human metabolic health and gut Clostridia species.

Scientific reports
Avec: Anders Ø Petersen , Hanna Julienne , Tuulia Hyötyläinen , Partho Sen , Yong Fan , Helle Krogh Pedersen , Sirkku Jäntti , Tue H Hansen , Trine Nielsen , Torben Jørgensen , Torben Hansen , Pernille Neve Myers , H Bjørn Nielsen , S Dusko Ehrlich , Matej Orešič , Oluf Pedersen

Metabolic signatures across the full spectrum of non-alcoholic fatty liver disease.

JHEP reports : innovation in hepatology
Avec: Aidan J McGlinchey , Olivier Govaere , Dawei Geng , Vlad Ratziu , Michael Allison , Jerome Bousier , Salvatore Petta , Claudia de Oliviera , Elisabetta Bugianesi , Jörn M Schattenberg , Ann K Daly , Tuulia Hyötyläinen , Quentin M Anstee , Matej Orešič

Circulating metabolic signatures of rapid and slow progression to type 1 diabetes in islet autoantibody-positive children.

Frontiers in endocrinology
Avec: Santosh Lamichhane , Partho Sen , Alex M Dickens , Matilda Kråkström , Jorma Ilonen , Johanna Lempainen , Heikki Hyöty , Riitta Lahesmaa , Riitta Veijola , Jorma Toppari , Tuulia Hyötyläinen , Mikael Knip , Matej Orešič

Altering environmental conditions induce shifts in simulated deep terrestrial subsurface bacterial communities-Secretion of primary and secondary metabolites.

Environmental microbiology
Avec: Merja Herzig , Tuulia Hyötyläinen , Gianni F Vettese , Gareth T W Law , Taavi Vierinen , Malin Bomberg

Controlled mechanical stimuli reveal novel associations between basil metabolism and sensory quality.

Food chemistry
Avec: P Seeburger , A Herdenstam , P Kurtser , A Arunachalam , V C Castro-Alves , H Andreasson

The gut microbiota contributes to the pathogenesis of anorexia nervosa in humans and mice.

Nature microbiology
Avec: Yong Fan , René Klinkby Støving , Samar Berreira Ibraim , Tuulia Hyötyläinen , Florence Thirion , Tulika Arora , Liwei Lyu , Evelina Stankevic , Tue Haldor Hansen , Pierre Déchelotte , Tim Sinioja , Oddny Ragnarsdottir , Nicolas Pons , Nathalie Galleron , Benoît Quinquis , Florence Levenez , Hugo Roume , Gwen Falony , Sara Vieira-Silva , Jeroen Raes , Loa Clausen , Gry Kjaersdam Telléus , Fredrik Bäckhed , Matej Oresic , S Dusko Ehrlich , Oluf Pedersen

Cardiomyocyte-specific PCSK9 deficiency compromises mitochondrial bioenergetics and heart function.

Cardiovascular research
Avec: Marion Laudette , Malin Lindbom , Muhammad Arif , Mathieu Cinato , Mario Ruiz , Stephen Doran , Azra Miljanovic , Mikael Rutberg , Linda Andersson , Martina Klevstig , Marcus Henricsson , Per-Olof Bergh , Entela Bollano , Nay Aung , J Gustav Smith , Marc Pilon , Tuulia Hyötyläinen , Matej Orešič , Rosie Perkins , Adil Mardinoglu , Malin C Levin , Jan Borén

Infant microbes and metabolites point to childhood neurodevelopmental disorders.

Cell
Avec: Angelica P Ahrens , Tuulia Hyötyläinen , Joseph R Petrone , Kajsa Igelström , Christian D George , Timothy J Garrett , Matej Orešič , Eric W Triplett , Johnny Ludvigsson

Association Between Circulating Lipids and Future Weight Gain in Individuals With an At-Risk Mental State and in First-Episode Psychosis.

Schizophrenia bulletin
Avec: Santosh Lamichhane , Alex M Dickens , Partho Sen , Heikki Laurikainen , Faith Borgan , Jaana Suvisaari , Tuulia Hyötyläinen , Oliver Howes , Jarmo Hietala , Matej Orešič

Metabolic Signatures of the Exposome-Quantifying the Impact of Exposure to Environmental Chemicals on Human Health.

Metabolites
Avec: Matej Orešič , Aidan McGlinchey , Craig E Wheelock , Tuulia Hyötyläinen

Synergy between 15-lipoxygenase and secreted PLA

Proceedings of the National Academy of Sciences of the United States of America
Avec: Van Thai Ha , Duško Lainšček , Bernd Gesslbauer , Eva Jarc-Jovičić , Tuulia Hyötyläinen , Nejc Ilc , Katja Lakota , Matija Tomšič , Fons A J van de Loo , Valery Bochkov , Toni Petan , Roman Jerala , Mateja Manček-Keber

Multi- and transgenerational effects following early-life exposure of zebrafish to permethrin and coumarin 47: Impact on growth, fertility, behavior and lipid metabolism.

Ecotoxicology and environmental safety
Avec: Mélanie Blanc , Bettie Cormier , Tuulia Hyötyläinen , Martin Krauss , Nikolai Scherbak , Xavier Cousin , Steffen H Keiter

Linking Gut Microbiome and Lipid Metabolism: Moving beyond Associations.

Metabolites
Avec: Santosh Lamichhane , Partho Sen , Marina Amaral Alves , Henrique C Ribeiro , Peppi Raunioniemi , Tuulia Hyötyläinen , Matej Orešič

Analytical challenges in human exposome analysis with focus on environmental analysis combined with metabolomics.

Journal of separation science
Avec: Tuulia Hyötyläinen

Effects of a Lacto-Ovo-Vegetarian Diet on the Plasma Lipidome and Its Association with Atherosclerotic Burden in Patients with Coronary Artery Disease-A Randomized, Open-Label, Cross-over Study.

Nutrients
Avec: Demir Djekic , Lin Shi , Fredrik Calais , Frida Carlsson , Rikard Landberg , Tuulia Hyötyläinen , Ole Frøbert

Allostatic hypermetabolic response in PGC1α/β heterozygote mouse despite mitochondrial defects.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology
Avec: Sergio Rodriguez-Cuenca , Christopher J Lelliot , Mark Campbell , Gopal Peddinti , Maite Martinez-Uña , Camilla Ingvorsen , Ana Rita Dias , Joana Relat , Silvia Mora , Tuulia Hyötyläinen , Antonio Zorzano , Matej Orešič , Mikael Bjursell , Mohammad Bohlooly-Y , Daniel Lindén , Antonio Vidal-Puig

Pharmacometabolomic profiles in type 2 diabetic subjects treated with liraglutide or glimepiride.

Cardiovascular diabetology
Avec: J Jendle , M Orešič , T Nyström

Serum metabolome associated with severity of acute traumatic brain injury.

Nature communications
Avec: Ilias Thomas , Alex M Dickens , Jussi P Posti , Endre Czeiter , Daniel Duberg , Tim Sinioja , Matilda Kråkström , Isabel R A Retel Helmrich , Kevin K W Wang , Andrew I R Maas , Ewout W Steyerberg , David K Menon , Olli Tenovuo , Tuulia Hyötyläinen , András Büki , Matej Orešič , Auteur inconnu

Marked gut microbiota dysbiosis and increased imidazole propionate are associated with a NASH Göttingen Minipig model.

BMC microbiology
Avec: Ditte Olsen Lützhøft , Tim Sinioja , Berit Ø Christoffersen , Rasmus Riemer Jakobsen , Dawei Geng , Hajar Fauzan Bin Ahmad , Ellen Marie Straarup , Karen-Margrethe Pedersen , Witold Kot , Henrik Duelund Pedersen , Susanna Cirera , Tuulia Hyötyläinen , Dennis Sandris Nielsen , Axel Kornerup Hansen

Exposure to persistent organic pollutants alters the serum metabolome in non-obese diabetic mice.

Metabolomics : Official journal of the Metabolomic Society
Avec: Tim Sinioja , Johanna Bodin , Daniel Duberg , Hubert Dirven , Hanne Friis Berntsen , Karin Zimmer , Unni C Nygaard , Matej Orešič , Tuulia Hyötyläinen

Cord serum metabolic signatures of future progression to immune-mediated diseases.

iScience
Avec: Tuulia Hyötyläinen , Bagavathy Shanmugam Karthikeyan , Tannaz Ghaffarzadegan , Eric W Triplett , Matej Orešič , Johnny Ludvigsson

In utero exposures to perfluoroalkyl substances and the human fetal liver metabolome in Scotland: a cross-sectional study.

The Lancet. Planetary health
Avec: Tuulia Hyötyläinen , Aidan McGlinchey , Samira Salihovic , Antonia Schubert , Alex Douglas , David C Hay , Peter J O'Shaughnessy , John P Iredale , Sophie Shaw , Paul A Fowler , Matej Orešič

A complex mixture of polycyclic aromatic compounds causes embryotoxic, behavioral, and molecular effects in zebrafish larvae (Danio rerio), and in vitro bioassays.

The Science of the total environment
Avec: Greta Nilén , Maria Larsson , Tuulia Hyötyläinen , Steffen H Keiter

Comparative Metabolomics and Microbiome Analysis of Ethanol versus OMNImet/gene•GUT Fecal Stabilization.

Analytical chemistry
Avec: Heidi Isokääntä , Lucas Pinto da Silva , Naama Karu , Teemu Kallonen , Anna-Katariina Aatsinki , Thomas Hankemeier , Leyla Schimmel , Edgar Diaz , Tuulia Hyötyläinen , Pieter C Dorrestein , Rob Knight , Matej Orešič , Rima Kaddurah-Daouk , Alex M Dickens , Santosh Lamichhane

Metabolic and phenotypic changes induced by PFAS exposure in two human hepatocyte cell models.

Environment international
Avec: Andi Alijagic , Lisanna Sinisalu , Daniel Duberg , Oleksandr Kotlyar , Nikolai Scherbak , Magnus Engwall , Matej Orešič , Tuulia Hyötyläinen

Serum lipidome associates with neuroimaging features in patients with traumatic brain injury.

iScience
Avec: Ilias Thomas , Virginia F J Newcombe , Alex M Dickens , Sophie Richter , Jussi P Posti , Andrew I R Maas , Olli Tenovuo , Tuulia Hyötyläinen , András Büki , David K Menon , Matej Orešič , Auteur inconnu

Reproducible mass spectrometry data processing and compound annotation in MZmine 3.

Nature protocols
Avec: Steffen Heuckeroth , Tito Damiani , Aleksandr Smirnov , Olena Mokshyna , Corinna Brungs , Ansgar Korf , Joshua David Smith , Paolo Stincone , Nicola Dreolin , Louis-Félix Nothias , Tuulia Hyötyläinen , Matej Orešič , Uwe Karst , Pieter C Dorrestein , Daniel Petras , Xiuxia Du , Justin J J van der Hooft , Robin Schmid , Tomáš Pluskal

Exploring the circulating metabolome of sepsis: metabolomic and lipidomic profiles sampled in the ambulance.

Metabolomics : Official journal of the Metabolomic Society
Avec: Samira Salihovic , Daniel Eklund , Robert Kruse , Ulrika Wallgren , Tuulia Hyötyläinen , Eva Särndahl , Lisa Kurland

Targeted Clinical Metabolite Profiling Platform for the Stratification of Diabetic Patients.

Metabolites
Avec: Linda Ahonen , Sirkku Jäntti , Tommi Suvitaival , Simone Theilade , Claudia Risz , Risto Kostiainen , Peter Rossing , Matej Orešič , Tuulia Hyötyläinen

4

Frontiers in pharmacology
Avec: Tuire Salonurmi , Heba Nabil , Justiina Ronkainen , Tuulia Hyötyläinen , Heidi Hautajärvi , Markku J Savolainen , Ari Tolonen , Matej Orešič , Päivi Känsäkoski , Jaana Rysä , Jukka Hakkola , Janne Hukkanen

Links between central CB1-receptor availability and peripheral endocannabinoids in patients with first episode psychosis.

NPJ schizophrenia
Avec: Alex M Dickens , Faith Borgan , Heikki Laurikainen , Santosh Lamichhane , Tiago Marques , Tuukka Rönkkö , Mattia Veronese , Tuomas Lindeman , Tuulia Hyötyläinen , Oliver Howes , Jarmo Hietala , Matej Orešič

An environmentally relevant mixture of polychlorinated biphenyls (PCBs) and polybrominated diphenylethers (PBDEs) disrupts mitochondrial function, lipid metabolism and neurotransmission in the brain of exposed zebrafish and their unexposed F2 offspring.

The Science of the total environment
Avec: Mélanie Blanc , Sébastien Alfonso , Marie-Laure Bégout , Célia Barrachina , Tuulia Hyötyläinen , Steffen H Keiter , Xavier Cousin

Metabolic alterations in immune cells associate with progression to type 1 diabetes.

Diabetologia
Avec: Partho Sen , Alex M Dickens , María Asunción López-Bascón , Tuomas Lindeman , Esko Kemppainen , Santosh Lamichhane , Tuukka Rönkkö , Jorma Ilonen , Jorma Toppari , Riitta Veijola , Heikki Hyöty , Tuulia Hyötyläinen , Mikael Knip , Matej Orešič

Prenatal exposure to poly-/per-fluoroalkyl substances is associated with alteration of lipid profiles in cord-blood.

Metabolomics : Official journal of the Metabolomic Society
Avec: Lisanna Sinisalu , Leo W Y Yeung , Jinghua Wang , Yitao Pan , Jiayin Dai , Tuulia Hyötyläinen

Quantitative genome-scale metabolic modeling of human CD4

Cell reports
Avec: Partho Sen , Syed Bilal Ahmad Andrabi , Tanja Buchacher , Mohd Moin Khan , Ubaid Ullah Kalim , Tuomas Mikael Lindeman , Marina Amaral Alves , Victoria Hinkkanen , Esko Kemppainen , Alex M Dickens , Omid Rasool , Tuulia Hyötyläinen , Riitta Lahesmaa , Matej Orešič

Development of novel robotic platforms for mechanical stress induction, and their effects on plant morphology, elements, and metabolism.

Scientific reports
Avec: Polina Kurtser , Victor Castro-Alves , Ajay Arunachalam , Viktor Sjöberg , Ulf Hanell , Tuulia Hyötyläinen , Henrik Andreasson

Exposure to per- and polyfluoroalkyl substances associates with an altered lipid composition of breast milk.

Environment international
Avec: Santosh Lamichhane , Heli Siljander , Daniel Duberg , Jarno Honkanen , Suvi M Virtanen , Matej Orešič , Mikael Knip , Tuulia Hyötyläinen

Exposure to environmental contaminants is associated with altered hepatic lipid metabolism in non-alcoholic fatty liver disease.

Journal of hepatology
Avec: Partho Sen , Sami Qadri , Panu K Luukkonen , Oddny Ragnarsdottir , Aidan McGlinchey , Sirkku Jäntti , Anne Juuti , Johanna Arola , Jennifer J Schlezinger , Thomas F Webster , Matej Orešič , Hannele Yki-Järvinen , Tuulia Hyötyläinen

Integration of non-target metabolomics and sensory analysis unravels vegetable plant metabolite signatures associated with sensory quality: A case study using dill (Anethum graveolens).

Food chemistry
Avec: Victor Castro-Alves , Irina Kalbina , Asgeir Nilsen , Mats Aronsson , Eva Rosenqvist , Marcel A K Jansen , Minjie Qian , Åsa Öström , Tuulia Hyötyläinen , Åke Strid

Systems biology approaches to study lipidomes in health and disease.

Biochimica et biophysica acta. Molecular and cell biology of lipids
Avec: Marina Amaral Alves , Santosh Lamichhane , Alex Dickens , Aidan McGlinchey , Henrique Caracho Ribeiro , Partho Sen , Fang Wei , Tuulia Hyötyläinen , Matej Orešič

Activation of pregnane X receptor induces atherogenic lipids and PCSK9 by a SREBP2-mediated mechanism.

British journal of pharmacology
Avec: Mikko Karpale , Aki Juhani Käräjämäki , Outi Kummu , Helena Gylling , Tuulia Hyötyläinen , Matej Orešič , Ari Tolonen , Heidi Hautajärvi , Markku J Savolainen , Mika Ala-Korpela , Janne Hukkanen , Jukka Hakkola

Plasma lipid alterations in young adults with psychotic experiences: A study from the Avon Longitudinal Study of Parents and Children cohort.

Schizophrenia research
Avec: Xiaofei Yin , David Mongan , Mary Cannon , Stanley Zammit , Tuulia Hyötyläinen , Matej Orešič , Lorraine Brennan , David R Cotter

Lipidomic and Metabolomic Signature of Progression of Chronic Kidney Disease in Patients with Severe Obesity.

Metabolites
Avec: Borja Lanzon , Marina Martin-Taboada , Victor Castro-Alves , Rocio Vila-Bedmar , Ignacio González de Pablos , Daniel Duberg , Pilar Gomez , Elias Rodriguez , Matej Orešič , Tuulia Hyötyläinen , Enrique Morales , Francisco J Ruperez , Gema Medina-Gomez

Alterations in inflammasome-related immunometabolites in individuals with severe psychiatric disorders.

BMC psychiatry
Avec: Ulrika Hylén , Eva Särndahl , Susanne Bejerot , Mats B Humble , Tuulia Hyötyläinen , Samira Salihovic , Daniel Eklund

Impact of Environmental Exposures on Human Breast Milk Lipidome in Future Immune-Mediated Diseases.

Environmental science & technology
Avec: Tuulia Hyötyläinen , Tannaz Ghaffarzadegan , Bagavathy Shanmugam Karthikeyan , Eric Triplett , Matej Orešič , Johnny Ludvigsson

Exposure to environmental toxicants is associated with gut microbiome dysbiosis, insulin resistance and obesity.

Environment international
Avec: Partho Sen , Yong Fan , Jennifer J Schlezinger , Stanislav D Ehrlich , Thomas F Webster , Tuulia Hyötyläinen , Oluf Pedersen , Matej Orešič

Lipidomics in nutrition research.

Current opinion in clinical nutrition and metabolic care
Avec: Victor Castro-Alves , Matej Orešič , Tuulia Hyötyläinen

Dysregulation of secondary bile acid metabolism precedes islet autoimmunity and type 1 diabetes.

Cell reports. Medicine
Avec: Santosh Lamichhane , Partho Sen , Alex M Dickens , Marina Amaral Alves , Taina Härkönen , Jarno Honkanen , Tommi Vatanen , Ramnik J Xavier , Tuulia Hyötyläinen , Mikael Knip , Matej Orešič

Recent advances towards mass spectrometry-based clinical lipidomics.

Current opinion in chemical biology
Avec: Samira Salihovic , Santosh Lamichane , Tuulia Hyötyläinen , Matej Orešič

Metabolic Changes in

Metabolites
Avec: Muatasem Latif Ali , Lionel Ferrieres , Jana Jass , Tuulia Hyötyläinen

Metabolic changes associated with PFAS exposure in firefighters: A pilot study.

The Science of the total environment
Avec: Anna Rotander , Maria Jose Gomez Ramos , Jochen F Mueller , Leisa-Maree Toms , Tuulia Hyötyläinen

Réseau de co-auteurs

Tuulia Hyötyläinen 79 collaborations
Matej Orešič 57 collaborations
Santosh Lamichhane 15 collaborations
Alex M Dickens 15 collaborations
Partho Sen 15 collaborations
Mikael Knip 11 collaborations
Jorma Ilonen 8 collaborations
Aidan McGlinchey 8 collaborations
Samira Salihovic 7 collaborations
Daniel Duberg 7 collaborations
Heikki Hyöty 6 collaborations
Jorma Toppari 6 collaborations
Riitta Veijola 6 collaborations
Hannele Yki-Järvinen 6 collaborations
Tim Sinioja 6 collaborations
Heli Siljander 5 collaborations
Lisanna Sinisalu 5 collaborations
Panu K Luukkonen 5 collaborations
Suvi M Virtanen 5 collaborations
Dawei Geng 5 collaborations
Marina Amaral Alves 5 collaborations
Victor Castro-Alves 5 collaborations
Sami Qadri 4 collaborations
Leanne Hodson 4 collaborations
Eva Särndahl 4 collaborations
Johnny Ludvigsson 4 collaborations
Nikolai Scherbak 4 collaborations
Anne Juuti 4 collaborations
Esko Kemppainen 3 collaborations
Samira Salihović 3 collaborations
Tuomas Lindeman 3 collaborations
Jonas Halfvarson 3 collaborations
Amalia Gastaldelli 3 collaborations
Quentin M Anstee 3 collaborations
Daniel Eklund 3 collaborations
Bagavathy Shanmugam Karthikeyan 3 collaborations
Tannaz Ghaffarzadegan 3 collaborations
Matilda Kråkström 3 collaborations
Antti Hakkarainen 3 collaborations
Marju Orho-Melander 3 collaborations
Linda Ahonen 3 collaborations
Cecilia Carlsson 3 collaborations
Magnus Engwall 3 collaborations
Matej Oresic 3 collaborations
None None 3 collaborations
Johanna Bodin 3 collaborations
Hubert Dirven 3 collaborations
Unni C Nygaard 3 collaborations
Ilias Thomas 3 collaborations
Jussi P Posti 3 collaborations
Olli Tenovuo 3 collaborations
Yong Fan 3 collaborations
Sirkku Jäntti 3 collaborations
Oluf Pedersen 3 collaborations
Steffen H Keiter 3 collaborations
Ida Schoultz 2 collaborations
Frida Fart 2 collaborations
Maija Ruuth 2 collaborations
Mari Lahelma 2 collaborations
Petri T Kovanen 2 collaborations
Katariina Öörni 2 collaborations
Ulrika Hylén 2 collaborations
Susanne Bejerot 2 collaborations
Mats B Humble 2 collaborations
Eric Triplett 2 collaborations
Olivier Govaere 2 collaborations
Vlad Ratziu 2 collaborations
Elisabetta Bugianesi 2 collaborations
Jörn M Schattenberg 2 collaborations
Antonio Vidal-Puig 2 collaborations
Michael Allison 2 collaborations
Ann K Daly 2 collaborations
Susanna Lallukka-Brück 2 collaborations
You Zhou 2 collaborations
Tommi Suvitaival 2 collaborations
Mary Cannon 2 collaborations
Stanley Zammit 2 collaborations
David R Cotter 2 collaborations
Lorraine Brennan 2 collaborations
Trine Nielsen 2 collaborations
Sara Vieira-Silva 2 collaborations
Gwen Falony 2 collaborations
Nicolas Pons 2 collaborations
Torben Hansen 2 collaborations
Jeroen Raes 2 collaborations
Linda Andersson 2 collaborations
Mathieu Cinato 2 collaborations
Azra Miljanovic 2 collaborations
Muhammad Arif 2 collaborations
Malin Lindbom 2 collaborations
Marion Laudette 2 collaborations
Entela Bollano 2 collaborations
Martina Klevstig 2 collaborations
Marcus Henricsson 2 collaborations
Stephen Doran 2 collaborations
Adil Mardinoglu 2 collaborations
Jan Borén 2 collaborations
Malin C Levin 2 collaborations
Eva Rosenqvist 2 collaborations
Åke Strid 2 collaborations
P Seeburger 2 collaborations
Taina Härkönen 2 collaborations
Tommi Vatanen 2 collaborations
Andi Alijagic 2 collaborations
Oleksandr Kotlyar 2 collaborations
Maria Larsson 2 collaborations
Dirk Repsilber 2 collaborations
Robert Kruse 2 collaborations
Henna Sammalkorpi 2 collaborations
Hanne Friis Berntsen 2 collaborations
Karin Zimmer 2 collaborations
Johanna Arola 2 collaborations
S Dusko Ehrlich 2 collaborations
Riitta Lahesmaa 2 collaborations
Oddny Ragnarsdottir 2 collaborations
Eric W Triplett 2 collaborations
Heikki Laurikainen 2 collaborations
Faith Borgan 2 collaborations
Oliver Howes 2 collaborations
Jarmo Hietala 2 collaborations
Mélanie Blanc 2 collaborations
Xavier Cousin 2 collaborations
Andrew I R Maas 2 collaborations
David K Menon 2 collaborations
András Büki 2 collaborations
Pieter C Dorrestein 2 collaborations
Heidi Hautajärvi 2 collaborations
Markku J Savolainen 2 collaborations
Ari Tolonen 2 collaborations
Jukka Hakkola 2 collaborations
Janne Hukkanen 2 collaborations
Tuukka Rönkkö 2 collaborations
Jarno Honkanen 2 collaborations
Jennifer J Schlezinger 2 collaborations
Thomas F Webster 2 collaborations
Kajetan Trošt 1 collaboration
J J Schlezinger 1 collaboration
T Sinioja 1 collaboration
C Boston 1 collaboration
H Puckett 1 collaboration
J Oliver 1 collaboration
W Heiger-Bernays 1 collaboration
T F Webster 1 collaboration
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Simon Cockell 1 collaboration
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Markku Peltonen 1 collaboration
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S Holster 1 collaboration
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Outi Kummu 1 collaboration
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David Mongan 1 collaboration
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Ignacio González de Pablos 1 collaboration
Pilar Gomez 1 collaboration
Elias Rodriguez 1 collaboration
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Ramnik J Xavier 1 collaboration
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Anna Rotander 1 collaboration
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