Symon Gathiaka

Affiliations

Department of Discovery Chemistry, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States.

Publications (6)

Discovery of MK-1084: An Orally Bioavailable and Low-Dose KRAS

Journal of medicinal chemistry

Avec: Xiaoshen Ma , David L Sloman , Ruchia Duggal , Kenneth D Anderson , Jeanine E Ballard , Indu Bharathan , Christopher Brynczka , Timothy J Henderson , Thomas W Lyons , Richard Miller , Erik V Munsell , Peter Orth , Ryan D Otte , Anandan Palani , Danica A Rankic , Michelle R Robinson , Aaron C Sather , Nicolas Solban , Xuelei Sherry Song , Xin Wen , Zangwei Xu , Yi Yang , Ruojing Yang , Phil J Day , Alexander Stoeck , David Jonathan Bennett , Yongxin Han

Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors.

ACS medicinal chemistry letters

Avec: Derun Li , Hongjun Zhang , Thomas W Lyons , Min Lu , Abdelghani Achab , Qinglin Pu , Matthew Childers , Matthew J Mitcheltree , Jialiang Wang , Theodore A Martinot , Spencer E McMinn , David L Sloman , Anandan Palani , Adam Beard , Lisa Nogle , Josep Saurí , Hai-Young Kim , Donovon Adpressa , Peter Spacciapoli , J Richard Miller , Rachel L Palte , Charles A Lesburg , Jared Cumming , Christian Fischer

Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.

ACS medicinal chemistry letters

Avec: Min Lu , Hongjun Zhang , Derun Li , Matthew Childers , Qinglin Pu , Rachel L Palte , Thomas W Lyons , Anandan Palani , Peter W Fan , Peter Spacciapoli , J Richard Miller , Hyelim Cho , Mangeng Cheng , Kalyan Chakravarthy , Jennifer O'Neil , Padmanabhan Eangoor , Adam Beard , Hai-Young Kim , Josep Saurí , Hakan Gunaydin , David L Sloman , Phieng Siliphaivanh , Jared Cumming , Christian Fischer

Cryo-EM structures of inhibitory antibodies complexed with arginase 1 provide insight into mechanism of action.

Communications biology

Avec: Rachel L Palte , Veronica Juan , Yacob Gomez-Llorente , Marc Andre Bailly , Kalyan Chakravarthy , Xun Chen , Daniel Cipriano , Ghassan N Fayad , Laurence Fayadat-Dilman , Heiko Greb , Brian Hall , Mas Handa , Mark Hsieh , Esther Kofman , Heping Lin , J Richard Miller , Nhung Nguyen , Jennifer O'Neil , Hussam Shaheen , Eric Sterner , Corey Strickland , Angie Sun , Shane Taremi , Giovanna Scapin

Discovery of non-boronic acid Arginase 1 inhibitors through virtual screening and biophysical methods.

Bioorganic & medicinal chemistry letters

Avec: Rachel L Palte , Sung-Sau So , Xiaomei Chai , J Richard Miller , Reshma Kuvelkar , Xiujuan Wen , Steven Cifelli , Anthony Kreamer , Andy Liaw , David G McLaren , Christian Fischer

Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy.

ACS medicinal chemistry letters

Avec: Matthew J Mitcheltree , Derun Li , Abdelghani Achab , Adam Beard , Kalyan Chakravarthy , Mangeng Cheng , Hyelim Cho , Padmanabhan Eangoor , Peter Fan , Hai-Young Kim , Charles A Lesburg , Thomas W Lyons , Theodore A Martinot , J Richard Miller , Spencer McMinn , Jennifer O'Neil , Anandan Palani , Rachel L Palte , Josep Saurí , David L Sloman , Hongjun Zhang , Jared N Cumming , Christian Fischer

Réseau de co-auteurs

J Richard Miller 5 collaborations

Rachel L Palte 5 collaborations

David L Sloman 4 collaborations

Thomas W Lyons 4 collaborations

Anandan Palani 4 collaborations

Christian Fischer 4 collaborations

Derun Li 3 collaborations

Hongjun Zhang 3 collaborations

Adam Beard 3 collaborations

Josep Saurí 3 collaborations

Hai-Young Kim 3 collaborations

Kalyan Chakravarthy 3 collaborations

Jennifer O'Neil 3 collaborations

Min Lu 2 collaborations

Abdelghani Achab 2 collaborations

Qinglin Pu 2 collaborations

Matthew Childers 2 collaborations

Matthew J Mitcheltree 2 collaborations

Theodore A Martinot 2 collaborations

Peter Spacciapoli 2 collaborations

Charles A Lesburg 2 collaborations

Jared Cumming 2 collaborations

Hyelim Cho 2 collaborations

Mangeng Cheng 2 collaborations

Padmanabhan Eangoor 2 collaborations

Xiaoshen Ma 1 collaboration

Ruchia Duggal 1 collaboration

Kenneth D Anderson 1 collaboration

Jeanine E Ballard 1 collaboration

Indu Bharathan 1 collaboration

Christopher Brynczka 1 collaboration

Timothy J Henderson 1 collaboration

Richard Miller 1 collaboration

Erik V Munsell 1 collaboration

Peter Orth 1 collaboration

Ryan D Otte 1 collaboration

Danica A Rankic 1 collaboration

Michelle R Robinson 1 collaboration

Aaron C Sather 1 collaboration

Nicolas Solban 1 collaboration

Xuelei Sherry Song 1 collaboration

Xin Wen 1 collaboration

Zangwei Xu 1 collaboration

Yi Yang 1 collaboration

Ruojing Yang 1 collaboration

Phil J Day 1 collaboration

Alexander Stoeck 1 collaboration

David Jonathan Bennett 1 collaboration

Yongxin Han 1 collaboration

Jialiang Wang 1 collaboration

Spencer E McMinn 1 collaboration

Lisa Nogle 1 collaboration

Donovon Adpressa 1 collaboration

Peter W Fan 1 collaboration

Hakan Gunaydin 1 collaboration

Phieng Siliphaivanh 1 collaboration

Veronica Juan 1 collaboration

Yacob Gomez-Llorente 1 collaboration

Marc Andre Bailly 1 collaboration

Xun Chen 1 collaboration

Daniel Cipriano 1 collaboration

Ghassan N Fayad 1 collaboration

Laurence Fayadat-Dilman 1 collaboration

Heiko Greb 1 collaboration

Brian Hall 1 collaboration

Mas Handa 1 collaboration

Mark Hsieh 1 collaboration

Esther Kofman 1 collaboration

Heping Lin 1 collaboration

Nhung Nguyen 1 collaboration

Hussam Shaheen 1 collaboration

Eric Sterner 1 collaboration

Corey Strickland 1 collaboration

Angie Sun 1 collaboration

Shane Taremi 1 collaboration

Giovanna Scapin 1 collaboration

Sung-Sau So 1 collaboration

Xiaomei Chai 1 collaboration

Reshma Kuvelkar 1 collaboration

Xiujuan Wen 1 collaboration

Steven Cifelli 1 collaboration

Anthony Kreamer 1 collaboration

Andy Liaw 1 collaboration

David G McLaren 1 collaboration

Peter Fan 1 collaboration

Spencer McMinn 1 collaboration

Jared N Cumming 1 collaboration