David L Sloman

ORCID: 0000-0003-3404-9382

Publications (10)

Oxetane Promise Delivered: Discovery of Long-Acting IDO1 Inhibitors Suitable for Q3W Oral or Parenteral Dosing.

Journal of medicinal chemistry

Avec: Derun Li , Abdelghani Achab , Hua Zhou , Meredeth A McGowan , Catherine White , Craig Gibeau , Hongjun Zhang , Qinglin Pu , Indu Bharathan , Brett Hopkins , Kun Liu , Heidi Ferguson , Xavier Fradera , Charles A Lesburg , Theodore A Martinot , Ji Qi , Zhiguo J Song , Jingjun Yin , Huangguang Zhang , Licheng Song , Baoqiang Wan , Suzanne DAddio , Nicolas Solban , J Richard Miller , Beata Zamlynny , Alan Bass , Elizabeth Freeland , Bridget Ykoruk , Catherine Hilliard , Jude Ferraro , Jin Zhai , Ian Knemeyer , Karin M Otte , Stella Vincent , Nunzio Sciammetta , Alexander Pasternak , David Jonathan Bennett , Yongxin Han

Discovery of Potent and Orally Available Bicyclo[1.1.1]pentane-Derived Indoleamine-2,3-dioxygenase 1 (IDO1) Inhibitors.

ACS medicinal chemistry letters

Avec: Qinglin Pu , Hongjun Zhang , Liangqin Guo , Mangeng Cheng , Amy C Doty , Heidi Ferguson , Xavier Fradera , Charles A Lesburg , Meredeth A McGowan , J Richard Miller , Prasanthi Geda , Xuelei Song , Karin Otte , Nunzio Sciammetta , Nicolas Solban , Wensheng Yu , Hua Zhou , Alfred Lammens , Lars Neumann , David Jonathan Bennett , Alexander Pasternak , Yongxin Han

Discovery and Optimization of Rationally Designed Bicyclic Inhibitors of Human Arginase to Enhance Cancer Immunotherapy.

ACS medicinal chemistry letters

Avec: Matthew J Mitcheltree , Derun Li , Abdelghani Achab , Adam Beard , Kalyan Chakravarthy , Mangeng Cheng , Hyelim Cho , Padmanabhan Eangoor , Peter Fan , Symon Gathiaka , Hai-Young Kim , Charles A Lesburg , Thomas W Lyons , Theodore A Martinot , J Richard Miller , Spencer McMinn , Jennifer O'Neil , Anandan Palani , Rachel L Palte , Josep Saurí , Hongjun Zhang , Jared N Cumming , Christian Fischer

Combination of EP

Oncoimmunology

Avec: Yun Wang , Long Cui , Peter Georgiev , Latika Singh , Yanyan Zheng , Ying Yu , Jeff Grein , Chunsheng Zhang , Eric S Muise , Heidi Ferguson , Hongshi Yu , Cristina St Pierre , Pranal J Dakle , Vincenzo Pucci , James Baker , Andrey Loboda , Doug Linn , Christopher Brynczka , Doug Wilson , Brian B Haines , Brian Long , Richard Wnek , Svetlana Sadekova , Michael Rosenzweig , Andrew Haidle , Yongxin Han , Sheila H Ranganath

Discovery of MK-1084: An Orally Bioavailable and Low-Dose KRAS

Journal of medicinal chemistry

Avec: Xiaoshen Ma , Ruchia Duggal , Kenneth D Anderson , Jeanine E Ballard , Indu Bharathan , Christopher Brynczka , Symon Gathiaka , Timothy J Henderson , Thomas W Lyons , Richard Miller , Erik V Munsell , Peter Orth , Ryan D Otte , Anandan Palani , Danica A Rankic , Michelle R Robinson , Aaron C Sather , Nicolas Solban , Xuelei Sherry Song , Xin Wen , Zangwei Xu , Yi Yang , Ruojing Yang , Phil J Day , Alexander Stoeck , David Jonathan Bennett , Yongxin Han

A Selective Synthesis of 2,2-Difluorobicyclo[1.1.1]pentane Analogues: "BCP-F

Organic letters

Avec: Xiaoshen Ma , Yongxin Han , David J Bennett

Comprehensive Strategies to Bicyclic Prolines: Applications in the Synthesis of Potent Arginase Inhibitors.

ACS medicinal chemistry letters

Avec: Derun Li , Hongjun Zhang , Thomas W Lyons , Min Lu , Abdelghani Achab , Qinglin Pu , Matthew Childers , Matthew J Mitcheltree , Jialiang Wang , Theodore A Martinot , Spencer E McMinn , Anandan Palani , Adam Beard , Lisa Nogle , Symon Gathiaka , Josep Saurí , Hai-Young Kim , Donovon Adpressa , Peter Spacciapoli , J Richard Miller , Rachel L Palte , Charles A Lesburg , Jared Cumming , Christian Fischer

Diminishing GSH-Adduct Formation of Tricyclic Diazepine-based Mutant IDH1 Inhibitors.

ACS medicinal chemistry letters

Avec: Chunhui Huang , Christian Fischer , Michelle R Machacek , Stephane Bogen , Tesfaye Biftu , Xianhai Huang , Michael H Reutershan , Ryan Otte , Qingmei Hong , Zhicai Wu , Yang Yu , Min Park , Lei Chen , Purakkattle Biju , Ian Knemeyer , Ping Lu , Christopher J Kochansky , Michael Brendan Hicks , Yong Liu , Roy Helmy , Xavier Fradera , Anthony Donofrio , Josh Close , Matthew L Maddess , Catherine White , Nunzio Sciammetta , Jun Lu , Craig Gibeau , Vladimir Simov , Hongjun Zhang , Peter Fuller , David Witter

Structure-Based Discovery of Proline-Derived Arginase Inhibitors with Improved Oral Bioavailability for Immuno-Oncology.

ACS medicinal chemistry letters

Avec: Min Lu , Hongjun Zhang , Derun Li , Matthew Childers , Qinglin Pu , Rachel L Palte , Symon Gathiaka , Thomas W Lyons , Anandan Palani , Peter W Fan , Peter Spacciapoli , J Richard Miller , Hyelim Cho , Mangeng Cheng , Kalyan Chakravarthy , Jennifer O'Neil , Padmanabhan Eangoor , Adam Beard , Hai-Young Kim , Josep Saurí , Hakan Gunaydin , Phieng Siliphaivanh , Jared Cumming , Christian Fischer

Unexpected Noncovalent Off-Target Activity of Clinical BTK Inhibitors Leads to Discovery of a Dual NUDT5/14 Antagonist.

Journal of medicinal chemistry

Avec: Esra Balıkçı , Anne-Sophie M C Marques , Ludwig G Bauer , Raina Seupel , James Bennett , Brigitt Raux , Karly Buchan , Klemensas Simelis , Usha Singh , Catherine Rogers , Jennifer Ward , Carol Cheng , Tamas Szommer , Kira Schützenhofer , Jonathan M Elkins , Ivan Ahel , Oleg Fedorov , Paul E Brennan , Kilian V M Huber

Réseau de co-auteurs

Hongjun Zhang 6 collaborations

J Richard Miller 5 collaborations

Yongxin Han 5 collaborations

Derun Li 4 collaborations

Qinglin Pu 4 collaborations

Charles A Lesburg 4 collaborations

Symon Gathiaka 4 collaborations

Thomas W Lyons 4 collaborations

Anandan Palani 4 collaborations

Christian Fischer 4 collaborations

Abdelghani Achab 3 collaborations

Heidi Ferguson 3 collaborations

Xavier Fradera 3 collaborations

Theodore A Martinot 3 collaborations

Nicolas Solban 3 collaborations

Nunzio Sciammetta 3 collaborations

David Jonathan Bennett 3 collaborations

Mangeng Cheng 3 collaborations

Adam Beard 3 collaborations

Hai-Young Kim 3 collaborations

Rachel L Palte 3 collaborations

Josep Saurí 3 collaborations

Hua Zhou 2 collaborations

Meredeth A McGowan 2 collaborations

Catherine White 2 collaborations

Craig Gibeau 2 collaborations

Indu Bharathan 2 collaborations

Ian Knemeyer 2 collaborations

Alexander Pasternak 2 collaborations

Matthew J Mitcheltree 2 collaborations

Kalyan Chakravarthy 2 collaborations

Hyelim Cho 2 collaborations

Padmanabhan Eangoor 2 collaborations

Jennifer O'Neil 2 collaborations

Christopher Brynczka 2 collaborations

Xiaoshen Ma 2 collaborations

Min Lu 2 collaborations

Matthew Childers 2 collaborations

Peter Spacciapoli 2 collaborations

Jared Cumming 2 collaborations

Brett Hopkins 1 collaboration

Kun Liu 1 collaboration

Ji Qi 1 collaboration

Zhiguo J Song 1 collaboration

Jingjun Yin 1 collaboration

Huangguang Zhang 1 collaboration

Licheng Song 1 collaboration

Baoqiang Wan 1 collaboration

Suzanne DAddio 1 collaboration

Beata Zamlynny 1 collaboration

Alan Bass 1 collaboration

Elizabeth Freeland 1 collaboration

Bridget Ykoruk 1 collaboration

Catherine Hilliard 1 collaboration

Jude Ferraro 1 collaboration

Jin Zhai 1 collaboration

Karin M Otte 1 collaboration

Stella Vincent 1 collaboration

Liangqin Guo 1 collaboration

Amy C Doty 1 collaboration

Prasanthi Geda 1 collaboration

Xuelei Song 1 collaboration

Karin Otte 1 collaboration

Wensheng Yu 1 collaboration

Alfred Lammens 1 collaboration

Lars Neumann 1 collaboration

Peter Fan 1 collaboration

Spencer McMinn 1 collaboration

Jared N Cumming 1 collaboration

Yun Wang 1 collaboration

Long Cui 1 collaboration

Peter Georgiev 1 collaboration

Latika Singh 1 collaboration

Yanyan Zheng 1 collaboration

Ying Yu 1 collaboration

Jeff Grein 1 collaboration

Chunsheng Zhang 1 collaboration

Eric S Muise 1 collaboration

Hongshi Yu 1 collaboration

Cristina St Pierre 1 collaboration

Pranal J Dakle 1 collaboration

Vincenzo Pucci 1 collaboration

James Baker 1 collaboration

Andrey Loboda 1 collaboration

Doug Linn 1 collaboration

Doug Wilson 1 collaboration

Brian B Haines 1 collaboration

Brian Long 1 collaboration

Richard Wnek 1 collaboration

Svetlana Sadekova 1 collaboration

Michael Rosenzweig 1 collaboration

Andrew Haidle 1 collaboration

Sheila H Ranganath 1 collaboration

Ruchia Duggal 1 collaboration

Kenneth D Anderson 1 collaboration

Jeanine E Ballard 1 collaboration

Timothy J Henderson 1 collaboration

Richard Miller 1 collaboration

Erik V Munsell 1 collaboration

Peter Orth 1 collaboration

Ryan D Otte 1 collaboration

Danica A Rankic 1 collaboration

Michelle R Robinson 1 collaboration

Aaron C Sather 1 collaboration

Xuelei Sherry Song 1 collaboration

Xin Wen 1 collaboration

Zangwei Xu 1 collaboration

Yi Yang 1 collaboration

Ruojing Yang 1 collaboration

Phil J Day 1 collaboration

Alexander Stoeck 1 collaboration

David J Bennett 1 collaboration

Jialiang Wang 1 collaboration

Spencer E McMinn 1 collaboration

Lisa Nogle 1 collaboration

Donovon Adpressa 1 collaboration

Chunhui Huang 1 collaboration

Michelle R Machacek 1 collaboration

Stephane Bogen 1 collaboration

Tesfaye Biftu 1 collaboration

Xianhai Huang 1 collaboration

Michael H Reutershan 1 collaboration

Ryan Otte 1 collaboration

Qingmei Hong 1 collaboration

Zhicai Wu 1 collaboration

Yang Yu 1 collaboration

Min Park 1 collaboration

Lei Chen 1 collaboration

Purakkattle Biju 1 collaboration

Ping Lu 1 collaboration

Christopher J Kochansky 1 collaboration

Michael Brendan Hicks 1 collaboration

Yong Liu 1 collaboration

Roy Helmy 1 collaboration

Anthony Donofrio 1 collaboration

Josh Close 1 collaboration

Matthew L Maddess 1 collaboration

Jun Lu 1 collaboration

Vladimir Simov 1 collaboration

Peter Fuller 1 collaboration

David Witter 1 collaboration

Peter W Fan 1 collaboration

Hakan Gunaydin 1 collaboration

Phieng Siliphaivanh 1 collaboration

Esra Balıkçı 1 collaboration

Anne-Sophie M C Marques 1 collaboration

Ludwig G Bauer 1 collaboration

Raina Seupel 1 collaboration

James Bennett 1 collaboration

Brigitt Raux 1 collaboration

Karly Buchan 1 collaboration

Klemensas Simelis 1 collaboration

Usha Singh 1 collaboration

Catherine Rogers 1 collaboration

Jennifer Ward 1 collaboration

Carol Cheng 1 collaboration

Tamas Szommer 1 collaboration

Kira Schützenhofer 1 collaboration

Jonathan M Elkins 1 collaboration

Ivan Ahel 1 collaboration

Oleg Fedorov 1 collaboration

Paul E Brennan 1 collaboration

Kilian V M Huber 1 collaboration