Stanley T Crooke

Affiliations

Ionis Pharmaceuticals, Inc., Carlsbad, California 92010-6670, United States.

ORCID: 0000-0002-4260-1520

Publications (30)

The Interaction of Phosphorothioate-Containing RNA Targeted Drugs with Proteins Is a Critical Determinant of the Therapeutic Effects of These Agents.

Journal of the American Chemical Society

Avec: Punit P Seth , Timothy A Vickers , Xue-Hai Liang

Integrated Assessment of the Clinical Performance of GalNAc

Nucleic acid therapeutics

Avec: Brenda F Baker , Shuting Xia , Rosie Z Yu , Nicholas J Viney , Yanfeng Wang , Sotirios Tsimikas , Richard S Geary

Golgi-58K can re-localize to late endosomes upon cellular uptake of PS-ASOs and facilitates endosomal release of ASOs.

Nucleic acids research

Avec: Xue-Hai Liang , Joshua G Nichols , Cheryl Li De Hoyos , Hong Sun , Lingdi Zhang ,

Perinuclear positioning of endosomes can affect PS-ASO activities.

Nucleic acids research

Avec: Xue-Hai Liang , Joshua G Nichols , Dario Tejera ,

The Combination of Mesyl-Phosphoramidate Inter-Nucleotide Linkages and 2'-

Nucleic acid therapeutics

Avec: Lingdi Zhang , Xue-Hai Liang , Cheryl Li De Hoyos , Michael Migawa , Joshua G Nichols , Graeme Freestone , Jun Tian , Punit P Seth ,

Progress in molecular biology and translational science addressing the needs of nano-rare patients.

Progress in molecular biology and translational science

Avec:

Characterization of cooperative PS-oligo activation of human TLR9.

Molecular therapy. Nucleic acids

Avec: Adam J Pollak , Luyi Zhao ,

Interaction of ASOs with PC4 Is Highly Influenced by the Cellular Environment and ASO Chemistry.

Journal of the American Chemical Society

Avec: Timothy A Vickers , Michael T Migawa , Punit P Seth ,

Some ASOs that bind in the coding region of mRNAs and induce RNase H1 cleavage can cause increases in the pre-mRNAs that may blunt total activity.

Nucleic acids research

Avec: Xue-Hai Liang , Joshua G Nichols , Cheryl L De Hoyos ,

Antisense drug discovery and development technology considered in a pharmacological context.

Biochemical pharmacology

Avec: Xue-Hai Liang , Rosanne M Crooke , Brenda F Baker , Richard S Geary

Towards next generation antisense oligonucleotides: mesylphosphoramidate modification improves therapeutic index and duration of effect of gapmer antisense oligonucleotides.

Nucleic acids research

Avec: Brooke A Anderson , Graeme C Freestone , Audrey Low , Cheryl L De-Hoyos , William J Drury Iii , Michael E Østergaard , Michael T Migawa , Michael Fazio , W Brad Wan , Andres Berdeja , Eli Scandalis , Sebastien A Burel , Timothy A Vickers , Eric E Swayze , Xuehai Liang , Punit P Seth

Site-specific replacement of phosphorothioate with alkyl phosphonate linkages enhances the therapeutic profile of gapmer ASOs by modulating interactions with cellular proteins.

Nucleic acids research

Avec: Michael T Migawa , Wen Shen , W Brad Wan , Guillermo Vasquez , Michael E Oestergaard , Audrey Low , Cheryl L De Hoyos , Ruchi Gupta , Susan Murray , Michael Tanowitz , Melanie Bell , Joshua G Nichols , Hans Gaus , Xue-Hai Liang , Eric E Swayze , Punit P Seth

Kinetic and subcellular analysis of PS-ASO/protein interactions with P54nrb and RNase H1.

Nucleic acids research

Avec: Timothy A Vickers , Meghdad Rahdar , Thazha P Prakash ,

Lipid Conjugates Enhance Endosomal Release of Antisense Oligonucleotides Into Cells.

Nucleic acid therapeutics

Avec: Shiyu Wang , Nickolas Allen , Thazha P Prakash , Xue-Hai Liang ,

Origins of the Increased Affinity of Phosphorothioate-Modified Therapeutic Nucleic Acids for Proteins.

Journal of the American Chemical Society

Avec: Malwina Hyjek-Składanowska , Timothy A Vickers , Agnieszka Napiórkowska , Brooke A Anderson , Michael Tanowitz , Xue-Hai Liang , Punit P Seth , Marcin Nowotny

Addressing the Needs of Patients with Ultra-Rare Mutations One Patient at a Time: The n-Lorem Approach.

Nucleic acid therapeutics

Avec:

Solid-Phase Separation of Toxic Phosphorothioate Antisense Oligonucleotide-Protein Nucleolar Aggregates Is Cytoprotective.

Nucleic acid therapeutics

Avec: Xue-Hai Liang , Cheryl Li De Hoyos , Wen Shen , Lingdi Zhang , Michael Fazio ,

Insights into innate immune activation via PS-ASO-protein-TLR9 interactions.

Nucleic acids research

Avec: Adam J Pollak , Luyi Zhao , Timothy A Vickers , Ian J Huggins , Xue-Hai Liang ,

Understanding the effect of controlling phosphorothioate chirality in the DNA gap on the potency and safety of gapmer antisense oligonucleotides.

Nucleic acids research

Avec: Michael E Østergaard , Cheryl L De Hoyos , W Brad Wan , Wen Shen , Audrey Low , Andres Berdeja , Guillermo Vasquez , Susan Murray , Michael T Migawa , Xue-Hai Liang , Eric E Swayze , Punit P Seth

Phosphorothioate modified oligonucleotide-protein interactions.

Nucleic acids research

Avec: Timothy A Vickers , Xue-Hai Liang

Golgi-endosome transport mediated by M6PR facilitates release of antisense oligonucleotides from endosomes.

Nucleic acids research

Avec: Xue-Hai Liang , Hong Sun , Chih-Wei Hsu , Joshua G Nichols , Timothy A Vickers , Cheryl L De Hoyos ,

Gapmer Antisense Oligonucleotides Targeting 5S Ribosomal RNA Can Reduce Mature 5S Ribosomal RNA by Two Mechanisms.

Nucleic acid therapeutics

Avec: Adam J Pollak , Justin H Hickman , Xue-Hai Liang ,

Chemical modification of PS-ASO therapeutics reduces cellular protein-binding and improves the therapeutic index.

Nature biotechnology

Avec: Wen Shen , Cheryl L De Hoyos , Michael T Migawa , Timothy A Vickers , Hong Sun , Audrey Low , Thomas A Bell , Meghdad Rahdar , Swagatam Mukhopadhyay , Christopher E Hart , Melanie Bell , Stan Riney , Susan F Murray , Sarah Greenlee , Rosanne M Crooke , Xue-Hai Liang , Punit P Seth ,

Antisense technology: A review.

The Journal of biological chemistry

Avec: Xue-Hai Liang , Brenda F Baker , Rosanne M Crooke

Binding of phosphorothioate oligonucleotides with RNase H1 can cause conformational changes in the protein and alter the interactions of RNase H1 with other proteins.

Nucleic acids research

Avec: Lingdi Zhang , Timothy A Vickers , Hong Sun , Xue-Hai Liang ,

Site-specific Incorporation of 2',5'-Linked Nucleic Acids Enhances Therapeutic Profile of Antisense Oligonucleotides.

ACS medicinal chemistry letters

Avec: Thazha P Prakash , Jinghua Yu , Wen Shen , Cheryl Li De Hoyos , Andres Berdeja , Hans Gaus , Xue-Hai Liang , Punit P Seth

Meeting the needs of patients with ultrarare diseases.

Trends in molecular medicine

Avec:

NAT10 and DDX21 Proteins Interact with RNase H1 and Affect the Performance of Phosphorothioate Oligonucleotides.

Nucleic acid therapeutics

Avec: Lingdi Zhang , Karla D Bernardo , Timothy A Vickers , Jun Tian , Xue-Hai Liang ,

Antisense oligonucleotide therapy in an individual with KIF1A-associated neurological disorder.

Nature medicine

Avec: Alban Ziegler , Joanne Carroll , Jennifer M Bain , Tristan T Sands , Robert J Fee , David Uher , Cara H Kanner , Jacqueline Montes , Sarah Glass , Julie Douville , Laurence Mignon , Joseph G Gleeson , Wendy K Chung

Hsc70 Facilitates Mannose-6-Phosphate Receptor-Mediated Intracellular Trafficking and Enhances Endosomal Release of Phosphorothioate-Modified Antisense Oligonucleotides.

Nucleic acid therapeutics

Avec: Xue-Hai Liang , Joshua G Nichols , Chih-Wei Hsu ,

Réseau de co-auteurs

Xue-Hai Liang 21 collaborations

Timothy A Vickers 11 collaborations

Punit P Seth 9 collaborations

Joshua G Nichols 7 collaborations

Lingdi Zhang 5 collaborations

Michael T Migawa 5 collaborations

Cheryl L De Hoyos 5 collaborations

Wen Shen 5 collaborations

Cheryl Li De Hoyos 4 collaborations

Hong Sun 4 collaborations

Audrey Low 4 collaborations

Brenda F Baker 3 collaborations

Adam J Pollak 3 collaborations

Rosanne M Crooke 3 collaborations

W Brad Wan 3 collaborations

Andres Berdeja 3 collaborations

Eric E Swayze 3 collaborations

Thazha P Prakash 3 collaborations

Richard S Geary 2 collaborations

Jun Tian 2 collaborations

Luyi Zhao 2 collaborations

Brooke A Anderson 2 collaborations

Michael E Østergaard 2 collaborations

Michael Fazio 2 collaborations

Guillermo Vasquez 2 collaborations

Susan Murray 2 collaborations

Michael Tanowitz 2 collaborations

Melanie Bell 2 collaborations

Hans Gaus 2 collaborations

Meghdad Rahdar 2 collaborations

Chih-Wei Hsu 2 collaborations

Shuting Xia 1 collaboration

Rosie Z Yu 1 collaboration

Nicholas J Viney 1 collaboration

Yanfeng Wang 1 collaboration

Sotirios Tsimikas 1 collaboration

Dario Tejera 1 collaboration

Michael Migawa 1 collaboration

Graeme Freestone 1 collaboration

Graeme C Freestone 1 collaboration

Cheryl L De-Hoyos 1 collaboration

William J Drury Iii 1 collaboration

Eli Scandalis 1 collaboration

Sebastien A Burel 1 collaboration

Xuehai Liang 1 collaboration

Michael E Oestergaard 1 collaboration

Ruchi Gupta 1 collaboration

Shiyu Wang 1 collaboration

Nickolas Allen 1 collaboration

Malwina Hyjek-Składanowska 1 collaboration

Agnieszka Napiórkowska 1 collaboration

Marcin Nowotny 1 collaboration

Ian J Huggins 1 collaboration

Justin H Hickman 1 collaboration

Thomas A Bell 1 collaboration

Swagatam Mukhopadhyay 1 collaboration

Christopher E Hart 1 collaboration

Stan Riney 1 collaboration

Susan F Murray 1 collaboration

Sarah Greenlee 1 collaboration

Jinghua Yu 1 collaboration

Karla D Bernardo 1 collaboration

Alban Ziegler 1 collaboration

Joanne Carroll 1 collaboration

Jennifer M Bain 1 collaboration

Tristan T Sands 1 collaboration

Robert J Fee 1 collaboration

David Uher 1 collaboration

Cara H Kanner 1 collaboration

Jacqueline Montes 1 collaboration

Sarah Glass 1 collaboration

Julie Douville 1 collaboration

Laurence Mignon 1 collaboration

Joseph G Gleeson 1 collaboration

Wendy K Chung 1 collaboration