Perry J Blackshear

Affiliations

Laboratory of Signal Transduction, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina.

Publications (32)

Tristetraprolin Promotes Hepatic Inflammation and Tumor Initiation but Restrains Cancer Progression to Malignancy.

Cellular and molecular gastroenterology and hepatology

Avec: Dobrochna Dolicka , Cyril Sobolewski , Monika Gjorgjieva , Marta Correia de Sousa , Flavien Berthou , Claudio De Vito , Didier J Colin , Olivia Bejuy , Margot Fournier , Christine Maeder , Laura Rubbia-Brandt , Michelangelo Foti

Backbone and sidechain

Biomolecular NMR assignments

Avec: Stephanie N Hicks , Ronald A Venters ,

RNA-Binding Protein-Mediated mRNA Deadenylation in Mammalian Cell Extracts.

Methods in molecular biology (Clifton, N.J.)

Avec: Wi S Lai , Stephanie N Hicks ,

Tip60- and sirtuin 2-regulated MARCKS acetylation and phosphorylation are required for diabetic embryopathy.

Nature communications

Avec: Penghua Yang , Cheng Xu , E Albert Reece , Xi Chen , Jianxiang Zhong , Min Zhan , Deborah J Stumpo , Peixin Yang

Tristetraprolin expression by keratinocytes protects against skin carcinogenesis.

JCI insight

Avec: Assiya Assabban , Ingrid Dubois-Vedrenne , Laurye Van Maele , Rosalba Salcedo , Brittany L Snyder , Lecong Zhou , Abdulkader Azouz , Bérengère de Toeuf , Gaëlle Lapouge , Caroline La , Maxime Melchior , Muriel Nguyen , Séverine Thomas , Si Fan Wu , Wenqian Hu , Véronique Kruys , Cédric Blanpain , Giorgio Trinchieri , Cyril Gueydan , Stanislas Goriely

Tristetraprolin overexpression drives hematopoietic changes in young and middle-aged mice generating dominant mitigating effects on induced inflammation in murine models.

GeroScience

Avec: Mayuri Tanaka-Yano , Le Zong , Bongsoo Park , Hagai Yanai , Ferda Tekin-Turhan , Isabel Beerman

Tristetraprolin targets Nos2 expression in the colonic epithelium.

Scientific reports

Avec: Melanie A Eshelman , Stephen M Matthews , Emily M Schleicher , Rebecca M Fleeman , Yuka Imamura Kawasawa , Deborah J Stumpo , Walter A Koltun , Faoud T Ishmael , Gregory S Yochum

Importance of the Conserved Carboxyl-Terminal CNOT1 Binding Domain to Tristetraprolin Activity

Molecular and cellular biology

Avec: Wi S Lai , Deborah J Stumpo , Melissa L Wells , Artiom Gruzdev , Stephanie N Hicks , Cindo O Nicholson , Zhengfeng Yang , Roberta Faccio , Michael W Webster , Lori A Passmore ,

Inhibiting transcription in cultured metazoan cells with actinomycin D to monitor mRNA turnover.

Methods (San Diego, Calif.)

Avec: Wi S Lai , Rene M Arvola , Aaron C Goldstrohm ,

Tristetraprolin Overexpression in Non-hematopoietic Cells Protects Against Acute Lung Injury in Mice.

Frontiers in immunology

Avec: Ishita Choudhary , Thao Vo , Chandra S Bathula , Richa Lamichhane , Brandon W Lewis , Jayme Looper , Samithamby Jeyaseelan , Yogesh Saini , Sonika Patial

Clinical implications of tristetraprolin (TTP) modulation in the treatment of inflammatory diseases.

Pharmacology & therapeutics

Avec: Brittany L Snyder ,

Beta-hydroxybutyrate dampens adipose progenitors' profibrotic activation through canonical Tgfβ signaling and non-canonical ZFP36-dependent mechanisms.

Molecular metabolism

Avec: Simon Lecoutre , Fatiha Merabtene , Elie-Julien El Hachem , Camille Gamblin , Christine Rouault , Nataliya Sokolovska , Hedi Soula , Wi S Lai , Karine Clément , Isabelle Dugail

Lethal eosinophilic crystalline pneumonia in mice expressing a stabilized Csf2 mRNA.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Yukitomo Arao , Deborah J Stumpo , Mark J Hoenerhoff , Robert M Tighe , Yen-Rei Yu , Deloris Sutton , Amogh Kashyap , Isabel Beerman ,

Tristetraprolin regulates the skeletal phenotype and osteoclastogenic potential through monocytic myeloid-derived suppressor cells.

FASEB journal : official publication of the Federation of American Societies for Experimental Biology

Avec: Lixia Zhang , Kyu Hwan Kwack , Ramkumar Thiyagarajan , Kylie K Mullaney , Natalie A Lamb , Jonathan E Bard , Jiho Sohn , Kenneth L Seldeen , Yukitomo Arao , Scott I Abrams , Bruce R Troen , Keith L Kirkwood

The mRNA-binding Protein TTP/ZFP36 in Hepatocarcinogenesis and Hepatocellular Carcinoma.

Cancers

Avec: Tarek Kröhler , Sonja M Kessler , Kevan Hosseini , Markus List , Ahmad Barghash , Sonika Patial , Stephan Laggai , Katja Gemperlein , Johannes Haybaeck , Rolf Müller , Volkhard Helms , Marcel H Schulz , Jessica Hoppstädter , Alexandra K Kiemer

The tandem zinc finger RNA binding domain of members of the tristetraprolin protein family.

Wiley interdisciplinary reviews. RNA

Avec: Wi S Lai , Melissa L Wells , Lalith Perera ,

Bone marrow deficiency of mRNA decaying protein Tristetraprolin increases inflammation and mitochondrial ROS but reduces hepatic lipoprotein production in LDLR knockout mice.

Redox biology

Avec: Fatma Saaoud , Junfeng Wang , Stephen Iwanowycz , Yuzhen Wang , Diego Altomare , Ying Shao , Jianguo Liu , Susan M Lessner , E Angela Murphy , Hong Wang , Xiaofeng Yang , Daping Fan

Tristetraprolin regulates necroptosis during tonic Toll-like receptor 4 (TLR4) signaling in murine macrophages.

The Journal of biological chemistry

Avec: Ardeshir Ariana , Norah A Alturki , Stephanie Hajjar , Deborah J Stumpo , Christopher Tiedje , Emad S Alnemri , Matthias Gaestel , Subash Sad

Tristetraprolin Regulates T

Frontiers in immunology

Avec: Hui Peng , Huan Ning , Qinghong Wang , Jinping Lai , Lin Wei , Deborah J Stumpo , Mingui Fu , Rong Hou , Daniel F Hoft , Jianguo Liu

ZFP36L1 Regulates Fgf21 mRNA Turnover and Modulates Alcoholic Hepatic Steatosis and Inflammation in Mice.

The American journal of pathology

Avec: Chandra S Bathula , Jian Chen , Rahul Kumar , Yogesh Saini , Sonika Patial

Regulated Tristetraprolin Overexpression Dampens the Development and Pathogenesis of Experimental Autoimmune Uveitis.

Frontiers in immunology

Avec: Biying Xu , Jihong Tang , Cancan Lyu , Wambui S Wandu , Deborah J Stumpo , Mary J Mattapallil , Reiko Horai , Igal Gery , Rachel R Caspi

Identification of Alternative Polyadenylation in

Frontiers in genetics

Avec: Leonard Schärfen , Dagmar Zigackova , Kirsten A Reimer , Martha R Stark , Viktor A Slat , Nancy J Francoeur , Melissa L Wells , Lecong Zhou , Karla M Neugebauer , Stephen D Rader

ZFP36L2 suppresses mTORc1 through a P53-dependent pathway to prevent peripartum cardiomyopathy in mice.

The Journal of clinical investigation

Avec: Hidemichi Kouzu , Yuki Tatekoshi , Hsiang-Chun Chang , Jason S Shapiro , Warren A McGee , Adam De Jesus , Issam Ben-Sahra , Zoltan Arany , Jonathan Leor , Chunlei Chen , Hossein Ardehali

Tristetraprolin limits age-related expansion of myeloid-derived suppressor cells.

Frontiers in immunology

Avec: Kyu Hwan Kwack , Lixia Zhang , Elliot D Kramer , Ramkumar Thiyagarajan , Natalie A Lamb , Yukitomo Arao , Jonathan E Bard , Kenneth L Seldeen , Bruce R Troen , Scott I Abrams , Keith L Kirkwood

Synergistic roles of tristetraprolin family members in myeloid cells in the control of inflammation.

Life science alliance

Avec: Brittany L Snyder , Rui Huang , Adam B Burkholder , Danielle R Donahue , Beth W Mahler , Carl D Bortner , Wi S Lai ,

Regulation of Zfp36 by ISGF3 and MK2 restricts the expression of inflammatory cytokines during necroptosis stimulation.

Cell death & disease

Avec: Sahil Yadav , Rayan El Hamra , Norah A Alturki , Ardeshir Ariana , Avni Bhan , Kate Hurley , Matthias Gaestel , Alexandre Blais , Subash Sad

The RNA-binding protein tristetraprolin regulates RALDH2 expression by intestinal dendritic cells and controls local Treg homeostasis.

Mucosal immunology

Avec: Caroline La , Bérengère de Toeuf , Laure B Bindels , Laurye Van Maele , Assiya Assabban , Maxime Melchior , Justine Smout , Arnaud Köhler , Muriel Nguyen , Séverine Thomas , Romuald Soin , Nadège Delacourt , Hsüehlei Li , Wenqian Hu , Véronique Kruys , Cyril Gueydan , Guillaume Oldenhove , Stanislas Goriely

Single-Cell Transcriptomics Uncovers Glial Progenitor Diversity and Cell Fate Determinants during Development and Gliomagenesis.

Cell stem cell

Avec: Qinjie Weng , Jincheng Wang , Jiajia Wang , Danyang He , Zuolin Cheng , Feng Zhang , Ravinder Verma , Lingli Xu , Xinran Dong , Yunfei Liao , Xuelian He , Andrew Potter , Liguo Zhang , Chuntao Zhao , Mei Xin , Qian Zhou , Bruce J Aronow , Jeremy N Rich , Qiaojun He , Wenhao Zhou , Mario L Suvà , Ronald R Waclaw , S Steven Potter , Guoqiang Yu , Q Richard Lu

A post-transcriptional regulon controlled by TtpA, the single tristetraprolin family member expressed in Dictyostelium discoideum.

Nucleic acids research

Avec: Wenli Bai , Melissa L Wells , Wi S Lai , Stephanie N Hicks , Adam B Burkholder , Lalith Perera , Alan R Kimmel ,

Tristetraprolin Prevents Gastric Metaplasia in Mice by Suppressing Pathogenic Inflammation.

Cellular and molecular gastroenterology and hepatology

Avec: Jonathan T Busada , Stuti Khadka , Kylie N Peterson , Sara R Druffner , Deborah J Stumpo , Lecong Zhou , Robert H Oakley , John A Cidlowski ,

ZFP36L2 Role in Thyroid Functionality.

International journal of molecular sciences

Avec: Francesco Albano , Valeria Tucci , Carla Reale , Luca Roberto , Filomena Russo , Pina Marotta , Immacolata Porreca , Marco Colella , Massimo Mallardo , Mario de Felice , Concetta Ambrosino

The ZFP36 family of RNA binding proteins regulates homeostatic and autoreactive T cell responses.

Science immunology

Avec: Melissa E Cook , Tara R Bradstreet , Ashlee M Webber , Jongshin Kim , Andrea Santeford , Kevin M Harris , Maegan K Murphy , Jennifer Tran , Nada M Abdalla , Elizabeth A Schwarzkopf , Suellen C Greco , Carmen M Halabi , Rajendra S Apte , Brian T Edelson

Réseau de co-auteurs

Deborah J Stumpo 8 collaborations

Wi S Lai 7 collaborations

Stephanie N Hicks 4 collaborations

Melissa L Wells 4 collaborations

Brittany L Snyder 3 collaborations

Lecong Zhou 3 collaborations

Sonika Patial 3 collaborations

Yukitomo Arao 3 collaborations

Assiya Assabban 2 collaborations

Laurye Van Maele 2 collaborations

Bérengère de Toeuf 2 collaborations

Caroline La 2 collaborations

Maxime Melchior 2 collaborations

Muriel Nguyen 2 collaborations

Séverine Thomas 2 collaborations

Wenqian Hu 2 collaborations

Véronique Kruys 2 collaborations

Cyril Gueydan 2 collaborations

Stanislas Goriely 2 collaborations

Isabel Beerman 2 collaborations

Chandra S Bathula 2 collaborations

Yogesh Saini 2 collaborations

Lixia Zhang 2 collaborations

Kyu Hwan Kwack 2 collaborations

Ramkumar Thiyagarajan 2 collaborations

Natalie A Lamb 2 collaborations

Jonathan E Bard 2 collaborations

Kenneth L Seldeen 2 collaborations

Scott I Abrams 2 collaborations

Bruce R Troen 2 collaborations

Keith L Kirkwood 2 collaborations

Lalith Perera 2 collaborations

Jianguo Liu 2 collaborations

Ardeshir Ariana 2 collaborations

Norah A Alturki 2 collaborations

Matthias Gaestel 2 collaborations

Subash Sad 2 collaborations

Adam B Burkholder 2 collaborations

Dobrochna Dolicka 1 collaboration

Cyril Sobolewski 1 collaboration

Monika Gjorgjieva 1 collaboration

Marta Correia de Sousa 1 collaboration

Flavien Berthou 1 collaboration

Claudio De Vito 1 collaboration

Didier J Colin 1 collaboration

Olivia Bejuy 1 collaboration

Margot Fournier 1 collaboration

Christine Maeder 1 collaboration

Laura Rubbia-Brandt 1 collaboration

Michelangelo Foti 1 collaboration

Ronald A Venters 1 collaboration

Penghua Yang 1 collaboration

Cheng Xu 1 collaboration

E Albert Reece 1 collaboration

Xi Chen 1 collaboration

Jianxiang Zhong 1 collaboration

Min Zhan 1 collaboration

Peixin Yang 1 collaboration

Ingrid Dubois-Vedrenne 1 collaboration

Rosalba Salcedo 1 collaboration

Abdulkader Azouz 1 collaboration

Gaëlle Lapouge 1 collaboration

Si Fan Wu 1 collaboration

Cédric Blanpain 1 collaboration

Giorgio Trinchieri 1 collaboration

Mayuri Tanaka-Yano 1 collaboration

Le Zong 1 collaboration

Bongsoo Park 1 collaboration

Hagai Yanai 1 collaboration

Ferda Tekin-Turhan 1 collaboration

Melanie A Eshelman 1 collaboration

Stephen M Matthews 1 collaboration

Emily M Schleicher 1 collaboration

Rebecca M Fleeman 1 collaboration

Yuka Imamura Kawasawa 1 collaboration

Walter A Koltun 1 collaboration

Faoud T Ishmael 1 collaboration

Gregory S Yochum 1 collaboration

Artiom Gruzdev 1 collaboration

Cindo O Nicholson 1 collaboration

Zhengfeng Yang 1 collaboration

Roberta Faccio 1 collaboration

Michael W Webster 1 collaboration

Lori A Passmore 1 collaboration

Rene M Arvola 1 collaboration

Aaron C Goldstrohm 1 collaboration

Ishita Choudhary 1 collaboration

Thao Vo 1 collaboration

Richa Lamichhane 1 collaboration

Brandon W Lewis 1 collaboration

Jayme Looper 1 collaboration

Samithamby Jeyaseelan 1 collaboration

Simon Lecoutre 1 collaboration

Fatiha Merabtene 1 collaboration

Elie-Julien El Hachem 1 collaboration

Camille Gamblin 1 collaboration

Christine Rouault 1 collaboration

Nataliya Sokolovska 1 collaboration

Hedi Soula 1 collaboration

Karine Clément 1 collaboration

Isabelle Dugail 1 collaboration

Mark J Hoenerhoff 1 collaboration

Robert M Tighe 1 collaboration

Yen-Rei Yu 1 collaboration

Deloris Sutton 1 collaboration

Amogh Kashyap 1 collaboration

Kylie K Mullaney 1 collaboration

Jiho Sohn 1 collaboration

Tarek Kröhler 1 collaboration

Sonja M Kessler 1 collaboration

Kevan Hosseini 1 collaboration

Markus List 1 collaboration

Ahmad Barghash 1 collaboration

Stephan Laggai 1 collaboration

Katja Gemperlein 1 collaboration

Johannes Haybaeck 1 collaboration

Rolf Müller 1 collaboration

Volkhard Helms 1 collaboration

Marcel H Schulz 1 collaboration

Jessica Hoppstädter 1 collaboration

Alexandra K Kiemer 1 collaboration

Fatma Saaoud 1 collaboration

Junfeng Wang 1 collaboration

Stephen Iwanowycz 1 collaboration

Yuzhen Wang 1 collaboration

Diego Altomare 1 collaboration

Ying Shao 1 collaboration

Susan M Lessner 1 collaboration

E Angela Murphy 1 collaboration

Hong Wang 1 collaboration

Xiaofeng Yang 1 collaboration

Daping Fan 1 collaboration

Stephanie Hajjar 1 collaboration

Christopher Tiedje 1 collaboration

Emad S Alnemri 1 collaboration

Hui Peng 1 collaboration

Huan Ning 1 collaboration

Qinghong Wang 1 collaboration

Jinping Lai 1 collaboration

Lin Wei 1 collaboration

Mingui Fu 1 collaboration

Rong Hou 1 collaboration

Daniel F Hoft 1 collaboration

Jian Chen 1 collaboration

Rahul Kumar 1 collaboration

Biying Xu 1 collaboration

Jihong Tang 1 collaboration

Cancan Lyu 1 collaboration

Wambui S Wandu 1 collaboration

Mary J Mattapallil 1 collaboration

Reiko Horai 1 collaboration

Igal Gery 1 collaboration

Rachel R Caspi 1 collaboration

Leonard Schärfen 1 collaboration

Dagmar Zigackova 1 collaboration

Kirsten A Reimer 1 collaboration

Martha R Stark 1 collaboration

Viktor A Slat 1 collaboration

Nancy J Francoeur 1 collaboration

Karla M Neugebauer 1 collaboration

Stephen D Rader 1 collaboration

Hidemichi Kouzu 1 collaboration

Yuki Tatekoshi 1 collaboration

Hsiang-Chun Chang 1 collaboration

Jason S Shapiro 1 collaboration

Warren A McGee 1 collaboration

Adam De Jesus 1 collaboration

Issam Ben-Sahra 1 collaboration

Zoltan Arany 1 collaboration

Jonathan Leor 1 collaboration

Chunlei Chen 1 collaboration

Hossein Ardehali 1 collaboration

Elliot D Kramer 1 collaboration

Rui Huang 1 collaboration

Danielle R Donahue 1 collaboration

Beth W Mahler 1 collaboration

Carl D Bortner 1 collaboration

Sahil Yadav 1 collaboration

Rayan El Hamra 1 collaboration

Avni Bhan 1 collaboration

Kate Hurley 1 collaboration

Alexandre Blais 1 collaboration

Laure B Bindels 1 collaboration

Justine Smout 1 collaboration

Arnaud Köhler 1 collaboration

Romuald Soin 1 collaboration

Nadège Delacourt 1 collaboration

Hsüehlei Li 1 collaboration

Guillaume Oldenhove 1 collaboration

Qinjie Weng 1 collaboration

Jincheng Wang 1 collaboration

Jiajia Wang 1 collaboration

Danyang He 1 collaboration

Zuolin Cheng 1 collaboration

Feng Zhang 1 collaboration

Ravinder Verma 1 collaboration

Lingli Xu 1 collaboration

Xinran Dong 1 collaboration

Yunfei Liao 1 collaboration

Xuelian He 1 collaboration

Andrew Potter 1 collaboration

Liguo Zhang 1 collaboration

Chuntao Zhao 1 collaboration

Mei Xin 1 collaboration

Qian Zhou 1 collaboration

Bruce J Aronow 1 collaboration

Jeremy N Rich 1 collaboration

Qiaojun He 1 collaboration

Wenhao Zhou 1 collaboration

Mario L Suvà 1 collaboration

Ronald R Waclaw 1 collaboration

S Steven Potter 1 collaboration

Guoqiang Yu 1 collaboration

Q Richard Lu 1 collaboration

Wenli Bai 1 collaboration

Alan R Kimmel 1 collaboration

Jonathan T Busada 1 collaboration

Stuti Khadka 1 collaboration

Kylie N Peterson 1 collaboration

Sara R Druffner 1 collaboration

Robert H Oakley 1 collaboration

John A Cidlowski 1 collaboration

Francesco Albano 1 collaboration

Valeria Tucci 1 collaboration

Carla Reale 1 collaboration

Luca Roberto 1 collaboration

Filomena Russo 1 collaboration

Pina Marotta 1 collaboration

Immacolata Porreca 1 collaboration

Marco Colella 1 collaboration

Massimo Mallardo 1 collaboration

Mario de Felice 1 collaboration

Concetta Ambrosino 1 collaboration

Melissa E Cook 1 collaboration

Tara R Bradstreet 1 collaboration

Ashlee M Webber 1 collaboration

Jongshin Kim 1 collaboration

Andrea Santeford 1 collaboration

Kevin M Harris 1 collaboration

Maegan K Murphy 1 collaboration

Jennifer Tran 1 collaboration

Nada M Abdalla 1 collaboration

Elizabeth A Schwarzkopf 1 collaboration

Suellen C Greco 1 collaboration

Carmen M Halabi 1 collaboration

Rajendra S Apte 1 collaboration

Brian T Edelson 1 collaboration