Patrick T Gunning

Affiliations

Department of Chemical and Physical Sciences , University of Toronto Mississauga , 3359 Mississauga Rd N. , Mississauga , Ontario L5L 1C6 , Canada . Email: patrick.gunning@utoronto.ca.
Department of Chemistry , University of Toronto , 80 St. George Street , Toronto , Ontario M5S 3H6 , Canada.

ORCID: 0000-0003-0654-735X

Publications (17)

Targeting prenylation inhibition through the mevalonate pathway.

RSC medicinal chemistry

Avec: Pimyupa Manaswiyoungkul , Elvin D de Araujo ,

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer.

Journal of medicinal chemistry

Avec: Andrew E Shouksmith , Fenil Shah , Michelle L Grimard , Justyna M Gawel , Yasir S Raouf , Mulu Geletu , Angelika Berger-Becvar , Elvin D de Araujo , H Artee Luchman , William L Heaton , David Bakhshinyan , Ashley A Adile , Chitra Venugopal , Thomas O'Hare , Michael W Deininger , Sheila K Singh , Stephen F Konieczny , Samuel Weiss , Melissa L Fishel ,

Targeting STAT3 and STAT5 in Cancer.

Cancers

Avec: Elvin D de Araujo , György M Keserű , Richard Moriggl

Optical chemosensors for the detection of proximally phosphorylated peptides and proteins.

RSC chemical biology

Avec: Aaron D Cabral , Tudor B Radu , Elvin D de Araujo ,

Structural and mutational analysis of member-specific STAT functions.

Biochimica et biophysica acta. General subjects

Avec: Fettah Erdogan , Abdul K Qadree , Tudor B Radu , Anna Orlova , Elvin D de Araujo , Johan Israelian , Peter Valent , Satu M Mustjoki , Marco Herling , Richard Moriggl ,

Discovery of HDAC6-Selective Inhibitor NN-390 with

Journal of medicinal chemistry

Avec: Nabanita Nawar , Shazreh Bukhari , Ashley A Adile , Yujin Suk , Pimyupa Manaswiyoungkul , Krimo Toutah , Olasunkanmi O Olaoye , Yasir S Raouf , Abootaleb Sedighi , Harsimran Kaur Garcha , Muhammad Murtaza Hassan , William Gwynne , Johan Israelian , Tudor B Radu , Mulu Geletu , Ayah Abdeldayem , Justyna M Gawel , Aaron D Cabral , Chitra Venugopal , Elvin D de Araujo , Sheila K Singh ,

Unlocking Long-Term Stability of Upconversion Nanoparticles with Biocompatible Phosphonate-Based Polymer Coatings.

Nano letters

Avec: Karan Malhotra , Richard Fuku , Balmiki Kumar , David Hrovat , Justin Van Houten , Paul A E Piunno , Patrick Thomas Gunning , Ulrich J Krull

Phenotypic Screening of Histone Deacetylase (HDAC) Inhibitors against Schistosoma mansoni.

ChemMedChem

Avec: Muhammad Murtaza Hassan , Abootaleb Sedighi , Olasunkanmi O Olaoye , Cécile Häberli , Annika Merz , Elizabeth Ramos-Morales , Elvin D de Araujo , Christophe Romier , Manfred Jung , Jennifer Keiser ,

Fluorescence Polarization-Based Competition Assays to Evaluate Histone Deacetylase 6 Inhibitors.

Methods in molecular biology (Clifton, N.J.)

Avec: Qirat F Ashraf , Erica J Quilates , Olasunkanmi O Olaoye , Elvin D de Araujo ,

Medicinal chemistry advances in targeting class I histone deacetylases.

Exploration of targeted anti-tumor therapy

Avec: Diaaeldin I Abdallah , Elvin D de Araujo , Naman H Patel , Lina S Hasan , Richard Moriggl , Oliver H Krämer ,

PTG-0861: A novel HDAC6-selective inhibitor as a therapeutic strategy in acute myeloid leukaemia.

European journal of medicinal chemistry

Avec: Justyna M Gawel , Andrew E Shouksmith , Yasir S Raouf , Nabanita Nawar , Krimo Toutah , Shazreh Bukhari , Pimyupa Manaswiyoungkul , Olasunkanmi O Olaoye , Johan Israelian , Tudor B Radu , Aaron D Cabral , Diana Sina , Abootaleb Sedighi , Elvin D de Araujo ,

STAT5 is Expressed in CD34

Cancers

Avec: Emir Hadzijusufovic , Alexandra Keller , Daniela Berger , Georg Greiner , Bettina Wingelhofer , Nadine Witzeneder , Daniel Ivanov , Emmanuel Pecnard , Harini Nivarthi , Florian K M Schur , Yüksel Filik , Christoph Kornauth , Heidi A Neubauer , Leonhard Müllauer , Gary Tin , Jisung Park , Elvin D de Araujo , Gregor Hoermann , Fabrice Gouilleux , Robert Kralovics , Richard Moriggl , Peter Valent

Structural Implications of STAT3 and STAT5 SH2 Domain Mutations.

Cancers

Avec: Elvin D de Araujo , Anna Orlova , Heidi A Neubauer , Dávid Bajusz , Hyuk-Soo Seo , Sirano Dhe-Paganon , György M Keserű , Richard Moriggl ,

The ERBB-STAT3 Axis Drives Tasmanian Devil Facial Tumor Disease.

Cancer cell

Avec: Lindsay Kosack , Bettina Wingelhofer , Alexandra Popa , Anna Orlova , Benedikt Agerer , Bojan Vilagos , Peter Majek , Katja Parapatics , Alexander Lercher , Anna Ringler , Johanna Klughammer , Mark Smyth , Kseniya Khamina , Hatoon Baazim , Elvin D de Araujo , David A Rosa , Jisung Park , Gary Tin , Siawash Ahmar , Christoph Bock , Hannah V Siddle , Gregory M Woods , Stefan Kubicek , Elizabeth P Murchison , Keiryn L Bennett , Richard Moriggl , Andreas Bergthaler

Unique Molecular Interaction with the Histone Deacetylase 6 Catalytic Tunnel: Crystallographic and Biological Characterization of a Model Chemotype.

Journal of medicinal chemistry

Avec: Olasunkanmi O Olaoye , Paris R Watson , Nabanita Nawar , Mulu Geletu , Abootaleb Sedighi , Shazreh Bukhari , Yasir S Raouf , Pimyupa Manaswiyoungkul , Fettah Erdogan , Ayah Abdeldayem , Aaron D Cabral , Muhammad Murtaza Hassan , Krimo Toutah , Andrew E Shouksmith , Justyna M Gawel , Johan Israelian , Tudor B Radu , Niyati Kachhiyapatel , Elvin D de Araujo , David W Christianson ,

JAK-STAT core cancer pathway: An integrative cancer interactome analysis.

Journal of cellular and molecular medicine

Avec: Fettah Erdogan , Tudor Bogdan Radu , Anna Orlova , Abdul Khawazak Qadree , Elvin Dominic de Araujo , Johan Israelian , Peter Valent , Satu M Mustjoki , Marco Herling , Richard Moriggl , Patrick Thomas Gunning

High Efficacy and Drug Synergy of HDAC6-Selective Inhibitor NN-429 in Natural Killer (NK)/T-Cell Lymphoma.

Pharmaceuticals (Basel, Switzerland)

Avec: Harsimran Kaur Garcha , Nabanita Nawar , Helena Sorger , Fettah Erdogan , Myint Myat Khine Aung , Abootaleb Sedighi , Pimyupa Manaswiyoungkul , Hyuk-Soo Seo , Susann Schönefeldt , Daniel Pölöske , Sirano Dhe-Paganon , Heidi A Neubauer , Satu M Mustjoki , Marco Herling , Elvin D de Araujo , Richard Moriggl ,

Réseau de co-auteurs

Elvin D de Araujo 15 collaborations

Richard Moriggl 8 collaborations

Pimyupa Manaswiyoungkul 5 collaborations

Tudor B Radu 5 collaborations

Johan Israelian 5 collaborations

Olasunkanmi O Olaoye 5 collaborations

Abootaleb Sedighi 5 collaborations

Justyna M Gawel 4 collaborations

Yasir S Raouf 4 collaborations

Aaron D Cabral 4 collaborations

Fettah Erdogan 4 collaborations

Anna Orlova 4 collaborations

Nabanita Nawar 4 collaborations

Andrew E Shouksmith 3 collaborations

Mulu Geletu 3 collaborations

Peter Valent 3 collaborations

Satu M Mustjoki 3 collaborations

Marco Herling 3 collaborations

Shazreh Bukhari 3 collaborations

Krimo Toutah 3 collaborations

Muhammad Murtaza Hassan 3 collaborations

Heidi A Neubauer 3 collaborations

Ashley A Adile 2 collaborations

Chitra Venugopal 2 collaborations

Sheila K Singh 2 collaborations

György M Keserű 2 collaborations

Harsimran Kaur Garcha 2 collaborations

Ayah Abdeldayem 2 collaborations

Patrick Thomas Gunning 2 collaborations

Bettina Wingelhofer 2 collaborations

Gary Tin 2 collaborations

Jisung Park 2 collaborations

Hyuk-Soo Seo 2 collaborations

Sirano Dhe-Paganon 2 collaborations

Fenil Shah 1 collaboration

Michelle L Grimard 1 collaboration

Angelika Berger-Becvar 1 collaboration

H Artee Luchman 1 collaboration

William L Heaton 1 collaboration

David Bakhshinyan 1 collaboration

Thomas O'Hare 1 collaboration

Michael W Deininger 1 collaboration

Stephen F Konieczny 1 collaboration

Samuel Weiss 1 collaboration

Melissa L Fishel 1 collaboration

Abdul K Qadree 1 collaboration

Yujin Suk 1 collaboration

William Gwynne 1 collaboration

Karan Malhotra 1 collaboration

Richard Fuku 1 collaboration

Balmiki Kumar 1 collaboration

David Hrovat 1 collaboration

Justin Van Houten 1 collaboration

Paul A E Piunno 1 collaboration

Ulrich J Krull 1 collaboration

Cécile Häberli 1 collaboration

Annika Merz 1 collaboration

Elizabeth Ramos-Morales 1 collaboration

Christophe Romier 1 collaboration

Manfred Jung 1 collaboration

Jennifer Keiser 1 collaboration

Qirat F Ashraf 1 collaboration

Erica J Quilates 1 collaboration

Diaaeldin I Abdallah 1 collaboration

Naman H Patel 1 collaboration

Lina S Hasan 1 collaboration

Oliver H Krämer 1 collaboration

Diana Sina 1 collaboration

Emir Hadzijusufovic 1 collaboration

Alexandra Keller 1 collaboration

Daniela Berger 1 collaboration

Georg Greiner 1 collaboration

Nadine Witzeneder 1 collaboration

Daniel Ivanov 1 collaboration

Emmanuel Pecnard 1 collaboration

Harini Nivarthi 1 collaboration

Florian K M Schur 1 collaboration

Yüksel Filik 1 collaboration

Christoph Kornauth 1 collaboration

Leonhard Müllauer 1 collaboration

Gregor Hoermann 1 collaboration

Fabrice Gouilleux 1 collaboration

Robert Kralovics 1 collaboration

Dávid Bajusz 1 collaboration

Lindsay Kosack 1 collaboration

Alexandra Popa 1 collaboration

Benedikt Agerer 1 collaboration

Bojan Vilagos 1 collaboration

Peter Majek 1 collaboration

Katja Parapatics 1 collaboration

Alexander Lercher 1 collaboration

Anna Ringler 1 collaboration

Johanna Klughammer 1 collaboration

Mark Smyth 1 collaboration

Kseniya Khamina 1 collaboration

Hatoon Baazim 1 collaboration

David A Rosa 1 collaboration

Siawash Ahmar 1 collaboration

Christoph Bock 1 collaboration

Hannah V Siddle 1 collaboration

Gregory M Woods 1 collaboration

Stefan Kubicek 1 collaboration

Elizabeth P Murchison 1 collaboration

Keiryn L Bennett 1 collaboration

Andreas Bergthaler 1 collaboration

Paris R Watson 1 collaboration

Niyati Kachhiyapatel 1 collaboration

David W Christianson 1 collaboration

Tudor Bogdan Radu 1 collaboration

Abdul Khawazak Qadree 1 collaboration

Elvin Dominic de Araujo 1 collaboration

Helena Sorger 1 collaboration

Myint Myat Khine Aung 1 collaboration

Susann Schönefeldt 1 collaboration

Daniel Pölöske 1 collaboration