H Artee Luchman

Affiliations

Hotchkiss Brain Institute and Arnie Charbonneau Cancer Institute, Department of Cell Biology and Anatomy, Cumming School of Medicine, University of Calgary, Calgary, Alberta, Canada.

Publications (15)

EGFR blockade in GBM brain tumor stem cells synergizes with JAK2/STAT3 pathway inhibition to abrogate compensatory mechanisms in vitro and in vivo.

Neuro-oncology advances

Avec: Katharine V Jensen , Xiaoguang Hao , Ahmed Aman , Samuel Weiss

A phase I study of vistusertib (dual mTORC1/2 inhibitor) in patients with previously treated glioblastoma multiforme: a CCTG study.

Investigational new drugs

Avec: Sarah Lapointe , Warren Mason , Mary MacNeil , Craig Harlos , Roger Tsang , Joana Sederias , Samuel Weiss , John P Rossiter , Dongsheng Tu , Lesley Seymour , Martin Smoragiewicz

Genome-Wide CRISPR-Cas9 Screens Expose Genetic Vulnerabilities and Mechanisms of Temozolomide Sensitivity in Glioblastoma Stem Cells.

Cell reports

Avec: Graham MacLeod , Danielle A Bozek , Nishani Rajakulendran , Vernon Monteiro , Moloud Ahmadi , Zachary Steinhart , Michelle M Kushida , Helen Yu , Fiona J Coutinho , Florence M G Cavalli , Ian Restall , Xiaoguang Hao , Traver Hart , Samuel Weiss , Peter B Dirks , Stephane Angers

Metabolic imaging detects elevated glucose flux through the pentose phosphate pathway associated with TERT expression in low-grade gliomas.

Neuro-oncology

Avec: Pavithra Viswanath , Georgios Batsios , Vinay Ayyappan , Céline Taglang , Anne Marie Gillespie , Peder E Z Larson , Joseph F Costello , Russell O Pieper , Sabrina M Ronen

Single-cell chromatin accessibility profiling of glioblastoma identifies an invasive cancer stem cell population associated with lower survival.

eLife

Avec: Paul Guilhamon , Charles Chesnelong , Michelle M Kushida , Ana Nikolic , Divya Singhal , Graham MacLeod , Seyed Ali Madani Tonekaboni , Florence Mg Cavalli , Christopher Arlidge , Nishani Rajakulendran , Naghmeh Rastegar , Xiaoguang Hao , Rozina Hassam , Laura J Smith , Heather Whetstone , Fiona J Coutinho , Bettina Nadorp , Katrina I Ellestad , Jennifer Ai-Wen Chan , Molly S Shoichet , Michael D Taylor , Benjamin Haibe-Kains , Samuel Weiss , Stephane Angers , Marco Gallo , Peter B Dirks , Mathieu Lupien

Rational Drug Design of Targeted and Enzyme-Cleavable Vitamin E Analogs as a Neoadjuvant to Chemotherapy:

ACS pharmacology & translational science

Avec: Raghu S Pandurangi , Orsolya Cseh , Hema Artee Luchman , Cynthia Xiuguang Ma , Sanjeewa N Senadheera , Marcus Laird Forrest

Early Noninvasive Metabolic Biomarkers of Mutant IDH Inhibition in Glioma.

Metabolites

Avec: Marina Radoul , Donghyun Hong , Anne Marie Gillespie , Chloé Najac , Pavithra Viswanath , Russell O Pieper , Joseph F Costello , Hema Artee Luchman , Sabrina M Ronen

Comprehensive genomic profiling of glioblastoma tumors, BTICs, and xenografts reveals stability and adaptation to growth environments.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Yaoqing Shen , Cameron J Grisdale , Sumaiya A Islam , Pinaki Bose , Jake Lever , Eric Y Zhao , Natalie Grinshtein , Yussanne Ma , Andrew J Mungall , Richard A Moore , Xueqing Lun , Donna L Senger , Stephen M Robbins , Alice Yijun Wang , Julia L MacIsaac , Michael S Kobor , Samuel Weiss , Jennifer A Chan , Michael D Blough , David R Kaplan , J Gregory Cairncross , Marco A Marra , Steven J M Jones

Identification and Characterization of AES-135, a Hydroxamic Acid-Based HDAC Inhibitor That Prolongs Survival in an Orthotopic Mouse Model of Pancreatic Cancer.

Journal of medicinal chemistry

Avec: Andrew E Shouksmith , Fenil Shah , Michelle L Grimard , Justyna M Gawel , Yasir S Raouf , Mulu Geletu , Angelika Berger-Becvar , Elvin D de Araujo , William L Heaton , David Bakhshinyan , Ashley A Adile , Chitra Venugopal , Thomas O'Hare , Michael W Deininger , Sheila K Singh , Stephen F Konieczny , Samuel Weiss , Melissa L Fishel , Patrick T Gunning

PD-1 independent of PD-L1 ligation promotes glioblastoma growth through the NFκB pathway.

Science advances

Avec: Reza Mirzaei , Ashley Gordon , Franz J Zemp , Mehul Kumar , Susobhan Sarkar , Anita C Bellail , Chunhai Hao , Douglas J Mahoney , Jeff F Dunn , Pinaki Bose , V Wee Yong

SLUG Directs the Precursor State of Human Brain Tumor Stem Cells.

Cancers

Avec: Charles Chesnelong , Xiaoguang Hao , Orsolya Cseh , Alice Yijun Wang , Samuel Weiss

Non-invasive assessment of telomere maintenance mechanisms in brain tumors.

Nature communications

Avec: Pavithra Viswanath , Georgios Batsios , Joydeep Mukherjee , Anne Marie Gillespie , Peder E Z Larson , Joanna J Phillips , Joseph F Costello , Russell O Pieper , Sabrina M Ronen

Brain Tumor Stem Cell Dependence on Glutaminase Reveals a Metabolic Vulnerability through the Amino Acid Deprivation Response Pathway.

Cancer research

Avec: Ian J Restall , Orsolya Cseh , Laura M Richards , Trevor J Pugh , Samuel Weiss

Gradient of Developmental and Injury Response transcriptional states defines functional vulnerabilities underpinning glioblastoma heterogeneity.

Nature cancer

Avec: Laura M Richards , Owen K N Whitley , Graham MacLeod , Florence M G Cavalli , Fiona J Coutinho , Julia E Jaramillo , Nataliia Svergun , Mazdak Riverin , Danielle C Croucher , Michelle Kushida , Kenny Yu , Paul Guilhamon , Naghmeh Rastegar , Moloud Ahmadi , Jasmine K Bhatti , Danielle A Bozek , Naijin Li , Lilian Lee , Clare Che , Erika Luis , Nicole I Park , Zhiyu Xu , Troy Ketela , Richard A Moore , Marco A Marra , Julian Spears , Michael D Cusimano , Sunit Das , Mark Bernstein , Benjamin Haibe-Kains , Mathieu Lupien , Samuel Weiss , Stephane Angers , Peter B Dirks , Gary D Bader , Trevor J Pugh

Epigenetic and molecular coordination between HDAC2 and SMAD3-SKI regulates essential brain tumour stem cell characteristics.

Nature communications

Avec: Ravinder K Bahia , Xiaoguang Hao , Rozina Hassam , Orsolya Cseh , Danielle A Bozek , Samuel Weiss

Réseau de co-auteurs

Samuel Weiss 10 collaborations

Xiaoguang Hao 5 collaborations

Orsolya Cseh 4 collaborations

Graham MacLeod 3 collaborations

Danielle A Bozek 3 collaborations

Fiona J Coutinho 3 collaborations

Peter B Dirks 3 collaborations

Stephane Angers 3 collaborations

Pavithra Viswanath 3 collaborations

Anne Marie Gillespie 3 collaborations

Joseph F Costello 3 collaborations

Russell O Pieper 3 collaborations

Sabrina M Ronen 3 collaborations

Nishani Rajakulendran 2 collaborations

Moloud Ahmadi 2 collaborations

Michelle M Kushida 2 collaborations

Florence M G Cavalli 2 collaborations

Georgios Batsios 2 collaborations

Peder E Z Larson 2 collaborations

Paul Guilhamon 2 collaborations

Charles Chesnelong 2 collaborations

Naghmeh Rastegar 2 collaborations

Rozina Hassam 2 collaborations

Benjamin Haibe-Kains 2 collaborations

Mathieu Lupien 2 collaborations

Hema Artee Luchman 2 collaborations

Pinaki Bose 2 collaborations

Richard A Moore 2 collaborations

Alice Yijun Wang 2 collaborations

Marco A Marra 2 collaborations

Laura M Richards 2 collaborations

Trevor J Pugh 2 collaborations

Katharine V Jensen 1 collaboration

Ahmed Aman 1 collaboration

Sarah Lapointe 1 collaboration

Warren Mason 1 collaboration

Mary MacNeil 1 collaboration

Craig Harlos 1 collaboration

Roger Tsang 1 collaboration

Joana Sederias 1 collaboration

John P Rossiter 1 collaboration

Dongsheng Tu 1 collaboration

Lesley Seymour 1 collaboration

Martin Smoragiewicz 1 collaboration

Vernon Monteiro 1 collaboration

Zachary Steinhart 1 collaboration

Helen Yu 1 collaboration

Ian Restall 1 collaboration

Traver Hart 1 collaboration

Vinay Ayyappan 1 collaboration

Céline Taglang 1 collaboration

Ana Nikolic 1 collaboration

Divya Singhal 1 collaboration

Seyed Ali Madani Tonekaboni 1 collaboration

Florence Mg Cavalli 1 collaboration

Christopher Arlidge 1 collaboration

Laura J Smith 1 collaboration

Heather Whetstone 1 collaboration

Bettina Nadorp 1 collaboration

Katrina I Ellestad 1 collaboration

Jennifer Ai-Wen Chan 1 collaboration

Molly S Shoichet 1 collaboration

Michael D Taylor 1 collaboration

Marco Gallo 1 collaboration

Raghu S Pandurangi 1 collaboration

Cynthia Xiuguang Ma 1 collaboration

Sanjeewa N Senadheera 1 collaboration

Marcus Laird Forrest 1 collaboration

Marina Radoul 1 collaboration

Donghyun Hong 1 collaboration

Chloé Najac 1 collaboration

Yaoqing Shen 1 collaboration

Cameron J Grisdale 1 collaboration

Sumaiya A Islam 1 collaboration

Jake Lever 1 collaboration

Eric Y Zhao 1 collaboration

Natalie Grinshtein 1 collaboration

Yussanne Ma 1 collaboration

Andrew J Mungall 1 collaboration

Xueqing Lun 1 collaboration

Donna L Senger 1 collaboration

Stephen M Robbins 1 collaboration

Julia L MacIsaac 1 collaboration

Michael S Kobor 1 collaboration

Jennifer A Chan 1 collaboration

Michael D Blough 1 collaboration

David R Kaplan 1 collaboration

J Gregory Cairncross 1 collaboration

Steven J M Jones 1 collaboration

Andrew E Shouksmith 1 collaboration

Fenil Shah 1 collaboration

Michelle L Grimard 1 collaboration

Justyna M Gawel 1 collaboration

Yasir S Raouf 1 collaboration

Mulu Geletu 1 collaboration

Angelika Berger-Becvar 1 collaboration

Elvin D de Araujo 1 collaboration

William L Heaton 1 collaboration

David Bakhshinyan 1 collaboration

Ashley A Adile 1 collaboration

Chitra Venugopal 1 collaboration

Thomas O'Hare 1 collaboration

Michael W Deininger 1 collaboration

Sheila K Singh 1 collaboration

Stephen F Konieczny 1 collaboration

Melissa L Fishel 1 collaboration

Patrick T Gunning 1 collaboration

Reza Mirzaei 1 collaboration

Ashley Gordon 1 collaboration

Franz J Zemp 1 collaboration

Mehul Kumar 1 collaboration

Susobhan Sarkar 1 collaboration

Anita C Bellail 1 collaboration

Chunhai Hao 1 collaboration

Douglas J Mahoney 1 collaboration

Jeff F Dunn 1 collaboration

V Wee Yong 1 collaboration

Joydeep Mukherjee 1 collaboration

Joanna J Phillips 1 collaboration

Ian J Restall 1 collaboration

Owen K N Whitley 1 collaboration

Julia E Jaramillo 1 collaboration

Nataliia Svergun 1 collaboration

Mazdak Riverin 1 collaboration

Danielle C Croucher 1 collaboration

Michelle Kushida 1 collaboration

Kenny Yu 1 collaboration

Jasmine K Bhatti 1 collaboration

Naijin Li 1 collaboration

Lilian Lee 1 collaboration

Clare Che 1 collaboration

Erika Luis 1 collaboration

Nicole I Park 1 collaboration

Zhiyu Xu 1 collaboration

Troy Ketela 1 collaboration

Julian Spears 1 collaboration

Michael D Cusimano 1 collaboration

Sunit Das 1 collaboration

Mark Bernstein 1 collaboration

Gary D Bader 1 collaboration

Ravinder K Bahia 1 collaboration