Nikolaos Louros

Affiliations

VIB Center for Brain & Disease Research, Switch Laboratory, Leuven, 3000, Belgium.
KU Leuven, Department of Cellular and Molecular Medicine, Leuven, 3000, Belgium.

Publications (29)

WALTZ-DB 2.0: an updated database containing structural information of experimentally determined amyloid-forming peptides.

Nucleic acids research

Avec: Katerina Konstantoulea , Matthias De Vleeschouwer , Meine Ramakers , Joost Schymkowitz , Frederic Rousseau

StAmP-DB: a platform for structures of polymorphic amyloid fibril cores.

Bioinformatics (Oxford, England)

Avec: Rob van der Kant , Joost Schymkowitz , Frederic Rousseau

CORDAX web server: An online platform for the prediction and 3D visualization of aggregation motifs in protein sequences.

Bioinformatics (Oxford, England)

Avec: Frederic Rousseau , Joost Schymkowitz

The structural basis for an on-off switch controlling Gβγ-mediated inhibition of TRPM3 channels.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Marc Behrendt , Fabian Gruss , Raissa Enzeroth , Sandeep Dembla , Siyuan Zhao , Pierre-Antoine Crassous , Florian Mohr , Mieke Nys , Rodrigo Gallardo , Valentina Zorzini , Doris Wagner , Anastassios Economou , Frederic Rousseau , Joost Schymkowitz , Stephan E Philipp , Tibor Rohacs , Chris Ulens , Johannes Oberwinkler

Reverse engineering synthetic antiviral amyloids.

Nature communications

Avec: Emiel Michiels , Kenny Roose , Rodrigo Gallardo , Ladan Khodaparast , Laleh Khodaparast , Rob van der Kant , Maxime Siemons , Bert Houben , Meine Ramakers , Hannah Wilkinson , Patricia Guerreiro , Suzanne J F Kaptein , Lorena Itatí Ibañez , Anouk Smet , Pieter Baatsen , Shu Liu , Ina Vorberg , Guy Bormans , Johan Neyts , Xavier Saelens , Frederic Rousseau , Joost Schymkowitz

Exploiting Ligand-binding Domain Dimerization for Development of Novel Androgen Receptor Inhibitors.

Molecular cancer therapeutics

Avec: Christine Helsen , Tien T Nguyen , Xiao Yin Lee , Roy Eerlings , Joost Schymkowitz , Frederic Rousseau , Frank Claessens , Arnout Voet

Medin co-aggregates with vascular amyloid-β in Alzheimer's disease.

Nature

Avec: Jessica Wagner , Karoline Degenhardt , Marleen Veit , Katerina Konstantoulea , Angelos Skodras , Katleen Wild , Ping Liu , Ulrike Obermüller , Vikas Bansal , Anupriya Dalmia , Lisa M Häsler , Marius Lambert , Matthias De Vleeschouwer , Hannah A Davies , Jillian Madine , Deborah Kronenberg-Versteeg , Regina Feederle , Domenico Del Turco , K Peter R Nilsson , Tammaryn Lashley , Thomas Deller , Marla Gearing , Lary C Walker , Peter Heutink , Frederic Rousseau , Joost Schymkowitz , Mathias Jucker , Jonas J Neher

EndophilinA-dependent coupling between activity-induced calcium influx and synaptic autophagy is disrupted by a Parkinson-risk mutation.

Neuron

Avec: Adekunle T Bademosi , Marianna Decet , Sabine Kuenen , Carles Calatayud , Jef Swerts , Sandra F Gallego , Nils Schoovaerts , Spyridoula Karamanou , Ella Martin , Jean-Baptiste Sibarita , Katlijn Vints , Natalia V Gounko , Frédéric A Meunier , Anastassios Economou , Wim Versées , Frederic Rousseau , Joost Schymkowitz , Sandra-F Soukup , Patrik Verstreken

Mechanisms and pathology of protein misfolding and aggregation.

Nature reviews. Molecular cell biology

Avec: Joost Schymkowitz , Frederic Rousseau

Entropic Bristles Tune the Seeding Efficiency of Prion-Nucleating Fragments.

Cell reports

Avec: Emiel Michiels , Shu Liu , Rodrigo Gallardo , Marion Mathelié-Guinlet , Yves Dufrêne , Joost Schymkowitz , Ina Vorberg , Frederic Rousseau

Heterotypic interactions in amyloid function and disease.

The FEBS journal

Avec: Katerina Konstantoulea , Frederic Rousseau , Joost Schymkowitz

Bcl-xL acts as an inhibitor of IP

Cell death and differentiation

Avec: Nicolas Rosa , Hristina Ivanova , Larry E Wagner , Justin Kale , Rita La Rovere , Kirsten Welkenhuyzen , Spyridoula Karamanou , Victoria Shabardina , Irma Lemmens , Elien Vandermarliere , Kozo Hamada , Hideaki Ando , Frederic Rousseau , Joost Schymkowitz , Jan Tavernier , Katsuhiko Mikoshiba , Anastassios Economou , David W Andrews , Jan B Parys , David I Yule , Geert Bultynck

Investigating the Sequence Determinants of the Curling of Amyloid Fibrils Using Ovalbumin as a Case Study.

Biomacromolecules

Avec: Joëlle A J Housmans , Bert Houben , Margarita Monge-Morera , Diego Asvestas , Hung Huy Nguyen , Grigoria Tsaka , Sebastien Carpentier , Jan A Delcour , Frederic Rousseau , Joost Schymkowitz

Enhanced therapeutic window for antimicrobial Pept-ins by investigating their structure-activity relationship.

PloS one

Avec: Guiqin Wu , Laleh Khodaparast , Ladan Khodaparast , Matthias De Vleeschouwer , Rodrigo Gallardo , Pengpeng Yi , Frederic Rousseau , Joost Schymkowitz

Exploiting the intrinsic misfolding propensity of the KRAS oncoprotein.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Kobe Janssen , Filip Claes , Dido Van de Velde , Vanessa L Wehbi , Bert Houben , Yulia Lampi , Mieke Nys , Laleh Khodaparast , Ladan Khodaparast , Rob van der Kant , Joffre Verniers , Teresa Garcia , Meine Ramakers , Katerina Konstantoulea , Katerina Maragkou , Ramon Duran-Romaña , Mónica Musteanu , Mariano Barbacid , Bernard Scorneaux , Els Beirnaert , Joost Schymkowitz , Frederic Rousseau

LRRC37B is a human modifier of voltage-gated sodium channels and axon excitability in cortical neurons.

Cell

Avec: Baptiste Libé-Philippot , Amélie Lejeune , Keimpe Wierda , Emir Erkol , Ine Vlaeminck , Sofie Beckers , Vaiva Gaspariunaite , Angéline Bilheu , Katerina Konstantoulea , Hajnalka Nyitrai , Matthias De Vleeschouwer , Kristel M Vennekens , Niels Vidal , Thomas W Bird , Daniela C Soto , Tom Jaspers , Maarten Dewilde , Megan Y Dennis , Frederic Rousseau , Davide Comoletti , Joost Schymkowitz , Tom Theys , Joris de Wit , Pierre Vanderhaeghen

Thermodynamic and Evolutionary Coupling between the Native and Amyloid State of Globular Proteins.

Cell reports

Avec: Tobias Langenberg , Rodrigo Gallardo , Rob van der Kant , Emiel Michiels , Ramon Duran-Romaña , Bert Houben , Rafaela Cassio , Hannah Wilkinson , Teresa Garcia , Chris Ulens , Joost Van Durme , Frederic Rousseau , Joost Schymkowitz

Exposure of a cryptic Hsp70 binding site determines the cytotoxicity of the ALS-associated SOD1-mutant A4V.

Protein engineering, design & selection : PEDS

Avec: Filip Claes , Stanislav Rudyak , Angela S Laird , Jacinte Beerten , Maja Debulpaep , Emiel Michiels , Rob van der Kant , Joost Van Durme , Greet De Baets , Bert Houben , Meine Ramakers , Kristy Yuan , Serene S L Gwee , Sara Hernandez , Kerensa Broersen , Mikael Oliveberg , Barbara Moahamed , Janine Kirstein , Wim Robberecht , Frederic Rousseau , Joost Schymkowitz

Repurposing the Antidepressant Sertraline as SHMT Inhibitor to Suppress Serine/Glycine Synthesis-Addicted Breast Tumor Growth.

Molecular cancer therapeutics

Avec: Shauni Lien Geeraerts , Kim Rosalie Kampen , Gianmarco Rinaldi , Purvi Gupta , Mélanie Planque , Elien Heylen , Kaat De Cremer , Katrijn De Brucker , Stijn Vereecke , Benno Verbelen , Pieter Vermeersch , Joost Schymkowitz , Frederic Rousseau , David Cassiman , Sarah-Maria Fendt , Arnout Voet , Bruno P A Cammue , Karin Thevissen , Kim De Keersmaecker

Heterotypic amyloid interactions: Clues to polymorphic bias and selective cellular vulnerability?

Current opinion in structural biology

Avec: Joost Schymkowitz , Frederic Rousseau

Thermodynamic analysis of amyloid fibril structures reveals a common framework for stability in amyloid polymorphs.

Structure (London, England : 1993)

Avec: Rob van der Kant , Joost Schymkowitz , Frederic Rousseau

Mapping the sequence specificity of heterotypic amyloid interactions enables the identification of aggregation modifiers.

Nature communications

Avec: Meine Ramakers , Emiel Michiels , Katerina Konstantoulea , Chiara Morelli , Teresa Garcia , Nele Moonen , Sam D'Haeyer , Vera Goossens , Dietmar Rudolf Thal , Dominique Audenaert , Frederic Rousseau , Joost Schymkowitz

N-glycosylation as a eukaryotic protective mechanism against protein aggregation.

Science advances

Avec: Ramon Duran-Romaña , Bert Houben , Matthias De Vleeschouwer , Matthew P Wilson , Gert Matthijs , Joost Schymkowitz , Frederic Rousseau

Local structural preferences in shaping tau amyloid polymorphism.

Nature communications

Avec: Martin Wilkinson , Grigoria Tsaka , Meine Ramakers , Chiara Morelli , Teresa Garcia , Rodrigo Gallardo , Sam D'Haeyer , Vera Goossens , Dominique Audenaert , Dietmar Rudolf Thal , Ian R Mackenzie , Rosa Rademakers , Neil A Ranson , Sheena E Radford , Frederic Rousseau , Joost Schymkowitz

Autonomous aggregation suppression by acidic residues explains why chaperones favour basic residues.

The EMBO journal

Avec: Bert Houben , Emiel Michiels , Meine Ramakers , Katerina Konstantoulea , Joffré Verniers , Rob van der Kant , Matthias De Vleeschouwer , Nuno Chicória , Thomas Vanpoucke , Rodrigo Gallardo , Joost Schymkowitz , Frederic Rousseau

Structure-based machine-guided mapping of amyloid sequence space reveals uncharted sequence clusters with higher solubilities.

Nature communications

Avec: Gabriele Orlando , Matthias De Vleeschouwer , Frederic Rousseau , Joost Schymkowitz

Heterotypic Amyloid β interactions facilitate amyloid assembly and modify amyloid structure.

The EMBO journal

Avec: Katerina Konstantoulea , Patricia Guerreiro , Meine Ramakers , Liam D Aubrey , Bert Houben , Emiel Michiels , Matthias De Vleeschouwer , Yulia Lampi , Luís F Ribeiro , Joris de Wit , Wei-Feng Xue , Joost Schymkowitz , Frederic Rousseau

Pharmacological modulation of septins restores calcium homeostasis and is neuroprotective in models of Alzheimer's disease.

Science (New York, N.Y.)

Avec: Katrien Princen , Tom Van Dooren , Marit van Gorsel , Xiaojuan Yang , Michael Dumbacher , Ilse Bastiaens , Kristel Coupet , Shana Dupont , Eva Cuveliers , Annick Lauwers , Mohamed Laghmouchi , Thomas Vanwelden , Sofie Carmans , Nele Van Damme , Hein Duhamel , Seppe Vansteenkiste , Jovan Prerad , Karolien Pipeleers , Olivier Rodiers , Liese De Ridder , Sofie Claes , Yoni Busschots , Lentel Pringels , Vanessa Verhelst , Eveline Debroux , Marinka Brouwer , Sam Lievens , Jan Tavernier , Melissa Farinelli , Sandrine Hughes-Asceri , Marieke Voets , Joris Winderickx , Stefaan Wera , Joris de Wit , Joost Schymkowitz , Frederic Rousseau , Henrik Zetterberg , Jeffrey L Cummings , Wim Annaert , Tom Cornelissen , Hans De Winter , Koen De Witte , Marc Fivaz , Gerard Griffioen

An end-to-end approach for single-cell infrared absorption spectroscopy of bacterial inclusion bodies: from AFM-IR measurement to data interpretation of large sample sets.

Journal of nanobiotechnology

Avec: Wouter Duverger , Grigoria Tsaka , Ladan Khodaparast , Laleh Khodaparast , Frederic Rousseau , Joost Schymkowitz

Réseau de co-auteurs

Joost Schymkowitz 29 collaborations

Frederic Rousseau 29 collaborations

Katerina Konstantoulea 8 collaborations

Matthias De Vleeschouwer 8 collaborations

Meine Ramakers 8 collaborations

Bert Houben 8 collaborations

Rob van der Kant 7 collaborations

Rodrigo Gallardo 7 collaborations

Emiel Michiels 7 collaborations

Ladan Khodaparast 4 collaborations

Laleh Khodaparast 4 collaborations

Teresa Garcia 4 collaborations

Anastassios Economou 3 collaborations

Grigoria Tsaka 3 collaborations

Ramon Duran-Romaña 3 collaborations

Joris de Wit 3 collaborations

Mieke Nys 2 collaborations

Chris Ulens 2 collaborations

Hannah Wilkinson 2 collaborations

Patricia Guerreiro 2 collaborations

Shu Liu 2 collaborations

Ina Vorberg 2 collaborations

Arnout Voet 2 collaborations

Spyridoula Karamanou 2 collaborations

Jan Tavernier 2 collaborations

Filip Claes 2 collaborations

Yulia Lampi 2 collaborations

Joost Van Durme 2 collaborations

Chiara Morelli 2 collaborations

Sam D'Haeyer 2 collaborations

Vera Goossens 2 collaborations

Dietmar Rudolf Thal 2 collaborations

Dominique Audenaert 2 collaborations

Marc Behrendt 1 collaboration

Fabian Gruss 1 collaboration

Raissa Enzeroth 1 collaboration

Sandeep Dembla 1 collaboration

Siyuan Zhao 1 collaboration

Pierre-Antoine Crassous 1 collaboration

Florian Mohr 1 collaboration

Valentina Zorzini 1 collaboration

Doris Wagner 1 collaboration

Stephan E Philipp 1 collaboration

Tibor Rohacs 1 collaboration

Johannes Oberwinkler 1 collaboration

Kenny Roose 1 collaboration

Maxime Siemons 1 collaboration

Suzanne J F Kaptein 1 collaboration

Lorena Itatí Ibañez 1 collaboration

Anouk Smet 1 collaboration

Pieter Baatsen 1 collaboration

Guy Bormans 1 collaboration

Johan Neyts 1 collaboration

Xavier Saelens 1 collaboration

Christine Helsen 1 collaboration

Tien T Nguyen 1 collaboration

Xiao Yin Lee 1 collaboration

Roy Eerlings 1 collaboration

Frank Claessens 1 collaboration

Jessica Wagner 1 collaboration

Karoline Degenhardt 1 collaboration

Marleen Veit 1 collaboration

Angelos Skodras 1 collaboration

Katleen Wild 1 collaboration

Ping Liu 1 collaboration

Ulrike Obermüller 1 collaboration

Vikas Bansal 1 collaboration

Anupriya Dalmia 1 collaboration

Lisa M Häsler 1 collaboration

Marius Lambert 1 collaboration

Hannah A Davies 1 collaboration

Jillian Madine 1 collaboration

Deborah Kronenberg-Versteeg 1 collaboration

Regina Feederle 1 collaboration

Domenico Del Turco 1 collaboration

K Peter R Nilsson 1 collaboration

Tammaryn Lashley 1 collaboration

Thomas Deller 1 collaboration

Marla Gearing 1 collaboration

Lary C Walker 1 collaboration

Peter Heutink 1 collaboration

Mathias Jucker 1 collaboration

Jonas J Neher 1 collaboration

Adekunle T Bademosi 1 collaboration

Marianna Decet 1 collaboration

Sabine Kuenen 1 collaboration

Carles Calatayud 1 collaboration

Jef Swerts 1 collaboration

Sandra F Gallego 1 collaboration

Nils Schoovaerts 1 collaboration

Ella Martin 1 collaboration

Jean-Baptiste Sibarita 1 collaboration

Katlijn Vints 1 collaboration

Natalia V Gounko 1 collaboration

Frédéric A Meunier 1 collaboration

Wim Versées 1 collaboration

Sandra-F Soukup 1 collaboration

Patrik Verstreken 1 collaboration

Marion Mathelié-Guinlet 1 collaboration

Yves Dufrêne 1 collaboration

Nicolas Rosa 1 collaboration

Hristina Ivanova 1 collaboration

Larry E Wagner 1 collaboration

Justin Kale 1 collaboration

Rita La Rovere 1 collaboration

Kirsten Welkenhuyzen 1 collaboration

Victoria Shabardina 1 collaboration

Irma Lemmens 1 collaboration

Elien Vandermarliere 1 collaboration

Kozo Hamada 1 collaboration

Hideaki Ando 1 collaboration

Katsuhiko Mikoshiba 1 collaboration

David W Andrews 1 collaboration

Jan B Parys 1 collaboration

David I Yule 1 collaboration

Geert Bultynck 1 collaboration

Joëlle A J Housmans 1 collaboration

Margarita Monge-Morera 1 collaboration

Diego Asvestas 1 collaboration

Hung Huy Nguyen 1 collaboration

Sebastien Carpentier 1 collaboration

Jan A Delcour 1 collaboration

Guiqin Wu 1 collaboration

Pengpeng Yi 1 collaboration

Kobe Janssen 1 collaboration

Dido Van de Velde 1 collaboration

Vanessa L Wehbi 1 collaboration

Joffre Verniers 1 collaboration

Katerina Maragkou 1 collaboration

Mónica Musteanu 1 collaboration

Mariano Barbacid 1 collaboration

Bernard Scorneaux 1 collaboration

Els Beirnaert 1 collaboration

Baptiste Libé-Philippot 1 collaboration

Amélie Lejeune 1 collaboration

Keimpe Wierda 1 collaboration

Emir Erkol 1 collaboration

Ine Vlaeminck 1 collaboration

Sofie Beckers 1 collaboration

Vaiva Gaspariunaite 1 collaboration

Angéline Bilheu 1 collaboration

Hajnalka Nyitrai 1 collaboration

Kristel M Vennekens 1 collaboration

Niels Vidal 1 collaboration

Thomas W Bird 1 collaboration

Daniela C Soto 1 collaboration

Tom Jaspers 1 collaboration

Maarten Dewilde 1 collaboration

Megan Y Dennis 1 collaboration

Davide Comoletti 1 collaboration

Tom Theys 1 collaboration

Pierre Vanderhaeghen 1 collaboration

Tobias Langenberg 1 collaboration

Rafaela Cassio 1 collaboration

Stanislav Rudyak 1 collaboration

Angela S Laird 1 collaboration

Jacinte Beerten 1 collaboration

Maja Debulpaep 1 collaboration

Greet De Baets 1 collaboration

Kristy Yuan 1 collaboration

Serene S L Gwee 1 collaboration

Sara Hernandez 1 collaboration

Kerensa Broersen 1 collaboration

Mikael Oliveberg 1 collaboration

Barbara Moahamed 1 collaboration

Janine Kirstein 1 collaboration

Wim Robberecht 1 collaboration

Shauni Lien Geeraerts 1 collaboration

Kim Rosalie Kampen 1 collaboration

Gianmarco Rinaldi 1 collaboration

Purvi Gupta 1 collaboration

Mélanie Planque 1 collaboration

Elien Heylen 1 collaboration

Kaat De Cremer 1 collaboration

Katrijn De Brucker 1 collaboration

Stijn Vereecke 1 collaboration

Benno Verbelen 1 collaboration

Pieter Vermeersch 1 collaboration

David Cassiman 1 collaboration

Sarah-Maria Fendt 1 collaboration

Bruno P A Cammue 1 collaboration

Karin Thevissen 1 collaboration

Kim De Keersmaecker 1 collaboration

Nele Moonen 1 collaboration

Matthew P Wilson 1 collaboration

Gert Matthijs 1 collaboration

Martin Wilkinson 1 collaboration

Ian R Mackenzie 1 collaboration

Rosa Rademakers 1 collaboration

Neil A Ranson 1 collaboration

Sheena E Radford 1 collaboration

Joffré Verniers 1 collaboration

Nuno Chicória 1 collaboration

Thomas Vanpoucke 1 collaboration

Gabriele Orlando 1 collaboration

Liam D Aubrey 1 collaboration

Luís F Ribeiro 1 collaboration

Wei-Feng Xue 1 collaboration

Katrien Princen 1 collaboration

Tom Van Dooren 1 collaboration

Marit van Gorsel 1 collaboration

Xiaojuan Yang 1 collaboration

Michael Dumbacher 1 collaboration

Ilse Bastiaens 1 collaboration

Kristel Coupet 1 collaboration

Shana Dupont 1 collaboration

Eva Cuveliers 1 collaboration

Annick Lauwers 1 collaboration

Mohamed Laghmouchi 1 collaboration

Thomas Vanwelden 1 collaboration

Sofie Carmans 1 collaboration

Nele Van Damme 1 collaboration

Hein Duhamel 1 collaboration

Seppe Vansteenkiste 1 collaboration

Jovan Prerad 1 collaboration

Karolien Pipeleers 1 collaboration

Olivier Rodiers 1 collaboration

Liese De Ridder 1 collaboration

Sofie Claes 1 collaboration

Yoni Busschots 1 collaboration

Lentel Pringels 1 collaboration

Vanessa Verhelst 1 collaboration

Eveline Debroux 1 collaboration

Marinka Brouwer 1 collaboration

Sam Lievens 1 collaboration

Melissa Farinelli 1 collaboration

Sandrine Hughes-Asceri 1 collaboration

Marieke Voets 1 collaboration

Joris Winderickx 1 collaboration

Stefaan Wera 1 collaboration

Henrik Zetterberg 1 collaboration

Jeffrey L Cummings 1 collaboration

Wim Annaert 1 collaboration

Tom Cornelissen 1 collaboration

Hans De Winter 1 collaboration

Koen De Witte 1 collaboration

Marc Fivaz 1 collaboration

Gerard Griffioen 1 collaboration

Wouter Duverger 1 collaboration