Neil Segil

Affiliations

Tina and Rick Caruso Department of Otolaryngology-Head and Neck Surgery, University of Southern California, Los Angles, CA, USA.
Eli and Edythe Broad CIRM Center for Regenerative Medicine and Stem Cell Research, University of Southern California, Los Angles, CA, USA.

ORCID: http://orcid.org/0000-0002-0441-2067

Publications (14)

Small-molecule inhibition of Lats kinases may promote Yap-dependent proliferation in postmitotic mammalian tissues.

Nature communications

Avec: Nathaniel Kastan , Ksenia Gnedeva , Theresa Alisch , Aleksandra A Petelski , David J Huggins , Jeanne Chiaravalli , Alla Aharanov , Avraham Shakked , Eldad Tzahor , Aaron Nagiel , A J Hudspeth

Foxc1 establishes enhancer accessibility for craniofacial cartilage differentiation.

eLife

Avec: Pengfei Xu , Haoze V Yu , Kuo-Chang Tseng , Mackenzie Flath , Peter Fabian , J Gage Crump

SoxC transcription factors shape the epigenetic landscape to establish competence for sensory differentiation in the mammalian organ of Corti.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Xizi Wang , Juan Llamas , Talon Trecek , Tuo Shi , Litao Tao , Welly Makmura , J Gage Crump , Ksenia Gnedeva

Organ of Corti size is governed by Yap/Tead-mediated progenitor self-renewal.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Ksenia Gnedeva , Xizi Wang , Melissa M McGovern , Matthew Barton , Litao Tao , Talon Trecek , Tanner O Monroe , Juan Llamas , Welly Makmura , James F Martin , Andrew K Groves , Mark Warchol ,

Cellular reprogramming with ATOH1, GFI1, and POU4F3 implicate epigenetic changes and cell-cell signaling as obstacles to hair cell regeneration in mature mammals.

eLife

Avec: Amrita A Iyer , Ishwar Hosamani , John D Nguyen , Tiantian Cai , Sunita Singh , Melissa M McGovern , Lisa Beyer , Hongyuan Zhang , Hsin-I Jen , Rizwan Yousaf , Onur Birol , Jenny J Sun , Russell S Ray , Yehoash Raphael , Andrew K Groves

Transcriptomic and epigenetic regulation of hair cell regeneration in the mouse utricle and its potentiation by Atoh1.

eLife

Avec: Hsin-I Jen , Matthew C Hill , Litao Tao , Kuanwei Sheng , Wenjian Cao , Hongyuan Zhang , Haoze V Yu , Juan Llamas , Chenghang Zong , James F Martin , Andrew K Groves

Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration.

Developmental cell

Avec: Litao Tao , Haoze V Yu , Juan Llamas , Talon Trecek , Xizi Wang , Zlatka Stojanova , Andrew K Groves ,

GFI1 regulates hair cell differentiation by acting as an off-DNA transcriptional co-activator of ATOH1, and a DNA-binding repressor.

Scientific reports

Avec: Hsin-I Jen , Sunita Singh , Litao Tao , Helen R Maunsell , Andrew K Groves

STAT3 promotes a youthful epigenetic state in articular chondrocytes.

Aging cell

Avec: Arijita Sarkar , Nancy Q Liu , Jenny Magallanes , Jade Tassey , Siyoung Lee , Ruzanna Shkhyan , Youngjoo Lee , Jinxiu Lu , Yuxin Ouyang , Hanhan Tang , Fangzhou Bian , Litao Tao , Jason Ernst , Karen Lyons , Steve Horvath , Denis Evseenko

Generation of inner ear hair cells by direct lineage conversion of primary somatic cells.

eLife

Avec: Louise Menendez , Talon Trecek , Suhasni Gopalakrishnan , Litao Tao , Alexander L Markowitz , Haoze V Yu , Xizi Wang , Juan Llamas , Chichou Huang , James Lee , Radha Kalluri , Justin Ichida ,

Single-cell transcriptomic profiling of the zebrafish inner ear reveals molecularly distinct hair cell and supporting cell subtypes.

eLife

Avec: Tuo Shi , Marielle O Beaulieu , Lauren M Saunders , Peter Fabian , Cole Trapnell , J Gage Crump , David W Raible

POU4F3 pioneer activity enables ATOH1 to drive diverse mechanoreceptor differentiation through a feed-forward epigenetic mechanism.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Haoze V Yu , Litao Tao , Juan Llamas , Xizi Wang , John D Nguyen , Talon Trecek ,

CDK2 regulates aminoglycoside-induced hair cell death through modulating c-Jun activity: Inhibiting CDK2 to preserve hearing.

Frontiers in molecular neuroscience

Avec: Litao Tao ,

DNA methylation in the mouse cochlea promotes maturation of supporting cells and contributes to the failure of hair cell regeneration.

Proceedings of the National Academy of Sciences of the United States of America

Avec: John D Nguyen , Juan Llamas , Tuo Shi , J Gage Crump , Andrew K Groves ,

Réseau de co-auteurs

Litao Tao 9 collaborations

Juan Llamas 7 collaborations

Andrew K Groves 6 collaborations

Haoze V Yu 5 collaborations

Xizi Wang 5 collaborations

Talon Trecek 5 collaborations

J Gage Crump 4 collaborations

Ksenia Gnedeva 3 collaborations

Tuo Shi 3 collaborations

John D Nguyen 3 collaborations

Hsin-I Jen 3 collaborations

Peter Fabian 2 collaborations

Welly Makmura 2 collaborations

Melissa M McGovern 2 collaborations

James F Martin 2 collaborations

Sunita Singh 2 collaborations

Hongyuan Zhang 2 collaborations

Nathaniel Kastan 1 collaboration

Theresa Alisch 1 collaboration

Aleksandra A Petelski 1 collaboration

David J Huggins 1 collaboration

Jeanne Chiaravalli 1 collaboration

Alla Aharanov 1 collaboration

Avraham Shakked 1 collaboration

Eldad Tzahor 1 collaboration

Aaron Nagiel 1 collaboration

A J Hudspeth 1 collaboration

Pengfei Xu 1 collaboration

Kuo-Chang Tseng 1 collaboration

Mackenzie Flath 1 collaboration

Matthew Barton 1 collaboration

Tanner O Monroe 1 collaboration

Mark Warchol 1 collaboration

Amrita A Iyer 1 collaboration

Ishwar Hosamani 1 collaboration

Tiantian Cai 1 collaboration

Lisa Beyer 1 collaboration

Rizwan Yousaf 1 collaboration

Onur Birol 1 collaboration

Jenny J Sun 1 collaboration

Russell S Ray 1 collaboration

Yehoash Raphael 1 collaboration

Matthew C Hill 1 collaboration

Kuanwei Sheng 1 collaboration

Wenjian Cao 1 collaboration

Chenghang Zong 1 collaboration

Zlatka Stojanova 1 collaboration

Helen R Maunsell 1 collaboration

Arijita Sarkar 1 collaboration

Nancy Q Liu 1 collaboration

Jenny Magallanes 1 collaboration

Jade Tassey 1 collaboration

Siyoung Lee 1 collaboration

Ruzanna Shkhyan 1 collaboration

Youngjoo Lee 1 collaboration

Jinxiu Lu 1 collaboration

Yuxin Ouyang 1 collaboration

Hanhan Tang 1 collaboration

Fangzhou Bian 1 collaboration

Jason Ernst 1 collaboration

Karen Lyons 1 collaboration

Steve Horvath 1 collaboration

Denis Evseenko 1 collaboration

Louise Menendez 1 collaboration

Suhasni Gopalakrishnan 1 collaboration

Alexander L Markowitz 1 collaboration

Chichou Huang 1 collaboration

James Lee 1 collaboration

Radha Kalluri 1 collaboration

Justin Ichida 1 collaboration

Marielle O Beaulieu 1 collaboration

Lauren M Saunders 1 collaboration

Cole Trapnell 1 collaboration

David W Raible 1 collaboration