Enhancer decommissioning imposes an epigenetic barrier to sensory hair cell regeneration.

Animals Basic Helix-Loop-Helix Transcription Factors / metabolism Cell Differentiation / physiology Cell Transdifferentiation / genetics Epigenesis, Genetic / genetics Hair Cells, Auditory / cytology Mice, Transgenic Receptors, Notch / metabolism Regeneration / physiology Regulatory Sequences, Nucleic Acid / genetics
ATOH1 targetome H3K4me1 enhancer decommissioning epigenetics inner ear maturation regeneration sensory hair cell transdifferentiation potential

Journal

Developmental cell
ISSN: 1878-1551
Titre abrégé: Dev Cell
Pays: United States
ID NLM: 101120028

Informations de publication

Date de publication:
13 09 2021
Historique:
received: 16 03 2021
revised: 24 06 2021
accepted: 08 07 2021
pubmed: 1 8 2021
medline: 27 11 2021
entrez: 31 7 2021
Statut: ppublish

Résumé

Adult mammalian tissues such as heart, brain, retina, and the sensory structures of the inner ear do not effectively regenerate, although a latent capacity for regeneration exists at embryonic and perinatal times. We explored the epigenetic basis for this latent regenerative potential in the mouse inner ear and its rapid loss during maturation. In perinatal supporting cells, whose fate is maintained by Notch-mediated lateral inhibition, the hair cell enhancer network is epigenetically primed (H3K4me1) but silenced (active H3K27 de-acetylation and trimethylation). Blocking Notch signaling during the perinatal period of plasticity rapidly eliminates epigenetic silencing and allows supporting cells to transdifferentiate into hair cells. Importantly, H3K4me1 priming of the hair cell enhancers in supporting cells is removed during the first post-natal week, coinciding with the loss of transdifferentiation potential. We hypothesize that enhancer decommissioning during cochlear maturation contributes to the failure of hair cell regeneration in the mature organ of Corti.

Identifiants

DOI: 10.1016/j.devcel.2021.07.003 PMID: 34331868 PMC: PMC8650127
pubmed: 34331868
pii: S1534-5807(21)00559-1
doi: 10.1016/j.devcel.2021.07.003
pmc: PMC8650127
mid: NIHMS1730090
pii:
doi:

Substances chimiques

Basic Helix-Loop-Helix Transcription Factors 0
Receptors, Notch 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

2471-2485.e5

Subventions

Organisme : NIDCD NIH HHS
ID : F31 DC017376
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC014832
Pays : United States
Organisme : NIDCD NIH HHS
ID : R01 DC015829
Pays : United States
Organisme : NIDCD NIH HHS
ID : T32 DC009975
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2021 Elsevier Inc. All rights reserved.

Déclaration de conflit d'intérêts

Declaration of interests The authors declare no competing interests.

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Auteurs

Litao Tao (L)

Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Biology at USC, 1425 San Pablo Street, Los Angeles, CA 90033, USA; Caruso Department of Otolaryngology - Head and Neck Surgery, Keck School of Medicine of the University of Southern California, 1450 San Pablo Street, Suite 5100, Los Angeles, CA 90033, USA.

Haoze V Yu (HV)

Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Biology at USC, 1425 San Pablo Street, Los Angeles, CA 90033, USA.

Juan Llamas (J)

Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Biology at USC, 1425 San Pablo Street, Los Angeles, CA 90033, USA; Caruso Department of Otolaryngology - Head and Neck Surgery, Keck School of Medicine of the University of Southern California, 1450 San Pablo Street, Suite 5100, Los Angeles, CA 90033, USA.

Talon Trecek (T)

Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Biology at USC, 1425 San Pablo Street, Los Angeles, CA 90033, USA.

Xizi Wang (X)

Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Biology at USC, 1425 San Pablo Street, Los Angeles, CA 90033, USA.

Zlatka Stojanova (Z)

Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Biology at USC, 1425 San Pablo Street, Los Angeles, CA 90033, USA.

Andrew K Groves (AK)

Department of Molecular and Human Genetics, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA; Department of Neuroscience, Baylor College of Medicine, 1 Baylor Plaza, Houston, TX 77030, USA.

Neil Segil (N)

Department of Stem Cell Biology and Regenerative Medicine, Keck School of Medicine of the University of Southern California, Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Biology at USC, 1425 San Pablo Street, Los Angeles, CA 90033, USA; Caruso Department of Otolaryngology - Head and Neck Surgery, Keck School of Medicine of the University of Southern California, 1450 San Pablo Street, Suite 5100, Los Angeles, CA 90033, USA. Electronic address: nsegil@med.usc.edu.

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Classifications MeSH

Recherchemedicale.com › Eucaryotes › Animaux › Enhancer decommissioning imposes an epigenetic...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription à motif basique hélice-boucle-hélice › Enhancer decommissioning imposes an epigenetic...
Recherchemedicale.com › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Enhancer decommissioning imposes an epigenetic...
Recherchemedicale.com › Phénomènes physiologiques cellulaires › Transdifférenciation cellulaire › Enhancer decommissioning imposes an epigenetic...
Recherchemedicale.com › Phénomènes génétiques › Régulation de l'expression des gènes › Épigenèse génétique › Enhancer decommissioning imposes an epigenetic...
Recherchemedicale.com › Cellules › Neurones › Neurones afférents › Cellules réceptrices sensorielles › Mécanorécepteurs › Cellules neuroépithéliales › Cellules ciliées auditives › Enhancer decommissioning imposes an epigenetic...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Souris transgéniques › Enhancer decommissioning imposes an epigenetic...
Recherchemedicale.com › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Récepteurs Notch › Enhancer decommissioning imposes an epigenetic...
Recherchemedicale.com › Phénomènes biologiques › Régénération › Enhancer decommissioning imposes an epigenetic...
Recherchemedicale.com › Phénomènes génétiques › Structures génétiques › Séquences d'acides nucléiques régulatrices › Enhancer decommissioning imposes an epigenetic...