Natasha M Kafai

Affiliations

Department of Medicine, Washington University School of Medicine, St Louis, MO, USA.
Department of Pathology and Immunology, Washington University School of Medicine, St Louis, MO, USA.

ORCID: http://orcid.org/0000-0002-3115-3400

Publications (26)

LDLRAD3 is a receptor for Venezuelan equine encephalitis virus.

Nature

Avec: Hongming Ma , Arthur S Kim , James T Earnest , Aadit P Shah , James Brett Case , Katherine Basore , Theron C Gilliland , Chengqun Sun , Christopher A Nelson , Larissa B Thackray , William B Klimstra , Daved H Fremont , Michael S Diamond

Ultrapotent miniproteins targeting the SARS-CoV-2 receptor-binding domain protect against infection and disease.

Cell host & microbe

Avec: James Brett Case , Rita E Chen , Longxing Cao , Baoling Ying , Emma S Winkler , Max Johnson , Inna Goreshnik , Minh N Pham , Swathi Shrihari , Adam L Bailey , Xuping Xie , Pei-Yong Shi , Rashmi Ravichandran , Lauren Carter , Lance Stewart , David Baker , Michael S Diamond

The low-density lipoprotein receptor promotes infection of multiple encephalitic alphaviruses.

Nature communications

Avec: Hongming Ma , Lucas J Adams , Saravanan Raju , Alan Sariol , Hana Janova , William B Klimstra , Daved H Fremont , Michael S Diamond

A Potently Neutralizing Antibody Protects Mice against SARS-CoV-2 Infection.

Journal of immunology (Baltimore, Md. : 1950)

Avec: Wafaa B Alsoussi , Jackson S Turner , James B Case , Haiyan Zhao , Aaron J Schmitz , Julian Q Zhou , Rita E Chen , Tingting Lei , Amena A Rizk , Katherine M McIntire , Emma S Winkler , Julie M Fox , Larissa B Thackray , Ahmed O Hassan , Fatima Amanat , Florian Krammer , Corey T Watson , Steven H Kleinstein , Daved H Fremont , Michael S Diamond , Ali H Ellebedy

SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function.

Nature immunology

Avec: Emma S Winkler , Adam L Bailey , Sharmila Nair , Broc T McCune , Jinsheng Yu , Julie M Fox , Rita E Chen , James T Earnest , Shamus P Keeler , Jon H Ritter , Liang-I Kang , Sarah Dort , Annette Robichaud , Richard Head , Michael J Holtzman , Michael S Diamond

Broadly neutralizing monoclonal antibodies protect against multiple tick-borne flaviviruses.

The Journal of experimental medicine

Avec: Laura A VanBlargan , John M Errico , Katherine E Burgomaster , Prashant N Jethva , Rebecca M Broeckel , Kimberly Meade-White , Christopher A Nelson , Sunny Himansu , David Wang , Scott A Handley , Michael L Gross , Sonja M Best , Theodore C Pierson , Daved H Fremont , Michael S Diamond

Ultrapotent miniproteins targeting the receptor-binding domain protect against SARS-CoV-2 infection and disease in mice.

bioRxiv : the preprint server for biology

Avec: James Brett Case , Rita E Chen , Longxing Cao , Baoling Ying , Emma S Winkler , Inna Goreshnik , Swathi Shrihari , Adam L Bailey , Xuping Xie , Pei-Yong Shi , Rashmi Ravichandran , Lauren Carter , Lance Stewart , David Baker , Michael S Diamond

Replication-competent vesicular stomatitis virus vaccine vector protects against SARS-CoV-2-mediated pathogenesis.

bioRxiv : the preprint server for biology

Avec: James Brett Case , Paul W Rothlauf , Rita E Chen , Julie M Fox , Swathi Shrihari , Broc T McCune , Ian B Harvey , Brittany Smith , Shamus P Keeler , Louis-Marie Bloyet , Emma S Winkler , Michael J Holtzman , Daved H Fremont , Sean P J Whelan , Michael S Diamond

A Single-Dose Intranasal ChAd Vaccine Protects Upper and Lower Respiratory Tracts against SARS-CoV-2.

Cell

Avec: Ahmed O Hassan , Igor P Dmitriev , Julie M Fox , Brittany K Smith , Ian B Harvey , Rita E Chen , Emma S Winkler , Alex W Wessel , James Brett Case , Elena Kashentseva , Broc T McCune , Adam L Bailey , Haiyan Zhao , Laura A VanBlargan , Ya-Nan Dai , Meisheng Ma , Lucas J Adams , Swathi Shrihari , Jonathan E Danis , Lisa E Gralinski , Yixuan J Hou , Alexandra Schäfer , Arthur S Kim , Shamus P Keeler , Daniela Weiskopf , Ralph S Baric , Michael J Holtzman , Daved H Fremont , David T Curiel , Michael S Diamond

Pan-protective anti-alphavirus human antibodies target a conserved E1 protein epitope.

Cell

Avec: Arthur S Kim , Emma S Winkler , Theron C Gilliland , Emily L Cottle , James T Earnest , Prashant N Jethva , Paulina Kaplonek , Aadit P Shah , Rachel H Fong , Edgar Davidson , Ryan J Malonis , Jose A Quiroz , Lauren E Williamson , Lo Vang , Matthias Mack , James E Crowe , Benjamin J Doranz , Jonathan R Lai , Galit Alter , Michael L Gross , William B Klimstra , Daved H Fremont , Michael S Diamond

Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains.

bioRxiv : the preprint server for biology

Avec: Baoling Ying , Bradley Whitener , Laura A VanBlargan , Ahmed O Hassan , Swathi Shrihari , Chieh-Yu Liang , Courtney E Karl , Samantha Mackin , Rita E Chen , Samuel H Wilks , Derek J Smith , Juan Manuel Carreño , Gagandeep Singh , Florian Krammer , Andrea Carfi , Sayda Elbashir , Darin K Edwards , Larissa B Thackray , Michael S Diamond

Potently neutralizing and protective human antibodies against SARS-CoV-2.

Nature

Avec: Seth J Zost , Pavlo Gilchuk , James Brett Case , Elad Binshtein , Rita E Chen , Joseph P Nkolola , Alexandra Schäfer , Joseph X Reidy , Andrew Trivette , Rachel S Nargi , Rachel E Sutton , Naveenchandra Suryadevara , David R Martinez , Lauren E Williamson , Elaine C Chen , Taylor Jones , Samuel Day , Luke Myers , Ahmed O Hassan , Emma S Winkler , Julie M Fox , Swathi Shrihari , Benjamin K Mueller , Jens Meiler , Abishek Chandrashekar , Noe B Mercado , James J Steinhardt , Kuishu Ren , Yueh-Ming Loo , Nicole L Kallewaard , Broc T McCune , Shamus P Keeler , Michael J Holtzman , Dan H Barouch , Lisa E Gralinski , Ralph S Baric , Larissa B Thackray , Michael S Diamond , Robert H Carnahan , James E Crowe

Potently neutralizing human antibodies that block SARS-CoV-2 receptor binding and protect animals.

bioRxiv : the preprint server for biology

Avec: Seth J Zost , Pavlo Gilchuk , James Brett Case , Elad Binshtein , Rita E Chen , Joseph X Reidy , Andrew Trivette , Rachel S Nargi , Rachel E Sutton , Naveenchandra Suryadevara , Lauren E Williamson , Elaine C Chen , Taylor Jones , Samuel Day , Luke Myers , Ahmed O Hassan , Emma S Winkler , Julie M Fox , James J Steinhardt , Kuishu Ren , Yueh-Ming Loo , Nicole L Kallewaard , David R Martinez , Alexandra Schäfer , Lisa E Gralinski , Ralph S Baric , Larissa B Thackray , Michael S Diamond , Robert H Carnahan , James E Crowe

Structure of Venezuelan equine encephalitis virus in complex with the LDLRAD3 receptor.

Nature

Avec: Katherine Basore , Hongming Ma , Samantha Mackin , Arthur S Kim , Christopher A Nelson , Michael S Diamond , Daved H Fremont

Protective activity of mRNA vaccines against ancestral and variant SARS-CoV-2 strains.

Science translational medicine

Avec: Baoling Ying , Bradley Whitener , Laura A VanBlargan , Ahmed O Hassan , Swathi Shrihari , Chieh-Yu Liang , Courtney E Karl , Samantha Mackin , Rita E Chen , Samuel H Wilks , Derek J Smith , Juan Manuel Carreño , Gagandeep Singh , Florian Krammer , Andrea Carfi , Sayda M Elbashir , Darin K Edwards , Larissa B Thackray , Michael S Diamond

The antigenic anatomy of SARS-CoV-2 receptor binding domain.

Cell

Avec: Wanwisa Dejnirattisai , Daming Zhou , Helen M Ginn , Helen M E Duyvesteyn , Piyada Supasa , James Brett Case , Yuguang Zhao , Thomas S Walter , Alexander J Mentzer , Chang Liu , Beibei Wang , Guido C Paesen , Jose Slon-Campos , César López-Camacho , Adam L Bailey , Rita E Chen , Baoling Ying , Craig Thompson , Jai Bolton , Alex Fyfe , Sunetra Gupta , Tiong Kit Tan , Javier Gilbert-Jaramillo , William James , Michael Knight , Miles W Carroll , Donal Skelly , Christina Dold , Yanchun Peng , Robert Levin , Tao Dong , Andrew J Pollard , Julian C Knight , Paul Klenerman , Nigel Temperton , David R Hall , Mark A Williams , Neil G Paterson , Felicity K R Bertram , C Alistair Siebert , Daniel K Clare , Andrew Howe , Julika Radecke , Yun Song , Alain R Townsend , Kuan-Ying A Huang , Elizabeth E Fry , Juthathip Mongkolsapaya , Michael S Diamond , Jingshan Ren , David I Stuart , Gavin R Screaton

Multivalent designed proteins protect against SARS-CoV-2 variants of concern.

bioRxiv : the preprint server for biology

Avec: Andrew C Hunt , James Brett Case , Young-Jun Park , Longxing Cao , Kejia Wu , Alexandra C Walls , Zhuoming Liu , John E Bowen , Hsien-Wei Yeh , Shally Saini , Louisa Helms , Yan Ting Zhao , Tien-Ying Hsiang , Tyler N Starr , Inna Goreshnik , Lisa Kozodoy , Lauren Carter , Rashmi Ravichandran , Lydia B Green , Wadim L Matochko , Christy A Thomson , Bastain Vögeli , Antje Krüger-Gericke , Laura A VanBlargan , Rita E Chen , Baoling Ying , Adam L Bailey , Scott Boyken , Ajasja Ljubetič , Natasha Edman , George Ueda , Cameron Chow , Amin Addetia , Nuttada Panpradist , Michael Gale , Benjamin S Freedman , Barry R Lutz , Jesse D Bloom , Hannele Ruohola-Baker , Sean P J Whelan , Lance Stewart , Michael S Diamond , David Veesler , Michael C Jewett , David Baker

Multivalent designed proteins neutralize SARS-CoV-2 variants of concern and confer protection against infection in mice.

Science translational medicine

Avec: Andrew C Hunt , James Brett Case , Young-Jun Park , Longxing Cao , Kejia Wu , Alexandra C Walls , Zhuoming Liu , John E Bowen , Hsien-Wei Yeh , Shally Saini , Louisa Helms , Yan Ting Zhao , Tien-Ying Hsiang , Tyler N Starr , Inna Goreshnik , Lisa Kozodoy , Lauren Carter , Rashmi Ravichandran , Lydia B Green , Wadim L Matochko , Christy A Thomson , Bastian Vögeli , Antje Krüger , Laura A VanBlargan , Rita E Chen , Baoling Ying , Adam L Bailey , Scott E Boyken , Ajasja Ljubetič , Natasha Edman , George Ueda , Cameron M Chow , Max Johnson , Amin Addetia , Mary-Jane Navarro , Nuttada Panpradist , Michael Gale , Benjamin S Freedman , Jesse D Bloom , Hannele Ruohola-Baker , Sean P J Whelan , Lance Stewart , Michael S Diamond , David Veesler , Michael C Jewett , David Baker

SARS-CoV-2 infection in the lungs of human ACE2 transgenic mice causes severe inflammation, immune cell infiltration, and compromised respiratory function.

bioRxiv : the preprint server for biology

Replication-Competent Vesicular Stomatitis Virus Vaccine Vector Protects against SARS-CoV-2-Mediated Pathogenesis in Mice.

Cell host & microbe

Avec: James Brett Case , Paul W Rothlauf , Rita E Chen , Julie M Fox , Brittany K Smith , Swathi Shrihari , Broc T McCune , Ian B Harvey , Shamus P Keeler , Louis-Marie Bloyet , Haiyan Zhao , Meisheng Ma , Lucas J Adams , Emma S Winkler , Michael J Holtzman , Daved H Fremont , Sean P J Whelan , Michael S Diamond

A SARS-CoV-2 Infection Model in Mice Demonstrates Protection by Neutralizing Antibodies.

Cell

Avec: Ahmed O Hassan , James Brett Case , Emma S Winkler , Larissa B Thackray , Adam L Bailey , Broc T McCune , Julie M Fox , Rita E Chen , Wafaa B Alsoussi , Jackson S Turner , Aaron J Schmitz , Tingting Lei , Swathi Shrihari , Shamus P Keeler , Daved H Fremont , Suellen Greco , Paul B McCray , Stanley Perlman , Michael J Holtzman , Ali H Ellebedy , Michael S Diamond

Publisher Correction: SARS-CoV-2 infection of human ACE2-transgenic mice causes severe lung inflammation and impaired function.

Nature immunology

Neutralizing antibodies protect mice against Venezuelan equine encephalitis virus aerosol challenge.

The Journal of experimental medicine

Avec: Lauren E Williamson , Elad Binshtein , Soila Sukupolvi-Petty , Christina L Gardner , Jaclyn Liu , Samantha Mackin , Arthur S Kim , Nurgun Kose , Robert H Carnahan , Ana Jung , Lindsay Droit , Douglas S Reed , Scott A Handley , William B Klimstra , James E Crowe , Michael S Diamond

Distinct Cellular Tropism and Immune Responses to Alphavirus Infection.

Annual review of immunology

Avec: Michael S Diamond , Julie M Fox

Entry receptors - the gateway to alphavirus infection.

The Journal of clinical investigation

Avec: Ofer Zimmerman , Autumn C Holmes , Lucas J Adams , Michael S Diamond

Entry receptor LDLRAD3 is required for Venezuelan equine encephalitis virus peripheral infection and neurotropism leading to pathogenesis in mice.

Cell reports

Avec: Hana Janova , Matthew D Cain , Yael Alippe , Stefanie Muraro , Alan Sariol , Michelle Elam-Noll , Robyn S Klein , Michael S Diamond

Réseau de co-auteurs

Michael S Diamond 26 collaborations

Rita E Chen 17 collaborations

Emma S Winkler 13 collaborations

James Brett Case 12 collaborations

Julie M Fox 11 collaborations

Daved H Fremont 10 collaborations

Adam L Bailey 10 collaborations

Swathi Shrihari 9 collaborations

Broc T McCune 8 collaborations

Shamus P Keeler 8 collaborations

Michael J Holtzman 8 collaborations

Larissa B Thackray 7 collaborations

Baoling Ying 7 collaborations

Ahmed O Hassan 7 collaborations

Laura A VanBlargan 6 collaborations

Arthur S Kim 5 collaborations

James T Earnest 5 collaborations

William B Klimstra 4 collaborations

Longxing Cao 4 collaborations

Inna Goreshnik 4 collaborations

Rashmi Ravichandran 4 collaborations

Lauren Carter 4 collaborations

Lance Stewart 4 collaborations

David Baker 4 collaborations

Lucas J Adams 4 collaborations

Sean P J Whelan 4 collaborations

Lauren E Williamson 4 collaborations

James E Crowe 4 collaborations

Samantha Mackin 4 collaborations

Hongming Ma 3 collaborations

Christopher A Nelson 3 collaborations

Haiyan Zhao 3 collaborations

Florian Krammer 3 collaborations

Sharmila Nair 3 collaborations

Jinsheng Yu 3 collaborations

Jon H Ritter 3 collaborations

Liang-I Kang 3 collaborations

Sarah Dort 3 collaborations

Annette Robichaud 3 collaborations

Richard Head 3 collaborations

Ian B Harvey 3 collaborations

Lisa E Gralinski 3 collaborations

Alexandra Schäfer 3 collaborations

Ralph S Baric 3 collaborations

Elad Binshtein 3 collaborations

Robert H Carnahan 3 collaborations

Aadit P Shah 2 collaborations

Katherine Basore 2 collaborations

Theron C Gilliland 2 collaborations

Max Johnson 2 collaborations

Xuping Xie 2 collaborations

Pei-Yong Shi 2 collaborations

Alan Sariol 2 collaborations

Hana Janova 2 collaborations

Wafaa B Alsoussi 2 collaborations

Jackson S Turner 2 collaborations

Aaron J Schmitz 2 collaborations

Tingting Lei 2 collaborations

Ali H Ellebedy 2 collaborations

Prashant N Jethva 2 collaborations

Scott A Handley 2 collaborations

Michael L Gross 2 collaborations

Paul W Rothlauf 2 collaborations

Louis-Marie Bloyet 2 collaborations

Brittany K Smith 2 collaborations

Meisheng Ma 2 collaborations

Bradley Whitener 2 collaborations

Chieh-Yu Liang 2 collaborations

Courtney E Karl 2 collaborations

Samuel H Wilks 2 collaborations

Derek J Smith 2 collaborations

Juan Manuel Carreño 2 collaborations

Gagandeep Singh 2 collaborations

Andrea Carfi 2 collaborations

Darin K Edwards 2 collaborations

Seth J Zost 2 collaborations

Pavlo Gilchuk 2 collaborations

Joseph X Reidy 2 collaborations

Andrew Trivette 2 collaborations

Rachel S Nargi 2 collaborations

Rachel E Sutton 2 collaborations

Naveenchandra Suryadevara 2 collaborations

David R Martinez 2 collaborations

Elaine C Chen 2 collaborations

Taylor Jones 2 collaborations

Samuel Day 2 collaborations

Luke Myers 2 collaborations

James J Steinhardt 2 collaborations

Kuishu Ren 2 collaborations

Yueh-Ming Loo 2 collaborations

Nicole L Kallewaard 2 collaborations

Andrew C Hunt 2 collaborations

Young-Jun Park 2 collaborations

Kejia Wu 2 collaborations

Alexandra C Walls 2 collaborations

Zhuoming Liu 2 collaborations

John E Bowen 2 collaborations

Hsien-Wei Yeh 2 collaborations

Shally Saini 2 collaborations

Louisa Helms 2 collaborations

Yan Ting Zhao 2 collaborations

Tien-Ying Hsiang 2 collaborations

Tyler N Starr 2 collaborations

Lisa Kozodoy 2 collaborations

Lydia B Green 2 collaborations

Wadim L Matochko 2 collaborations

Christy A Thomson 2 collaborations

Ajasja Ljubetič 2 collaborations

Natasha Edman 2 collaborations

George Ueda 2 collaborations

Amin Addetia 2 collaborations

Nuttada Panpradist 2 collaborations

Michael Gale 2 collaborations

Benjamin S Freedman 2 collaborations

Jesse D Bloom 2 collaborations

Hannele Ruohola-Baker 2 collaborations

David Veesler 2 collaborations

Michael C Jewett 2 collaborations

Chengqun Sun 1 collaboration

Minh N Pham 1 collaboration

Saravanan Raju 1 collaboration

James B Case 1 collaboration

Julian Q Zhou 1 collaboration

Amena A Rizk 1 collaboration

Katherine M McIntire 1 collaboration

Fatima Amanat 1 collaboration

Corey T Watson 1 collaboration

Steven H Kleinstein 1 collaboration

John M Errico 1 collaboration

Katherine E Burgomaster 1 collaboration

Rebecca M Broeckel 1 collaboration

Kimberly Meade-White 1 collaboration

Sunny Himansu 1 collaboration

David Wang 1 collaboration

Sonja M Best 1 collaboration

Theodore C Pierson 1 collaboration

Brittany Smith 1 collaboration

Igor P Dmitriev 1 collaboration

Alex W Wessel 1 collaboration

Elena Kashentseva 1 collaboration

Ya-Nan Dai 1 collaboration

Jonathan E Danis 1 collaboration

Yixuan J Hou 1 collaboration

Daniela Weiskopf 1 collaboration

David T Curiel 1 collaboration

Emily L Cottle 1 collaboration

Paulina Kaplonek 1 collaboration

Rachel H Fong 1 collaboration

Edgar Davidson 1 collaboration

Ryan J Malonis 1 collaboration

Jose A Quiroz 1 collaboration

Lo Vang 1 collaboration

Matthias Mack 1 collaboration

Benjamin J Doranz 1 collaboration

Jonathan R Lai 1 collaboration

Galit Alter 1 collaboration

Sayda Elbashir 1 collaboration

Joseph P Nkolola 1 collaboration

Benjamin K Mueller 1 collaboration

Jens Meiler 1 collaboration

Abishek Chandrashekar 1 collaboration

Noe B Mercado 1 collaboration

Dan H Barouch 1 collaboration

Sayda M Elbashir 1 collaboration

Wanwisa Dejnirattisai 1 collaboration

Daming Zhou 1 collaboration

Helen M Ginn 1 collaboration

Helen M E Duyvesteyn 1 collaboration

Piyada Supasa 1 collaboration

Yuguang Zhao 1 collaboration

Thomas S Walter 1 collaboration

Alexander J Mentzer 1 collaboration

Chang Liu 1 collaboration

Beibei Wang 1 collaboration

Guido C Paesen 1 collaboration

Jose Slon-Campos 1 collaboration

César López-Camacho 1 collaboration

Craig Thompson 1 collaboration

Jai Bolton 1 collaboration

Alex Fyfe 1 collaboration

Sunetra Gupta 1 collaboration

Tiong Kit Tan 1 collaboration

Javier Gilbert-Jaramillo 1 collaboration

William James 1 collaboration

Michael Knight 1 collaboration

Miles W Carroll 1 collaboration

Donal Skelly 1 collaboration

Christina Dold 1 collaboration

Yanchun Peng 1 collaboration

Robert Levin 1 collaboration

Tao Dong 1 collaboration

Andrew J Pollard 1 collaboration

Julian C Knight 1 collaboration

Paul Klenerman 1 collaboration

Nigel Temperton 1 collaboration

David R Hall 1 collaboration

Mark A Williams 1 collaboration

Neil G Paterson 1 collaboration

Felicity K R Bertram 1 collaboration

C Alistair Siebert 1 collaboration

Daniel K Clare 1 collaboration

Andrew Howe 1 collaboration

Julika Radecke 1 collaboration

Yun Song 1 collaboration

Alain R Townsend 1 collaboration

Kuan-Ying A Huang 1 collaboration

Elizabeth E Fry 1 collaboration

Juthathip Mongkolsapaya 1 collaboration

Jingshan Ren 1 collaboration

David I Stuart 1 collaboration

Gavin R Screaton 1 collaboration

Bastain Vögeli 1 collaboration

Antje Krüger-Gericke 1 collaboration

Scott Boyken 1 collaboration

Cameron Chow 1 collaboration

Barry R Lutz 1 collaboration

Bastian Vögeli 1 collaboration

Antje Krüger 1 collaboration

Scott E Boyken 1 collaboration

Cameron M Chow 1 collaboration

Mary-Jane Navarro 1 collaboration

Suellen Greco 1 collaboration

Paul B McCray 1 collaboration

Stanley Perlman 1 collaboration

Soila Sukupolvi-Petty 1 collaboration

Christina L Gardner 1 collaboration

Jaclyn Liu 1 collaboration

Nurgun Kose 1 collaboration

Ana Jung 1 collaboration

Lindsay Droit 1 collaboration

Douglas S Reed 1 collaboration

Ofer Zimmerman 1 collaboration

Autumn C Holmes 1 collaboration

Matthew D Cain 1 collaboration

Yael Alippe 1 collaboration

Stefanie Muraro 1 collaboration

Michelle Elam-Noll 1 collaboration

Robyn S Klein 1 collaboration