Lauri A Aaltonen

Affiliations

Applied Tumor Genomics Research Program and Department of Medical and Clinical Genetics, Biomedicum, University of Helsinki, Helsinki, Finland.

Publications (17)

Colibactin DNA-damage signature indicates mutational impact in colorectal cancer.

Nature medicine

Avec: Paulina J Dziubańska-Kusibab , Hilmar Berger , Federica Battistini , Britta A M Bouwman , Amina Iftekhar , Riku Katainen , Tatiana Cajuso , Nicola Crosetto , Modesto Orozco , Thomas F Meyer

Candidate susceptibility variants in angioimmunoblastic T-cell lymphoma.

Familial cancer

Avec: Iikki Donner , Riku Katainen , Eevi Kaasinen , Mervi Aavikko , Lauri J Sipilä , Eero Pukkala ,

Impact of constitutional TET2 haploinsufficiency on molecular and clinical phenotype in humans.

Nature communications

Avec: Eevi Kaasinen , Outi Kuismin , Kristiina Rajamäki , Heikki Ristolainen , Mervi Aavikko , Johanna Kondelin , Silva Saarinen , Davide G Berta , Riku Katainen , Elina A M Hirvonen , Auli Karhu , Aurora Taira , Tomas Tanskanen , Amjad Alkodsi , Minna Taipale , Ekaterina Morgunova , Kaarle Franssila , Rainer Lehtonen , Markus Mäkinen , Kristiina Aittomäki , Aarno Palotie , Mitja I Kurki , Olli Pietiläinen , Morgane Hilpert , Elmo Saarentaus , Jaakko Niinimäki , Juhani Junttila , Kari Kaikkonen , Pia Vahteristo , Radek C Skoda , Mikko R J Seppänen , Kari K Eklund , Jussi Taipale , Outi Kilpivaara ,

Uterine leiomyomas in hereditary leiomyomatosis and renal cell cancer (HLRCC) syndrome can be identified through distinct clinical characteristics and typical morphology.

Acta obstetricia et gynecologica Scandinavica

Avec: Outi Uimari , Anne Ahtikoski , Kati Kämpjärvi , Ralf Butzow , Ilkka Y Järvelä , Markku Ryynänen , Pia Vahteristo , Outi Kuismin

Deficient H2A.Z deposition is associated with genesis of uterine leiomyoma.

Nature

Avec: Davide G Berta , Heli Kuisma , Niko Välimäki , Maritta Räisänen , Maija Jäntti , Annukka Pasanen , Auli Karhu , Jaana Kaukomaa , Aurora Taira , Tatiana Cajuso , Sanna Nieminen , Rosa-Maria Penttinen , Saija Ahonen , Rainer Lehtonen , Miika Mehine , Pia Vahteristo , Jyrki Jalkanen , Biswajyoti Sahu , Janne Ravantti , Netta Mäkinen , Kristiina Rajamäki , Kimmo Palin , Jussi Taipale , Oskari Heikinheimo , Ralf Bützow , Eevi Kaasinen ,

WNT2 activation through proximal germline deletion predisposes to small intestinal neuroendocrine tumors and intestinal adenocarcinomas.

Human molecular genetics

Avec: Mervi Aavikko , Eevi Kaasinen , Noora Andersson , Nalle Pentinmikko , Päivi Sulo , Iikki Donner , Päivi Pihlajamaa , Anna Kuosmanen , Simona Bramante , Riku Katainen , Lauri J Sipilä , Samantha Martin , Johanna Arola , Olli Carpén , Ilkka Heiskanen , Jukka-Pekka Mecklin , Jussi Taipale , Ari Ristimäki , Kaisa Lehti , Erika Gucciardo , Pekka Katajisto , Camilla Schalin-Jäntti , Pia Vahteristo ,

Genome-Wide Association Study Identifies 4 Novel Risk Loci for Small Intestinal Neuroendocrine Tumors Including a Missense Mutation in LGR5.

Gastroenterology

Avec: Anil K Giri , Mervi Aavikko , Linnea Wartiovaara , Toni Lemmetyinen , Juha Karjalainen , Juha Mehtonen , Kimmo Palin , Niko Välimäki , Max Tamlander , Riikka Saikkonen , Auli Karhu , Ekaterina Morgunova , Benjamin Sun , Heiko Runz , Priit Palta , Shuang Luo , Heikki Joensuu , Tomi P Mäkelä , Iiro Kostiainen , Camilla Schalin-Jäntti , FinnGen , Aarno Palotie , Saara Ollila , Mark J Daly

Paneth cells as the origin of intestinal cancer in the context of inflammation.

Research square

Avec: Mathijs P Verhagen , Rosalie Joosten , Mark Schmitt , Andrea Sacchetti , Jiahn Choi , Niko Välimäki , Leonard H Augenlicht , Riccardo Fodde

Management of Uterine Fibroids and Sarcomas: the Palermo Position Paper.

Gynecologic and obstetric investigation

Avec: Antonio Simone Laganà , Andrea Romano , Arne Vanhie , Celine Bafort , Martin Götte , Aymara Mas , Christine De Bruyn , Thierry Van den Bosch , An Coosemans , Stefano Guerriero , Sergio Haimovich , Vasilios Tanos , Marlies Bongers , Fabio Barra , Ayman Al-Hendy , Vito Chiantera , Umberto Leone Roberti Maggiore

Genome-wide somatic mutation analysis of sinonasal adenocarcinoma with and without wood dust exposure.

Genes and environment : the official journal of the Japanese Environmental Mutagen Society

Avec: Lauri J Sipilä , Riku Katainen , Mervi Aavikko , Janne Ravantti , Iikki Donner , Rainer Lehtonen , Ilmo Leivo , Henrik Wolff , Reetta Holmila , Kirsti Husgafvel-Pursiainen ,

Non-stem cell lineages as an alternative origin of intestinal tumorigenesis in the context of inflammation.

Nature genetics

Avec: Mathijs P Verhagen , Rosalie Joosten , Mark Schmitt , Niko Välimäki , Andrea Sacchetti , Kristiina Rajamäki , Jiahn Choi , Paola Procopio , Sara Silva , Berdine van der Steen , Thierry P P van den Bosch , Danielle Seinstra , Annemarie C de Vries , Michail Doukas , Leonard H Augenlicht , Riccardo Fodde

Mutational processes of distinct POLE exonuclease domain mutants drive an enrichment of a specific TP53 mutation in colorectal cancer.

PLoS genetics

Avec: Hu Fang , Jayne A Barbour , Rebecca C Poulos , Riku Katainen , Jason W H Wong

Parity associates with chromosomal damage in uterine leiomyomas.

Nature communications

Avec: Heli Kuisma , Simona Bramante , Kristiina Rajamäki , Lauri J Sipilä , Eevi Kaasinen , Jaana Kaukomaa , Kimmo Palin , Netta Mäkinen , Jari Sjöberg , Nanna Sarvilinna , Jussi Taipale , Liisa Kauppi , Manuela Tumiati , Antti Hassinen , Janne Pitkäniemi , Jyrki Jalkanen , Sanna Heikkinen , Annukka Pasanen , Oskari Heikinheimo , Ralf Bützow , Niko Välimäki ,

Novel germline variant in the histone demethylase and transcription regulator KDM4C induces a multi-cancer phenotype.

Journal of medical genetics

Avec: Riku Katainen , Iikki Donner , Maritta Räisänen , Davide Berta , Anna Kuosmanen , Eevi Kaasinen , Marja Hietala ,

Mutation-Attention (MuAt): deep representation learning of somatic mutations for tumour typing and subtyping.

Genome medicine

Avec: Prima Sanjaya , Katri Maljanen , Riku Katainen , Sebastian M Waszak , Auteur inconnu , Oliver Stegle , Jan O Korbel , Esa Pitkänen

Retrotransposon insertions can initiate colorectal cancer and are associated with poor survival.

Nature communications

Avec: Tatiana Cajuso , Päivi Sulo , Tomas Tanskanen , Riku Katainen , Aurora Taira , Ulrika A Hänninen , Johanna Kondelin , Linda Forsström , Niko Välimäki , Mervi Aavikko , Eevi Kaasinen , Ari Ristimäki , Selja Koskensalo , Anna Lepistö , Laura Renkonen-Sinisalo , Toni Seppälä , Teijo Kuopio , Jan Böhm , Jukka-Pekka Mecklin , Outi Kilpivaara , Esa Pitkänen , Kimmo Palin ,

Exome and immune cell score analyses reveal great variation within synchronous primary colorectal cancers.

British journal of cancer

Avec: Ulrika A Hänninen , Erkki-Ville Wirta , Riku Katainen , Tomas Tanskanen , Jiri Hamberg , Minna Taipale , Jan Böhm , Laura Renkonen-Sinisalo , Anna Lepistö , Linda M Forsström , Esa Pitkänen , Kimmo Palin , Toni T Seppälä , Netta Mäkinen , Jukka-Pekka Mecklin ,

Réseau de co-auteurs

Riku Katainen 10 collaborations

Eevi Kaasinen 7 collaborations

Mervi Aavikko 6 collaborations

Niko Välimäki 6 collaborations

Kimmo Palin 5 collaborations

Iikki Donner 4 collaborations

Lauri J Sipilä 4 collaborations

Kristiina Rajamäki 4 collaborations

Pia Vahteristo 4 collaborations

Jussi Taipale 4 collaborations

Tatiana Cajuso 3 collaborations

Auli Karhu 3 collaborations

Aurora Taira 3 collaborations

Tomas Tanskanen 3 collaborations

Rainer Lehtonen 3 collaborations

Netta Mäkinen 3 collaborations

Jukka-Pekka Mecklin 3 collaborations

Esa Pitkänen 3 collaborations

Outi Kuismin 2 collaborations

Johanna Kondelin 2 collaborations

Davide G Berta 2 collaborations

Minna Taipale 2 collaborations

Ekaterina Morgunova 2 collaborations

Aarno Palotie 2 collaborations

Outi Kilpivaara 2 collaborations

Heli Kuisma 2 collaborations

Maritta Räisänen 2 collaborations

Annukka Pasanen 2 collaborations

Jaana Kaukomaa 2 collaborations

Jyrki Jalkanen 2 collaborations

Janne Ravantti 2 collaborations

Oskari Heikinheimo 2 collaborations

Ralf Bützow 2 collaborations

Päivi Sulo 2 collaborations

Anna Kuosmanen 2 collaborations

Simona Bramante 2 collaborations

Ari Ristimäki 2 collaborations

Camilla Schalin-Jäntti 2 collaborations

Mathijs P Verhagen 2 collaborations

Rosalie Joosten 2 collaborations

Mark Schmitt 2 collaborations

Andrea Sacchetti 2 collaborations

Jiahn Choi 2 collaborations

Leonard H Augenlicht 2 collaborations

Riccardo Fodde 2 collaborations

Ulrika A Hänninen 2 collaborations

Anna Lepistö 2 collaborations

Laura Renkonen-Sinisalo 2 collaborations

Jan Böhm 2 collaborations

Paulina J Dziubańska-Kusibab 1 collaboration

Hilmar Berger 1 collaboration

Federica Battistini 1 collaboration

Britta A M Bouwman 1 collaboration

Amina Iftekhar 1 collaboration

Nicola Crosetto 1 collaboration

Modesto Orozco 1 collaboration

Thomas F Meyer 1 collaboration

Eero Pukkala 1 collaboration

Heikki Ristolainen 1 collaboration

Silva Saarinen 1 collaboration

Elina A M Hirvonen 1 collaboration

Amjad Alkodsi 1 collaboration

Kaarle Franssila 1 collaboration

Markus Mäkinen 1 collaboration

Kristiina Aittomäki 1 collaboration

Mitja I Kurki 1 collaboration

Olli Pietiläinen 1 collaboration

Morgane Hilpert 1 collaboration

Elmo Saarentaus 1 collaboration

Jaakko Niinimäki 1 collaboration

Juhani Junttila 1 collaboration

Kari Kaikkonen 1 collaboration

Radek C Skoda 1 collaboration

Mikko R J Seppänen 1 collaboration

Kari K Eklund 1 collaboration

Outi Uimari 1 collaboration

Anne Ahtikoski 1 collaboration

Kati Kämpjärvi 1 collaboration

Ralf Butzow 1 collaboration

Ilkka Y Järvelä 1 collaboration

Markku Ryynänen 1 collaboration

Maija Jäntti 1 collaboration

Sanna Nieminen 1 collaboration

Rosa-Maria Penttinen 1 collaboration

Saija Ahonen 1 collaboration

Miika Mehine 1 collaboration

Biswajyoti Sahu 1 collaboration

Noora Andersson 1 collaboration

Nalle Pentinmikko 1 collaboration

Päivi Pihlajamaa 1 collaboration

Samantha Martin 1 collaboration

Johanna Arola 1 collaboration

Olli Carpén 1 collaboration

Ilkka Heiskanen 1 collaboration

Kaisa Lehti 1 collaboration

Erika Gucciardo 1 collaboration

Pekka Katajisto 1 collaboration

Anil K Giri 1 collaboration

Linnea Wartiovaara 1 collaboration

Toni Lemmetyinen 1 collaboration

Juha Karjalainen 1 collaboration

Juha Mehtonen 1 collaboration

Max Tamlander 1 collaboration

Riikka Saikkonen 1 collaboration

Benjamin Sun 1 collaboration

Heiko Runz 1 collaboration

Priit Palta 1 collaboration

Shuang Luo 1 collaboration

Heikki Joensuu 1 collaboration

Tomi P Mäkelä 1 collaboration

Iiro Kostiainen 1 collaboration

None FinnGen 1 collaboration

Saara Ollila 1 collaboration

Mark J Daly 1 collaboration

Antonio Simone Laganà 1 collaboration

Andrea Romano 1 collaboration

Arne Vanhie 1 collaboration

Celine Bafort 1 collaboration

Martin Götte 1 collaboration

Aymara Mas 1 collaboration

Christine De Bruyn 1 collaboration

Thierry Van den Bosch 1 collaboration

An Coosemans 1 collaboration

Stefano Guerriero 1 collaboration

Sergio Haimovich 1 collaboration

Vasilios Tanos 1 collaboration

Marlies Bongers 1 collaboration

Fabio Barra 1 collaboration

Ayman Al-Hendy 1 collaboration

Vito Chiantera 1 collaboration

Umberto Leone Roberti Maggiore 1 collaboration

Ilmo Leivo 1 collaboration

Henrik Wolff 1 collaboration

Reetta Holmila 1 collaboration

Kirsti Husgafvel-Pursiainen 1 collaboration

Paola Procopio 1 collaboration

Sara Silva 1 collaboration

Berdine van der Steen 1 collaboration

Thierry P P van den Bosch 1 collaboration

Danielle Seinstra 1 collaboration

Annemarie C de Vries 1 collaboration

Michail Doukas 1 collaboration

Hu Fang 1 collaboration

Jayne A Barbour 1 collaboration

Rebecca C Poulos 1 collaboration

Jason W H Wong 1 collaboration

Jari Sjöberg 1 collaboration

Nanna Sarvilinna 1 collaboration

Liisa Kauppi 1 collaboration

Manuela Tumiati 1 collaboration

Antti Hassinen 1 collaboration

Janne Pitkäniemi 1 collaboration

Sanna Heikkinen 1 collaboration

Davide Berta 1 collaboration

Marja Hietala 1 collaboration

Prima Sanjaya 1 collaboration

Katri Maljanen 1 collaboration

Sebastian M Waszak 1 collaboration

None None 1 collaboration

Oliver Stegle 1 collaboration

Jan O Korbel 1 collaboration

Linda Forsström 1 collaboration

Selja Koskensalo 1 collaboration

Toni Seppälä 1 collaboration

Teijo Kuopio 1 collaboration

Erkki-Ville Wirta 1 collaboration

Jiri Hamberg 1 collaboration

Linda M Forsström 1 collaboration

Toni T Seppälä 1 collaboration