John S Bomalaski

Affiliations

Medical Affairs, Polaris Pharmaceuticals Inc., San Diego, CA.

Publications (12)

Phase II Study of Arginine Deprivation Therapy With Pegargiminase in Patients With Relapsed Sensitive or Refractory Small-cell Lung Cancer.

Clinical lung cancer

Avec: Peter E Hall , Neal Ready , Amanda Johnston , Ralph R Venhaus , Michael Sheaff , Lee Krug , Peter W Szlosarek

MYC-Driven Small-Cell Lung Cancer is Metabolically Distinct and Vulnerable to Arginine Depletion.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Milind D Chalishazar , Sarah J Wait , Fang Huang , Abbie S Ireland , Anandaroop Mukhopadhyay , Younjee Lee , Sophia S Schuman , Matthew R Guthrie , Kristofer C Berrett , Jeffery M Vahrenkamp , Zeping Hu , Marek Kudla , Katarzyna Modzelewska , Guoying Wang , Nicholas T Ingolia , Jason Gertz , David H Lum , Sabina C Cosulich , Ralph J DeBerardinis , Trudy G Oliver

Assessment of pegylated arginine deiminase and modified FOLFOX6 in patients with advanced hepatocellular carcinoma: Results of an international, single-arm, phase 2 study.

Cancer

Avec: James J Harding , Tsai-Sheng Yang , Yen-Yang Chen , Yin-Hsun Feng , Chia-Jui Yen , Ching-Liang Ho , Wen-Tsung Huang , Imane El Dika , Mehmet Akce , Benjamin Tan , Stacey A Cohen , Timothy Meyer , Debashis Sarker , Dae-Won Lee , Baek-Yeol Ryoo , Ho Yeong Lim , Amanda Johnston , Eileen M O'Reilly , Shukui Qin , Ghassan K Abou-Alfa

Pilot Trial of Arginine Deprivation Plus Nivolumab and Ipilimumab in Patients with Metastatic Uveal Melanoma.

Cancers

Avec: Lukas Kraehenbuehl , Aliya Holland , Emma Armstrong , Sirinya O'Shea , Levi Mangarin , Sara Chekalil , Amanda Johnston , Joseph P Erinjeri , Christopher A Barker , Jasmine H Francis , Jedd D Wolchok , Taha Merghoub , Alexander N Shoushtari

A Phase 1 study of ADI-PEG20 (pegargiminase) combined with cisplatin and pemetrexed in ASS1-negative metastatic uveal melanoma.

Pigment cell & melanoma research

Avec: Pui Ying Chan , Melissa M Phillips , Stephen Ellis , Amanda Johnston , Xiaoxing Feng , Amit Arora , Gordon Hay , Victoria M L Cohen , Mandeep S Sagoo , Michael T Sheaff , Peter W Szlosarek

Exploiting Arginine Auxotrophy with Pegylated Arginine Deiminase (ADI-PEG20) to Sensitize Pancreatic Cancer to Radiotherapy via Metabolic Dysregulation.

Molecular cancer therapeutics

Avec: Pankaj K Singh , Amit A Deorukhkar , Bhanu P Venkatesulu , Xiaolin Li , Ramesh Tailor , Sunil Krishnan

A Phase I Study of Pegylated Arginine Deiminase (Pegargiminase), Cisplatin, and Pemetrexed in Argininosuccinate Synthetase 1-Deficient Recurrent High-grade Glioma.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Peter E Hall , Rachel Lewis , Nelofer Syed , Richard Shaffer , Jane Evanson , Stephen Ellis , Matthew Williams , Xiaoxing Feng , Amanda Johnston , Jim A Thomson , Fiona P Harris , Raj Jena , Tomasz Matys , Sarah Jefferies , Kate Smith , Bor-Wen Wu , Timothy Crook , Kevin O'Neill , Dimitris Paraskevopoulos , Ramsay S Khadeir , Michael Sheaff , Simon Pacey , Piers N Plowman , Peter W Szlosarek

Phase I study of ADI-PEG20 plus low-dose cytarabine for the treatment of acute myeloid leukemia.

Cancer medicine

Avec: Hui-Jen Tsai , Hui-Hua Hsiao , Ya-Ting Hsu , Yi-Chang Liu , Hsiao-Wen Kao , Ta-Chih Liu , Shih-Feng Cho , Xiaoxing Feng , Amanda Johnston , Ming-Chung Kuo , Tsai-Yun Chen

Phase 1b study of pegylated arginine deiminase (ADI-PEG 20) plus Pembrolizumab in advanced solid cancers.

Oncoimmunology

Avec: Kwang-Yu Chang , Nai-Jung Chiang , Shang-Yin Wu , Chia-Jui Yen , Shang-Hung Chen , Yu-Min Yeh , Chien-Feng Li , Xiaoxing Feng , Katherine Wu , Amanda Johnston , Bor-Wen Wu , Jianjun Gao , Sumit K Subudhi , Ahmed O Kaseb , Jorge M Blando , Shalini S Yadav , Peter W Szlosarek , Li-Tzong Chen

Pegylated arginine deiminase drives arginine turnover and systemic autophagy to dictate energy metabolism.

Cell reports. Medicine

Avec: Yiming Zhang , Cassandra B Higgins , Brian A Van Tine , Brian J DeBosch

Discovery and Targeting of a Noncanonical Mechanism of Sarcoma Resistance to ADI-PEG20 Mediated by the Microenvironment.

Clinical cancer research : an official journal of the American Association for Cancer Research

Avec: Leonard C Rogers , Jeff C Kremer , Caitlyn B Brashears , Zongtao Lin , Zhixian Hu , Alliny C S Bastos , Adriana Baker , Nicole Fettig , Dong Zhou , Kooresh I Shoghi , Carina A Dehner , John S A Chrisinger , Benjamin A Garcia , Toshinao Oyama , Eileen P White , Brian A Van Tine

Arginine Deprivation/Citrulline Augmentation with ADI-PEG20 As Novel Therapy for Complications in Type 2 Diabetes.

Molecular metabolism

Avec: Ammar A Abdelrahman , Porsche V Sandow , Jing Wang , Zhimin Xu , Modesto Rojas , Tahira Lemtalsi , Ruth B Caldwell , Robert W Caldwell

Réseau de co-auteurs

Amanda Johnston 7 collaborations

Peter W Szlosarek 4 collaborations

Xiaoxing Feng 4 collaborations

Peter E Hall 2 collaborations

Michael Sheaff 2 collaborations

Chia-Jui Yen 2 collaborations

Stephen Ellis 2 collaborations

Bor-Wen Wu 2 collaborations

Brian A Van Tine 2 collaborations

Neal Ready 1 collaboration

Ralph R Venhaus 1 collaboration

Lee Krug 1 collaboration

Milind D Chalishazar 1 collaboration

Sarah J Wait 1 collaboration

Fang Huang 1 collaboration

Abbie S Ireland 1 collaboration

Anandaroop Mukhopadhyay 1 collaboration

Younjee Lee 1 collaboration

Sophia S Schuman 1 collaboration

Matthew R Guthrie 1 collaboration

Kristofer C Berrett 1 collaboration

Jeffery M Vahrenkamp 1 collaboration

Zeping Hu 1 collaboration

Marek Kudla 1 collaboration

Katarzyna Modzelewska 1 collaboration

Guoying Wang 1 collaboration

Nicholas T Ingolia 1 collaboration

Jason Gertz 1 collaboration

David H Lum 1 collaboration

Sabina C Cosulich 1 collaboration

Ralph J DeBerardinis 1 collaboration

Trudy G Oliver 1 collaboration

James J Harding 1 collaboration

Tsai-Sheng Yang 1 collaboration

Yen-Yang Chen 1 collaboration

Yin-Hsun Feng 1 collaboration

Ching-Liang Ho 1 collaboration

Wen-Tsung Huang 1 collaboration

Imane El Dika 1 collaboration

Mehmet Akce 1 collaboration

Benjamin Tan 1 collaboration

Stacey A Cohen 1 collaboration

Timothy Meyer 1 collaboration

Debashis Sarker 1 collaboration

Dae-Won Lee 1 collaboration

Baek-Yeol Ryoo 1 collaboration

Ho Yeong Lim 1 collaboration

Eileen M O'Reilly 1 collaboration

Shukui Qin 1 collaboration

Ghassan K Abou-Alfa 1 collaboration

Lukas Kraehenbuehl 1 collaboration

Aliya Holland 1 collaboration

Emma Armstrong 1 collaboration

Sirinya O'Shea 1 collaboration

Levi Mangarin 1 collaboration

Sara Chekalil 1 collaboration

Joseph P Erinjeri 1 collaboration

Christopher A Barker 1 collaboration

Jasmine H Francis 1 collaboration

Jedd D Wolchok 1 collaboration

Taha Merghoub 1 collaboration

Alexander N Shoushtari 1 collaboration

Pui Ying Chan 1 collaboration

Melissa M Phillips 1 collaboration

Amit Arora 1 collaboration

Gordon Hay 1 collaboration

Victoria M L Cohen 1 collaboration

Mandeep S Sagoo 1 collaboration

Michael T Sheaff 1 collaboration

Pankaj K Singh 1 collaboration

Amit A Deorukhkar 1 collaboration

Bhanu P Venkatesulu 1 collaboration

Xiaolin Li 1 collaboration

Ramesh Tailor 1 collaboration

Sunil Krishnan 1 collaboration

Rachel Lewis 1 collaboration

Nelofer Syed 1 collaboration

Richard Shaffer 1 collaboration

Jane Evanson 1 collaboration

Matthew Williams 1 collaboration

Jim A Thomson 1 collaboration

Fiona P Harris 1 collaboration

Raj Jena 1 collaboration

Tomasz Matys 1 collaboration

Sarah Jefferies 1 collaboration

Kate Smith 1 collaboration

Timothy Crook 1 collaboration

Kevin O'Neill 1 collaboration

Dimitris Paraskevopoulos 1 collaboration

Ramsay S Khadeir 1 collaboration

Simon Pacey 1 collaboration

Piers N Plowman 1 collaboration

Hui-Jen Tsai 1 collaboration

Hui-Hua Hsiao 1 collaboration

Ya-Ting Hsu 1 collaboration

Yi-Chang Liu 1 collaboration

Hsiao-Wen Kao 1 collaboration

Ta-Chih Liu 1 collaboration

Shih-Feng Cho 1 collaboration

Ming-Chung Kuo 1 collaboration

Tsai-Yun Chen 1 collaboration

Kwang-Yu Chang 1 collaboration

Nai-Jung Chiang 1 collaboration

Shang-Yin Wu 1 collaboration

Shang-Hung Chen 1 collaboration

Yu-Min Yeh 1 collaboration

Chien-Feng Li 1 collaboration

Katherine Wu 1 collaboration

Jianjun Gao 1 collaboration

Sumit K Subudhi 1 collaboration

Ahmed O Kaseb 1 collaboration

Jorge M Blando 1 collaboration

Shalini S Yadav 1 collaboration

Li-Tzong Chen 1 collaboration

Yiming Zhang 1 collaboration

Cassandra B Higgins 1 collaboration

Brian J DeBosch 1 collaboration

Leonard C Rogers 1 collaboration

Jeff C Kremer 1 collaboration

Caitlyn B Brashears 1 collaboration

Zongtao Lin 1 collaboration

Zhixian Hu 1 collaboration

Alliny C S Bastos 1 collaboration

Adriana Baker 1 collaboration

Nicole Fettig 1 collaboration

Dong Zhou 1 collaboration

Kooresh I Shoghi 1 collaboration

Carina A Dehner 1 collaboration

John S A Chrisinger 1 collaboration

Benjamin A Garcia 1 collaboration

Toshinao Oyama 1 collaboration

Eileen P White 1 collaboration

Ammar A Abdelrahman 1 collaboration

Porsche V Sandow 1 collaboration

Jing Wang 1 collaboration

Zhimin Xu 1 collaboration

Modesto Rojas 1 collaboration

Tahira Lemtalsi 1 collaboration

Ruth B Caldwell 1 collaboration

Robert W Caldwell 1 collaboration