John Anthony Porco

Publications (21)

Acylphloroglucinols with acetylcholinesterase inhibitory effects from the fruits of Eucalyptus robusta.

Bioorganic chemistry

Avec: Hui Liu , Xiao-Zhi He , Mi-Yan Feng , Yuan-Zeng , Tyler J Rauwolf , Li-Dong Shao , Wei Ni , Hui Yan , John A Porco , Xiao-Jiang Hao , Xu-Jie Qin , Hai-Yang Liu

An oxindole efflux inhibitor potentiates azoles and impairs virulence in the fungal pathogen Candida auris.

Nature communications

Avec: Kali R Iyer , Kaddy Camara , Martin Daniel-Ivad , Richard Trilles , Sheila M Pimentel-Elardo , Jen L Fossen , Karen Marchillo , Zhongle Liu , Shakti Singh , José F Muñoz , Sang Hu Kim , John A Porco , Christina A Cuomo , Noelle S Williams , Ashraf S Ibrahim , John E Edwards , David R Andes , Justin R Nodwell , Lauren E Brown , Luke Whitesell , Nicole Robbins , Leah E Cowen

Inhibition of translation initiation factor eIF4a inactivates heat shock factor 1 (HSF1) and exerts anti-leukemia activity in AML.

Leukemia

Avec: Yuki Nishida , Ran Zhao , Lauren E Heese , Hiroki Akiyama , Shreya Patel , Alex M Jaeger , Rodrigo O Jacamo , Kensuke Kojima , Man Chun John Ma , Vivian R Ruvolo , Dhruv Chachad , William Devine , Susan Lindquist , R Eric Davis , John A Porco , Luke Whitesell , Michael Andreeff , Jo Ishizawa

Inhibition of the Translation Initiation Factor eIF4A Enhances Tumor Cell Radiosensitivity.

Molecular cancer therapeutics

Avec: Stacey L Lehman , Theresa Wechsler , Kayla Schwartz , Lauren E Brown , John A Porco , William G Devine , Jerry Pelletier , Uma T Shankavaram , Kevin Camphausen , Philip J Tofilon

Identification of structurally re-engineered rocaglates as inhibitors against hepatitis E virus replication.

Antiviral research

Avec: Dimas F Praditya , Mara Klöhn , Yannick Brüggemann , Lauren E Brown , John A Porco , Wenhan Zhang , Volker Kinast , Andreas Kirschning , Florian W R Vondran , Daniel Todt , Eike Steinmann

Eukaryotic Translation Initiation Factor 4AI: A Potential Novel Target in Neuroblastoma.

Cells

Avec: Christina Skofler , Florian Kleinegger , Stefanie Krassnig , Anna Maria Birkl-Toeglhofer , Georg Singer , Holger Till , Martin Benesch , Regina Cencic , John A Porco , Jerry Pelletier , Christoph Castellani , Andrea Raicht , Ewa Izycka-Swieszewska , Piotr Czapiewski , Johannes Haybaeck

Regiodivergent Photocyclization of Dearomatized Acylphloroglucinols: Asymmetric Syntheses of (-)-Nemorosone and (-)-6-

Journal of the American Chemical Society

Avec: Saishuai Wen , Jonathan H Boyce , Sunil K Kandappa , Jayaraman Sivaguru , John A Porco

Targeting translation initiation by synthetic rocaglates for treating MYC-driven lymphomas.

Leukemia

Avec: Xuan Zhang , Chengfeng Bi , Ting Lu , Weiwei Zhang , Ting Yue , Cheng Wang , Tian Tian , Xiaoyan Zhang , Yuhua Huang , Matthew Lunning , Xinbao Hao , Lauren E Brown , William G Devine , Julie Vose , John A Porco , Kai Fu

Drug-induced Stress Granule Formation Protects Sensory Hair Cells in Mouse Cochlear Explants During Ototoxicity.

Scientific reports

Avec: Ana Cláudia Gonçalves , Emily R Towers , Naila Haq , John A Porco , Jerry Pelletier , Sally J Dawson , Jonathan E Gale

Amidino-Rocaglates: A Potent Class of eIF4A Inhibitors.

Cell chemical biology

Avec: Jennifer Chu , Wenhan Zhang , Regina Cencic , William G Devine , Dmitri Beglov , Thomas Henkel , Lauren E Brown , Sandor Vajda , John A Porco , Jerry Pelletier

Oxo-aglaiastatin-Mediated Inhibition of Translation Initiation.

Scientific reports

Avec: Rayelle Itoua Maïga , Regina Cencic , Jennifer Chu , Daniel D Waller , Lauren E Brown , William G Devine , Wenhan Zhang , Michael Sebag , John A Porco , Jerry Pelletier

Asymmetric Synthesis of Griffipavixanthone Employing a Chiral Phosphoric Acid-Catalyzed Cycloaddition.

Journal of the American Chemical Society

Avec: Michael J Smith , Kyle D Reichl , Randolph A Escobar , Thomas J Heavey , David F Coker , Scott E Schaus , John A Porco

Translation Inhibition by Rocaglates Activates a Species-Specific Cell Death Program in the Emerging Fungal Pathogen Candida auris.

mBio

Avec: Kali R Iyer , Luke Whitesell , John A Porco , Thomas Henkel , Lauren E Brown , Nicole Robbins , Leah E Cowen

Asymmetric Synthesis of Nidulalin A and Nidulaxanthone A: Selective Carbonyl Desaturation Using an Oxoammonium Salt.

Journal of the American Chemical Society

Avec: Kaijie Ji , Richard P Johnson , James McNeely , Md Al Faruk , John A Porco

Amidino-Rocaglates (ADRs), a class of synthetic rocaglates, are potent inhibitors of SARS-CoV-2 replication through inhibition of viral protein synthesis.

Antiviral research

Avec: Patrick T Keiser , Wenhan Zhang , Michael Ricca , Alan Wacquiez , Autumn Grimins , Regina Cencic , J J Patten , Pranav Shah , Elias Padilha , John H Connor , Jerry Pelletier , Shawn M Lyons , Mohsan Saeed , Lauren E Brown , John A Porco , Robert A Davey

BRCA mutational status shapes the stromal microenvironment of pancreatic cancer linking clusterin expression in cancer associated fibroblasts with HSF1 signaling.

Nature communications

Avec: Lee Shaashua , Aviad Ben-Shmuel , Meirav Pevsner-Fischer , Gil Friedman , Oshrat Levi-Galibov , Subhiksha Nandakumar , Debra Barki , Reinat Nevo , Lauren E Brown , Wenhan Zhang , Yaniv Stein , Chen Lior , Han Sang Kim , Linda Bojmar , William R Jarnagin , Nicolas Lecomte , Shimrit Mayer , Roni Stok , Hend Bishara , Rawand Hamodi , Ephrat Levy-Lahad , Talia Golan , John A Porco , Christine A Iacobuzio-Donahue , Nikolaus Schultz , David A Tuveson , David Lyden , David Kelsen , Ruth Scherz-Shouval

Synthesis of Neocannabinoids Using Controlled Friedel-Crafts Reactions.

The Journal of organic chemistry

Avec: Alexandra M Millimaci , Richard V Trilles , James H McNeely , Lauren E Brown , Aaron B Beeler , John A Porco

Tracing MYC Expression for Small Molecule Discovery.

Cell chemical biology

Avec: Jutta Steinberger , Francis Robert , Maxime Hallé , David E Williams , Regina Cencic , Neha Sawhney , Dylan Pelletier , Philip Williams , Yasuhiro Igarashi , John A Porco , Abimael D Rodriguez , Brigitte Kopp , Brian Bachmann , Raymond J Andersen , Jerry Pelletier

Discovery of Macrocyclic Inhibitors of Apurinic/Apyrimidinic Endonuclease 1.

Journal of medicinal chemistry

Avec: Richard Trilles , Dmitri Beglov , Qiujia Chen , Hongzhen He , Randall Wireman , April Reed , Spandan Chennamadhavuni , James S Panek , Lauren E Brown , Sandor Vajda , John A Porco , Mark R Kelley , Millie M Georgiadis

Rocaglates Induce Gain-of-Function Alterations to eIF4A and eIF4F.

Cell reports

Avec: Jennifer Chu , Wenhan Zhang , Regina Cencic , Patrick B F O'Connor , Francis Robert , William G Devine , Asher Selznick , Thomas Henkel , William C Merrick , Lauren E Brown , Pavel V Baranov , John A Porco , Jerry Pelletier

Biomimetic Synthesis of Meroterpenoids by Dearomatization-Driven Polycyclization.

Angewandte Chemie (International ed. in English)

Avec: Zachary Powers , Adam Scharf , Andrea Cheng , Feng Yang , Martin Himmelbauer , Takaaki Mitsuhashi , Lena Barra , Yoshimasa Taniguchi , Takashi Kikuchi , Makoto Fujita , Ikuro Abe , John A Porco

Réseau de co-auteurs

John A Porco 21 collaborations

Lauren E Brown 12 collaborations

Jerry Pelletier 8 collaborations

Wenhan Zhang 6 collaborations

Regina Cencic 6 collaborations

William G Devine 5 collaborations

Luke Whitesell 3 collaborations

Jennifer Chu 3 collaborations

Thomas Henkel 3 collaborations

Kali R Iyer 2 collaborations

Richard Trilles 2 collaborations

Nicole Robbins 2 collaborations

Leah E Cowen 2 collaborations

Dmitri Beglov 2 collaborations

Sandor Vajda 2 collaborations

Francis Robert 2 collaborations

Hui Liu 1 collaboration

Xiao-Zhi He 1 collaboration

Mi-Yan Feng 1 collaboration

None Yuan-Zeng 1 collaboration

Tyler J Rauwolf 1 collaboration

Li-Dong Shao 1 collaboration

Wei Ni 1 collaboration

Hui Yan 1 collaboration

Xiao-Jiang Hao 1 collaboration

Xu-Jie Qin 1 collaboration

Hai-Yang Liu 1 collaboration

Kaddy Camara 1 collaboration

Martin Daniel-Ivad 1 collaboration

Sheila M Pimentel-Elardo 1 collaboration

Jen L Fossen 1 collaboration

Karen Marchillo 1 collaboration

Zhongle Liu 1 collaboration

Shakti Singh 1 collaboration

José F Muñoz 1 collaboration

Sang Hu Kim 1 collaboration

Christina A Cuomo 1 collaboration

Noelle S Williams 1 collaboration

Ashraf S Ibrahim 1 collaboration

John E Edwards 1 collaboration

David R Andes 1 collaboration

Justin R Nodwell 1 collaboration

Yuki Nishida 1 collaboration

Ran Zhao 1 collaboration

Lauren E Heese 1 collaboration

Hiroki Akiyama 1 collaboration

Shreya Patel 1 collaboration

Alex M Jaeger 1 collaboration

Rodrigo O Jacamo 1 collaboration

Kensuke Kojima 1 collaboration

Man Chun John Ma 1 collaboration

Vivian R Ruvolo 1 collaboration

Dhruv Chachad 1 collaboration

William Devine 1 collaboration

Susan Lindquist 1 collaboration

R Eric Davis 1 collaboration

Michael Andreeff 1 collaboration

Jo Ishizawa 1 collaboration

Stacey L Lehman 1 collaboration

Theresa Wechsler 1 collaboration

Kayla Schwartz 1 collaboration

Uma T Shankavaram 1 collaboration

Kevin Camphausen 1 collaboration

Philip J Tofilon 1 collaboration

Dimas F Praditya 1 collaboration

Mara Klöhn 1 collaboration

Yannick Brüggemann 1 collaboration

Volker Kinast 1 collaboration

Andreas Kirschning 1 collaboration

Florian W R Vondran 1 collaboration

Daniel Todt 1 collaboration

Eike Steinmann 1 collaboration

Christina Skofler 1 collaboration

Florian Kleinegger 1 collaboration

Stefanie Krassnig 1 collaboration

Anna Maria Birkl-Toeglhofer 1 collaboration

Georg Singer 1 collaboration

Holger Till 1 collaboration

Martin Benesch 1 collaboration

Christoph Castellani 1 collaboration

Andrea Raicht 1 collaboration

Ewa Izycka-Swieszewska 1 collaboration

Piotr Czapiewski 1 collaboration

Johannes Haybaeck 1 collaboration

Saishuai Wen 1 collaboration

Jonathan H Boyce 1 collaboration

Sunil K Kandappa 1 collaboration

Jayaraman Sivaguru 1 collaboration

Xuan Zhang 1 collaboration

Chengfeng Bi 1 collaboration

Ting Lu 1 collaboration

Weiwei Zhang 1 collaboration

Ting Yue 1 collaboration

Cheng Wang 1 collaboration

Tian Tian 1 collaboration

Xiaoyan Zhang 1 collaboration

Yuhua Huang 1 collaboration

Matthew Lunning 1 collaboration

Xinbao Hao 1 collaboration

Julie Vose 1 collaboration

Kai Fu 1 collaboration

Ana Cláudia Gonçalves 1 collaboration

Emily R Towers 1 collaboration

Naila Haq 1 collaboration

Sally J Dawson 1 collaboration

Jonathan E Gale 1 collaboration

Rayelle Itoua Maïga 1 collaboration

Daniel D Waller 1 collaboration

Michael Sebag 1 collaboration

Michael J Smith 1 collaboration

Kyle D Reichl 1 collaboration

Randolph A Escobar 1 collaboration

Thomas J Heavey 1 collaboration

David F Coker 1 collaboration

Scott E Schaus 1 collaboration

Kaijie Ji 1 collaboration

Richard P Johnson 1 collaboration

James McNeely 1 collaboration

Md Al Faruk 1 collaboration

Patrick T Keiser 1 collaboration

Michael Ricca 1 collaboration

Alan Wacquiez 1 collaboration

Autumn Grimins 1 collaboration

J J Patten 1 collaboration

Pranav Shah 1 collaboration

Elias Padilha 1 collaboration

John H Connor 1 collaboration

Shawn M Lyons 1 collaboration

Mohsan Saeed 1 collaboration

Robert A Davey 1 collaboration

Lee Shaashua 1 collaboration

Aviad Ben-Shmuel 1 collaboration

Meirav Pevsner-Fischer 1 collaboration

Gil Friedman 1 collaboration

Oshrat Levi-Galibov 1 collaboration

Subhiksha Nandakumar 1 collaboration

Debra Barki 1 collaboration

Reinat Nevo 1 collaboration

Yaniv Stein 1 collaboration

Chen Lior 1 collaboration

Han Sang Kim 1 collaboration

Linda Bojmar 1 collaboration

William R Jarnagin 1 collaboration

Nicolas Lecomte 1 collaboration

Shimrit Mayer 1 collaboration

Roni Stok 1 collaboration

Hend Bishara 1 collaboration

Rawand Hamodi 1 collaboration

Ephrat Levy-Lahad 1 collaboration

Talia Golan 1 collaboration

Christine A Iacobuzio-Donahue 1 collaboration

Nikolaus Schultz 1 collaboration

David A Tuveson 1 collaboration

David Lyden 1 collaboration

David Kelsen 1 collaboration

Ruth Scherz-Shouval 1 collaboration

Alexandra M Millimaci 1 collaboration

Richard V Trilles 1 collaboration

James H McNeely 1 collaboration

Aaron B Beeler 1 collaboration

Jutta Steinberger 1 collaboration

Maxime Hallé 1 collaboration

David E Williams 1 collaboration

Neha Sawhney 1 collaboration

Dylan Pelletier 1 collaboration

Philip Williams 1 collaboration

Yasuhiro Igarashi 1 collaboration

Abimael D Rodriguez 1 collaboration

Brigitte Kopp 1 collaboration

Brian Bachmann 1 collaboration

Raymond J Andersen 1 collaboration

Qiujia Chen 1 collaboration

Hongzhen He 1 collaboration

Randall Wireman 1 collaboration

April Reed 1 collaboration

Spandan Chennamadhavuni 1 collaboration

James S Panek 1 collaboration

Mark R Kelley 1 collaboration

Millie M Georgiadis 1 collaboration

Patrick B F O'Connor 1 collaboration

Asher Selznick 1 collaboration

William C Merrick 1 collaboration

Pavel V Baranov 1 collaboration

Zachary Powers 1 collaboration

Adam Scharf 1 collaboration

Andrea Cheng 1 collaboration

Feng Yang 1 collaboration

Martin Himmelbauer 1 collaboration

Takaaki Mitsuhashi 1 collaboration

Lena Barra 1 collaboration

Yoshimasa Taniguchi 1 collaboration

Takashi Kikuchi 1 collaboration

Makoto Fujita 1 collaboration

Ikuro Abe 1 collaboration