From the Department of Neurology (A.D.L., K.R.P., J.J., D.B.H., C.S.J., M.B.W., A.J.C., S.S.C.), Massachusetts General Hospital; Department of Neurology (R.A.S., B.A.D., J.W.L., D.S.W.), Brigham and Women's Hospital, Boston, MA; and Department of Neurology and Neurotherapeutics (R.Z.), UT Southwestern Medical Center, Dallas, TX.