Association of epileptiform abnormalities and seizures in Alzheimer disease.

Aged Alzheimer Disease / epidemiology Biomarkers Cross-Sectional Studies Electroencephalography Epilepsy / epidemiology Female Humans Male Risk Factors Seizures / epidemiology

Journal

Neurology
ISSN: 1526-632X
Titre abrégé: Neurology
Pays: United States
ID NLM: 0401060

Informations de publication

Date de publication:
20 10 2020
Historique:
received: 18 11 2019
accepted: 14 05 2020
pubmed: 9 8 2020
medline: 18 11 2020
entrez: 9 8 2020
Statut: ppublish

Résumé

To examine the relationship between scalp EEG biomarkers of hyperexcitability in Alzheimer disease (AD) and to determine how these electric biomarkers relate to the clinical expression of seizures in AD. In this cross-sectional study, we performed 24-hour ambulatory scalp EEGs on 43 cognitively normal elderly healthy controls (HC), 41 participants with early-stage AD with no history or risk factors for epilepsy (AD-NoEp), and 15 participants with early-stage AD with late-onset epilepsy related to AD (AD-Ep). Two epileptologists blinded to diagnosis visually reviewed all EEGs and annotated all potential epileptiform abnormalities. A panel of 9 epileptologists blinded to diagnosis was then surveyed to generate a consensus interpretation of epileptiform abnormalities in each EEG. Epileptiform abnormalities were seen in 53% of AD-Ep, 22% of AD-NoEp, and 4.7% of HC. Specific features of epileptiform discharges, including high frequency, robust morphology, right temporal location, and occurrence during wakefulness and REM, were associated with clinical seizures in AD. Multiple EEG biomarkers concordantly demonstrated a pattern of left temporal lobe hyperexcitability in early stages of AD, whereas clinical seizures in AD were often associated with bitemporal hyperexcitability. Frequent small sharp spikes were specifically associated with epileptiform EEGs and thus identified as a potential biomarker of hyperexcitability in AD. Epileptiform abnormalities are common in AD but not all equivalent. Specific features of epileptiform discharges are associated with clinical seizures in AD. Given the difficulty recognizing clinical seizures in AD, these EEG features could provide guidance on which patients with AD are at high risk for clinical seizures.

Identifiants

DOI: 10.1212/WNL.0000000000010612 PMID: 32764101 PMC: PMC7713786
pubmed: 32764101
pii: WNL.0000000000010612
doi: 10.1212/WNL.0000000000010612
pmc: PMC7713786
doi:

Substances chimiques

Biomarkers 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2259-e2270

Subventions

Organisme : NINDS NIH HHS
ID : R01 NS062092
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS102190
Pays : United States
Organisme : NIA NIH HHS
ID : P30 AG062421
Pays : United States
Organisme : NINDS NIH HHS
ID : K23 NS090900
Pays : United States
Organisme : NINDS NIH HHS
ID : K23 NS101037
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS102574
Pays : United States
Organisme : NINDS NIH HHS
ID : R25 NS065743
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS107291
Pays : United States
Organisme : NINDS NIH HHS
ID : K24 NS088568
Pays : United States

Commentaires et corrections

Type : CommentIn

Informations de copyright

© 2020 American Academy of Neurology.

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Auteurs

Alice D Lam (AD)

From the Department of Neurology (A.D.L., K.R.P., J.J., D.B.H., C.S.J., M.B.W., A.J.C., S.S.C.), Massachusetts General Hospital; Department of Neurology (R.A.S., B.A.D., J.W.L., D.S.W.), Brigham and Women's Hospital, Boston, MA; and Department of Neurology and Neurotherapeutics (R.Z.), UT Southwestern Medical Center, Dallas, TX. Lam.Alice@mgh.harvard.edu.

Rani A Sarkis (RA)

From the Department of Neurology (A.D.L., K.R.P., J.J., D.B.H., C.S.J., M.B.W., A.J.C., S.S.C.), Massachusetts General Hospital; Department of Neurology (R.A.S., B.A.D., J.W.L., D.S.W.), Brigham and Women's Hospital, Boston, MA; and Department of Neurology and Neurotherapeutics (R.Z.), UT Southwestern Medical Center, Dallas, TX.
ORCID: 0000-0001-8291-7864

Kyle R Pellerin (KR)

From the Department of Neurology (A.D.L., K.R.P., J.J., D.B.H., C.S.J., M.B.W., A.J.C., S.S.C.), Massachusetts General Hospital; Department of Neurology (R.A.S., B.A.D., J.W.L., D.S.W.), Brigham and Women's Hospital, Boston, MA; and Department of Neurology and Neurotherapeutics (R.Z.), UT Southwestern Medical Center, Dallas, TX.

Jin Jing (J)

From the Department of Neurology (A.D.L., K.R.P., J.J., D.B.H., C.S.J., M.B.W., A.J.C., S.S.C.), Massachusetts General Hospital; Department of Neurology (R.A.S., B.A.D., J.W.L., D.S.W.), Brigham and Women's Hospital, Boston, MA; and Department of Neurology and Neurotherapeutics (R.Z.), UT Southwestern Medical Center, Dallas, TX.

Barbara A Dworetzky (BA)

From the Department of Neurology (A.D.L., K.R.P., J.J., D.B.H., C.S.J., M.B.W., A.J.C., S.S.C.), Massachusetts General Hospital; Department of Neurology (R.A.S., B.A.D., J.W.L., D.S.W.), Brigham and Women's Hospital, Boston, MA; and Department of Neurology and Neurotherapeutics (R.Z.), UT Southwestern Medical Center, Dallas, TX.

Daniel B Hoch (DB)

From the Department of Neurology (A.D.L., K.R.P., J.J., D.B.H., C.S.J., M.B.W., A.J.C., S.S.C.), Massachusetts General Hospital; Department of Neurology (R.A.S., B.A.D., J.W.L., D.S.W.), Brigham and Women's Hospital, Boston, MA; and Department of Neurology and Neurotherapeutics (R.Z.), UT Southwestern Medical Center, Dallas, TX.

Claire S Jacobs (CS)

From the Department of Neurology (A.D.L., K.R.P., J.J., D.B.H., C.S.J., M.B.W., A.J.C., S.S.C.), Massachusetts General Hospital; Department of Neurology (R.A.S., B.A.D., J.W.L., D.S.W.), Brigham and Women's Hospital, Boston, MA; and Department of Neurology and Neurotherapeutics (R.Z.), UT Southwestern Medical Center, Dallas, TX.
ORCID: 0000-0003-2064-2249

Jong Woo Lee (JW)

From the Department of Neurology (A.D.L., K.R.P., J.J., D.B.H., C.S.J., M.B.W., A.J.C., S.S.C.), Massachusetts General Hospital; Department of Neurology (R.A.S., B.A.D., J.W.L., D.S.W.), Brigham and Women's Hospital, Boston, MA; and Department of Neurology and Neurotherapeutics (R.Z.), UT Southwestern Medical Center, Dallas, TX.

Daniel S Weisholtz (DS)

From the Department of Neurology (A.D.L., K.R.P., J.J., D.B.H., C.S.J., M.B.W., A.J.C., S.S.C.), Massachusetts General Hospital; Department of Neurology (R.A.S., B.A.D., J.W.L., D.S.W.), Brigham and Women's Hospital, Boston, MA; and Department of Neurology and Neurotherapeutics (R.Z.), UT Southwestern Medical Center, Dallas, TX.

Rodrigo Zepeda (R)

From the Department of Neurology (A.D.L., K.R.P., J.J., D.B.H., C.S.J., M.B.W., A.J.C., S.S.C.), Massachusetts General Hospital; Department of Neurology (R.A.S., B.A.D., J.W.L., D.S.W.), Brigham and Women's Hospital, Boston, MA; and Department of Neurology and Neurotherapeutics (R.Z.), UT Southwestern Medical Center, Dallas, TX.

M Brandon Westover (MB)

From the Department of Neurology (A.D.L., K.R.P., J.J., D.B.H., C.S.J., M.B.W., A.J.C., S.S.C.), Massachusetts General Hospital; Department of Neurology (R.A.S., B.A.D., J.W.L., D.S.W.), Brigham and Women's Hospital, Boston, MA; and Department of Neurology and Neurotherapeutics (R.Z.), UT Southwestern Medical Center, Dallas, TX.
ORCID: 0000-0003-4803-312X

Andrew J Cole (AJ)

From the Department of Neurology (A.D.L., K.R.P., J.J., D.B.H., C.S.J., M.B.W., A.J.C., S.S.C.), Massachusetts General Hospital; Department of Neurology (R.A.S., B.A.D., J.W.L., D.S.W.), Brigham and Women's Hospital, Boston, MA; and Department of Neurology and Neurotherapeutics (R.Z.), UT Southwestern Medical Center, Dallas, TX.

Sydney S Cash (SS)

From the Department of Neurology (A.D.L., K.R.P., J.J., D.B.H., C.S.J., M.B.W., A.J.C., S.S.C.), Massachusetts General Hospital; Department of Neurology (R.A.S., B.A.D., J.W.L., D.S.W.), Brigham and Women's Hospital, Boston, MA; and Department of Neurology and Neurotherapeutics (R.Z.), UT Southwestern Medical Center, Dallas, TX.
ORCID: 0000-0002-4557-6391

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Classifications MeSH

Recherchemedicale.com › Personnes › Tranches d'âge › Adulte › Sujet âgé › Association of epileptiform abnormalities and...
Recherchemedicale.com › Troubles mentaux › Troubles neurocognitifs › Démence › Maladie d'Alzheimer › Association of epileptiform abnormalities and...
Recherchemedicale.com › Facteurs biologiques › Marqueurs biologiques › Association of epileptiform abnormalities and...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études transversales › Association of epileptiform abnormalities and...
Recherchemedicale.com › Diagnostic › Techniques et procédures diagnostiques › Électrodiagnostic › Électroencéphalographie › Association of epileptiform abnormalities and...
Recherchemedicale.com › Maladies du système nerveux › Maladies du système nerveux central › Encéphalopathies › Épilepsie › Association of epileptiform abnormalities and...
Recherchemedicale.com › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Association of epileptiform abnormalities and...
Recherchemedicale.com › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Risque › Facteurs de risque › Association of epileptiform abnormalities and...
Recherchemedicale.com › États, signes et symptômes pathologiques › Signes et symptômes › Manifestations neurologiques › Crises épileptiques › Association of epileptiform abnormalities and...