Bernadeta Dadonaite

Affiliations

Basic Sciences Division and Computational Biology Program, Fred Hutchinson Cancer Center, Seattle, Washington, 98109, USA.

Publications (24)

Mapping the neutralizing specificity of human anti-HIV serum by deep mutational scanning.

bioRxiv : the preprint server for biology

Avec: Caelan E Radford , Philipp Schommers , Lutz Gieselmann , Katharine H D Crawford , Timothy C Yu , Adam S Dingens , Julie Overbaugh , Florian Klein , Jesse D Bloom

Receptor-Binding Domain (RBD) Antibodies Contribute More to SARS-CoV-2 Neutralization When Target Cells Express High Levels of ACE2.

Viruses

Avec: Ariana Ghez Farrell , Allison J Greaney , Rachel Eguia , Andrea N Loes , Nicholas M Franko , Jennifer Logue , Juan Manuel Carreño , Anass Abbad , Helen Y Chu , Kenneth A Matreyek , Jesse D Bloom

Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection.

bioRxiv : the preprint server for biology

Avec: Jamie Guenthoer , Michelle Lilly , Tyler N Starr , Klaus N Lovendahl , Jacob T Croft , Caitlin I Stoddard , Vrasha Chohan , Shilei Ding , Felicitas Ruiz , Mackenzie S Kopp , Andr S Finzi , Jesse D Bloom , Helen Y Chu , Kelly K Lee , Julie Overbaugh

A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike.

Cell

Avec: Katharine H D Crawford , Caelan E Radford , Ariana G Farrell , Timothy C Yu , William W Hannon , Panpan Zhou , Raiees Andrabi , Dennis R Burton , Lihong Liu , David D Ho , Helen Y Chu , Richard A Neher , Jesse D Bloom

Mapping the neutralizing specificity of human anti-HIV serum by deep mutational scanning.

Cell host & microbe

Avec: Caelan E Radford , Philipp Schommers , Lutz Gieselmann , Katharine H D Crawford , Timothy C Yu , Adam S Dingens , Julie Overbaugh , Florian Klein , Jesse D Bloom

Bispecific antibodies with broad neutralization potency against SARS-CoV-2 variants of concern.

bioRxiv : the preprint server for biology

Avec: Adonis A Rubio , Viren A Baharani , Megan Parada , Morgan E Abernathy , Zijun Wang , Yu E Lee , Michael R Eso , Jennie Phung , Israel Ramos , Teresia Chen , Gina El Nesr , Jesse D Bloom , Paul D Bieniasz , Michel C Nussenzweig , Christopher O Barnes

Computationally restoring the potency of a clinical antibody against Omicron.

Nature

Avec: Thomas A Desautels , Kathryn T Arrildt , Adam T Zemla , Edmond Y Lau , Fangqiang Zhu , Dante Ricci , Stephanie Cronin , Seth J Zost , Elad Binshtein , Suzanne M Scheaffer , Brenden K Petersen , Taylor B Engdahl , Elaine Chen , Laura S Handal , Lynn Hall , John W Goforth , Denis Vashchenko , Sam Nguyen , Dina R Weilhammer , Jacky Kai-Yin Lo , Bonnee Rubinfeld , Edwin A Saada , Tracy Weisenberger , Tek-Hyung Lee , Bradley Whitener , James B Case , Alexander Ladd , Mary S Silva , Rebecca M Haluska , Emilia A Grzesiak , Christopher G Earnhart , Svetlana Hopkins , Thomas W Bates , Larissa B Thackray , Brent W Segelke , Auteur inconnu , Antonietta Maria Lillo , Shivshankar Sundaram , Jesse D Bloom , Michael S Diamond , James E Crowe , Robert H Carnahan , Daniel M Faissol

Identification of broad, potent antibodies to functionally constrained regions of SARS-CoV-2 spike following a breakthrough infection.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Jamie Guenthoer , Michelle Lilly , Tyler N Starr , Klaus N Lovendahl , Jacob T Croft , Caitlin I Stoddard , Vrasha Chohan , Shilei Ding , Felicitas Ruiz , Mackenzie S Kopp , Andrés Finzi , Jesse D Bloom , Helen Y Chu , Kelly K Lee , Julie Overbaugh

Influenza virus transcription and progeny production are poorly correlated in single cells.

eLife

Avec: David J Bacsik , Andrew Butler , Allison J Greaney , Nicholas S Heaton , Jesse D Bloom

Jointly modeling deep mutational scans identifies shifted mutational effects among SARS-CoV-2 spike homologs.

bioRxiv : the preprint server for biology

Avec: Hugh K Haddox , Jared G Galloway , Jesse D Bloom , Frederick A Matsen Iv , William S DeWitt

Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination.

Cell reports. Medicine

Avec: William N Voss , Michael A Mallory , Patrick O Byrne , Jeffrey M Marchioni , Sean A Knudson , John M Powers , Sarah R Leist , Douglas R Townsend , Jessica Kain , Yimin Huang , Ed Satterwhite , Izabella N Castillo , Melissa Mattocks , Chelsea Paresi , Jennifer E Munt , Trevor Scobey , Allison Seeger , Lakshmanane Premkumar , Jesse D Bloom , George Georgiou , Jason S McLellan , Ralph S Baric , Jason J Lavinder , Gregory C Ippolito

Human Antibodies that Slow Erythrocyte Invasion Potentiate Malaria-Neutralizing Antibodies.

Cell

Avec: Daniel G W Alanine , Doris Quinkert , Rasika Kumarasingha , Shahid Mehmood , Francesca R Donnellan , Nana K Minkah , Ababacar Diouf , Francis Galaway , Sarah E Silk , Abhishek Jamwal , Jennifer M Marshall , Kazutoyo Miura , Lander Foquet , Sean C Elias , Geneviève M Labbé , Alexander D Douglas , Jing Jin , Ruth O Payne , Joseph J Illingworth , David J Pattinson , David Pulido , Barnabas G Williams , Willem A de Jongh , Gavin J Wright , Stefan H I Kappe , Carol V Robinson , Carole A Long , Brendan S Crabb , Paul R Gilson , Matthew K Higgins , Simon J Draper

Antibodies that neutralize all current SARS-CoV-2 variants of concern by conformational locking.

bioRxiv : the preprint server for biology

Avec: Lihong Liu , Ryan G Casner , Yicheng Guo , Qian Wang , Sho Iketani , Jasper Fuk-Woo Chan , Jian Yu , Manoj S Nair , Hiroshi Mohri , Eswar R Reddem , Shuofeng Yuan , Vincent Kwok-Man Poon , Chris Chung-Sing Chan , Kwok-Yung Yuen , Zizhang Sheng , Yaoxing Huang , Jesse D Bloom , Lawrence Shapiro , David D Ho

A pseudovirus system enables deep mutational scanning of the full SARS-CoV-2 spike.

bioRxiv : the preprint server for biology

Avec: Katharine H D Crawford , Caelan E Radford , Ariana G Farrell , Timothy C Yu , William W Hannon , Panpan Zhou , Raiees Andrabi , Dennis R Burton , Lihong Liu , David D Ho , Richard A Neher , Jesse D Bloom

Computationally restoring the potency of a clinical antibody against SARS-CoV-2 Omicron subvariants.

bioRxiv : the preprint server for biology

Avec: Thomas A Desautels , Kathryn T Arrildt , Adam T Zemla , Edmond Y Lau , Fangqiang Zhu , Dante Ricci , Stephanie Cronin , Seth J Zost , Elad Binshtein , Suzanne M Scheaffer , Brenden K Petersen , Taylor B Engdahl , Elaine Chen , Laura S Handal , Lynn Hall , John W Goforth , Denis Vashchenko , Sam Nguyen , Dina R Weilhammer , Jacky Kai-Yin Lo , Bonnee Rubinfeld , Edwin A Saada , Tracy Weisenberger , Tek-Hyung Lee , Bradley Whitener , James B Case , Alexander Ladd , Mary S Silva , Rebecca M Haluska , Emilia A Grzesiak , Christopher G Earnhart , Svetlana Hopkins , Thomas W Bates , Larissa B Thackray , Brent W Segelke , Antonietta Maria Lillo , Shivshankar Sundaram , Jesse Bloom , Michael S Diamond , James E Crowe , Robert H Carnahan , Daniel M Faissol

Antibodies targeting a quaternary site on SARS-CoV-2 spike glycoprotein prevent viral receptor engagement by conformational locking.

Immunity

Spike deep mutational scanning helps predict success of SARS-CoV-2 clades.

Nature

Avec: Jack Brown , Teagan E McMahon , Ariana G Farrell , Marlin D Figgins , Daniel Asarnow , Cameron Stewart , Jimin Lee , Jenni Logue , Trevor Bedford , Ben Murrell , Helen Y Chu , David Veesler , Jesse D Bloom

The structure of the influenza A virus genome.

Nature microbiology

Avec: Brad Gilbertson , Michael L Knight , Sanja Trifkovic , Steven Rockman , Alain Laederach , Lorena E Brown , Ervin Fodor , David L V Bauer

SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.

Cell reports

Avec: Tamara Davenne , Jenny Klintman , Sushma Sharma , Rachel E Rigby , Henry T W Blest , Chiara Cursi , Anne Bridgeman , Kim De Keersmaecker , Peter Hillmen , Andrei Chabes , Anna Schuh , Jan Rehwinkel

Shifting mutational constraints in the SARS-CoV-2 receptor-binding domain during viral evolution.

Science (New York, N.Y.)

Avec: Tyler N Starr , Allison J Greaney , William W Hannon , Andrea N Loes , Kevin Hauser , Josh R Dillen , Elena Ferri , Ariana Ghez Farrell , Matthew McCallum , Kenneth A Matreyek , Davide Corti , David Veesler , Gyorgy Snell , Jesse D Bloom

Deep mutational scanning of H5 hemagglutinin to inform influenza virus surveillance.

bioRxiv : the preprint server for biology

Avec: Jenny J Ahn , Jordan T Ort , Jin Yu , Colleen Furey , Annie Dosey , William W Hannon , Amy Vincent Baker , Richard J Webby , Neil P King , Yan Liu , Scott E Hensley , Thomas P Peacock , Louise H Moncla , Jesse D Bloom

Receptor binding domain (RBD) antibodies contribute more to SARS-CoV-2 neutralization when target cells express high levels of ACE2.

bioRxiv : the preprint server for biology

Full-spike deep mutational scanning helps predict the evolutionary success of SARS-CoV-2 clades.

bioRxiv : the preprint server for biology

Avec: Jack Brown , Teagan E McMahon , Ariana G Farrell , Daniel Asarnow , Cameron Stewart , Jenni Logue , Ben Murrell , Helen Y Chu , David Veesler , Jesse D Bloom

Hybrid immunity to SARS-CoV-2 arises from serological recall of IgG antibodies distinctly imprinted by infection or vaccination.

bioRxiv : the preprint server for biology

Réseau de co-auteurs

Jesse D Bloom 20 collaborations

Helen Y Chu 7 collaborations

Caelan E Radford 4 collaborations

Katharine H D Crawford 4 collaborations

Timothy C Yu 4 collaborations

Julie Overbaugh 4 collaborations

Allison J Greaney 4 collaborations

Ariana G Farrell 4 collaborations

William W Hannon 4 collaborations

Lihong Liu 4 collaborations

David D Ho 4 collaborations

Ariana Ghez Farrell 3 collaborations

Andrea N Loes 3 collaborations

Kenneth A Matreyek 3 collaborations

Tyler N Starr 3 collaborations

David Veesler 3 collaborations

Philipp Schommers 2 collaborations

Lutz Gieselmann 2 collaborations

Adam S Dingens 2 collaborations

Florian Klein 2 collaborations

Rachel Eguia 2 collaborations

Nicholas M Franko 2 collaborations

Jennifer Logue 2 collaborations

Juan Manuel Carreño 2 collaborations

Anass Abbad 2 collaborations

Jamie Guenthoer 2 collaborations

Michelle Lilly 2 collaborations

Klaus N Lovendahl 2 collaborations

Jacob T Croft 2 collaborations

Caitlin I Stoddard 2 collaborations

Vrasha Chohan 2 collaborations

Shilei Ding 2 collaborations

Felicitas Ruiz 2 collaborations

Mackenzie S Kopp 2 collaborations

Kelly K Lee 2 collaborations

Panpan Zhou 2 collaborations

Raiees Andrabi 2 collaborations

Dennis R Burton 2 collaborations

Richard A Neher 2 collaborations

Thomas A Desautels 2 collaborations

Kathryn T Arrildt 2 collaborations

Adam T Zemla 2 collaborations

Edmond Y Lau 2 collaborations

Fangqiang Zhu 2 collaborations

Dante Ricci 2 collaborations

Stephanie Cronin 2 collaborations

Seth J Zost 2 collaborations

Elad Binshtein 2 collaborations

Suzanne M Scheaffer 2 collaborations

Brenden K Petersen 2 collaborations

Taylor B Engdahl 2 collaborations

Elaine Chen 2 collaborations

Laura S Handal 2 collaborations

Lynn Hall 2 collaborations

John W Goforth 2 collaborations

Denis Vashchenko 2 collaborations

Sam Nguyen 2 collaborations

Dina R Weilhammer 2 collaborations

Jacky Kai-Yin Lo 2 collaborations

Bonnee Rubinfeld 2 collaborations

Edwin A Saada 2 collaborations

Tracy Weisenberger 2 collaborations

Tek-Hyung Lee 2 collaborations

Bradley Whitener 2 collaborations

James B Case 2 collaborations

Alexander Ladd 2 collaborations

Mary S Silva 2 collaborations

Rebecca M Haluska 2 collaborations

Emilia A Grzesiak 2 collaborations

Christopher G Earnhart 2 collaborations

Svetlana Hopkins 2 collaborations

Thomas W Bates 2 collaborations

Larissa B Thackray 2 collaborations

Brent W Segelke 2 collaborations

Antonietta Maria Lillo 2 collaborations

Shivshankar Sundaram 2 collaborations

Michael S Diamond 2 collaborations

James E Crowe 2 collaborations

Robert H Carnahan 2 collaborations

Daniel M Faissol 2 collaborations

William N Voss 2 collaborations

Michael A Mallory 2 collaborations

Patrick O Byrne 2 collaborations

Jeffrey M Marchioni 2 collaborations

Sean A Knudson 2 collaborations

John M Powers 2 collaborations

Sarah R Leist 2 collaborations

Douglas R Townsend 2 collaborations

Jessica Kain 2 collaborations

Yimin Huang 2 collaborations

Ed Satterwhite 2 collaborations

Izabella N Castillo 2 collaborations

Melissa Mattocks 2 collaborations

Chelsea Paresi 2 collaborations

Jennifer E Munt 2 collaborations

Trevor Scobey 2 collaborations

Allison Seeger 2 collaborations

Lakshmanane Premkumar 2 collaborations

George Georgiou 2 collaborations

Jason S McLellan 2 collaborations

Ralph S Baric 2 collaborations

Jason J Lavinder 2 collaborations

Gregory C Ippolito 2 collaborations

Ryan G Casner 2 collaborations

Yicheng Guo 2 collaborations

Qian Wang 2 collaborations

Sho Iketani 2 collaborations

Jasper Fuk-Woo Chan 2 collaborations

Jian Yu 2 collaborations

Manoj S Nair 2 collaborations

Hiroshi Mohri 2 collaborations

Eswar R Reddem 2 collaborations

Shuofeng Yuan 2 collaborations

Vincent Kwok-Man Poon 2 collaborations

Chris Chung-Sing Chan 2 collaborations

Kwok-Yung Yuen 2 collaborations

Zizhang Sheng 2 collaborations

Yaoxing Huang 2 collaborations

Lawrence Shapiro 2 collaborations

Jack Brown 2 collaborations

Teagan E McMahon 2 collaborations

Daniel Asarnow 2 collaborations

Cameron Stewart 2 collaborations

Jenni Logue 2 collaborations

Ben Murrell 2 collaborations

Andr S Finzi 1 collaboration

Adonis A Rubio 1 collaboration

Viren A Baharani 1 collaboration

Megan Parada 1 collaboration

Morgan E Abernathy 1 collaboration

Zijun Wang 1 collaboration

Yu E Lee 1 collaboration

Michael R Eso 1 collaboration

Jennie Phung 1 collaboration

Israel Ramos 1 collaboration

Teresia Chen 1 collaboration

Gina El Nesr 1 collaboration

Paul D Bieniasz 1 collaboration

Michel C Nussenzweig 1 collaboration

Christopher O Barnes 1 collaboration

None None 1 collaboration

Andrés Finzi 1 collaboration

David J Bacsik 1 collaboration

Andrew Butler 1 collaboration

Nicholas S Heaton 1 collaboration

Hugh K Haddox 1 collaboration

Jared G Galloway 1 collaboration

Frederick A Matsen Iv 1 collaboration

William S DeWitt 1 collaboration

Daniel G W Alanine 1 collaboration

Doris Quinkert 1 collaboration

Rasika Kumarasingha 1 collaboration

Shahid Mehmood 1 collaboration

Francesca R Donnellan 1 collaboration

Nana K Minkah 1 collaboration

Ababacar Diouf 1 collaboration

Francis Galaway 1 collaboration

Sarah E Silk 1 collaboration

Abhishek Jamwal 1 collaboration

Jennifer M Marshall 1 collaboration

Kazutoyo Miura 1 collaboration

Lander Foquet 1 collaboration

Sean C Elias 1 collaboration

Geneviève M Labbé 1 collaboration

Alexander D Douglas 1 collaboration

Jing Jin 1 collaboration

Ruth O Payne 1 collaboration

Joseph J Illingworth 1 collaboration

David J Pattinson 1 collaboration

David Pulido 1 collaboration

Barnabas G Williams 1 collaboration

Willem A de Jongh 1 collaboration

Gavin J Wright 1 collaboration

Stefan H I Kappe 1 collaboration

Carol V Robinson 1 collaboration

Carole A Long 1 collaboration

Brendan S Crabb 1 collaboration

Paul R Gilson 1 collaboration

Matthew K Higgins 1 collaboration

Simon J Draper 1 collaboration

Jesse Bloom 1 collaboration

Marlin D Figgins 1 collaboration

Jimin Lee 1 collaboration

Trevor Bedford 1 collaboration

Brad Gilbertson 1 collaboration

Michael L Knight 1 collaboration

Sanja Trifkovic 1 collaboration

Steven Rockman 1 collaboration

Alain Laederach 1 collaboration

Lorena E Brown 1 collaboration

Ervin Fodor 1 collaboration

David L V Bauer 1 collaboration

Tamara Davenne 1 collaboration

Jenny Klintman 1 collaboration

Sushma Sharma 1 collaboration

Rachel E Rigby 1 collaboration

Henry T W Blest 1 collaboration

Chiara Cursi 1 collaboration

Anne Bridgeman 1 collaboration

Kim De Keersmaecker 1 collaboration

Peter Hillmen 1 collaboration

Andrei Chabes 1 collaboration

Anna Schuh 1 collaboration

Jan Rehwinkel 1 collaboration

Kevin Hauser 1 collaboration

Josh R Dillen 1 collaboration

Elena Ferri 1 collaboration

Matthew McCallum 1 collaboration

Davide Corti 1 collaboration

Gyorgy Snell 1 collaboration

Jenny J Ahn 1 collaboration

Jordan T Ort 1 collaboration

Jin Yu 1 collaboration

Colleen Furey 1 collaboration

Annie Dosey 1 collaboration

Amy Vincent Baker 1 collaboration

Richard J Webby 1 collaboration

Neil P King 1 collaboration

Yan Liu 1 collaboration

Scott E Hensley 1 collaboration

Thomas P Peacock 1 collaboration

Louise H Moncla 1 collaboration