Andrei Chabes

Affiliations

Department of Medical Biochemistry and Biophysics, Umeå University, 901 87 Umeå, Sweden; paulina.wanrooij@umu.se andrei.chabes@umu.se.
Laboratory for Molecular Infection Medicine Sweden (MIMS), Umeå University, 901 87 Umeå, Sweden.

Publications (22)

Elimination of rNMPs from mitochondrial DNA has no effect on its stability.

Proceedings of the National Academy of Sciences of the United States of America

Avec: Paulina H Wanrooij , Phong Tran , Liam J Thompson , Gustavo Carvalho , Sushma Sharma , Katrin Kreisel , Clara Navarrete , Anna-Lena Feldberg , Danielle L Watt , Anna Karin Nilsson , Martin K M Engqvist , Anders R Clausen ,

A recurrent cancer-associated substitution in DNA polymerase ε produces a hyperactive enzyme.

Nature communications

Avec: Xuanxuan Xing , Daniel P Kane , Chelsea R Bulock , Elizabeth A Moore , Sushma Sharma , Polina V Shcherbakova

Altered dNTP pools accelerate tumor formation in mice.

Nucleic acids research

Avec: Phong Tran , Pradeep Mishra , Leonard G Williams , Roman Moskalenko , Sushma Sharma , Anna Karin Nilsson , Danielle L Watt , Pernilla Andersson , Anders Bergh , Zachary F Pursell ,

NME6: ribonucleotide salvage sustains mitochondrial transcription.

The EMBO journal

Avec: Paulina H Wanrooij ,

Impairment of the non-catalytic subunit Dpb2 of DNA Pol ɛ results in increased involvement of Pol δ on the leading strand.

DNA repair

Avec: Michal Dmowski , Karolina Makiela-Dzbenska , Sushma Sharma , Iwona J Fijalkowska

Quantitative Analysis of Nucleoside Triphosphate Pools in Mouse Muscle Using Hydrophilic Interaction Liquid Chromatography Coupled with Tandem Mass Spectrometry Detection.

Methods in molecular biology (Clifton, N.J.)

Avec: Sushma Sharma , Ziqing Kong , Shaodong Jia , Phong Tran , Anna Karin Nilsson ,

Ribonucleotides in mitochondrial DNA.

FEBS letters

Avec: Paulina H Wanrooij ,

A geographically matched control population efficiently limits the number of candidate disease-causing variants in an unbiased whole-genome analysis.

PloS one

Avec: Matilda Rentoft , Daniel Svensson , Andreas Sjödin , Pall I Olason , Olle Sjöström , Carin Nylander , Pia Osterman , Rickard Sjögren , Sergiu Netotea , Carl Wibom , Kristina Cederquist , Johan Trygg , Beatrice S Melin , Erik Johansson

High density of unrepaired genomic ribonucleotides leads to Topoisomerase 1-mediated severe growth defects in absence of ribonucleotide reductase.

Nucleic acids research

Avec: Susana M Cerritelli , Jaime Iranzo , Sushma Sharma , Robert J Crouch , David Tollervey , Aziz El Hage

SAMHD1 Limits the Efficacy of Forodesine in Leukemia by Protecting Cells against the Cytotoxicity of dGTP.

Cell reports

Avec: Tamara Davenne , Jenny Klintman , Sushma Sharma , Rachel E Rigby , Henry T W Blest , Chiara Cursi , Anne Bridgeman , Bernadeta Dadonaite , Kim De Keersmaecker , Peter Hillmen , Anna Schuh , Jan Rehwinkel

dNTP concentrations do not increase in mammalian cells in response to DNA damage.

Cell metabolism

Avec: Biswajit Das , Pradeep Mishra , Praveen Pandey , Sushma Sharma ,

The absence of the catalytic domains of Saccharomyces cerevisiae DNA polymerase ϵ strongly reduces DNA replication fidelity.

Nucleic acids research

Avec: Marta A Garbacz , Phillip B Cox , Sushma Sharma , Scott A Lujan , Thomas A Kunkel

A genetic screen pinpoints ribonucleotide reductase residues that sustain dNTP homeostasis and specifies a highly mutagenic type of dNTP imbalance.

Nucleic acids research

Avec: Tobias T Schmidt , Sushma Sharma , Gloria X Reyes , Kerstin Gries , Maike Gross , Boyu Zhao , Jui-Hung Yuan , Rebecca Wade , Hans Hombauer

Dinucleotide Degradation by REXO2 Maintains Promoter Specificity in Mammalian Mitochondria.

Molecular cell

Avec: Thomas J Nicholls , Henrik Spåhr , Shan Jiang , Stefan J Siira , Camilla Koolmeister , Sushma Sharma , Johanna H K Kauppila , Min Jiang , Volkhard Kaever , Oliver Rackham , Maria Falkenberg , Aleksandra Filipovska , Nils-Göran Larsson , Claes M Gustafsson

Mec1 Is Activated at the Onset of Normal S Phase by Low-dNTP Pools Impeding DNA Replication.

Molecular cell

Avec: Romain Forey , Ana Poveda , Sushma Sharma , Antoine Barthe , Ismael Padioleau , Claire Renard , Robin Lambert , Magdalena Skrzypczak , Krzysztof Ginalski , Armelle Lengronne , Benjamin Pardo , Philippe Pasero

Developmental signals control chromosome segregation fidelity during pluripotency and neurogenesis by modulating replicative stress.

Nature communications

Avec: Anchel de Jaime-Soguero , Janina Hattemer , Anja Bufe , Alexander Haas , Jeroen van den Berg , Vincent van Batenburg , Biswajit Das , Barbara di Marco , Stefania Androulaki , Nicolas Böhly , Jonathan J M Landry , Brigitte Schoell , Viviane S Rosa , Laura Villacorta , Yagmur Baskan , Marleen Trapp , Vladimir Benes , Marta Shahbazi , Anna Jauch , Ulrike Engel , Annarita Patrizi , Rocio Sotillo , Alexander van Oudenaarden , Josephine Bageritz , Julieta Alfonso , Holger Bastians , Sergio P Acebrón

[SAMHD1 acts at stalled replication forks to prevent interferon induction].

Comptes rendus biologies

Avec: F Coquel , M J Silva , H Técher , K Zadorozhny , S Sharma , J Nieminuszczy , C Mettling , E Dardillac , A Barthe , A L Schmitz , A Promonet , A Cribier , A Sarrazin , W Niedzwiedz , B Lopez , V Costanzo , L Krejci , A Chabes , M Benkirane , Y L Lin , P Pasero

The Journal of biological chemistry

Avec: Phong Tran , Paulina H Wanrooij , Paolo Lorenzon , Sushma Sharma , Lars Thelander , Anna Karin Nilsson , Anna-Karin Olofsson , Paolo Medini , Jonas von Hofsten , Per Stål ,

Inactivation of folylpolyglutamate synthetase Met7 results in genome instability driven by an increased dUTP/dTTP ratio.

Nucleic acids research

Avec: Tobias T Schmidt , Sushma Sharma , Gloria X Reyes , Anna Kolodziejczak , Tina Wagner , Brian Luke , Anders Hofer , Hans Hombauer

Chl1 helicase controls replication fork progression by regulating dNTP pools.

Life science alliance

Avec: Amandine Batté , Sophie C van der Horst , Mireille Tittel-Elmer , Su Ming Sun , Sushma Sharma , Jolanda van Leeuwen , Haico van Attikum

Increased contribution of DNA polymerase delta to the leading strand replication in yeast with an impaired CMG helicase complex.

DNA repair

Avec: Michal Dmowski , Malgorzata Jedrychowska , Karolina Makiela-Dzbenska , Milena Denkiewicz-Kruk , Sushma Sharma , Hiroyuki Araki , Iwona J Fijalkowska

Isocratic HPLC analysis for the simultaneous determination of dNTPs, rNTPs and ADP in biological samples.

Nucleic acids research

Avec: Farahnaz Ranjbarian , Sushma Sharma , Giulia Falappa , Walter Taruschio , Anders Hofer

Réseau de co-auteurs

Sushma Sharma 17 collaborations

Paulina H Wanrooij 4 collaborations

Phong Tran 4 collaborations

Anna Karin Nilsson 4 collaborations

Danielle L Watt 2 collaborations

Pradeep Mishra 2 collaborations

Michal Dmowski 2 collaborations

Karolina Makiela-Dzbenska 2 collaborations

Iwona J Fijalkowska 2 collaborations

Biswajit Das 2 collaborations

Tobias T Schmidt 2 collaborations

Gloria X Reyes 2 collaborations

Hans Hombauer 2 collaborations

Anders Hofer 2 collaborations

Liam J Thompson 1 collaboration

Gustavo Carvalho 1 collaboration

Katrin Kreisel 1 collaboration

Clara Navarrete 1 collaboration

Anna-Lena Feldberg 1 collaboration

Martin K M Engqvist 1 collaboration

Anders R Clausen 1 collaboration

Xuanxuan Xing 1 collaboration

Daniel P Kane 1 collaboration

Chelsea R Bulock 1 collaboration

Elizabeth A Moore 1 collaboration

Polina V Shcherbakova 1 collaboration

Leonard G Williams 1 collaboration

Roman Moskalenko 1 collaboration

Pernilla Andersson 1 collaboration

Anders Bergh 1 collaboration

Zachary F Pursell 1 collaboration

Ziqing Kong 1 collaboration

Shaodong Jia 1 collaboration

Matilda Rentoft 1 collaboration

Daniel Svensson 1 collaboration

Andreas Sjödin 1 collaboration

Pall I Olason 1 collaboration

Olle Sjöström 1 collaboration

Carin Nylander 1 collaboration

Pia Osterman 1 collaboration

Rickard Sjögren 1 collaboration

Sergiu Netotea 1 collaboration

Carl Wibom 1 collaboration

Kristina Cederquist 1 collaboration

Johan Trygg 1 collaboration

Beatrice S Melin 1 collaboration

Erik Johansson 1 collaboration

Susana M Cerritelli 1 collaboration

Jaime Iranzo 1 collaboration

Robert J Crouch 1 collaboration

David Tollervey 1 collaboration

Aziz El Hage 1 collaboration

Tamara Davenne 1 collaboration

Jenny Klintman 1 collaboration

Rachel E Rigby 1 collaboration

Henry T W Blest 1 collaboration

Chiara Cursi 1 collaboration

Anne Bridgeman 1 collaboration

Bernadeta Dadonaite 1 collaboration

Kim De Keersmaecker 1 collaboration

Peter Hillmen 1 collaboration

Anna Schuh 1 collaboration

Jan Rehwinkel 1 collaboration

Praveen Pandey 1 collaboration

Marta A Garbacz 1 collaboration

Phillip B Cox 1 collaboration

Scott A Lujan 1 collaboration

Thomas A Kunkel 1 collaboration

Kerstin Gries 1 collaboration

Maike Gross 1 collaboration

Boyu Zhao 1 collaboration

Jui-Hung Yuan 1 collaboration

Rebecca Wade 1 collaboration

Thomas J Nicholls 1 collaboration

Henrik Spåhr 1 collaboration

Shan Jiang 1 collaboration

Stefan J Siira 1 collaboration

Camilla Koolmeister 1 collaboration

Johanna H K Kauppila 1 collaboration

Min Jiang 1 collaboration

Volkhard Kaever 1 collaboration

Oliver Rackham 1 collaboration

Maria Falkenberg 1 collaboration

Aleksandra Filipovska 1 collaboration

Nils-Göran Larsson 1 collaboration

Claes M Gustafsson 1 collaboration

Romain Forey 1 collaboration

Ana Poveda 1 collaboration

Antoine Barthe 1 collaboration

Ismael Padioleau 1 collaboration

Claire Renard 1 collaboration

Robin Lambert 1 collaboration

Magdalena Skrzypczak 1 collaboration

Krzysztof Ginalski 1 collaboration

Armelle Lengronne 1 collaboration

Benjamin Pardo 1 collaboration

Philippe Pasero 1 collaboration

Anchel de Jaime-Soguero 1 collaboration

Janina Hattemer 1 collaboration

Anja Bufe 1 collaboration

Alexander Haas 1 collaboration

Jeroen van den Berg 1 collaboration

Vincent van Batenburg 1 collaboration

Barbara di Marco 1 collaboration

Stefania Androulaki 1 collaboration

Nicolas Böhly 1 collaboration

Jonathan J M Landry 1 collaboration

Brigitte Schoell 1 collaboration

Viviane S Rosa 1 collaboration

Laura Villacorta 1 collaboration

Yagmur Baskan 1 collaboration

Marleen Trapp 1 collaboration

Vladimir Benes 1 collaboration

Marta Shahbazi 1 collaboration

Anna Jauch 1 collaboration

Ulrike Engel 1 collaboration

Annarita Patrizi 1 collaboration

Rocio Sotillo 1 collaboration

Alexander van Oudenaarden 1 collaboration

Josephine Bageritz 1 collaboration

Julieta Alfonso 1 collaboration

Holger Bastians 1 collaboration

Sergio P Acebrón 1 collaboration

F Coquel 1 collaboration

M J Silva 1 collaboration

H Técher 1 collaboration

K Zadorozhny 1 collaboration

S Sharma 1 collaboration

J Nieminuszczy 1 collaboration

C Mettling 1 collaboration

E Dardillac 1 collaboration

A Barthe 1 collaboration

A L Schmitz 1 collaboration

A Promonet 1 collaboration

A Cribier 1 collaboration

A Sarrazin 1 collaboration

W Niedzwiedz 1 collaboration

B Lopez 1 collaboration

V Costanzo 1 collaboration

L Krejci 1 collaboration

A Chabes 1 collaboration

M Benkirane 1 collaboration

Y L Lin 1 collaboration

P Pasero 1 collaboration

Paolo Lorenzon 1 collaboration

Lars Thelander 1 collaboration

Anna-Karin Olofsson 1 collaboration

Paolo Medini 1 collaboration

Jonas von Hofsten 1 collaboration

Per Stål 1 collaboration

Anna Kolodziejczak 1 collaboration

Tina Wagner 1 collaboration

Brian Luke 1 collaboration

Amandine Batté 1 collaboration

Sophie C van der Horst 1 collaboration

Mireille Tittel-Elmer 1 collaboration

Su Ming Sun 1 collaboration

Jolanda van Leeuwen 1 collaboration

Haico van Attikum 1 collaboration

Malgorzata Jedrychowska 1 collaboration

Milena Denkiewicz-Kruk 1 collaboration

Hiroyuki Araki 1 collaboration

Farahnaz Ranjbarian 1 collaboration

Giulia Falappa 1 collaboration

Walter Taruschio 1 collaboration