Antonio Laghezza

Affiliations

Dipartimento di Farmacia-Scienze del Farmaco-University of Bari "Aldo Moro", Via E. Orabona 4, 70125 Bari, Italy.

ORCID: 0000-0001-6221-6155

Publications (28)

Natural Compounds for the Prevention and Treatment of Cardiovascular and Neurodegenerative Diseases.

Foods (Basel, Switzerland)

Avec: Rosalba Leuci , Leonardo Brunetti , Viviana Poliseno , Fulvio Loiodice , Paolo Tortorella , Luca Piemontese

A Series of Ferulic Acid Amides Reveals Unexpected Peroxiredoxin 1 Inhibitory Activity with in vivo Antidiabetic and Hypolipidemic Effects.

ChemMedChem

Avec: Sabina Yasmin , Carmen Cerchia , Vishnu Nayak Badavath , Fabrizio Dal Piaz , Susanta K Mondal , Özlem Atlı , Merve Baysal , Sankaran Vadivelan , S Shankar , Mohd Usman Mohd Siddique , Ashok Kumar Pattnaik , Ravi Pratap Singh , Fulvio Loiodice , Venkatesan Jayaprakash , Antonio Lavecchia

New Approaches to Cancer Therapy: Combining Fatty Acid Amide Hydrolase (FAAH) Inhibition with Peroxisome Proliferator-Activated Receptors (PPARs) Activation.

Journal of medicinal chemistry

Avec: Leonardo Brunetti , Fulvio Loiodice , Luca Piemontese , Paolo Tortorella ,

A Review of Recent Patents (2016-2019) on Plant Food Supplements with Potential Application in the Treatment of Neurodegenerative and Metabolic Disorders.

Recent patents on food, nutrition & agriculture

Avec: Rosalba Leuci , Leonardo Brunetti , Paolo Tortorella , Fulvio Loiodice , Luca Piemontese

Virtual screening identification and chemical optimization of substituted 2-arylbenzimidazoles as new non-zinc-binding MMP-2 inhibitors.

Bioorganic & medicinal chemistry

Avec: Grazia Luisi , Alessia Caradonna , Antonella Di Pizio , Luca Piemontese , Fulvio Loiodice , Mariangela Agamennone , Paolo Tortorella

Novel Phenyldiazenyl Fibrate Analogues as PPAR α/γ/δ Pan-Agonists for the Amelioration of Metabolic Syndrome.

ACS medicinal chemistry letters

Avec: Letizia Giampietro , Carmen Cerchia , Rosalba Florio , Lucia Recinella , Fabio Capone , Alessandra Ammazzalorso , Isabella Bruno , Barbara De Filippis , Marialuigia Fantacuzzi , Claudio Ferrante , Cristina Maccallini , Paolo Tortorella , Fabio Verginelli , Luigi Brunetti , Alessandro Cama , Rosa Amoroso , Fulvio Loiodice , Antonio Lavecchia

Derivatives of Tenuazonic Acid as Potential New Multi-Target Anti-Alzheimer's Disease Agents.

Biomolecules

Avec: Viviana Poliseno , Sílvia Chaves , Leonardo Brunetti , Fulvio Loiodice , Antonio Carrieri , Paolo Tortorella , João D Magalhães , Sandra M Cardoso , M Amélia Santos , Luca Piemontese

Novel Phenothiazine/Donepezil-like Hybrids Endowed with Antioxidant Activity for a Multi-Target Approach to the Therapy of Alzheimer's Disease.

Antioxidants (Basel, Switzerland)

Avec: Alessia Carocci , Alexia Barbarossa , Rosalba Leuci , Antonio Carrieri , Leonardo Brunetti , Marco Catto , Francesco Limongelli , Sílvia Chaves , Paolo Tortorella , Cosimo Damiano Altomare , Maria Amélia Santos , Fulvio Loiodice , Luca Piemontese

Synthesis and in vitro cytotoxicity of benzoxazole-based PPARα/γ antagonists in colorectal cancer cell lines.

Archiv der Pharmazie

Avec: Nazaret Moreno-Rodríguez , Carmen Cerchia , Darina V Sokolova , Tatiana S Spirina , Barbara De Filippis , Virgilio Romanelli , Rocío Recio , Inmaculada Fernández , Fulvio Loiodice , Vadim S Pokrovsky , Alessandra Ammazzalorso , Antonio Lavecchia

Sulfonimide and Amide Derivatives as Novel PPARα Antagonists: Synthesis, Antiproliferative Activity, and Docking Studies.

ACS medicinal chemistry letters

Avec: Alessandra Ammazzalorso , Isabella Bruno , Rosalba Florio , Laura De Lellis , Carmen Cerchia , Barbara De Filippis , Marialuigia Fantacuzzi , Letizia Giampietro , Cristina Maccallini , Paolo Tortorella , Serena Veschi , Fulvio Loiodice , Antonio Lavecchia , Alessandro Cama , Rosa Amoroso

An update about the crucial role of stereochemistry on the effects of Peroxisome Proliferator-Activated Receptor ligands.

European journal of medicinal chemistry

Avec: Luca Piemontese , Paolo Tortorella , Fulvio Loiodice

(2-Aminobenzothiazole)-Methyl-1,1-Bisphosphonic Acids: Targeting Matrix Metalloproteinase 13 Inhibition to the Bone.

Pharmaceuticals (Basel, Switzerland)

Avec: Luca Piemontese , Leonardo Brunetti , Alessia Caradonna , Mariangela Agamennone , Fulvio Loiodice , Paolo Tortorella

Development of novel phenoxyalkylpiperidines as high-affinity Sigma-1 (σ

European journal of medicinal chemistry

Avec: Francesca S Abatematteo , Philip D Mosier , Mauro Niso , Leonardo Brunetti , Francesco Berardi , Fulvio Loiodice , Marialessandra Contino , Benjamin Delprat , Tangui Maurice , Carmen Abate

A New Series of Aryloxyacetic Acids Endowed with Multi-Target Activity towards Peroxisome Proliferator-Activated Receptors (PPARs), Fatty Acid Amide Hydrolase (FAAH), and Acetylcholinesterase (AChE).

Molecules (Basel, Switzerland)

Avec: Rosalba Leuci , Leonardo Brunetti , Luca Piemontese , Antonio Carrieri , Leonardo Pisani , Paolo Tortorella , Marco Catto , Fulvio Loiodice

A New Antidiabetic Agent Showing Short- and Long-Term Effects Due to Peroxisome Proliferator-Activated Receptor Alpha/Gamma Dual Agonism and Mitochondrial Pyruvate Carrier Inhibition.

Journal of medicinal chemistry

Avec: Carmen Cerchia , Massimo Genovese , Rosalba Leuci , Erica Pranzini , Alice Santi , Leonardo Brunetti , Luca Piemontese , Paolo Tortorella , Abanish Biswas , Ravi Pratap Singh , Suhas Tambe , Sudeep Ca , Ashok Kumar Pattnaik , Venkatesan Jayaprakash , Paolo Paoli , Antonio Lavecchia , Fulvio Loiodice

A chemical modification of a peroxisome proliferator-activated receptor pan agonist produced a shift to a new dual alpha/gamma partial agonist endowed with mitochondrial pyruvate carrier inhibition and antidiabetic properties.

European journal of medicinal chemistry

Avec: Carmen Cerchia , Massimo Genovese , Roberta Montanari , Davide Capelli , Judith Wackerlig , Stefan Simic , Emanuele Falbo , Lucia Pecora , Rosalba Leuci , Leonardo Brunetti , Luca Piemontese , Paolo Tortorella , Abanish Biswas , Ravi Pratap Singh , Suhas Tambe , C A Sudeep , Ashok Kumar Pattnaik , Venkatesan Jayaprakash , Paolo Paoli , Antonio Lavecchia , Fulvio Loiodice

Bone-Seeking Matrix Metalloproteinase Inhibitors for the Treatment of Skeletal Malignancy.

Pharmaceuticals (Basel, Switzerland)

Avec: Luca Piemontese , Leonardo Brunetti , Alessia Caradonna , Mariangela Agamennone , Antonella Di Pizio , Giorgio Pochetti , Roberta Montanari , Davide Capelli , Marilena Tauro , Fulvio Loiodice , Paolo Tortorella

Discovery of 7-aminophenanthridin-6-one as a new scaffold for matrix metalloproteinase inhibitors with multitarget neuroprotective activity.

European journal of medicinal chemistry

Avec: Damiano Rocchi , Cristina Blázquez-Barbadillo , Mariangela Agamennone , Paolo Tortorella , David Vicente-Zurdo , Noelia Rosales-Conrado , Paula Moyano , Javier Del Pino , Juan F González , J Carlos Menéndez

Beyond the Canonical Endocannabinoid System. A Screening of PPAR Ligands as FAAH Inhibitors.

International journal of molecular sciences

Avec: Leonardo Brunetti , Antonio Carrieri , Luca Piemontese , Paolo Tortorella , Fulvio Loiodice ,

A chemoinformatics search for peroxisome proliferator-activated receptors ligands revealed a new pan-agonist able to reduce lipid accumulation and improve insulin sensitivity.

European journal of medicinal chemistry

Avec: Sabina Sblano , Carmen Cerchia , Luca Piemontese , Leonardo Brunetti , Rosalba Leuci , Federica Gilardi , Aurelien Thomas , Massimo Genovese , Alice Santi , Paolo Tortorella , Paolo Paoli , Antonio Lavecchia , Fulvio Loiodice

Cisplatin and zoledronic acid: two drugs combined in a Pt(II) complex with potential antitumor activity towards bone tumors and metastases.

Dalton transactions (Cambridge, England : 2003)

Avec: Alessandra Barbanente , Nicoletta Ditaranto , Paolo Tortorella , Francesco P Intini , Concetta Pacifico , Giovanni Natile , Nicola Margiotta

Rivastigmine structure-based hybrids as potential multi-target anti-Alzheimer's drug candidates.

Bioorganic chemistry

Avec: Rosalba Leuci , Stefan Simic , Antonio Carrieri , Sílvia Chaves , Gabriella La Spada , Leonardo Brunetti , Paolo Tortorella , Fulvio Loiodice , Marco Catto , M Amélia Santos , Vincenzo Tufarelli , Judith Wackerlig , Luca Piemontese

Synthesis of novel benzothiazole amides: Evaluation of PPAR activity and anti-proliferative effects in paraganglioma, pancreatic and colorectal cancer cell lines.

Bioorganic & medicinal chemistry letters

Avec: Alessandra Ammazzalorso , Laura De Lellis , Rosalba Florio , Barbara De Filippis , Marialuigia Fantacuzzi , Letizia Giampietro , Cristina Maccallini , Paolo Tortorella , Serena Veschi , Fulvio Loiodice , Alessandro Cama , Rosa Amoroso

Thiazolidinedione "Magic Bullets" Simultaneously Targeting PPARγ and HDACs: Design, Synthesis, and Investigations of their

Journal of medicinal chemistry

Avec: Kalpana Tilekar , Jessica D Hess , Neha Upadhyay , Alessandra Lo Bianco , Markus Schweipert , Fulvio Loiodice , Franz-Josef Meyer-Almes , Renato J Aguilera , Antonio Lavecchia , Ramaa C S

Structure-based design of novel donepezil-like hybrids for a multi-target approach to the therapy of Alzheimer's disease.

European journal of medicinal chemistry

Avec: Leonardo Brunetti , Rosalba Leuci , Antonio Carrieri , Marco Catto , Sara Occhineri , Giuseppe Vinci , Lucia Gambacorta , Hanna Baltrukevich , Sílvia Chaves , Cosimo Damiano Altomare , Paolo Tortorella , M Amélia Santos , Fulvio Loiodice , Luca Piemontese

AMALPHI: A Machine Learning Platform for Predicting Drug-Induced PhospholIpidosis.

Molecular pharmaceutics

Avec: Maria Cristina Lomuscio , Carmen Abate , Domenico Alberga , Nicola Corriero , Nicola Antonio Colabufo , Michele Saviano , Pietro Delre , Giuseppe Felice Mangiatordi

Development of

Journal of medicinal chemistry

Avec: Francesca Intranuovo , Leonardo Brunetti , Pietro DelRe , Giuseppe Felice Mangiatordi , Angela Stefanachi , Mauro Niso , Francesco Leonetti , Fulvio Loiodice , Alessia Ligresti , Magdalena Kostrzewa , Jose Brea , Maria Isabel Loza , Eddy Sotelo , Michele Saviano , Nicola Antonio Colabufo , Chiara Riganti , Carmen Abate , Marialessandra Contino

Biological Screening and Crystallographic Studies of Hydroxy γ-Lactone Derivatives to Investigate PPARγ Phosphorylation Inhibition.

Biomolecules

Avec: Davide Capelli , Giulia Cazzaniga , Matteo Mori , Fulvio Loiodice , Martina Quaglia , Elisa Negro , Fiorella Meneghetti , Stefania Villa , Roberta Montanari

Réseau de co-auteurs

Fulvio Loiodice 25 collaborations

Paolo Tortorella 21 collaborations

Leonardo Brunetti 16 collaborations

Luca Piemontese 16 collaborations

Rosalba Leuci 9 collaborations

Antonio Lavecchia 8 collaborations

Carmen Cerchia 7 collaborations

Antonio Carrieri 6 collaborations

Mariangela Agamennone 4 collaborations

Alessandra Ammazzalorso 4 collaborations

Barbara De Filippis 4 collaborations

Sílvia Chaves 4 collaborations

Marco Catto 4 collaborations

Ashok Kumar Pattnaik 3 collaborations

Ravi Pratap Singh 3 collaborations

Venkatesan Jayaprakash 3 collaborations

Alessia Caradonna 3 collaborations

Letizia Giampietro 3 collaborations

Rosalba Florio 3 collaborations

Marialuigia Fantacuzzi 3 collaborations

Cristina Maccallini 3 collaborations

Alessandro Cama 3 collaborations

Rosa Amoroso 3 collaborations

M Amélia Santos 3 collaborations

Carmen Abate 3 collaborations

Massimo Genovese 3 collaborations

Paolo Paoli 3 collaborations

Roberta Montanari 3 collaborations

Davide Capelli 3 collaborations

Viviana Poliseno 2 collaborations

Antonella Di Pizio 2 collaborations

Isabella Bruno 2 collaborations

Cosimo Damiano Altomare 2 collaborations

Laura De Lellis 2 collaborations

Serena Veschi 2 collaborations

Mauro Niso 2 collaborations

Marialessandra Contino 2 collaborations

Alice Santi 2 collaborations

Abanish Biswas 2 collaborations

Suhas Tambe 2 collaborations

Judith Wackerlig 2 collaborations

Stefan Simic 2 collaborations

Nicola Antonio Colabufo 2 collaborations

Michele Saviano 2 collaborations

Giuseppe Felice Mangiatordi 2 collaborations

Sabina Yasmin 1 collaboration

Vishnu Nayak Badavath 1 collaboration

Fabrizio Dal Piaz 1 collaboration

Susanta K Mondal 1 collaboration

Özlem Atlı 1 collaboration

Merve Baysal 1 collaboration

Sankaran Vadivelan 1 collaboration

S Shankar 1 collaboration

Mohd Usman Mohd Siddique 1 collaboration

Grazia Luisi 1 collaboration

Lucia Recinella 1 collaboration

Fabio Capone 1 collaboration

Claudio Ferrante 1 collaboration

Fabio Verginelli 1 collaboration

Luigi Brunetti 1 collaboration

João D Magalhães 1 collaboration

Sandra M Cardoso 1 collaboration

Alessia Carocci 1 collaboration

Alexia Barbarossa 1 collaboration

Francesco Limongelli 1 collaboration

Maria Amélia Santos 1 collaboration

Nazaret Moreno-Rodríguez 1 collaboration

Darina V Sokolova 1 collaboration

Tatiana S Spirina 1 collaboration

Virgilio Romanelli 1 collaboration

Rocío Recio 1 collaboration

Inmaculada Fernández 1 collaboration

Vadim S Pokrovsky 1 collaboration

Francesca S Abatematteo 1 collaboration

Philip D Mosier 1 collaboration

Francesco Berardi 1 collaboration

Benjamin Delprat 1 collaboration

Tangui Maurice 1 collaboration

Leonardo Pisani 1 collaboration

Erica Pranzini 1 collaboration

Sudeep Ca 1 collaboration

Emanuele Falbo 1 collaboration

Lucia Pecora 1 collaboration

C A Sudeep 1 collaboration

Giorgio Pochetti 1 collaboration

Marilena Tauro 1 collaboration

Damiano Rocchi 1 collaboration

Cristina Blázquez-Barbadillo 1 collaboration

David Vicente-Zurdo 1 collaboration

Noelia Rosales-Conrado 1 collaboration

Paula Moyano 1 collaboration

Javier Del Pino 1 collaboration

Juan F González 1 collaboration

J Carlos Menéndez 1 collaboration

Sabina Sblano 1 collaboration

Federica Gilardi 1 collaboration

Aurelien Thomas 1 collaboration

Alessandra Barbanente 1 collaboration

Nicoletta Ditaranto 1 collaboration

Francesco P Intini 1 collaboration

Concetta Pacifico 1 collaboration

Giovanni Natile 1 collaboration

Nicola Margiotta 1 collaboration

Gabriella La Spada 1 collaboration

Vincenzo Tufarelli 1 collaboration

Kalpana Tilekar 1 collaboration

Jessica D Hess 1 collaboration

Neha Upadhyay 1 collaboration

Alessandra Lo Bianco 1 collaboration

Markus Schweipert 1 collaboration

Franz-Josef Meyer-Almes 1 collaboration

Renato J Aguilera 1 collaboration

Ramaa C S 1 collaboration

Sara Occhineri 1 collaboration

Giuseppe Vinci 1 collaboration

Lucia Gambacorta 1 collaboration

Hanna Baltrukevich 1 collaboration

Maria Cristina Lomuscio 1 collaboration

Domenico Alberga 1 collaboration

Nicola Corriero 1 collaboration

Pietro Delre 1 collaboration

Francesca Intranuovo 1 collaboration

Pietro DelRe 1 collaboration

Angela Stefanachi 1 collaboration

Francesco Leonetti 1 collaboration

Alessia Ligresti 1 collaboration

Magdalena Kostrzewa 1 collaboration

Jose Brea 1 collaboration

Maria Isabel Loza 1 collaboration

Eddy Sotelo 1 collaboration

Chiara Riganti 1 collaboration

Giulia Cazzaniga 1 collaboration

Matteo Mori 1 collaboration

Martina Quaglia 1 collaboration

Elisa Negro 1 collaboration

Fiorella Meneghetti 1 collaboration

Stefania Villa 1 collaboration